Editor’s Note Gaibrie Stephen
Dear Reader, It is my pleasure to present to you the sixth issue of Brock Health! Brock Health is a student run academic magazine that was started in 2009 with the purpose of presenting scholarly and personal interest articles on issues related to health, biomedical applications, public health issues and opportunities within Brock University. Brock Health emphasizes peer-to-peer education and presents students with articles that highlight the most current and pressing research within Brock University and society as a whole. Health is a term often misunderstood as something that refers purely to physical wellness. However, health is very broad and multi-dimensional. From a holistic perspective, the term health also includes areas that identify mental, occupational, environmental and social categories. Each of these dimensions works in synchronous to produce a balanced and self-aware individual. In this issue, Brock Health hopes to share with you a balanced representation of health as major issues in every facet of the term is highlighted by our writers.
before birth as it relates to the impact of disease development later in life. Global and environmental health is also a topic of interest as Puneet Nayyar explores emerging viruses while Ryder Damen provides a sobering piece reflecting on Canadian health. Among other topics, mental and physical health as it relates to preventative care is all explored in this issue. Finally, I am very excited to present to you our faculty spotlight and master’s highlight this issue as both Dr. Tsiani and Hisham Sharif’s research and stories are explored respectively. This publication could not have been created without the support of the wonderful people involved. I would like to thank Brock Health’s managing editors, Saumik Biswas, Amen Idahosa and Yasmeen Mann for all their hard work! Further, I would also like to thank Brock Health’s layout and graphic guru Scott Alguire for his expert advice and quality job on the layout and cover page. Thank you to Dr. Neil McCartney, The Faculty of Applied Health Sciences, BUSU and BUSAC for funding our magazine! A special thank you goes out to all our graduate editors who were not only flexible but also incredibly punctual. Also, I would like to thank Dr. Kelli-an Lawrance and Joanne Boucher for their continued support towards this publication! This is my first issue as the Editor in Chief and I appreciate all those who have made this transition smooth and successful! A final biggest thank you goes out to Yumna Ahmed, last year’s Editor in Chief who continues to be a valuable and powerful support to the Brock Health team!
Our featured article for this semester sees Breanne Kramer tackle the popular topic of aging as she explores the possible use of telomerase in order to preserve cell life. Articles communicating the Live long and prosper and I ENCODE project, three parent em- hope you all have a wonderful time bryos and fetal programming will reading this issue! address the effect of interventions 1
Brock Health Team Editor-in-Chief Gaibrie Stephen Managing Editors Saumik Biswas Amen Idahosa Yasmeen Mann Layout Design Scott Alguire Gaibrie Stephen Editorial Board Sharmeel Bhatti Saumik Biswas Franco Cardone Joyce Chong Ryder Damen Amen Idahosa Breanne Kramer Yasmeen Mann Nathaniel Mannella Colin Maslink Amanda Milburn Puneet Nayyar Niya Patel Graduate Editors Phuc Dang David Dodington Kaitlyn LaForge Jenna Lorusso Rebecca MacPherson Yasmeen Mezil Amber Muir Becky Roberts Graphic Design Scott Alguire Faculty Consultant Kelli-an Lawrance (PhD)
Disclaimer: Brock Health is a neutral magazine. It is not strictly hardcore sciences nor public health issues; it is a platform for students to present scholarly, peer reviewed research in any topic related to health.
Contents • Running the Risks
Page 3
• The ENCODE Project: Giving A New Meaning to “Junk DNA”.
Page 4
• Two Moms and One Dad: A Potential Cure to Mitochondrial Disease
Page 5
• Memory Consolidation and Stress: Therapeutic Advancements for PTSD Victims? Page 6 • Faculty Spotlight- Dr Evangelia Litsa Tsiani
Page 7
• Fetal Programming
Page 8
• Featured Article: Want to Live for 1,000 Years?: The Long and Short on
Page 9
Telomeres • The Crossfit System
Page 11
• Oversleep: Too much of a good thing?
Page 12
• Master’s Highlight: Hisham Sharif
Page 13
• Out With the Old, In With the New – New & Emerging Viruses
Page 14
• If Brock was the World
Page 15
• Hot Headlines
Page 16
• Brock Health Team
Page 17
• References
Page 18
November 2012 - Issue 6
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Running the Risks Joyce Chong
To what extent is exercise bad for your health? It is not uncommon to hear about traumatic team sport injuries such as broken bones, sprains, or concussions, which damage players’ careers, but what about solitary exercise? The less informed are led to believe that running is dangerous to your health instead of beneficial. It is true that while running, your limbs are impacting the ground at anywhere from one and a half to five times your body weight1. This stress has been suggested to be detrimental to joints and limbs due to the repetitive nature of the exercise1. Articular cartilage, located at joints such as the knee, provide a smooth layer between interacting bones, but is avascular, meaning it receives no blood flow and heals at a rate much slower than other connective tissues2. A study published by the American Journal of Sports Medicine tested the relationship between marathon running and articular cartilage damage, and found evidence suggesting that articular cartilage is capable of recovering and retaining its functional traits after a marathon3. The results suggested that running instigates bio3
chemical changes, such as fluid shifts within the cartilage matrix, though no significant morphological changes or structural defects were found in the cartilage after running3. Long term effects of marathon running may prove to be damaging to your health, but as with all behaviour, moderation is a key factor and anything can become unhealthy if pursued in excess.
Finally, what does running do for you, as a student? The Journal of Adolescent Health published a study that found when students ran a minimum of thirty minutes every morning for three weeks, there was a significant improvement in both objective and subjective sleep patterns and psychological functioning5. This study was conducted on a group of fifty-one students with a mean age of eighteen. Participants showed a reduction in daytime sleepiness as well as a reduction in sleep loss, combined with a longer duration of sleep. An improved mood and even greater self-esteem were noted in comparison with the control group.
The role of physical activity on stress management is already established, but the added benefits of a regulated sleep schedule and emotional well-being make running an ideal activity for stressed and sleepless students. The ebenefits of running certainly outweigh the risks. Not only does it help increase bone density, but it will keep you fit, feeling good, and There is a general misconcep- help you out in stressful times. Can’t tion that running is an activity that sleep? Too stressed? Why not go for wears down joints and puts a damag- a run? ing amount of stress on bones. In fact, running and physical activity in general has been known to improve bone density by stimulating osteoblasts and promoting bone growth, which is a key factor in preventing brittle bones and osteoporosis2. A study revealed Interested in joining the a correlation between early physiBrock Health team? cal activity and bone mineral content later in life, suggesting that practising a physical lifestyle from a young age can benefit bone density in individuContact us at: als later in life4. The implications of brockuhealth@gmail.com such a study are important in the prevention of degenerative bone disease, or osteoporosis.
The ENCODE Project: Giving a New Meaning to “Junk DNA” Colin Maslink a segment of DNA that encodes a certain product (such as a protein or noncoding RNA) or has some biochemical function2. By identifying these elements, a much broader understanding of the human genome would exist, which could lead to advances in our understanding of human disease from a genetic standpoint. What the ENCODE Project found was revolutionizing. One major initial conclusion was that 80.4% of the human genome is involved in at least one biochemical event in at least one cell type2. This refutes the commonly held belief that the vast majority of human DNA is “junk DNA”, or evolutionary relics that are of no use to us anymore3.
Almost a decade ago, the
study of genetics saw a major breakthrough with the completion of the Human Genome Project, a lengthy study that determined the makeup of human DNA, in terms of nucleotide sequence, and identified and mapped all of the 20,000-25,0000 genes within it1. Now, nine years later, a new major study has delved even further into what makes us who we are.
The ENCODE Project, or Encyclopedia of DNA Elements Project, is a decade-long endeavor that aimed to outline all functional elements within the human genome, not just genes. A functional element refers to November 2012 - Issue 6
From a human disease perspective, the results of the ENCODE project are indispensable. It was found that single nucleotide polymorphisms (single nucleotides on the genome that vary between individual humans) that have been previously associated with diseases are mostly located within the non-coding functional elements described in the ENCODE project, outside of protein-coding genes2.
a transcription start site, which may suggest that it is alterations to how protein-coding genes are switched on and off, rather than alterations to the genes themselves, that cause many diseases5. In addition, it has been found that 88.1% of DNA regions with noncoding variations associated with diseases and traits are active in the early stages of fetal growth. Many of these variations are associated with diseases that occur later in life. As a result, ENCODE data suggests that what occurs within the genome before birth may have an impact on getting diseases later in life6. Further discoveries include the observation that mutations leading to certain diseases tend to occur in sections of DNA read by proteins that regulate processes of those diseases, and the finding that cell types playing a role in specific diseases can be identified without any prior knowledge of the disease6.
Overall, the ENCODE Project has allowed for a major advancement in knowledge and understanding of human disease from a genetic perspective. Although there is still much work to be done, we are one step clos When ENCODE data is er to being able to fully understand the compared to GWAS analyses, the structure, role, and function of the hupotential for significant advance- man genome, and how genomic variments can be seen. GWAS analyses, ants can impact human disease. or genome-wide association studies, examine the DNA of people with and without a specific disease in an attempt to find regions on the genome that influence the risk of acquiring the disease4. It has been found that 76% of variable non-coding DNA that are linked to diseases are located close to 4
3 Parent Embryos: A cure for Disease? Franco Cardone The embryo contains the nuclear DNA from two parents, the intended mother and father, and the cytoplasm, containing the mitochondria and the mtDNA of the donor female. This makes a three-parent embryo that will develop healthy mitochondria5. Two scientists by the name of McGrath and Solter were the first to perform Pronuclear Transfer on mice, back in 19835. This concept has been proven to work in human embryos in recent work by the Mitochondrial Research Group at Newcastle University’s Institute for Ageing and Health6. However, this research has yet to show the long-term developmental effects of Pro Nuclear transfer, but the answers are only years away.
Anyone who has taken high school biology within the past 10 years knows of mitochondria as the “power house” of a cell responsible for energy production1. Mitochondria were at one point believed to be a type of bacteria that formed a symbiotic relationship with other organisms. For this reason, mitochondria have their own DNA, known as mtDNA, separate from the nucleus, and only the mother of a child passes on this mtDNA2. Mutations can occur in the mtDNA and while a single mutation in mtDNA may cause no harmful effects, the accumulation of mutations can be the difference between a normal life, and possibly an early death. A Stanford University publication cited over 191 different diseases that researchers believe to be a direct effect of a mutation in mtDNA3. Mitochondria are found in nearly every cell type in the body, therefore these diseases can affect almost every system of the body from the cardiovascular system to the central nervous 5
system causing psychiatric issues. A specific example of a mitochondrial disease is Kearns-Sayre disease. This is a neuromuscular disease that paralyzes eye muscles, causes chronic inflammation in the retina and can lead to cardiac electrical defects. Mothers who are afflicted by mitochondrial disease have to live with the fear that they may be sentencing their child to a lifelong disease or early death by giving birth to them. A solution to preventing these diseases has been within the grasp of science for many years. There are a few suggested treatments for mitochondrial disease such as germinal vesicle transport, metaphase chromosome transfer or even exercise4. However, the one most talked about in the media, especially in the United Kingdom, is that of Pronuclear Transfer4.
Some people are uncomfortable with Pronuclear Transfer according to an article published by the BBC; many are worried that such modification would open the door for the dreaded “designer baby”7. Others believe that migrating around what nature has planned, is out of the scope of our intervention as a scientifically conscious society. With alternative options for starting a family such as adoption or surrogacy, there is speculation as to whether debating Pronuclear Transfer is even worth the time and money8. Mitochondrial disease will continue to be one of the rarely talked about issues affecting a women’s ability to give birth to a healthy child. We have the scientific capabilities to put an end to this issue within the near future. Now that there is confirmation of the easy scientific processes involved, the difficult task of Pronuclear transfer involves convincing politicians, ethical groups, transferring the nucleus of a zygote and the public must commence for into another healthy zygote, from this solution to end mitochondrial diswhich the nucleus has been removed. ease.
Memory Consolidation and Stress: Therapeutic Advances for PTSD Victims? Niya Patel One of the
most intriguing processes in neuroscience is the mystery behind the making of memory. A key pathway involved in memory consolidation is emotional arousal. An individual is likely to recall emotionally arousing episodes in their life compared to recalling information that has no personal relevance1. People suffering from Post-Traumatic Stress Disorder (PTSD) generally have difficulty forgetting painful experiences in their life due to an emotional association with the traumatic memory. It is important to note that PTSD patients form strong memories in times of increased stress levels2. So the main idea trickles down to the association between stress and memory consolidation. In order to understand memory consolidation, it is important to first understand how the brain functions under stressful conditions. It has been proposed that the interaction between the amygdala and stress hormones stimulate memory formation. Moreover, during a stress response the sympathetic nervous system (SNS) is activated, which in turn activates the hypothalamic-pituitary-adrenal (HPA) axis where hormones are released from the pituitary gland in the brain3. The emotional experience during a stressful response heightens the release of stress hormones, specifically glucocorticoids, known as cortisol in humans from the adrenal gland. The activation of the amygdala plays a crucial role in increasing attention, perception, learning, as well as memory1. During a stress response, the sympathetic nervous system is November 2012 - Issue 6
activated to increase epinephrine levels, which binds to adrenoreceptors, activating cAMP production. Glucocorticoids are able to enter the brain and bind to its receptors facilitating further release of norepinephrine. The activation of the noradrenergic pathway is thought to result in memory consolidation in other brain regions, where information during the stress response can be stored as long-term memory 4. Kuhlmann and Wolf conducted a study where memory consolidation was measured in relation to elevated cortisol levels5. Twenty-nine male university students were tested over two consecutive days in a double-blind placebo design test. The experimental group was given three cortisol pills, while the control group was given 3 three placebo pills. Participants were shown 30 photographs, 10 of which were categorized as positive, 10 negative, and 10 netural. Immediate recall was tested and participants were instructed to return in 24 hours, where a second set of pictures were shown. Saliva samples were collected to measure cortisol levels at different time points of memory consolidation. Results showed that both groups had better recall of emotionally stimulating pictures (negative and positive pictures) in comparison to the neutral stimuli over delayed recall. An interaction between emotional stimuli, cortisol treatment, and consolidation was observed. This study was able to manipulate cortisol levels in order to demonstrate memory enhancement to emotionally arousing stimuli under elevated cortisol levels, concurrently
impairing delayed-recall of neutral stimuli5. The positive correlation and outcome of this study being reviewed can be attributed to the cortisol pills given to the participants, inducing a stress response. It is clear that there is an underlying process present that consolidates emotionally arousing information into long-term storage, which is further enhanced during a stress response. The increase in cortisol interacts with adrenergic pathways, essentially strengthening memory consolidation. The interaction between stress, glucocorticoids, hormones, and emotional stimuli holds great promise for further developing therapeutic advancements in treating PTSD patients as researchers attempt to unravel the underlying cause of this disorder1. It provides insight on how memories are physiologically consolidated, ultimately furthering our knowledge in neuropsychology and human behaviour.
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FACULTY SPOTLIGHT Dr. Evangelia Litsa Tsiani BSc, MSc, PhD Dr Evangelia Litsa Tsiani is an associate professor in the Department of Community Health Sciences at Brock University. Dr. Tsiani has been a professor at Brock University for 12 years, and her current undergraduate courses include “Principles of Human Physiology” and “Human Endocrinology”. In the past she has also taught a graduate course on “Cell Signaling Pathways in Health and Disease”. Dr. Tsiani was born and raised in a small town in Greece near Mount Olympus (the home of ancient Greek Gods). She completed her Bachelor of Science in Physical Education and Sport Sciences from Aristotle University of Thessaloniki, Greece. During this time, she worked in an exercise physiology lab for an undergraduate thesis, which solidified her desire to pursue knowledge through research. Upon graduation, she worked for one year as a physical education teacher in a secondary school in Thessaloniki, Greece while studying and preparing for a National Scholarship Exam. Her hard work paid off and she was awarded a prestigious, national threeyear scholarship to study abroad. She completed her Master’s of Science degree in the Department of Physiology, at University College in London, England. Dr. Tsiani then moved to Canada to pursue her doctoral studies in the Department of Physiology, at the University of Toronto. Her main research interest was to examine skeletal muscle insulin resistance and she was very excited to study at the same institution where insulin was discovered. She also chose to study in Canada because of the pictures she had seen of snow and she imagined many skiing opportunities around the 7
University of Toronto! After moving to the Brock community and experiencing wine country first hand, Dr. Tsiani became influenced by wine and the polyphenol compound found in red wine, resveratrol. Her current research is focused on understanding the health effects of polyphenols such as resveratrol as well as other compounds found in food, wine, and herbs. Using cells grown in culture dishes in the lab, she examines the effects of these compounds at the cellular and molecular levels. One line of her current research is focused on the understanding of muscle insulin resistance, which is the main characteristic of Type II Diabetes. Specifically, she is investigating how we can prevent and inhibit muscle insulin resistance by using natural food components. Her other area of research interest includes the understanding the molecular signaling pathways that lead to cancer cell growth and survival, as well as finding strategies to stop the growth of cancer cells. Dr. Tsiani is currently collaborating with other scientists from the University of Toronto and McMaster University in terms of both of these projects. Dr.Tsiani loves academia and enjoys the everyday challenge of gaining new knowledge. She believes in the ancient Greek «Γηράσκω αεί διδασκόμενος», translated as “I Always Learn as I Age”. When not working in her lab or her office, Dr. Tsiani is busy taking care of her three children and driving them to their many extracurricular activities. She is married to an
accomplished clinician/scientist who works at the Juravinski Cancer Centre and shares the same interest in understanding molecular mechanisms and cell functions! She also loves cooking, skiing, playing tennis, and reading for pleasure by the fireplace with a good glass of (yes, you guessed it) red wine! Her advice for students is to aim high and to not be intimidated to set ambitious goals in life. With hard work, dedication, and persistence, students can achieve their dreams. She tells her students that they may be surprised at their own strength and potential: “you are smarter and stronger than you think”!
Written by: Amen Idahosa
Fetal Programming Amanda Milburn diet during pregnancy and lactation5. In both cases, the offspring show an increase in body fat and body weight although when fed a regular or HF diet themselves but the results are highest for the offspring from mothers fed a HF diet throughout their life, pregnancy and lactation5. It is evident that eating healthy is essential not only for ourselves but also for the health of our future generations.
One out of every two adults in the United States is overweight and on top of that, one in every five is obese9. In addition, over the last 20 years the obesity epidemic in children has become an even greater problem with a 40% increase in childhood obesity worldwide5. That accounts for an estimated 42 million preschool children in developed and developing nations that are overweight or obese and 92 million at risk to be2. With obesity rates in children continuing to climb, experts have started looking at the impact of the health of the parents on the children. Fetal programming is a theory defined as the influence of maternal nutrition during critical early life periods of the offspring on later life wellbeing and metabolism7. It has been found that being overweight in the infancy to childhood stages significantly increases the risk for being obese in adulthood which we all know is linked to numerous metabolic risks and diseases such as type II diabetes 5;9 . November 2012 - Issue 6
One explanation may be epigenetic modification in which the DNA sequence of the offspring stays the same but phenotypes are differentially expressed due to DNA methylation which changes gene expression10;1. Epigenetic modification ideally makes upcoming generations more fit in their surroundings so they can evolve to live a long and healthy life12;4. However, epigenetics can also act in a harmful manner by passing on negative traits, therefore making the offspring less fit and more susceptibility to disease12;4. Susceptibility to obesity can be passed on not only by the mother but also through second generation fathers coming from obese mothers.
Adverse effects have been found in offspring of mothers on a high fat (HF) diet or who have been defined as obese. Most studies discovered that offspring from a HF fed mother, in animal and human models, did not have a higher birth weight3;6;8;11. However, that did not necessarily remain to be the case as they grew older. Rat offspring from obese mothers fed a HF diet had a higher percent body fat as well as a higher initial body weight at weaning (when they come off of their mother’s milk) compared to the control group on a standard diet9;;11. Offspring from HF-fed rat mothers that were fed a HF diet post-weaning showed an even higher percentage of fat body composition than those on a standard diet9;11. The offspring of obese mothers who were maintained on a standard diet still had a greater percentage of adipose tissue at 130 days old than the offspring from lean mothers on the standard diet9. Eating a HF diet throughout life, during pregnancy and lactation has similar effects on offspring to simply eating a HF
Interested in joining the Brock Health team? Contact us at: brockuhealth@gmail.com
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Want to Live for 1,000 Years?: The Long and Short on Telomeres Breanne Kramer
As a child, one of the most
thrilling things to talk about is what your going to do when you grow up. You make plans about all of the important things your going to do, and everything you will achieve. Your perception is as though you will live forever. Unfortunately, there comes a time in your life when your body becomes weak and frail, your mind becomes lost, and illness may strike in shorter intervals than it used to. Aging is an ample issue in our society; in which many people are becoming obsessed with looking and feeling younger, even in their elderly years. Cosmetic surgery and weight loss programs are on the rise, however these techniques are only temporary fixes to the unsolvable problem that is age. However, modern science tells us that there is something more to aging, something very small called a Telomere. Telomeres can be compared
to the plastic tip on your shoelace 1. Our genes are located in the nucleus of the cell, on small double twisted strands called chromosomes.The function of the telomeres, which sit on the the end of every single chromosome are to protect our data, make cell division possible, and hold mysteries as to how we age and develop cancer. A telomere is just a simple sequence of DNA made up of the same bases used for classic DNA strands; the exact sequence is TTAGGG1. The connection between aging and telomeres lies in this: every time a cell divides, the telomere becomes shorter. When a telomere becomes extremely short, the chromosome ends will fuse together and degrade the cell’s genetic map causing the cell to become either cancerous or die2. In DNA replication, after the strand has been unwound and separated, a molecule called DNA polymerase begins to make new strands with the help of small RNA pieces1. The prolem is,
these pieces of RNA take up a tiny space on the end of each new chromosome, making it shorter than the previous one1. In human blood cells, the length of telomeres range from 8,000 base pairs at birth to 3,000 base pairs as people age and as low as 1,500 in elderly people1. Each time a cell divides, an average person loses 30 to 200 base pairs from the ends of that cell’s telomeres1. The only thing produced in the body that can lengthen telomeres is the enzyme telomerase 1. This enzyme is prevalent in young people to ensure that telomeres are not wearing down too fast1. Unfortunately, as we age, telomerase is not produced any longer, therefore the telomeres become shorter and the cells age1. A geneticist by the name of Richard Cawthon discovered that people who live shorter lives are associated with having shorter telomeres1. Among people over the age of 60, those who were plagued by heart disease and infectious disease were coincidentally those with shorter telomeres. The big question of this decades science is can telomerase prevent cells from aging? Can we inject telomerase into normal cells to induce immortality? Scientists have been very successful in making human cells divide much past their lifespan in laboratory experiments1. Cawthon concluded that those who had the longer telomeres in his study were living approximately five years longer than those who had the shorter telomeres1. This could mean that if scientists were able to stop telomere shortening completely, it would add between 10-30 years to the human lifespan1.
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This improvement would raise men’s life expectancy to about 86-106 years, and women’s 92-112 years based the current life expectancies at this time. Looking at other factors besides telomere shortening, oxidative stress and disease also contribute to human aging. Looking retrospectively at this century, the lifespan of both males and females has continued to increase dramatically over the years, and this would suggest that it will continue to move in an upward fashion. If the lifespan can be extended due to telomerase activity, as well as the absence of other factors it is hypothesized by Cawthon that the human lifespan could eventually reach 1,000 years1. It is interesting to study the factors affecting telomere length, particularly because some of them can be controlled by lifestyle choices. Dietary factors have been studied and it has been concluded that fiber intake is positively associated with telomere length, specifically in women2. This would imply that if one wants to extend their lifespan by extending their telomere length, they should eat foods high in fiber November 2012 - Issue 6
such as whole grain cereal, celery, nuts, and beans. Another nutrient that can be taken in is an anti aging peptide called Carnosine3. Carnosine has antioxidant properties, along with properties that supposedly prevent telomere shortening3. This protein can be found in various meats, or can be taken as a pill supplement. These dietary options are a great chance to extend your lifespan in young adulthood. It has also been found that paternal age can affect an offsprings telomere length Although this is not something we can control, it is another way to determine lifespan. Children who are born from older fathers have longer telomeres than those born from younger fathers The reason for this phenomenon is telomeres in sperm lengthen with age, therefore older sperm produce offspring with longer telomeres4. In today’s society where everyone wants to remain young, having an older father is a great advantage. Finally, telomeres play a major role in the development of cancer. As telomeres become very short, the cell approaches death,
however it has the option of escaping this fate by converting itself into a cancer cell4. The enzyme telomerase will then be activated, and the cancer cell will live on. Researchers have recognized the presence of shortened telomeres in pancreatic, bone, lung, prostate, bladder, and kidney cancers1. The measurement of telomerase may be a new way to detect cancer1. If scientists could figure out how to stop telomerase, it may be possible to fight cancer by making cancer cells age and die1 . It is clear that this field of research is a emerging and promising. Our knowledge of telomeres is limited, and we have a long way to go before humans could live for 1,000 years. However, current research has opened up a new branch of thinking, and new possibilities for extending and improving human life. It seems as though one day we will achieve our dream of extended youth, and will live to see much more than we do today.
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The Crossfi t System Sharmeel Bhatti A new revolutionary exercise regime is gathering attention from coast-to-coast; from world star athletes to your average out of shape neighbours and more—it’s the CrossFit system. Have you heard about it? The success of the CrossFit system largely stems from the fact that it can be modified to fuel the needs of any user-regardless of their sex, lifestyle and age1. Due to this inherent malleability, it’s believed to be the most efficient method of getting fit1. The CrossFit system uses a wide variety of exercises-that can be mixed and matched to provide an endless number of workouts. The system caters to both broad and targeted fitness goals2. Key exercises like the overhead squats and the butterfly pullups focus on maximizing the repetition count while engaging your hips, legs, core, back, and shoulders-which provides a challenge to even the fittest individuals. It combines weight training, endurance training and gymnastics to provide efficiency in reaching any fitness goals2. According to CrossFit researcher, the 10 main fitness domains in the body are targeted by promoting neurological and hormonal response4. These domains include respiratory and cardio endurance, Stamina, Strength, Coordination, Flexibility, Power, Speed, Agility, Balance, and Accuracy3. By constantly varying, high-intensity, multi-joint functional movements the neurons are forced to constantly be firing and releasing high levels of hormones to support the physical workload being placed on the body3. In the CrossFit system, the speed and the amount of weight be11
ing moved in each exercise is emphasized rather than the proper form of the exercise4. This allows equal parts of tension of the exercise to be placed on the entire body, thus resulting in a balanced physique2. As a result of these unique workout movements the user is prone to increased injury hazards. This is especially the case with inexperienced individuals as they are highly susceptible to injury4. Conversely, learn the fundamentals of the CrossFit exercises from the professionals drastically reduce injuries6. Ultimately, the risk of injury with this type of workout is the same as any other workout where the participant chooses to disregard the instructions. However, the CrossFit concept has gathered a fair amount of critique due to injury rates5. CrossFit training is available in a variety of ways, including affiliated gyms and free online content3. There are currently over 2000 CrossFit gyms located around the world and The CrossFit Inc company, is verifying new affiliated gyms everyday6. The CrossFit system is also
utilized in various professional fields. Police officers, professional athletes, and martial artists-readily employ the CrossFit system within their regular training6. These gruelling workouts train the human body to respond with the most efficiency1. The long term presence of the CrossFit movement was made prevalent in 2007 with the launch of the first annual CrossFit Games1. This competition challenges CrossFit elites to determine the fittest individual each year. The winner is awarded a monetary reward for their achievements1. This competition is sponsored by Reebok, who have also begun to produce CrossFit gear3. The intensity, the atmosphere and the challenge that CrossFit offers has gathered its loyal users. The rush obtained from the workouts has become an addiction for many, and for others-a reason to get up and take action towards a better and active lifestyle.
Oversleep: Too much of a good thing? Nathaniel Mannella and it can also throw off one’s dietary schedule. Sleeping in too long could cause you to miss breakfast, decreasing cognitive function, something that is extremely important in school5. These complications are far from the worst of it though; oversleeping has been found to increase risk of obesity by 21%, cardiac disease by 38%, and diabetes by a whopping 50%6. Scientists have not fully made connections between the increased risks of these diseases and sleeping excessively, though a correlation has been shown relating increased morbidity to problem sleeping. Researchers do caution, however, that there is no concrete evidence in these conclusions, and more laboratory results are needed before full acceptance of the problems associated with oversleeping7.
S
acrificing sleep for schoolwork is something University and College students know all too well. Staying up until the wee hours of the morning, and, on occasion, missing an entire night’s sleep to study is a common occurrence around campuses across the country1. Most people are familiar with the effects of lack of sleep: a change in mood, loss of concentration and a decreased ability to retain or learn new information2. Studies have shown that it is more beneficial to sleep the night before a big exam, than to stay up late studying3. Post-secondary education is more demanding than ever before, and the effects can physically be felt by the body. As a university student, a good night’s sleep is absolutely essential now more than previous points in our lives, to cope with the demands November 2012 - Issue 6
of daily life. But is there such thing as too much sleep? Will your health and well being be negatively effected by oversleeping? It is recommended that healthy adults get an average of 8 hours of sleep per night, with young adults needing slightly more, at 9 hours per night4. A good night’s sleep is essential to revitalize the mind, and allow the body to recover from daily stressors. It’s easy to think that increasing one’s hours of sleep per night would allow for more focus, and feeling better throughout the day. However, almost the exact opposite has been proven to be true. The more sleep you get the night before, the sleepier you feel throughout the day. Excess sleep has also been shown to produce headaches and back pain
Oversleeping can be caused by multiple different diseases, such as hypersomnia, depression, or sleep apnea8. Occasionally, and more commonly among young adults, sleeping for extended hours can be caused by poor sleep habits, excessive alcohol and drug use, laziness, stress, and the misconception that the more sleep you get, the better you will feel in the morning. Here is a simple recommendation for students: set the alarm. Keep a regular sleeping pattern, do not take naps throughout the day, and have the motivation to get up and start your day; it will make you feel a lot better. Remember, sleeping in is doing almost as much harm as only sleeping a few hours each night. So wake up!
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Master’s Highlight Hisham Sharif BA, MSc
Hisham Sharif, a highly determined and opportunistic current PhD student here at Brock University, has gone above and beyond in developing his own pathway for success. As an undergraduate student of McMaster University in the Kinesiology Department, Hisham turned his focus to spinal cord injury research. He also completed his Masters Degree in Health Science Kinesiology for two years. Hisham has brilliantly managed to create a pathway that involves the application of his research and the ability to help individuals every day through rehabilitation. Prior to his undergraduate studies, Hisham held a strong interest in biological sciences and was an active member in sports. He then directed himself towards kinesiology where he was introduced to the idea of combining rehabilitation with scientific research. Currently, Hisham works in the Spinal Cord Injury Lab here at Brock University. He is also a PhD candidate under the supervision of David Ditor, who runs the Spinal Cord Injury Lab. Upon completion of his PhD, Hisham’s goal is to work in an area that involves neuroprotection and regeneration, aiming to repair damaged neuro cells. When asked for advice to give others entering the study of rehabilitation, Hisham suggested that when individuals enter this field their main goal is to help others. However, along the way their path may become disorganized and difficult at times, which is why it is easy to begin focusing on methods rather than tasks. This implies that you do not forget the reason why you have entered this field of rehabilitation, despite the workload that it may bring along. 13
“Focus more on research rather than Written by: Yasmeen Mann purpose” Hisham cleverly stated. By this Hisham further explains that, when in this field, allow yourself to continue to find new discoveries that may benefit mankind rather than fulfilling a certain purpose. Hisham concludes, “This is what will keep you motivated through it all”. Still managing a healthy lifestyle, Hisham participates in boxing recreationally and beach volleyball throughout the summer. He enters his job everyday with a strong sense of motivation as he feels that he can have a positive impact on the lives of others daily. He describes a sense of incredible gratification from helping people in the lab everyday. Hisham also mentioned that with his research, he is building more knowledge to help benefit others in future years, forming a platform for long-term health benefits.
Interested in joining the Brock Health team? Contact us at: brockuhealth@gmail.com
Out With the Old, In With the New - New & Emerging Viruses Puneet Nayyar also tougher to treat for. One of the biggest challenges when faced with emerging viruses is finding the right cure swiftly. In the case of the 2009 H1N1 outbreak, the first vaccines were not distributed until October of that year; some eight months5 after the initial cases of the virus were reported. The challenge in synthesizing an effective treatment against new viruses adds to the length of time before vaccines can be administered since the emergent virus is new, and new treatment must be discovered. Although viruses and diseases will continue to adapt to the changing world, there are measures for potentially limiting the risk factors. Our world is dynamic and ever-changing, and we as humans are inclined to instinctively strive for perfection in everything that we do, and in doing so we become much more efficient at our tasks. Just like humans, viruses and diseases evolve over time to become more efficient, and ultimately much more difficult to detect1. The battle to permanently eradicate viruses is a long one, which ultimately may never see an end. Most people, at some point in their life, have experienced some kind of virus or disease, from something as simple as the common cold to something more serious like malaria. These nuisances have been around since the dawn of civilization itself, and each time we try to destroy them, they return with a vengeance, often having built immunities to newly developed medicines2. Researches at Michigan State University (MSU) conducted several experiments on different types of viruses, and concluded they are always evolving: as the viruses encounter new medicines and challenges, they build immunities against previously November 2012 - Issue 6
successful treatments3. It would follow that if viruses are constantly evolving, why are we working so hard to fight them? The reason for this is so we don’t become overwhelmed with a plethora of viruses and diseases. In fighting the viruses, we reduce the number of risk factors we face, as opposed to fighting each and every one of them. As viruses constantly adapt, we too must find new ways of combating them lest we are overtaken completely. A famous example of a newly emergent virus is the H1N1 Influenza Virus, better known as “swine flu”, which was responsible for inducing mass hysteria all around the world when news of a new, evolved strain broke in 2009. Although the influenza strain has been known for a long time (the influenza virus was responsible for the early 20thcentury Spanish Flu pandemic), the H1N1strain is entirely different. As the colloquial name suggests, the typical influenza virus mutated into a composite strain of human, avian and swine genetic elements4, not only making it harder to detect, but
Studies suggest immunities build naturally when a specific type of virus or disease is first encountered. While it’s not usually recommended to go and contract as many viruses as you can for the best chance of immunizing yourself, there are many other ways to protect oneself against new and emerging viruses, the obvious example being to just stay hygienic! Poor hygiene is an invitation for diseases and viruses to come and wreak havoc on our health. Using anti-bacterial soaps every time you use the bathroom is a sure way to eliminate bad pathogens. As the world changes, so too do the pathogens that litter it. While much great advancement in science and medicine are made daily, we are only human, and thus vulnerable still to a plethora of natural viruses and diseases. Will it ever be possible to eradicate the mean, ugly bad germs forever? Perhaps, but until that time we must try our best to stay clean, and most importantly, stay informed of emerging threats.
14
If Brock was the World Ryder Damen diagnosed with some form of cancer11. In addition, 312 students will be diagnosed with depression12.
Living on campus in your first year, it is easy to think that the world beyond the escarpment doesn’t exist – with the exception of the Pen Centre of course. In the spirit of that wonderful callowness, let us assume for 5 minutes that Brock University is the world and all its inhabitants, countries, and groups of people are equally represented among our 18,000 students. First off, Canadians in this world can be represented by the Neuroscience students at Brock – there are about 90 of them1,2. Twenty-one of these Canadians are considered obese3. Nevertheless, these Canadians enjoy a long life expectancy of 80.8 years4, in comparison to the 61 firstyear nursing students from Mozambique who face a significantly shorter life expectancy of 49.7 years4,5. If you’re a student from the Faculty of Mathematics and Science, you live in Europe or Central Asia; we have 58 doctors to serve the approximate 1100 of you1,6. On the other hand, if you’re one of ap15
Perhaps the most shocking statistics occur when you take a look at the basic health requirements. All 2,600 students with in the Faculty of Business have inadequate access to water1, 13 . Add to them every single student in Applied Linguistics, Canadian Studies, Classics, Dramatic Arts, English, History, Liberal Arts, French, Music, Philosophy, and Visual Arts, and you still have not reached the number of students that lack basic sanitation1, 13 . Finally, the number of students in Kinesiology, Health Sciences, and Recreation and Leisure combined approaches the number of people withproximately 3000 students in the out access to health care systems1,8. Faculty of Applied Health Sciences, you live in Sub-Saharan AfWhen applied to the Brock rica; we have 3 doctors for you1,6. population, it is easy to see that there is a large population of people in the The most common causes of world who do not fit the definition of death are heart disease (18 students per health. When looking at groups of stuyear), stroke (15 students per year), dents in this article – large or small – and lower respiratory tract infections it is important to remember that these (9 students per year)7. Twenty stu- diseases affect far more than a handdents are children under five that have ful of people; multiply each statistic died this year, all of them being from in this article a little over 387,000 low to middle income country. In a times, and you will begin to approach high-income country, one child of the the real world prevalence rates. same age group dies every five years. Though we are not free and Infectious diseases run ram- safe from disease, we have the opporpant in this student population. From tunity to study in a country free from a viral standpoint, 86 students are water accessibility and sanitation isinfected and living with HIV; four sues, general poverty, and rampant, will die each year from it, seven uncontrolled infectious diseases. As more will become infected, one of recipients of this luxury, it underthose seven will be a child9. Looking scores our responsibility to make a at bacterial infections, an estimated difference in world health care for 1,032 students are infected with Ma- those who do not have the opportunity laria, 825 of them are children from to make a difference themselves. Africa – twice the population of first year CHSC 1F90 students1,10. One of the most well known diseases will only affect 31 students; they will be
HOT HEADLINES Exercise may protect against brain shrinkage.
Artery Damage, One Fatty Meal At a Time
Article by: Anahad O’connor
Article by: Avis Favaro
Summarized by: Gaibrie Stephen
Summarized by: Yasmeen Mann
In a news report published in the Journal of Neurology, a team at the University of Edinburgh followed a sample population of 600 individuals starting at the age of 70. The participants provided information regarding physical, mental and social activities that they engaged in throughout the day for a length of 3 years. At the end of the period of time, using imaging scans, scientists determined that the subjects who engaged in the most physical exercise had less shrinkage and damage in the brain’s white matter. The white matter of the brain is associated with being the “wiring system” that coordinates communication between different regions of the brain. This relationship was sustained even after scientists controlled for IQ, social class and health status. The study only shows an association between brain shrinkage and lack of physical activity so it is not possible for researchers to rule out that people with less deterioration in the brains were simply more likely to be physically active.
According to two Canadian studies, a single junk meal has the potential to damage arteries inside the human body. The participants of this upcoming research were required to eat two meals. The first was salmon based, consisting mainly of monounsaturated and polyunsaturated fats. A week later the second meal was given, composed of food similar to that served in a fast-food breakfast, with mainly saturated fat and no Omega-3 fats. Research found that the arteries of participants dilated 24% less after the junk food meal and dilated normally after the healthy, salmon based meal. Another study found that the arteries’ ability to increase blood flow under stress for students that ate a 900-calorie sandwich, was lowered by 1520%. This effect may be noticed after a sandwich from a fast food location as well.These findings advise that the food we eat at home can significantly contribute to our weight change and cardiovascular health, meal by meal. Perhaps individuals can approach healthier substitutes.
Link Found Between Alzheimer’s disease and Protein Regulation in the Brain- Hope for New Treatments Article by: Kobi Rosenblum, Summarized by:Saumik Biswas A new study was conducted to identify important factors that could be linked to Alzheimer’s disease even before the irreversible amyloid plaques are produced. The current study compared mice that exhibited the human Apoe4 gene - a gene known as a main risk factor for Alzheimer’s- with a group of mice with the parallel Apoe3 gene, which does not form a risk factor for the disease. Mice in the former group showed a change in the regulating mechanism for protein generation involving the eIF2alpha protein that damaged the cognitive abilities of those mice at a young age. This type of mechanism change is characteristic of aging, and so also hinted at the tendency of these mice toward premature aging. This is the first time that a link has been found between the activity of eIF2alpha and the Apoe4 gene in relation to Alzheimer’s disease. Modification treatments for the eIF2alpha mechanism are being widely researched and are developing quickly, and so the more we can understand about the connection between this mechanism and Alzheimer’s, the more we can find ways to identify and slow the progress of the disease.
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@BrockUHealth November 2012 - Issue 6
16
THE TEAM
Saumik Biswas
Sharmeel Bhatti
Yasmeen Mann
Scott Alguire
Puneet Nayyar
Nathaniel Mannella
Niya Patel
Colin Maslink
Amanda Milburn
Joyce Chong
Amen Idahosa
Breanne Kramer
Ryder Damen
Franco Cardone
References Running the Risks
postnatal diet. J Physiol, 905-915.
Meyer,J. (2012, January). “How Viruses Evolve”. Retrieved from http://news.msu.edu/story/10262/#
1. O’Leary K., Vorpahl K. A., Heiderscheit B. (2008). Effect of Cushioned Insoles on Impact Forces During Running. Journal of the American
6. Mingrone, G., Manco, M., Mora, M., Guidone, C., Iaconelli, A., Gniuli, D., Lecessi, L., Chiellini, C., & Ghirlanda, G. (2008). Influence of
3.World Health Organization. Retrieved from http://www.who.int/topics/emerging_diseases/en/ [Retrieved Oct. 2012]
Podiatric Medical Association, 98(1), 36-47.
maternal obesity on insulin sensitivity and secretion in offspring. Diabetes Care, 15 (9), 1872-1876.
4.BodyAndHealth Canada (2011). Retrieved from http://bodyandhealth.canada.com/channel_condition_info_details.asp?channel_
2. Martini F. H., Timmons M. J., Tallitsch R. B., et al. (2012). Human Anatomy: Volume 1. (2nd Custom Ed.). San Francisco (CA): Pearson.
7. Mortensen, E., Wang, T., Malte, H., Raubenheimer, D., & Mayntz, D. (2010). Maternal preconceptional nutrition leads to variable fat
id=2098&relation_id=74074&disease_id=350&page_no=1
3. Luke A. C., Stehling C., Stahl R., Li X., Kay T., Takamoto S., Ma B., Majurndar S., Link T. (2010). High-Field Magnetic Resonance
deposition and gut dimensions of adult offspring mice (C57BL/6JBom). International Journal of Obesity, (34), 1618-1624.
5. Jacobson, S. (2009, October) “First Round of Swine Flu Vaccine Shipped to Texas, Other States” Retrieved from http://www.webcitation.
Imaging Assessment of Articular Cartilage Before and After Marathon Running. The American Journal of Sports Medicine, 38(11),
8. Ray, J., Vermeulen, M., Sharpio, J., & Kenshole, A. (2001). Maternal and neonatal outcomes in pregestational and gestational diabetes
org/5kGGfFAUR
2273-2280.
mellitus, and the influence of maternal obesity and weight gain: DEPOSIT* study. Q J Med, 94, 347-356.
If Brock Was the World
4. Janz K. F., Letuchy E. M., Gilmore J.M., et al. (2010). Early Physical Activity Provides Sustained Bone Health Benefits Later in Childhood.
9. Shankar, K., Harrell, A., Liu, X., Gilchrist, J., & Ronis, M. (2007). Maternal obesity at conception programs obesity in the offspring. Am J
1.Brock University Office of Institutional Analysis, (2011). Head count enrolment report fall 2011. St. Catharines, ON: Brock University.
Medical Science Sports Exercise, 42(6), 1072-1078.
Physiol Regul Integr Comp Physiol, 294, 528-538.
2.Statistics Canada. Table 051-0001 - Estimates of population, by age group and sex for July 1, Canada, provinces and territories, annual
5. Kalak N., Gerber M., Kirov R., et al. (2012). Daily Morning Running for 3 Weeks Improved Sleep and Psychological Functioning in
10. Surani, A. (2001). Insight review articles: Reprogramming of genome function through epigenetic inheritance. Nature, 414, 122-128.
(persons unless otherwise noted), CANSIM (database).
Healthy Adolescents Compared with Controls. Journal of Adolescent Health. Retrieved October 15, 2012, from ScienceDirect database.The
11. White, C., Purpera, M., & Morrison C. (2009). Maternal obesity is necessary for programming effect of high-fat diet on offspring. Am J
3. Shields, M., Carroll, M. D., & Ogden, C. L. U.S. Department of Health & Human Services, Centre for Disease Control. (2011). Adult
ENCONE Project: Giving a New Meaning to “Junk DNA”
Physiol Regul Integr Comp Physiol, 296, 1464-1472.
obesity prevalence in Canada and the United States. Hyattsville.
1.International Human Genome Sequencing Consortium (2004). Finishing the euchromatic sequence of the human genome. Nature, 431,
12. Wu, Q., & Suzuki, M. (2006). Parental obesity and overweight affect the body-fat accumulation in the offspring: the possible effects of a
4. The World Bank Group, (2012). Life expectancy at birth, total (years).
931-945.
high-fat diet through epigenetic inheritance. Obesity reviews, 7, 201-208.
5. The World Bank Group, (2012). Health, nutrition and population statistics.
2. The ENCODE Project Consortium (2012). An integrated encyclopedia of DNA elements in the human genome. Nature, 489, 57-74.
Want to Live for a 1000 Years?: The Long and Short on Telomeres
6. World Health Organization, (2006). Global atlas of the health workforce. France: WHO Press.
3.Andersson, J. O., & Anersson, S. G. E. (2001). Psudogenes, junk DNA, and the dynamics of Rickettsia genomes. Molecular Biology and
1. Siegal Lee J. (2012) Are Telomeres the key to aging and cancer? The University of Utah (1) http:// learn.genetics.edu/content/begin/traits
7. World Health Organization, (2008). World health statistics. France: WHO Press.
Evolution, 18(5), 829-839.
telomeres
8. Shah, A. Global Issues (2011) Health Issues. Updated: September 22, 2011
4. Manolio, T. A. (2010). Genomewide association studies and assessment of the risk of disease. The New England Journal of Medicine,
2.Cassidy, Aedin et al (2010) Associations between diet, lifestyle factors, and telomere length in women. The American Journal of Clinical
9. UNAIDS, (2009). Aids epidemic update. Geneva: United Nations & WHO Press.
363(2), 166-176.
Nutrition (1273-1280)
10. 2007 Human Development Report (HDR), United Nations Development Program, November 27, 2007, p.25.
5.Wang, H., Maurano, M. T., Qu, H., Varley, K. E., Gertz, J., Pauli, F., … Stamatoyannopoulos, J. A. (2012). Widespread plasticity in CTCF
3.Hipkiss, Alan (1998) Carosine, a protective, anti aging Peptide? The International Journal of Biochemistry and Cell Biology (863-868) www.
11. International Agency for Research on Cancer, (2008). GLOBOCAN Database. World Health Organization.
occupancy linked to DNA methylation. Genome Research, 22, 1680-1688.
sciencedirect.com/science/article
12. Glover H., (2011) Global depression statistics. BMC Medicine 2011, 9:90 doi:10.1186
6. Maurano, M. T., Humbert, R., Rynes, E., Thurman, R. E., Haugen, E., Wang, H., … Stamatoyannopoulos, J. A. (2012). Systematic
4.Unryn, Brad (2005) Paternal Age is Positively Linked with Telomere length of Children. Aging Cell (97-101) http://onlinelibrary.wiley.com/
13. 2006 United Nations Human Development Report, pp.6, 7, 35
localization of common disease-associated variation in regulatory DNA. Science, 337, 1190-1195.
doi/10.111
Hot Headline!
3 Parent Embryos: Potential Cure for Disease?
The CrossFit System
Exercise may protect against brain shrinkage.
1. Foetus with three parents created. (2003, October 14). Retrieved from BBC News: http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/3189718.stm
1. Englehart, J. (2012, August 07). Cossfit guide: think inside the box. Retrieved from http://www.cutandjacked.com/
1. O’Connor, Anahad. “Exercise May Help Preserve Memory and Thinking Skills - NYTimes.com.” Health and Wellness - Well Blog
2. Akiko Yabuuchi, Z. B. (2011). Prevention of mitochondrial disease inheritance by assisted reproductive technologies: Prospects and
CrossFit-Think-Inside-The-Box
- NYTimes.com. N.p., 26 Oct. 2012. Web. 27 Oct. 2012. <http://well.blogs.nytimes.com/2012/10/26/exercise-may-protect-against-brain-
Challenges. Biochimica et Biophysica Acta, 637-642.
2.Glassman, G. (2007). Understanding crossfit. The CrossFit journal articles, (56), Retrieved from http://library.crossfit.com/free/pdf/56-07_
shrinkage/?ref=health>.
3.Curt Scharfe, H. H.-S. (2009). Mapping Gene Associations in Human Mitochondria using Clinical Disease PhenotypesP. PLoS
Understanding_CF.pdf
Artery Damage, One Fatty Meal at a Time
Computational Biology, 5(4): e1000374. doi:10.1371/journal.pcbi.1000374.
3.Mitchell, B. (2008, August 16). Lawsit alleges crossfit workout damaging. Retrieved from www.marinecorpstimes.com/news/2008/08/
1. Favaro, Avis. “Just one fatty meal can restrict bloodflow to arteries: studies | CTV News .” CTV News | Top Stories - Breaking News - Top
4.Emma Yu, J. M. (2012). Mitochondria in vascular disease. Cardiovascular Research, 173-182.
marine_crossfit_081608w/
News Headlines. N.p., 30 Oct. 2012. Web. 30 Oct. 2012. <http://www.ctvnews.ca/health/just-one-fatty-meal-can-restrict-bloodflow-to-
5. James McGrath, D. S. (1983). Nuclear Transplantation in the Mouse Embryo by Microsurgery and Cell Fusion. Science, 1300-1302.
3. Stewart, A. (2012, August 31). Is crossfit friend or fad?. Retrieved from http://www.bodybuilding.com/fun/crossfit-friend-or-fad.htm
arteries-studies-1.1017405>.
6. Lyndsey Craven, H. T. (2010). Pronuclear Transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature,
4. Stoddard, G. (2011, October 11). Inside the cult of crossfit. Retrieved from http://www.menshealth.com/fitness/cult-crossfit
Link Found Between Alzheimer’s disease and Protein Regulation in the Brain- Hope for New Treatments
82-85.
5. The editors of PureHealthMD (June 2010).CrossFit. Discovery Health Channel. Retrieved from http://health.howstuffworks.com/wellness/
1. University of Haifa (2012, October 22). Link found between Alzheimer’s disease and protein regulation in the brain -- hope for new treat-
7. BBC News. (2008, February 5). Three-parent embryo formed in lab. Retrieved October 12, 2012, from BBC News: http://news.bbc.co.uk/
diet-fitness/information/crossfit.htm
ments. ScienceDaily. Retrieved October 29, 2012, from http://www.sciencedaily.com¬/releases/2012/10/121022092855.htm
go/pr/fr/-/2/hi/health/7227861.stm
Oversleeping: Too much of a good thing?
8. Serena Braun, E. S. (2007). Movement of Endosymbiotic Organelles. Current Protien and Peptide Science, 426-438.
1.Buboltz, W. C., Brown, F., & Barlow, S. (2001). Sleep habits and patterns of college students: a preliminary study. Journal of American
Health, 50(3),131-135.
1. Beckner et al. (2006). The differential effects of stress on memory and consolidation: A potential involvement of consolidation?.
2. Harvard Medical School. (n.d.). Consequences of insufficient sleep. Retrieved from http://healthysleep.med.harvard.edu/healthy/matters/
Behavioural Neuroscience, 120(3), 735-738.
consequences
2.Quervain, D. J., Aerni, A., Schelling, G., & Roozendaalis, B. (2009). Glucocorticoid and the regulation of memory in health and disease.
3. Gillen-O’Neel, C., Huynh, V. W., & Fuligni, A. J. (2012). To study or to sleep? the academic costs of extra studying at the expense of sleep.
Frontiers of Neuroendocrinology, 30, 358-370.
Child Development. doi: 10.111/j.1467-8624.2012.01834.x
3. Beckner, V. E., Tucker, D. M., Delville, Y., & Mohr, D. C. (2006). Stress facilitates consolidation of verbal memory for a film but does not
4. Song, S. (2006, January 8). Staying sharp: sleeping your way to the top. Time Magazine, Retrieved from http://www.time.com/time/
affect retrieval. Behavioural Neuroscience, 120(3), 518-527.
magazine/article/0,9171,1147196,00.html
4. Blundell, J., Blaiss, C., Lagace, D., Eisch, A., & Powell, C. (2011). Block of glucocorticoid synthesis during re-activation inhibits extinction
5. Simeon, J. T., & Grantham-McGregor, S. (1989). Effects of missing breakfast on the cognitive functions of school children of differing
of an established fear memory. Neurobiology of Learning and Memory, 95, 453-460.
nutritional status. The American Journal for Clinical Nutrition, 49, 646-653.
5. Kuhlmann, S., & Wolf, O. T. (2006). Arousal and cortisol interact in modulating memory consolidation in healthy young men. Behavioural
6. Parker, H. (2008, October 14). Is oversleeping hazardous to your health?. CBS News. Retrieved from http://www.cbsnews.
Neuroscience, 120(1), 217-223.
com/2100-500368_162-4521622.html
Fetal Programming
7. National Sleep Foundation. (n.d.). How much sleep do we really need?. Retrieved from http://www.sleepfoundation.org/article/
1. Berger, S., Kouzarides, T., Shiekhattar, R., & Shilatifard, A. (2009). An operational definition of epigenetics. Genes Dev, 23, 781-783
how-sleep-works/how-much-sleep-do-we-really-need
2. de Onis, M., Blossner, M., & Borghi, E. (2010). Global prevalence and trends of overweight and obesity among preschool children. Am J
8. Ireland, J. T. (2011, March 28). Causes of oversleeping. Livestrong Foundation, Retrieved from http://www.livestrong.com/
Clin Nutr, 92, 1257–1264.
article/127972-causes-oversleeping/
3. Dong, Y., Li, Y., Ning, H., Wang, C., Liu, J., & Sun, C. (2011). High dietary intake of medium-chain fatty acids during pregnancy in rats
Out With the Old, In With The New
prevents later-life obesity in their offspring. Journal of Nutritional Biochemistry, 22, 791-797.
1. Burke DS. Recombination in HIV: An Important Viral Evolutionary Strategy. Emerg Infect Dis [http://wwwnc.cdc.gov/eid/
4. Dunn, G., & Bale, T. (2011). Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage.
article/3/3/97-0301_article.htm]. 1997, Sep [2012].
Endocrinology, 152(6), 2228-2236.
2. Gary, J. (2007, December). Understanding evolution. Retrieved from http://evolution.berkeley.edu/evolibrary/news/071201_adenovirus
Memory Consolidation and Stress: Therapeutic Advancements for PTSD Victims?
5. Howie, G., Sloboda, D., Kamal, T., & Vickers, M. (2009). Maternal nutritional history predicts obesity in adult offspring independent of
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