Hepatitis C Drug- Hepcvel(Sofosbuvir/Velpatasvir) Description Of Hepcvel:
Hepcvel Combination of Sofosbuvir 400mg&Velpatasvir 100mg which is a Cipla product get approved by FDA.
The combination of sofosbuvir & Velpatasvir is highly effective in chronic hepatitis C viral infection caused by genotypes I to VI.
Hepcvel is not a curable medication; it is used for diminishing the disease progression by depleting the multiplication of virus in the body.
Hepcvel tablets are prescription medicine which is used only under the guidance of medical practitioner. Brand name : Hepcvel Ingredient : Sofosbuvir 400mg/Velpatasvir 100mg Tablet Count: 28 Tablets Company Name : Cipla
Hepcvel Tablet Uses:
Hepcvel(Sofosbuvir/Velpatasvir) used to treat Chronic Hepatitis C,a viral infection of the liver.
Hepcvel Tablet Side effects:
Headache
Fatigue
Nausea
Asthenia
Insomnia
Diarrhea
Pharmacokinetics of Hepcvel Absorption The maximal peak plasma concentration time of;
Sofosbuvir 0.5 to 1 hour
Velpatasvir 3 hours
Distribution After absorption occurs, Hepcvel get binds to human plasma protein by;
Sofosbuvir 61 to 65%
Velpatasvir >99.5%
The blood plasma ratio of Hepcvel;
Sofosbuvir: 0.7; Velpatasvir: 0.52 to 0.67
Metabolism
The metabolism of Hepcvel is occurs widely in liver
Sofosbuvir: cathepsin A, carboxyl esterase 1 or HINT1
Velpatasvir: CYP2B6, CYP2C8, or CYP3A4
Indication of Hepcvel Tablet:
Hepcvel tablets are primarily indicated for the treatment of chronic hepatitis C viral infection associated with genotype I to VI.
Hepcvel is indicated for the conditions;
Patients without cirrhosis or with compensated cirrhosis
Patients with decompensated cirrhosis
Dosage & Administration of Hepcvel: Before initiating the treatment;
Patient’s HBsAg & anti-HBc levels should be examined before starting the therapy with hepcvel tablets.
The recommended dose of Hepcvel tablets;
Hepcvel tablets are two medicine fixed dose combination consists of 400mg of sofosbuvir & 100mg of Velpatasvir.
Hepcvel is a single use tablet.
Warning & precautions
This fatal case should be occurred in the patients with HCV/HBV co infection & also who receiving anti-HCV agents but not getting anti-HBV treatment.
Before starting the treatment, patient should be tested by measuring HBsAg 7 anti-HBc counts.
Monitor the liver function test.
Initiate the HBV infection management.
Pregnancy & lactation
Hepcvel pregnancy category is B
Hepcvel with ribavirin pregnancy category is X
This combination should not be used in pregnancy period.
Breast feeding should not be recommended.
Storage
Hepcvel tablet container should be stored at temperature below 30oC.
Keep the container away from heat, moisture & light.
Missed dose
In case of missed dose condition, patients should be consult with medical adviser &
follow the instructions. Maintain the regular dosing schedule. Avoid self medication.
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