Symposium on UK UK-Japan Japan university university-industry industry partnerships Building International University-Business links
AK project
(Astellas -Kyoto Univ. Project)
Ichiro Aramori, PhD, Astellas Pharma Inc project j
Astellas AK Project Leader Professor , Kyoto Univ., Grad.Sch. Med. at the British Embassy Tokyo on 10 January, 2012
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Industry--Academia Industry Academia--Government collaborations Drug Target Discovery y
Optimization Seed/lead リード探 (Screening) 索最適 索 compounds p (Tox,Metabolism) 化
Non-clinical studies
Clinical development
E plorator research for drug Exploratory dr g target disco discovery er Joint research projects with universities and research institutes in Japan and abroad
Enhancing g the compound p discovery y ability y ((drug g designing) g g) Structural analysis of proteins with the High Energy Accelerator Research Organization
Increases in the speed p and quality q y of toxicity y assessment Toxicogenomics with the NIBIO and the National Institute of Health Sciences
Promotion of translational sciences Bio-imaging using PET in cooperation with the Medical and Pharmacological Research Center Foundation, Translational research with Tsukuba Univ. Hospital
Fusion of drug discovery and medical science and R&D of drugs
Development of immunoregulatory drugs with Kyoto Univ. (AK-PJ)
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Cooperation between Industry and Academia g Discovery y Network for Drug â—?Researchers from companies: no direct access to patients and unable to study diseases â—?University researchers engaged in basic study or clinical medicine have no drug discovery technology â—?Cooperation between industry and academia: to develop drugs that meet unmet medical needs using information f on diseases obtained ffrom patients.
Delivery D li off drugs d to t patients ti t developed using information obtained from them
Patients
Academia: studies on diseases and identification of targets o drug d ug discovery d sco e y for
Companies: d drug discovery
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The Center for Innovation in Immunoregulative Technology gy and Therapeutics p (AK ( project) p j )
Best Drugs on Best Science! Kyoto University Advanced immunology research
Astellas Discovery of global medicine
Drugs for immunoregulation Cure of intractable diseases and Novel immunoregulation technologies for transplantation Special coordination funds for promoting science and technology Long-term, large-scale collaboration system (10 years, 2007 - ) Identification and validation of new drug targets/biomarkers (Kyoto Univ.) Drug discovery and development (Astellas) Innovation of drug discovery system Establishment of an intellectual property management system necessary for the industry-academia industry academia collaboration Encourage the talents comprehensive for medical research, drug discovery and intellectual properties
Organization of Research at AK Project Identification of Biomarkers
Kyoto y Univ. Astellas Fusion Lab.
Clinical Dept. Groups ďźˆClinical Res. Grant 3 Core Professors and their team Narumiya Lab Minato Lab Sakaguchi Lab
Lab. Supervisor Lab. Sub-supervisor Advice on research and development
15 Young Investigator Groups
Intellectual Property Office Coordinates p publication and patent application Translational Research Center
3 Astellas Groups
Technical support Groups
Astellas Drug Discovery
Identification and Validation of New Drug Targets Prediction of clinical usefulness of Targets/Compounds 5
Road map and Achievements 2007
2010
Set up Fusion Lab.
2012
2014
2017
Started Clinical Res. Grants. Expand Fusion Lab. Lab
Identification of targets ( > 25) Establishment of platform technologies for early prediction of clinical usefulness of compounds p D Drug di discovery research h Candidates (>3)
Targets identified in Kyoto University ⇒ 15 Patent applications 19 Papers >100 Drug discovery programs in Astellas ⇒ 7 High throughput screening Antibodies Evaluation of the compounds/antibodies
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