Research and Innovation
Summer 2017
Hilary’s story … Can you tell me a bit about yourself? “I used to be a Health Visitor and retired in 1998. Since retiring I keep myself busy and active, walking and birding. My favourite bird is the Long Tailed Tit.” What type of study are you taking part in? “It’s for high cholesterol levels. They think mine is familial and I just inherited it because my lifestyle and diet doesn’t justify what it was. The study’s called Odyssey Outcomes.” How did you find out about it? “I had a heart attack three and a half years ago now, 4 years in December, and had two stents put in here at Wycombe hospital. Excellent it was. I think Nicola (Research Sister) approached me on the ward after the stents were put in.” Why did you decide to take part? “Because if it’s familial then my sons and grandchildren might inherit it. That’s the sole reason really.”
Hilary in clinic with Nicola Bowers, Senior Cardiac Research Nurse
What do you have to do? “I have to inject myself every two weeks. They give us a diary to fill in with dates and times you do it. I started off coming to see the team monthly at first for four months and it’s gone gradually longer to every six months now. The drug’s now been licenced in the UK and the trial’s stopping early, I have two more visits left.” What would you say are the benefits to you? “I’m participating in something that will benefit others and that I’m monitored. When I did have a problem I could contact the team and come in. It’s been reassuring.” What would you say to anyone thinking about taking part in research? “Definitely people should take part. It’s for the benefit of everyone else in the future isn’t it.”
Odyssey Outcomes Trial This phase III trial involves 18,000 patients from 57 countries and is looking a drug called Alirocumab which lowers a type of cholesterol called LDL (low-density lipoprotein). Alirocumab was already approved for use in some countries including the USA and EU & has now been approved for use in the UK. The study aims to find out whether it can help patients who have recently suffered a heart attack prevent future cardiovascular events such as angina or stroke. Patient recruits were taught how to inject themselves under the skin every two weeks with the Alirocumab medication or a placebo for approximately 2 years. All the patients are monitored regularly by the research team at Wycombe which is led by Consultant Cardiologist, Dr Piers Clifford and Senior Cardiac Research Nurse, Nicola Bowers. The team were the 5th highest recruiting centre in the UK. For more information on cardiac research call 01494 425901.
What does Informed Consent mean? Prior to taking part in research it is essential that a person freely gives informed consent. The potential participant must be given the information to make a voluntary decision about whether to take part or not, this includes the purpose of the research, what’s involved for them and understanding the risks and benefits. The research professionals taking consent must also be trained and qualified to take it. For further information about research opportunities at Bucks Healthcare NHS Trust please contact the Research and Innovation Department at Stoke Mandeville hospital on 01296 316065 or see the website at www.buckshealthcare.nhs.uk/research