ANZUP trials – bladder

This bladder cancer trial is currently being run by ANZUP. For more information about this trial, go to the ANZUP bladder cancer trials web page: https://anzup.org.au/clinical-trials/bladder-cancer-trials/

Principal Investigator: Professor Dickon Hayne

BCG + MM

ANZUP 1301

Status: Open & recruiting

Location: Australia

Activated sites: 17

Patients recruited: 456

Patients required: Stage one: 130 / Stage two: 370

Non-muscle invasive bladder cancer is common and causes substantial suffering. It requires removal or irradiation of the bladder within five years in more than 30% of people with high-risk tumours, despite best current treatment.

Recent preliminary studies show promising results from adding mitomycin (MM), a chemotherapy drug, to current treatment with BCG (Bacillus Calmette-Guérin, a strain of modified bacteria which stimulates an immune response to early cancer cells).

This randomised trial will determine the effects of adding mitomycin on cure rates, survival, side effects and quality of life. This could potentially provide a simple and costeffective treatment for patients who suffer from this cancer.

This study is currently active and recruiting. Please speak with your doctor if this is of interest to you or someone you know.

ANZUP collaborates with the University of Sydney through the National Health and Medical Research Council Clinical Trials Centre (NHMRC CTC).

This ANZUP investigator-initiated study is being funded by Cancer Australia and the National Health and Medical Research Council. We acknowledge Omegapharm and Merck Sharp & Dohme for providing the study drugs.

Current site locations for the BCG + MM trial are:

NSW

• Concord Repatriation General Hospital • John Hunter Hospital • Nepean Hospital • Northern Cancer Institute (GenesisCare) • SAN Clinical Trials Unit • Southside Cancer Care Centre • The Tweed Hospital • Westmead Hospital

VIC

• Austin Health • Epworth HealthCare (Richmond) • Footscray Hospital • Frankston Hospital • Royal Melbourne Hospital • The Alfred Hospital

WA

• Fiona Stanley Hospital

QLD

• Redcliffe Hospital

UK

• Nottingham University Hospital