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Journals News Call for Papers – Emerging Roles of Lipids in Membrane Protein Function A special section on the many active roles of membrane lipids in the structure, function, and ligand recognition of integral membrane proteins such as GPCRs and ion channels is planned for publication in the February 2023 issue of Molecular Pharmacology. Submissions will be taken through the end of June 2022. The roles of cell membranes in the proper localization, structure, and function of integral membrane proteins are well established. However, a growing body of evidence suggests that membrane lipids play more sophisticated roles in protein function. For example, lipids may directly or indirectly act as allosteric modulators of signaling receptors and ion channels to regulate their function. Further, the
diversity in the lipid composition and biophysical properties of membranes in different organelles by determining conformational dynamics of receptors can drive spatial bias in signaling and functional outcomes. This special issue will broadly cover original research and review articles on how membrane lipids regulate integral membrane proteins. Review articles addressing any aspects of the structural and functional roles of membrane lipids will also be considered. Proposals for such articles should be sent to the guest editors, Senthil Natesan (senthil.natesan@wsu.edu) and Manoj Puthenveedu (puthenve@umich.edu), for approval before submission.
DMD Special Section of Bile Acids, Drug Metabolism, and Toxicity This Drug Metabolism and Disposition Special Section of “Bile acids, drug metabolism, and toxicity” includes five featured review articles and one research article that focuses on bile acids, drug metabolism, and toxicity. The review articles cover molecular mechanisms in regulation of bile acid homeostasis; environmental chemical contribution to the modulation of bile acid homeostasis through FXR signaling; the role of PXR in gut-liver interactions on drug metabolism and toxicity; a novel approach for
The Pharmacologist • June 2022
diagnosing nonalcoholic steatohepatitis by applying advanced pharmacokinetic biomarkers; the role of Nrf2 in allergy and asthma; and the mechanisms for alterations of drug metabolism by thyroid hormones. The research article highlights effects on drug metabolism by overexpression of FGF15/19. All articles in the special section found in Drug Metabolism and Disposition April 2022 (50/4) issue are freely accessible through October 31, 2022.
