ANZUP trials – testicular

Principal Investigator:

Associate Professor Ben Tran

CLIMATE

ANZUP 1906

Status: Open & recruiting

Location: Australia wide

Planned sites: 11

Patients recruited: 39 • Patients required: 200

Testicular cancer is the most common cancer diagnosed in people aged between 15 and 39 in Western countries, however it can occur at any age. Most people diagnosed with testicular cancer will have cancer confined to the testicle, without evidence of spread to other areas of the body. These people are highly likely to be cured following surgical removal of the testicle (orchidectomy) alone, and most will not require additional chemotherapy or radiotherapy. Sometimes, a person with testicular cancer may choose to undergo preventive chemotherapy or radiotherapy, which reduces the risk of their cancer coming back; however, this may result in long-term side effects for some people.

For this reason, most people in Australia are recommended “active surveillance,” which involves regular reviews with their doctor, computerised tomography (CT) scans and blood tests, but no chemotherapy or radiotherapy.

With this approach, most will be spared from unnecessary treatment and side effects. However, a small number of these will have recurrent cancer detected during active surveillance. Reassuringly, these people are also highly likely to have a positive outcome following additional treatment.

A new blood test, micro-ribonucleic acid (miRNA), which evaluates a protein commonly found in testicular cancer is under investigation. Early studies have found that miRNA is detectable in blood samples of people who have known testicular cancer. CLIMATE is an investigator-initiated research project led by ANZUP in collaboration with the Walter and Eliza Hall Institute for Medical Research (WEHI). This study has been co-funded by the ANZUP Cancer Trials Group Discretionary Funding Initiative and WEHI.

For more information please go to the trials page on the ANZUP website:

https://anzup.org.au/clinical-trial/climate/

Active site: NSW

• Calvary Mater Newcastle

Pending sites: NSW

• Chris O’Brien Lifehouse • Southside Cancer Care Centre • St Vincent’s Hospital - Sydney • Sydney Adventist Hospital

VIC

• Austin Health • Barwon Health • Eastern Health • Epworth Healthcare • Peter MacCallum Cancer Centre

QLD

• Royal Brisbane & Women’s Hospital

Principal Investigator:

Associate Professor Peter Grimison (ANZ) P3BEP

ANZUP 1302

Status: Active & recruiting

Location: Australia wide & Internationally

Activated sites: 89

Patients recruited: 228 • Patients required: Stage 1 (150) Stage 2 (350)

The current standard practice for the treatment of germ cell tumours is the use of the chemotherapy combination called BEP, which consists of three chemotherapy agents – Bleomycin, Etoposide and Cisplatin – administered on a three-weekly cycle. BEP is given with a drug called pegylated G-CSF (or pegfilgrastim) that stimulates white blood cell production. The purpose of this study is to determine whether giving the same dose of BEP on a two-weekly schedule will be more effective and better tolerated than a three-weekly schedule. The two-weekly schedule is called “accelerated BEP” and the three-weekly schedule is called “standard BEP”.

For more information, please go to the trials page on the ANZUP website: https://anzup.org.au/

clinical-trial/p3bep/.

ANZUP collaborates with the University of Sydney through the NHMRC CTC to conduct P3BEP Trial.

This ANZUP investigator initiated study is being funded by a Cancer Australia grant.

Current locations for the P3BEP trial:

NSW

• Chris O’Brien Lifehouse • Nepean Hospital • Prince of Wales Hospital • Calvary Mater Newcastle • Concord Repatriation General

Hospital • Macquarie Cancer Clinical Trials

QLD

• Princess Alexandra Hospital • Royal Brisbane & Women’s Hospital • Queensland Children’s Hospital

SA

• Royal Adelaide Hospital • Flinders Medical Centre

TAS

• Royal Hobart Hospital

VIC

• Peter MacCallum Cancer Centre • Border Medical Oncology • Austin Health • Box Hill Hospital

WA

• Fiona Stanley Hospital

NEW ZEALAND

• Auckland Hospital • Christchurch Hospital • Starship Hospital – Paediatric • Palmerston North Hospital • Christchurch Children’s Haematology

Hospital

UK

• Royal Marsden Hospital • University Hospital Southampton • St James’s Hospital – Leeds • Cambridge University Hospital Paediatric • Royal Preston Hospital • Beatson West of Scotland Cancer Centre • Belfast City Hospital • Nottingham University Hospital • St Bartholomew’s Hospital • Bristol University Hospital • Velindre Hospital • Derriford Hospital, Plymouth • Northern General Hospital • Aberdeen Royal Infirmary • University College Hospital, London • The Christie

USA

• Memorial Sloan Kettering Cancer Center • Lucile Packard Children’s Hospital

Stanford • USC / Norris Comprehensive Cancer

Care • Washington University School of

Medicine • Rady Children’s Hospital • Geisinger Medical Center • University of Texas Science Center at San

Antonio • Carolinas Medical Center • Advocate Children’s Hospital – Park

Ridge • Advocate Children’s Hospital – Oak Lawn • Mayo Clinic • Driscoll Children’s Hospital • Wake Forest University Health Sciences • UT Southwestern Simmons Cancer Center • Dell Children’s Medical Center • Augusta University Medical Center • Vanderbilt University Medical Center • Memorial Health University Medical Center • University of Mississippi Medical Center • Palmetto Health Richland • Methodist Children’s Hospital of South

Texas • University of Wisconsin Hospital • East Tennessee Children’s Hospital • Miller Children’s and Women’s Hospital

Long Beach • Roswell Park Cancer Center • Broward HealthCare • Dana Farber Cancer Center • LA Biomedical Research Institute at

Harbor– UCLA • Dayton Children’s Hospital • Loma Linda University Medical Center • University of Iowa • Presbyterian Hospital New Mexico • Saint Mary’s Hospital • Hackensack University Medical Center • Providence Sacred Heart Medical Center and Children’s Hospital • University of Minnesota/Masonic Cancer

Centre • Tufts Children’s Hospital • Dartmouth-Hitchcock Medical Center • Children’s Hospital of Alabama • Ann & Robert H. Lurie Children’s Hospital • NYU Winthrop Hospital • Kaiser Permanente Downey Medical

Center • Children’s Healthcare of Atlanta - Egleston • Children’s Hospitals and Clinics of

Minnesota • Golisano Children’s Hospital of Southwest

Florida • Yale University • Johns Hopkins University/Sidney Kimmel

Cancer Center • University of Alberta Hospital • BI-LO Charities Children’s Cancer Centre • Massachusetts General Hospital Cancer

Center • Rutgers Cancer Institute