Wellbeing

OXIDATIVE STRESS WELLBEING AND HEALTH: ANTIAGEING AND GENERAL HEALTHCARE PASSPORT

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What is oxidative stress?

Why is it important to measure the Oxidative Stress (FORT and FORD) CR3000?

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Putting advice into action Some Basic Steps for an Effective Oxidative Stress Assessment

WHAT IS OXIDATIVE STRESS? The signs of oxidative reactions are present in our everyday life: apples turn brown, butter turns rancid, iron rusts. But what exactly is oxidative stress, what implications does it have on health and what is the reason of it?

Oxidative Stress (OS) is an imbalance between free radicals and existing antioxidant defences (AC) (for example level of Vitamin C or E in the body) Long terms effects of high oxidative stress will occur if your antioxidant status is low and free radicals levels are high and you allow this to go undetected.Oxidative stress (when FR are high and your AC are low) can affect your health and performance from mild complaints (such as the cold, respiratory conditions, aches and pains, gum disease etc) ageing, inflammation to more serious illness.

WHY IS IT IMPORTANT TO MEASURE THE OXIDATIVE STRESS (FORT AND FORD) CR3000?

OS is a silent enemy with no symptoms. A test is required to identify subjects with high free radical levels and low defences.

S ubsequently,

OS detection allows the development of intervention strategies, which can contribute to delay the progression of a disease/condition as well as to ameliorate the outcome. It will allow you to slow down ageing. If you improve your levels of antioxidants and lower your free radicals level you will decrease the chances of suffering from many illnesses and diseases, reduce the severity of symptoms and length of illness and reduce ageing and inflammation.

Therefore any health conscious individual should routinely monitor their oxidative stress state and do something to prevent OS. By increasing your Antioxidant levels via diet, namely fruit and vegetables, exercise, lifestyle and supplementation (such as Vitamin C) you will increase your defences against many conditions.

Callegari (Catellani Group) offers the public an innovative and well-established test, employed by thousands of users around the world, which reveals the level of OS and level of defences of your body in a matter of minutes. Ask you local healthcare operator for more information.

PUTTING ADVICE INTO ACTION • Maintain a well-balanced and healthful diet; drink plenty of mineral water and avoid excess of fatty, fried and processed foods.

• Eat a minimum of three or four portions of vegetables and at least three portions of fruit every day.

• Drink more tea and less coffee. Try jasmine tea or green tea after a meal.

• A single glass of red wine a day is sufficient to offer unique antioxidant benefits.

More than two glasses a day and the goodness conferred gets lost in the antinutrient effects of alcohol.

• Follow a balanced training program that emphasizes moderate but regular physical activity. Do not overdo any sport, as this will have the opposite effect, especially if you are untrained.

• Do not smoke. Avoid pollutants as much as possible.

• Keep your blood glucose, lipid profile and blood pressure under control.

• Sleep and take time to relax and enjoy the things you like doing.

• Ask a qualified health operator to recommend good quality supplementation (Vitamin, echinea etc.)

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A wide variety of fruits and vegetables, especially orange-coloured fruits/vegetables and green leafy vegetables are antioxidant rich.

• Vegetable oils, wheat germ, whole grain, seeds and nuts, egg yolk and green leafy vegetables (Vitamin E).

• Orange and red/yellow-coloured fruits/vegetables (vitamin A and carotenoids).

• Leafy greens • Organic meats such as liver, seafood, nuts and seeds (copper and selenium).

• Meat, liver, eggs and seafood (Zinc).

NOTE: It is unlikely that a standard diet will provide all

these antioxidants, but when changes in diet is not sufficient or viable the administration of a good antioxidant cocktail advised by a health professional is necessary.

The advice above is based on medical professional advice and from reviews of scientific literature. It is not intended to be a substitute for advice from a licensed health care professional.

SOME BASIC STEPS FOR AN EFFECTIVE OXIDATIVE STRESS ASSESSMENT 1. Establish Your Reference OS Value.

2. Get into the habit of measuring your OS panel routinely.

Your reference OS value is your regular OS value although this also should be checked against established normal values. To do so, record both FORD and FORT values measured at your ‘normal conditions”. This means that testing should be avoided after a heavy meal, during the administration of medication, after heavy exercise and so on. It also means that testing should be performed at the same time and conditions to properly establish what your normal value is.

Referring to the table below, monitor your reference FORT and FORD values through time and against any particular event to evaluate any changes, e.g. before, during and after drug/supplementation, before and after giving up an unhealthy habit such as smoking or after having taking up moderate exercise, lifestyle and better eating habits.

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PROFILE A:

GOOD

IDEAL/NORMAL VALUES Redox Index: 0-25 FORT < 300 FORD ≥ 1.08

Maintain your healthy lifestyle and assure that OS is kept under control If the healthcare professional rules out stress in your lifestyle, no family history of disease and a healthy lifestyle, see below for next referral.

PROFILE B:

MONITOR YOUR STATE THROUGH TIME

LATENT OS Redox Index: 25-50 FORT < 300 FORD ≤ 1.07

Suggested referral for next profiling: 5-6 months.

This is a risk condition: individuals are potentially at risk of developing disorders and premature aging.

Antioxidant defenses need to be enhanced.

• Increase consumption of fresh fruit and vegetables, legumes, whole grains and nuts. Eat a colourful variety of food, better if in season, every day.

• A qualified professional may recommend the administration of a cocktail of antioxidants daily for at least 30-40 days.

• You may be advised phytonutrient supplements, herbal preparations, botanical beverages, etc.

• Take into account potential adverse side effects of medication.

• Prefer organic foods, occasionally even fortified ones.

• Take into account current medication administered and conditions/ disorders (e.g., drug treatment such as antibiotic, oral contraceptives, non-steroidal antiinflammatory drugs (NSAIDS), corticosteroids; or in case of digestive disorders such as colitis; or during caloric restricted diet, pregnancy and inflammation).

Suggested referral for next profiling: within 2 months, especially during supplementation.

PROFILE C:

WARNING

COMPENSATED OS Redox Index: 50-58.3 300 < FORT < 330 FORD ≥ 1.08

Preventive actions and healthier habits should be adopted to reduce free radical action and prevent it becoming a potential health risk factor.

• Follow a well-balanced and regular diet, with plenty of fruit and vegetables.

• Control weight avoiding excess kilos.

• Practice regular and adequate physical activity. Avoid strenuous exercise if not properly trained.

• No smoking

• Get the sleep you need (at least 5-6 hours a night)

• Avoid excessive mentally and physically stressful situation, if possible.

Suggested referral for next profiling: 3-4 months.

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PROFILE D:

AT RISK OF OS Redox Index: 58.3-66.6 300 < FORT < 330 FORD ≤ 1.07

MONITOR YOUR STATE THROUGH TIME

Free radicals formation is border-line and the normal capacity to neutralize them is overwhelmed. This condition may progressively worsen and OS could become evident soon.

The balance should be promptly restored.

• Adopt healthier diet and lifestyles (see above) • Reduce or avoid unhealthy habits such as smoking or excessive drinking.

• Consult a medical professional for appropriate antioxidant/vitamin supplementation. It may be necessary to increase the dosage and/ or length of treatment with respects to the OS latent status.

• Choose multivitamin-mineral supplements that provide about 200-300 percent of the RDA of all the vitamins and minerals, rather than a single ‘mega doses’ for one substance only.

• Beware of negative interaction between different products and drugs.

For example St. Johns Wort should be avoided with anti-depressants.

• Fully comply with professional advise on diet, lifestyle and supplementation.

Occasional changes or supplementation will not bring about the changes required.

Suggested referral for next profiling: 1-2 months, especially during supplementation to monitor effectiveness.

PROFILE E: OS IN PROGRESS Redox Index: 66.6-100 FORT ≥ 331 0.25 < FORD < 3.00

CAUTION

Free radicals production and antioxidant power is unbalanced. In the event FORD values are normal or high, the antioxidant capacity to counteract free radical-linked damage is currently ineffective.

• Further clinical investigation is advised (example, primary screening, heart rate - BPM, BMI, inflammation markers, vitamin D deficiency etc).

• Diet and lifestyle changes are highly recommended as well as the administration of a good antioxidant(s).

• Other forms of supplements may be suggested including ergogenic aids to increase energy and muscle recovery (e.g., creatine, amino acids), fat burners to decrease body fat, N-Acetyl-Cysteine, essential fatty acids (omega 3 & 6), phytonutrients, herbs, etc.

Suggested referral for next profiling: 4-6 weeks

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Patient Name:

Birth Date:

Own Reference Value: FORT:

FORD:

ROS Value (FORT units)

AC Value (mmol/l trolox)

REDOX INDEX

Date

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