Advances in Ion Channel Drug Discovery Approximately 13% of approved drugs have mechanisms involving the modulation of ion channel activity, which makes ion channels the second-largest mechanistic class of marketed compounds. Currently approved drugs address important disease areas including diabetes, epilepsy, hypertension, cardiac arrhythmia, anxiety, and pain. Approximately 35% of agents in development have big pharma sponsorship, with the remaining 65% under development by smaller biotech. CNS indications account for 45% of development programs. Agents in late-stage development include several first-in-class agents acting at the cystic fibrosis transmembrane regulator, and new NMDA and AMPA antagonists. Earlier-stage programs focus on selective Nav blockers (following on from genetic validation of Nav1.7 involvement in pain), subtype-selective NMDA and AMPA blockers, and a large number of TRP family members for a variety of indications. Request a Sample for or Inquire before buying the report Ion Channel Drug Discovery Features and benefits
Understand the competitive landscape in ion channel modulation and compare the pipelines of specialist companies operating in this area
Identify the most promising targets from a "likelihood of success" viewpoint.
Identify the targets with scope for ion channel intervention and major market opportunity.
Understand which advances in target discovery, technology, and clinical development will have biggest impact to move the area forward.
Benchmark available technologies against the gold standard for ion channel discovery. Major points covered in Table of Contents of this report include: EXECUTIVE SUMMARY Introduction Characteristics of ion channels Commercial exploitation Discovery approaches New opportunities
Specialist company profiles Outlook Appendix List of Tables List of Figures Report Details: Published: March 2012 No. of Pages: 194 Price: Single User License – US$3835
Corporate User License – US$14381
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