15 malcolm skingle gsk breakout 2

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“Breakout group 2 - Life Sciences” Co-Chairs:

Toshio Miyata (Tohoku University) Malcolm Skingle (GSK)

Tuesday 10th January 2012 Building University – Business links symposium British Embassy & British Council meeting


Emerging Markets & Asia Pacific Drives GSK Growth +7% -3% ViiV £1.6bn($2.4bn)

Consumer £5.0bn ($7.3bn)

Rest of World £1.0bn($1.5bn)

+9%

+22%

US growth rate impacted by losses to generics US Pharma £7.6bn ($11.9 bn)

Japan/AP Ph £3.1bn ($4.8bn) Emerging Markets Ph £3.6bn ($5.5bn)

-11%

Europe Pharma £6.5bn ($10.2bn)

Europe growth rate impacted by losses to generics and gov’t -6% austerity measures

2010 Turnover £28.4bn/$44.0bn (-1%) CER growth rates


Criteria for selection of collaborative projects

• Strategic fit to GSK research • Quality of science in the proposal • Availability of facilities & resources • High likelihood of useful new information or technology arising • Timing with respect to deliverables • Value for money


GSK Priority areas of science • Strongly committed to academic research collaborations to • • • • • • • •

advance scientific understanding relevant to our key areas of focus: Immuno-inflammation Oncology Neurosciences Metabolic Pathways Infectious diseases Biopharmaceuticals Respiratory Ophthalmology


Process for Internal Approval of Research Collaborations • Industrial scientist discusses proposal with academic to identify areas of common interest

• Assumes role of industrial champion & discusses project with Academic Liaison

• Review project priorities with respect to resources & budget • Academic Liaison negotiate & implement agreement • Use standard agreements wherever possible


Why Collaborate ?

• Share risks & rewards • Harness other sources of funding • Access knowledge & new thinking • Build global links • Networking • Recruitment • Think longer term


GSK today – larger pipeline and much more externalized More than 80 active projects from ~50 external engines 16 new partnerships since Feb 09

Tempero Pharmaceuticals

Alveonix Pentraxin Therapeutics

Updated January 2011

UCL Institute of Ophthalmology


Alliances are delivering a partnered pipeline Percentage GSK product development pipeline from in-license or other alliance relationship with third party, by phase of development

In-house

Alliance

100% 90%

27%

80%

39%

65%

38%

Phase II

Phase III

File / Reg

Percentage

70% 60% 50% 40% 30% 20% 10% 0%

Phase I

Source: GSK Product Development Pipeline, Feb 2010, available at www.gsk.com


We are looking for innovation wherever it may originate


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