Tissue distribution and excretion of deoxynivalenol in rainbow trout

Fusarium mycotoxins are the most common mycotoxins found in aquafeeds, reflecting the type and inclusion levels of plant meals used in these diets. Deoxynivalenol (DON) is a metabolite produced by the genus Fusarium and the main mycotoxin found in small grain cereals.

The kinetics of DON absorption, distribution, metabolism and elimination (ADME) must be understood before it can be tackled in aquatic species. The toxic effects and toxicokinetics of DON have been comprehensively described in terrestrial farmed animals, but less is known in aquatic animals. As

ADME mechanisms differ between animal species, the mechanisms specific to aquatic species should be studied. An experiment was therefore devised to assess the toxicokinetics of radiolabeled DON ([ 3 H]-DON) in rainbow trout (Oncorhynchus mykiss), focusing on tissue distribution and excretion (Gonçalves et al., 2018).