The year 2019 marks one hundred and one years of relations between the United States and the countries of Central Europe that emerged from the wreckage of the First World War. After a century of work together, of tragedy and achievement, Central Europe and the United States have much to celebrate and defend, but also much to do. After accessions to NATO and the European Union, Central Europeans may have thought that their long road to the institutions of the West, and to the security and prosperity associated with them, was finished. The United States began to think so as well, concluding that its work and special role in Central Europe were complete. Now, Central Europe, the United States, and the entire transatlantic community face new internal and external challenges. As a result, the transatlantic world has seen a rise of extremist politics and forms of nationalism that many thought had been banished forever after 1989.