LONG-ACTING PrEP

APRETUDE is a prescription medicine used for HIV-1 PrEP to reduce the risk of getting HIV-1 infection in adults and adolescents who weigh at least 77 pounds (at least 35 kg).

Reasons to ask your doctor about APRETUDE

APRETUDE is the first and only long-acting, injectable PrEP for reducing the risk of getting HIV-1

It’s an injection given every other month, instead of a pill you take every day

Studied in HIV-1 negative cisgender men, transgender women, and cisgender women at risk of getting HIV-1

APRETUDE is given every other month by a healthcare provider after initiation injections have been given 1 month apart for 2 consecutive months. Stay under a provider’s care while receiving APRETUDE. You must receive it as scheduled. If you will miss a scheduled injection by more than 7 days, call your provider right away.

IMPORTANT FACTS ABOUT APRETUDE

This is only a brief summary of important information about APRETUDE and does not replace talking to your healthcare provider about your medicine.

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MOST IMPORTANT INFORMATION ABOUT APRETUDE

Important information for people who receive APRETUDE to help reduce their risk of getting human immunodeficiency virus-1 (HIV-1) infection, also called pre-exposure prophylaxis or “PrEP”:

MOST IMPORTANT INFORMATION ABOUT APRETUDE (cont'd)

Before receiving APRETUDE to reduce your risk of getting HIV-1:

• You must be HIV-1 negative to start APRETUDE. You must get tested to make sure that you do not already have HIV-1 infection.

• Do not receive APRETUDE for HIV-1 PrEP unless you are confirmed to be HIV-1 negative.

• Some HIV-1 tests can miss HIV-1 infection in a person who has recently become infected. If you have flu-like symptoms, you could have recently become infected with HIV-1. Tell your healthcare provider if you had a flu-like illness within the last month before starting APRETUDE or at any time while receiving APRETUDE. Symptoms of new HIV-1 infection include: tiredness; joint or muscle aches; sore throat; rash; enlarged lymph nodes in the neck or groin; fever; headache; vomiting or diarrhea; night sweats. Please see additional Important Facts About APRETUDE at right.

Eligible patients may pay as little as a $0 co-pay per injection on prescribed APRETUDE.

IMPORTANT FACTS ABOUT APRETUDE (cont'd)

MOST IMPORTANT INFORMATION ABOUT APRETUDE (cont'd)

While you are receiving APRETUDE for HIV-1 PrEP:

• APRETUDE does not prevent other sexually transmitted infections. Practice safer sex by using a latex or polyurethane condom to reduce the risk of getting sexually transmitted infections.

• You must stay HIV-1 negative to keep receiving APRETUDE for HIV-1 PrEP.

° Know your HIV-1 status and the HIV-1 status of your partners.

° Ask your partners with HIV-1 if they are taking anti-HIV-1 medicines and have an undetectable viral load. An undetectable viral load is when the amount of virus in the blood is too low to be measured in a lab test. To maintain an undetectable viral load, your partners must keep taking HIV-1 medicine as prescribed. Your risk of getting HIV-1 is lower if your partners with HIV-1 are taking effective treatment.

° Get tested for HIV-1 with each APRETUDE injection or when your healthcare provider tells you. You should not miss any HIV-1 tests. If you become HIV-1 infected and continue receiving APRETUDE because you do not know you are HIV-1 infected, the HIV-1 infection may become harder to treat.

° Get tested for other sexually transmitted infections such as syphilis, chlamydia, and gonorrhea. These infections make it easier for HIV-1 to infect you.

° If you think you were exposed to HIV-1, tell your healthcare provider right away. They may want to do more tests to be sure you are still HIV-1 negative.

° Get information and support to help reduce sexual risk behaviors.

° Do not miss any injections of APRETUDE. Missing injections increases your risk of getting HIV-1 infection.

° If you do become HIV-1 positive, you will need to take other medicines to treat HIV-1. APRETUDE is not approved for treatment of HIV-1.

If you have HIV-1 and receive only APRETUDE, over time your HIV-1 may become harder to treat.

About Apretude

APRETUDE is a prescription medicine used for HIV-1 PrEP to reduce the risk of getting HIV-1 infection in adults and adolescents who weigh at least 77 pounds (at least 35 kg). HIV-1 is the virus that causes Acquired Immune Deficiency Syndrome (AIDS).

It is not known if APRETUDE is safe and effective in children younger than 12 years of age or weighing less than 77 pounds (less than 35 kg).

DO NOT RECEIVE

APRETUDE IF YOU:

• already have HIV-1 infection. If you are HIV-1 positive, you will need to take other medicines to treat HIV-1. APRETUDE is not approved for treatment of HIV-1.

• do not know your HIV-1 infection status. You may already be HIV-1 positive. You need to take other medicines to treat HIV-1. APRETUDE can only help reduce your risk of getting HIV-1 infection before you are infected.

• are allergic to cabotegravir.

• are taking any of the following medicines: carbamazepine; oxcarbazepine; phenobarbital; phenytoin; rifampin; rifapentine.

Before Receiving Apretude

Tell your healthcare provider about all your medical conditions, including if you:

• have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir.

• have or have had liver problems.

• have ever had mental health problems.

• are pregnant or plan to become pregnant. It is not known if APRETUDE will harm your unborn baby. APRETUDE can remain in your body for up to 12 months or longer after the last injection. Tell your healthcare provider if you become pregnant while receiving APRETUDE.

BEFORE RECEIVING APRETUDE (cont'd)

• are breastfeeding or plan to breastfeed. It is not known if APRETUDE can pass to your baby in your breast milk. Talk with your healthcare provider about the best way to feed your baby while receiving APRETUDE.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may interact with APRETUDE. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine. You can ask your healthcare provider or pharmacist for a list of medicines that interact with APRETUDE.

Do not start a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to receive APRETUDE with other medicines.

Possible Side Effects Of Apretude

APRETUDE may cause serious side effects, including:

• Allergic reactions. Call your healthcare provider right away if you develop a rash with APRETUDE. Stop receiving APRETUDE and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue.

• Liver problems. Liver problems have happened in people with or without a history of liver problems or other risk factors. Your healthcare provider may do blood tests to check your liver function.

Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: your skin or the white part of your eyes turns yellow (jaundice); dark or "tea-colored" urine; lightcolored stools (bowel movements); nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of your stomach area; itching.

• Depression or mood changes. Call your healthcare provider or get medical help right away if you have any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; have thoughts of hurting yourself (suicide) or have tried to hurt yourself.

The most common side effects of APRETUDE include: pain, tenderness, hardened mass or lump, swelling, bruising, redness, itching, warmth, loss of sensation at the injection site, abscess, and discoloration; diarrhea; headache; fever; tiredness; sleep problems; nausea; dizziness; passing gas; stomach pain; vomiting; muscle pain; rash; loss of appetite; drowsiness; back pain; upper respiratory infection. These are not all the possible side effects of APRETUDE.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Get More Information

• Talk to your healthcare provider or pharmacist.

• Go to APRETUDE.com or call 1-877-844-8872 where you can also get FDA-approved labeling.

December 2021 APR:1PIL

Trademark is owned by or licensed to the ViiV Healthcare group of companies. ©2022 ViiV Healthcare or licensor.

CBTADVT220018 September 2022

Produced in USA.

If you scroll on TikTok long enough, chances are you will stumble across some dance videos of an ensemble cast of dancers floating in and out of the screen while bopping to hip-hop and pop hits. The moves are carefully choreographed by Jose Ramos, better known as “Hollywood” or @ayhollywoood on TikTok (@hollywood Instagram). Hollywood is an accomplished choreographer who has worked with Beyoncé, Diddy, Megan Thee Stallion, Rihanna, Ciara, JLo, and Lil Mama just to name a few. He is also an author who has released a children’s book. He is also producing a short film. We chatted with him about his inspirations, creative process, and more.

DJ Chalant: What was the ah-ha moment when you knew dancing and choreographing was your path?

Hollywood: When I was seven, making up all the dances and movements for local talent shows and family parties.

DJ Chalant: Are there other dancers/ choreographers that have inspired you?

Hollywood: Hi-Hat, Fatima Robinson, Jamal Sims and Luam.

DJ Chalant: What is your creative process when it comes to creating choreography?

Hollywood: I let my soul decide what is next. I do not think about it too much! I listen to the music and close my eyes “feel the music and let the music take me on a journey.”

DJ Chalant: I see you are highly active on TikTok. Can you explain what “Organized Chaos” is?

Hollywood: Organized Chaos is the act of having people come in and out of cell phone frames but done cleanly.

DJ Chalant: Did you come up with that idea? How did that concept come about?

Hollywood: There was a challenge on TikTok called the “reel it in” challenge, and I was inspired by it and felt it could be so dope to add dance and choreography to it as the challenge was about reeling people into the frame! I thought to enhance that and add transitions.

DJ Chalant: What inspired you to become an author?

Hollywood: I always wanted to push myself to do other things! That is why I have my short film, card game, backpack and children’s book.

DJ Chalant: Nice. Can you talk more about your short film?

Hollywood: My short film I shot is called Stage Mom. It’s about a mother who stops at nothing to give her daughter the spotlight.

DJ Chalant: What is your favorite dancerelated movie?

Hollywood: You Got Served.

DJ Chalant: Is there someone you would like to choreograph for whom you have not had the chance to work with yet?

Hollywood: Yes, Doja Cat, Chloe Bailey, and Missy Elliot.

DJ Chalant: What is the best piece of advice someone has given you?

Hollywood: Don’t get married to your gigs?

DJ Chalant: What projects are you working on next?

Hollywood: Working on my next children’s book as well as a dance short film!

How to Spend a Weekend in the Emerald City

On a clear, sunny day, when Mount Rainier’s snowcapped peak is clearly visible, and the bodies of water surrounding the city shimmer varying hues of blue, Seattle is simply stunning. But even when the city, famous for innovation and greenery (of the pine tree, cannabis, and clean energy varieties), is gray and locked in with clouds, this hilly city built between the Puget Sound and Lake Washington is still a buzzy destination worthy of a weekend getaway.

From a fantastic culinary scene, featuring lots of fresh caught seafood, to vibrant nightlife and fun attractions, there is no shortage of things to do in Seattle. The city also hosts events yearround, like Taste Washington, this year from March 6-13, 2023, which is the country’s largest single-region wine and food festival. And is known for its sports scene with professional football, basketball, and baseball teams. This summer the city hosts the Major League Baseball’s 93rd All-Star Game on July 11, 2023.

Check out our Seattle city guide to learn more about the city.

Experience

Seattle has a few world famous signature attractions that you’ll want to hit up for a first time visit. One is the Space Needle, which celebrated its 60th birthday in 2022. Built for the 1962 World Fair, it towers 605-feet above the city and features the world’s first and only revolving glass floor. Unless it is a clear day, reserve a ride for the top after dark to see the city lights that look magical regardless of cloud cover. The top floors of the spire have an observation deck and a rotating restaurant.

Speaking of cool downtown structures, also check out the Amazon Spheres. The spherical buildings serve as office space for the tech giant and are also home to impressive indoor gardens that are open to the public on the first and third Saturday each month, by appointment only.

Seattle’s other most famous landmark is the Pike Place Market, which began as the city’s original farmers market in 1907. Today you can browse for fresh produce, handicrafts, and of course the fish market, where you can grab fish throwing content. Also take a wander through the floors below the main markets, where you’ll find shops selling everything from quirky collectibles to comic books.

Just around the corner from the Pike Place Market is the original Starbucks location. Still decked out in the colors it had when it opened in 1971, the Seattle Roastery Starbucks Reserve often has a line. It serves all the usual Starbucks drinks as well as two specials created just for this store.

The Museum of Pop Culture (MoPOP) is an immersive experience and has a few worthwhile exhibits. Contact High: A Visual History of Hip-Hop explores four decades of iconic Hip-Hop history through more than 170 images of the genre’s most influential artists. Check online as the museum features both temporary and permanent exhibits.

If you want to learn about Seattle’s history, check out one of the Beneath the Streets tours. The adults only Red Light District Tour takes place on weekends at 6:30pm and explores early Seattle’s “debauchery and vice.” In summer the Queer History Tour takes you around the city’s first gayborhood.

Eat

Seattle has a great culinary scene. While seafood features prominently on menus, the city features cuisines from around the globe with plenty of variety.

In the Pike Place Market, Pike Place Chowder should not be skipped if you want to taste classic Seattle seafood selections. A local institution, it serves traditional and specialty chowders in a counter service setting and at a few outdoor tables. If you can’t make it to the Pike Place location, you can grab some of the offerings at the airport locale on your way out.

One of downtown Seattle’s top restaurants is 2120. Serving an upscale American menu ranging from small plates to more substantive mains. I began with a dozen oysters and finished with the pappardelle and clams. The cocktail menu here is also creative, and the seasonal giant punch balls are a customer favorite. The restaurant also has a sweet view of the Amazon Sphere.

Fat’s Chicken & Waffles is a Black owned restaurant that serves up fantastic Southern comfort food for breakfast and lunch. The chicken and waffles dish is one excellent choice, but there are also vegetarian selections, shrimp and grits, and catfish and greens among other classics.

The renowned Chinese restaurant originally from Taiwan but now with locations around the world, Din Tai Fun, has a Seattle outpost. It is well worth a trip if you are a fan of soup dumplings and noodles. The Xiaolongbao is their signature dish and so good you’ll want to order seconds.

Seattle is also known for its oyster scene. Downtown you’ll find Shucker’s Oyster Bar, which is part of the Fairmont Olympic Hotel. It is one of the city’s oldest oyster bars, has lots of personality (think carved oak paneling and a unique tin ceiling) and is my pick for the city’s best oysters. The menu also features a selection of fresh fish and seafood.

Ben Paris is another good choice downtown in the State Hotel with lots of options for those who prefer meat to fish. The neighborhood restaurant has a lively ambiance and serves hearty Pacific Northwest fare for lunch and dinner. Mains include everything from braised short rib to buttermilk fried chicken and a Wagyu beef burger.

Nightlife

Seattle became famous in the 1990s for introducing the world to Grunge bands from Nirvana to Pearl Jam. Today it still has an energetic live music scene with numerous venues, from indoor music halls to outdoor amphitheaters. Some favorites include Sunset Tavern, which is where to catch indie bands, usually for less than $15; Sea Monster Lounge for jazz and funk that is free three nights a week; and The Crocodile, which has multiple stages.

Pony is a LBGTQ+ dive bar that pays tribute to the great West Village and Castro bars from the 1970s. It plays everything from Hip-Hop to new wave, has a retractable roof and cheap drinks. Also check out Metier Brewing Company Cherry Street Tap Room in the Central District. The brewery is one of the only Black owned beer companies in the Seattle area. The taproom offers a food menu by another Black owned business, Umami Kushi.

Sleep

The Kimpton Hotel Monaco Seattle has a convenient downtown location and offers swanky rooms and suites. If you are traveling with a dog, the hotel is pet friendly and never charges a fee for pups of any size.

Other top hotels include the Fairmont Olympic Hotel-Seattle, The State Hotel, Graduate Seattle, and the Thompson Seattle.

Words by: DÉVON CHRISTOPHER JOHNSON