LumixyL
速
Brightening System
Confidential Property of Envy Medical, Inc.
速 LUMIXYL
VIDEO
Confidential Property of Envy Medical, Inc.
A GLOBAL BRAND, LUMIXYL速 IS THE FIRST US PROFESSIONAL BRAND IN THE TOP FOUR GLOBAL SKIN CARE MARKETS (US, JAPAN, BRAZIL AND CHINA)
Existing Distribution Forthcoming Product Launches
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PRIMARY INDICATIONS Melasma consists of dark brown, sharply marginated, roughly symmetric patches of hyperpigmentation on the face.
Post inflammatory Hyperpigmentation occurs after injury (e.g., cuts and burns) or other causes of inflammation (e.g., acne)..
Solar Lentigos are flat, tan-to-brown oval spots. They are commonly due to chronic sun exposure..
Source: The Merck Manual (www.merck.com)
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WHY WE DEVELOPED
® LUMIXYL
While employed at Obagi Medical Products, we noted the following about the hydroquinone (HQ) based Obagi NuDerm® System:
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HQ Safety Concerns: HQ can cause irritant and allergic contact dermatitis, exogenous ochronosis, PIH and hypopigmentation.
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Tolerability Issues: 20 - 30% of patients who begin using the Nu-Derm system will discontinue doing so within the first two weeks due to severe skin irritation.
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Barriers to Entry: HQ products require a new drug application (NDA) in Europe, China and other select countries.
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Old formulas: The Obagi Nu-Derm formulas are over 15 years old and contain parabens, artificial colors, fragrances and known irritants such as sodium laurel sulfate.
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LUMIXYL® PRODUCT HIGHLIGHTS •
Safe for all skin types: In-use clinical testing results demonstrate that Lumixyl products are safe for use with all Fitzpatrick Phototypes.
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Dermatologist tested: Repeated Insult Patch Testing (RIPT) shows that Lumixyl products do not cause irritation.
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Allergy tested: Repeated Insult Patch Testing shows that Lumixyl products do not cause allergic reaction.
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Paraben-free: All Lumixyl products are free from potentially harmful preservatives.
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No artificial color: All Lumixyl products are free of artificial dyes.
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No prescription needed: Lumixyl products are classified as cosmetics or overthe counter products.
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COMPETITIVE ADVANTAGES • Lumixyl® does not contain hydroquinone - Instead, Lumixyl makes use of a proprietary Stanford University developed technology called decapeptide-12. Unlike hydroquinone, decapeptide-12 does not cause irritant contact dermatitis, post inflammatory hyperpigmentation (PIH), hypopigmentation,
ochronosis or allergic contact dermatitis. • No down-time to patient - Lumixyl patients do not go through an “ugly” phase and can continue their normal work and home routine. Other competitive professional skin care products can cause moderate to severe irritation, skin redness and peeling which can interfere with the patient’s daily routine. • Minimizes pores - Use of the Lumixyl system minimizes pores within hours. • Smoothens rough skin - Use of the Lumixyl system dramatically improves skin texture within the first 5 – 7 days. Lumixyl users enjoy more even looking makeup as a result!
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CLINICAL SAFETY REPEATED INSULT PATCH TEST
• Tested 0.01% (recommended dose) and 0.1% (10X recommended dose) decapeptide-12 • 150 subject test panel • Semi-occlusive patch • 6 week duration • RESULT: no reaction observed in the induction and challenge phases for 0.01% and 0.1% decapeptide-12
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BACKED BY SCIENCE 6 Publications (decapeptide-12 and finished products) Abu Ubeid A, Zhao L, Wang Y, Hantash BM. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. The Journal of Investigative Dermatology. Sep 2009;129(9):2242-2249. Hantash BM, Jimenez F. A split-face, double-blind, randomized and placebo-controlled pilot evaluation of a novel oligopeptide for the treatment of recalcitrant melasma. J Drugs Dermatol. Aug 2009;8(8):732-735. Kassim AT, Hussain M, Goldberg DJ. Open-Label Evaluation of the Skin-Brightening Efficacy of a Skin-Brightening System Using Decapeptide-12. J Cosmet Laser Ther 2012;14:117-21. Hantash BM, Jimenez F. Treatment of mild to moderate facial melasma with the lumixyl topical brightening system. J Drugs Dermatol. May 1 2012;11(5):660-662. Ramirez SP, Carvajal AC, Salazar JC, Arroyave G, Florez AM, Echeverry HF. Open-label evaluation of a novel skin brightening system containing 0.01% decapeptide-12 in combination with 20% buffered glycolic Acid for the treatment of mild to moderate facial melasma.. J Drugs Dermatol. 2013 Jun 1;12(6):e106-10. Ashish Bhatia, Jeffrey TS Hsu, Basil Hantash. Combined Topical Delivery and Dermalinfusion of Decapeptide-12 Accelerates Resolution of Post-Inflammatory Hyperpigmentation in Skin of Color. J Drugs Dermatol. Jan 2014;13(1):84-85.
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THE
® LUMIXYL
TECHNOLOGY
Hydroquinone
Lumixyl® (Decapeptide-12)
Chemical
Synthetic Peptide
Tyrosinase Inhibitor
Tyrosinase Inhibitor
IC50 = 700 μM
IC50 = 40 μM (17 times more potent than hydroquinone)
Competitive Inhibitor
Competitive Inhibitor
Oxidizes easily in water
Does not oxidize easily in water
Skin Irritant
No Irritation to Skin
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THE FOUR CORE PRODUCTS
Step 1 Cleanse
Step 2 Brighten
Step 3 Exfoliate
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Step 4 Protect
ACTIVE-PREP CLEANSER 6 FL OZ / 180 ML 1 | Cleanse
What does it do? •
Cleanses skin of dirt and oils
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Acidifies skin to improve penetration of decapeptide-12
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Slows melanin production with botanical antioxidants at the cellular level
Key Ingredients
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Rosmarinus Officinalis (Rosemary) Leaf Extract
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Salvia Officinalis (Sage) Leaf Extract
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Hordeum Distichon (Barley) Extract
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TOPICAL BRIGHTENING CRÈME 1 FL OZ / 30 ML 2 | Brighten
What does it do? •
Inhibits melanin production by inhibiting the tyrosinase enzyme (in melanocyte cells) that can overproduce melanin in skin
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Slows melanin production with powerful antioxidants at the cellular level
Key Ingredients •
Decapeptide-12 (proprietary tyrosinase inhibitor)
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Phenylethyl Resorcinol
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Phyllanthus Emblica Fruit Extract
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Glycyrrhiza glabra (licorice) Root Extract
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GLYCOPEEL 10 / 20 2 FL OZ / 60 ML 3 | Exfoliate
What does it do? •
Accelerates cellular turnover
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Removes hyperpigmented layers of the epidermis
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Refines skin texture
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Minimizes pores
Key Ingredients •
Glycolic Acid
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GLYCOPEEL PRODUCT COMPARISON GlycoPeel 10
GlycoPeel 20
• Light gel
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Lotion
• pH 3.6
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pH 3.1
• 10% glycolic acid
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20% glycolic acid
• 0.01% decapeptide-12
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Use every other day
• Use twice daily
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Patients with more tolerant skin types or accustomed to using tretinoin etc.
• All skin types
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MOISTURELOCK SUNSCREEN SPF 30 2 FL OZ / 60 ML 4 | Protect
What does it do? •
Provides broad spectrum sun protection
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Helps to prevent hyperpigmentation and photodamage
Key Ingredients •
8.4% Titanium Dioxide
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Symhelios 1031
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USING THE GP10 LUMIXYL速 SYSTEM This system is recommended for all skin types.
PM
PM
PM
Active-Prep Cleanser
Brightening Creme
GlycoPeel 10
apply liberally (try with Clarisonic)
apply two pumps (two pumps AM & PM)
apply thin layer (enough to cover entire face)
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MoistureLock Sunscreen apply liberally (apply before sun exposure)
USING THE GP20 LUMIXYL SYSTEM This system is recommended for more tolerant skin types; Fitzpatrick Types III and above with thicker, more oily skin.
Level 1: AM every other day Level 2: AM daily
Level 3: AM daily / PM every other day Level 4: Twice daily
Active-Prep Cleanser apply liberally (try with Clarisonic)
Brightening Creme
apply two pumps (two pumps AM & PM)
GlycoPeel 20
MoistureLock Sunscreen
apply liberally (apply before sun exposure) apply thin layer (enough to cover entire face)
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FOR BEST RESULTS, USE GP10 KIT W/ TRETINOIN
Active-Prep Cleanser apply liberally (try with Clarisonic)
Brightening Creme
apply two pumps (two pumps AM & PM)
GlycoPeel 10
Tretinoin*
apply thin layer (enough to cover entire face)
*Patients will need a doctor’s prescription to obtain tretinoin from their local pharmacy. Confidential Property of Envy Medical, Inc.
MoistureLock Sunscreen apply liberally (apply before sun exposure)
MANAGE EXPECTATIONS: TOLERABILITY •
Patients may experience irritation and redness 2 - 3 days after beginning use of the system
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Patients' skin may begin peeling one week after beginning use of the system
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Accelerated cellular turnover of the skin may cause hyperpigmentation to temporarily appear worse as hyperpigmented cells are brought to the surface of the skin faster than usual
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Hyperpigmentation will begin to appear diminished as hyperpigmented cells are exfoliated away
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MANAGE EXPECTATIONS: EFFICACY When might the typical patient expect to see visible results? •
Depends on skin type, depth and degree of hyperpigmentation.
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If the system is used properly, some patients can begin seeing improvement in their skin in as
little as 2 to 3 weeks. •
However, most patients will begin seeing improvements at 8 to 12 weeks. The 8 to 12 week timeframe should be the expectation conveyed to the patient.
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MY LUMIXYL速 EXPERIENCE
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RESULTS IN 6 WEEKS
6 Weeks
Baseline *Individual Results May Vary
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RESULTS IN 8 WEEKS Courtesy of Dr. Andres Luque (Bogota, Colombia)
8 Weeks
Baseline *Individual Results May Vary
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RESULTS IN 12 WEEKS
Baseline
12 Weeks *Individual Results May Vary
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RESULTS IN 12 WEEKS
Baseline
12 Weeks *Individual Results May Vary
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RESULTS IN 16 WEEKS Courtesy of Dr. Sandra Ramirez (Medillin, Colombia)
Baseline
16 Weeks *Individual Results May Vary
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RESULTS IN 24 WEEKS Courtesy of Dr. David J. Goldberg
Baseline
24 Weeks *Individual Results May Vary
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IDENTIFYING THE IDEAL LUMIXYL® PATIENT • Patients with sensitive skin • Patients with skin of color • Patients no longer receiving benefit from using hydroquinone products
• Patients needing a maintenance regimen while not using hydroquinone products • Patients who are worried about using hydroquinone
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OFFER YOUR PATIENTS A COMPREHENSIVE ANTI-AGING SOLUTION Botox速: Reduce wrinkles with Botox and diminish appearance of hyperpigmentation with the Lumixyl System
Lasers: Remove deep dermal hyperpigmentation with fractional laser and maintain results with the Lumixyl System
Fillers: Erase deep lines with fillers and diminish appearance of hyperpigmentation with the Lumixyl System
Plastic Surgery: Diminish appearance of hyperpigmentation in the neck and chest with the Lumixyl System to improve appearance of breast augmentations
Confidential Property of Envy Medical, Inc.
® LUMIXYL
BRIGHTENING PADS 60 PADS
Tone | Brighten What does it do? • Helps diminish the appearance of hyperpigmentation How do you use it? • Use after SilkPeel treatments • For best results, use twice daily after cleansing with the Lumixyl Active-Prep Cleanser (step 1), before applying the Lumixyl Brightening Crème (step 2) • Use after non-ablative laser or IPL treatments
Key Ingredients • Decapeptide-12 • Ethyl Ascorbic Acid
• Glycyrrhiza Glabra (Licorice) Root Extract Confidential Property of Envy Medical, Inc.
LUMIXYL® REVITALEYES 0.5 FL OZ / 15 ML Eye Cream What does it do? • Helps diminish the appearance of dark under-eye circles, under-eye bags and periorbital fine lines and wrinkles (rhytides) How do you use it? • Apply 2 – 3 dots of Revitaleyes underneath the eyes and spread around the eye following the orbital bone. • For best results, use twice daily after cleansing with the Lumixyl ActivePrep Cleanser (step 1) • If using Revitaleyes with the Lumixyl System, apply after application of the Brightening Crème (step 2), before applying Glycopeel 10 or 20 (step 3). Key Ingredients • Decapeptide-12 • n-hydroxysuccinamide, EDTA & Chrysin • Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Bambusa Vulgaris Extract & Pisum sativum (Pea) Extract
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REAL RESULTS WITH LUMIXYL速 REVITALEYES
Baseline
2 Weeks
Baseline
2 Weeks
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TRADE MEDIA
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CONSUMER MEDIA
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CONTINUING EDUCATION: WEBINARS Envy Medical conducts quarterly webinars to provide specific training and refreshers on products and procedures. • Each webinar includes exceptional promotions for participants. • Webinars are recorded and archived for future viewing. 2015 WEBINAR SCHEDULE March 4: SilkPeel June 3: SilkPeel Body September 2: ClarityMD December 2: Lumixyl
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CONTINUING EDUCATION: ENVY UNIVERSITY •
Monthly core curriculum trainings on ClarityMD™, SilkPeel® Dermalinfusion® and Lumixyl®
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For new hire education and refreshers
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Planned format is 30 minutes
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There will be a live Q&A session following the presentation
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SilkPeel University • Library containing video and instructional resources to educate on how the maximize the benefits of your Silkpeel Dermalinfuison. • http://silkpeel.com/envy-university-professionaltraining/ • Password (all lowercase): silkpeeltraining
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MARKETING CAMPAIGNS #12Days of Brightness
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SOCIAL MEDIA We have presence on all all major social media platforms Facebook
Video
Partnership with Aesthetic Everything™ a social network for aesthetic professionals with 245,000 followers and email database contacts. Envy promotes via these networks
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CONTACT US
Education Cindy Duncan (406) 531-7151 cindy@envymedical.com Technical Questions Felipe Jimenez, Ph.D. Email: felipe@envymedical.com Customer Service Telephone: (818) 483-1708 Email: krystal@envymedical.com
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