4-Bromobenzaldehyde + NaOAlkyl to 4-Alkoxybenzaldehyde [Reaxys, Reactions (2); 2016-01-22]

Query Query O

O

1. Query

+ Br

Na +

–

O

ALK O

Results

Date

2 reactions in Reaxys

2016-01-22 15h:13m:53s (EST)

ALK

Search as: As drawn, No salts, No mixtures

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

1/2

2016-01-22 15:33:24

O O–

O

Na +

O

Br

Rx-ID: 5332982 View in Reaxys 1/2 Yield

Conditions & References

91 %

With palladium diacetate, tri-tert-butyl phosphine in xylene, Time= 1h, T= 120 °C , Substitution, Suzuki coupling Watanabe, Makoto; Nishiyama, Masakazu; Koie, Yasuyuki; Tetrahedron Letters; vol. 40; nb. 50; (1999); p. 8837 8840 View in Reaxys O

O–

O

Na +

O Br

Br

O

O

Rx-ID: 4885565 View in Reaxys 2/2 Yield 2 % Chromat., 61 %

Conditions & References With 1,1'-bis-(diphenylphosphino)ferrocene, bis(1,5-cyclooctadiene)nickel (0) in methanol, toluene, Time= 2h, T= 70 °C Mann, Grace; Hartwig, John F.; Journal of Organic Chemistry; vol. 62; nb. 16; (1997); p. 5413 - 5418 View in Reaxys

Copyright © 2016 Reed Elsevier Properties SA. All rights reserved. Authorized use only. Reaxys® and the Reaxys® trademark are owned and protected by Reed Elsevier Properties SA and used under license.

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2016-01-22 15:33:24