HEPCVEL-Hepatitis C Drug

Hepatitis C Drug- Hepcvel(Sofosbuvir/Velpatasvir) Description Of Hepcvel: 

Hepcvel Combination of Sofosbuvir 400mg&Velpatasvir 100mg which is a Cipla product get approved by FDA.

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The combination of sofosbuvir & Velpatasvir is highly effective in chronic hepatitis C viral infection caused by genotypes I to VI.

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Hepcvel is not a curable medication; it is used for diminishing the disease progression by depleting the multiplication of virus in the body.

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Hepcvel tablets are prescription medicine which is used only under the guidance of medical practitioner.

Brand name : Hepcvel Ingredient : Sofosbuvir 400mg/Velpatasvir 100mg Tablet Count: 28 Tablets Company Name : Cipla

Hepcvel Tablet Uses: 

Hepcvel(Sofosbuvir/Velpatasvir) used to treat Chronic Hepatitis C,a viral infection of the liver.

Hepcvel Tablet Side effects: 

Headache

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Fatigue

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Nausea

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Asthenia

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Insomnia

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Diarrhea

Pharmacokinetics of Hepcvel Absorption The maximal peak plasma concentration time of; 

Sofosbuvir 0.5 to 1 hour

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Velpatasvir 3 hours

Distribution After absorption occurs, Hepcvel get binds to human plasma protein by; 

Sofosbuvir 61 to 65%

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Velpatasvir >99.5%

The blood plasma ratio of Hepcvel; 

Sofosbuvir: 0.7; Velpatasvir: 0.52 to 0.67

Metabolism 

The metabolism of Hepcvel is occurs widely in liver

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Sofosbuvir: cathepsin A, carboxyl esterase 1 or HINT1

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Velpatasvir: CYP2B6, CYP2C8, or CYP3A4

Indication of Hepcvel Tablet: 

Hepcvel tablets are primarily indicated for the treatment of chronic hepatitis C viral infection associated with genotype I to VI.

Hepcvel is indicated for the conditions; 

Patients without cirrhosis or with compensated cirrhosis

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Patients with decompensated cirrhosis

Dosage & Administration of Hepcvel: Before initiating the treatment; 

Patient’s HBsAg & anti-HBc levels should be examined before starting the therapy with hepcvel tablets.

The recommended dose of Hepcvel tablets; 

Hepcvel tablets are two medicine fixed dose combination consists of 400mg of sofosbuvir & 100mg of Velpatasvir.

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Hepcvel is a single use tablet.

Warning & precautions

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This fatal case should be occurred in the patients with HCV/HBV co infection & also who receiving anti-HCV agents but not getting anti-HBV treatment.

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Before starting the treatment, patient should be tested by measuring HBsAg 7 anti-HBc counts.

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Monitor the liver function test.

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Initiate the HBV infection management.

Pregnancy & lactation 

Hepcvel pregnancy category is B

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Hepcvel with ribavirin pregnancy category is X

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This combination should not be used in pregnancy period.

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Breast feeding should not be recommended.

Storage 

Hepcvel tablet container should be stored at temperature below 30oC.

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Keep the container away from heat, moisture & light.

Missed dose 

In case of missed dose condition, patients should be consult with medical adviser &

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follow the instructions.

Maintain the regular dosing schedule.

Avoid self medication.

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