The 2nd volume of the ONE Conference Book of Proceedings is prepared by EPMA with authorised inputs of experts as a supportive output of the ONE project (Observatory Network to Enhance ICT Structural Funds Absorption), www.oneproject.eu, co-funded by the INTERREG IVC programme of the EU. The publication puts forth an overview of different initiatives of EU regions and cities in mainstreaming digital benefits, in developing ICT observatories and using ICT for better service provision. The smart management of data, re-use of public sector information and understanding of the demands for Open Data creates challenges for the future, as it was reflected at the ONE Conference Brussels 2014.