Research

Today, the Institute continues to undertake cutting-edge research to push the boundaries of what we know about biology. Our three Institute Strategic Programmes (ISPs) are united in this endeavour, sharing expertise and collaborating in areas of synergy.

The Signalling ISP aims to understand the molecular and systems levels principles by which cells and organisms sense and adapt to challenges such as nutrient shortage or excess, infection, ageing and damage. Current work is built around long-term strengths in PI3K, Rac-GTPase and ERK/DYRK signalling and lipidomics. The Epigenetics ISP focuses on how reversible chemical modifications of our DNA and chromatin control access to the information stored within our genomes.

The Lymphocyte Signalling and Development ISP investigates how cells of the immune system develop and function, allowing us to resist infection and maintain homeostasis throughout life. The work underpins important practical applications in maintaining lifelong health.