Engineer Fall 2014 by Boston University College of Engineering

FALL 2014

IN SIDE BIONIC PANCREAS 足 MOBILE APPS

TWEETING BACTERIA And other breakthrough visions for synthetic biology

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MESSAGE FROM THE DEAN

The Challenges of Success BY DEAN KENNETH R. LUTCHEN

F STRONG TECHNICAL FOUNDATIONS ARE OBVIOUSLY ESSENTIAL, BUT TODAY’S ENGINEERS NEED MORE. INCREASINGLY, ENGINEERS INTERACT WITH OTHER PROFESSIONALS IN BUSINESS, LAW, MEDICINE AND OTHER FIELDS, AND MANY ENGINEERING GRADUATES GO ON TO PURSUE CAREERS IN THOSE FIELDS.

or years, we have been lamenting the lack of engineers at a time when technology is playing an ever-increasing role in society. Recently, however, we have seen some good news as enrollment in engineering schools has risen nationally. Boston University is no exception: Applications have almost doubled in the last five years, and we now have the largest freshman class in our history, even though we admit far fewer students than we did just a few years ago. The national enrollment rise may be recognition of the profession’s promising future, as well as the thriving job market available to today’s engineering graduates—something not unimportant to students and parents, who take on the expense of a college education. This burgeoning pipeline of future engineers is something that delights engineers and the leaders of engineering schools. It should also delight society, because an engineering foundation at the undergraduate level is an extraordinary foundation for success in virtually any career path imaginable. Nevertheless, this expansion of enrollment raises issues that should cause engineering deans and university presidents to take a deeper look at who our students are, how we are teaching them and how we allocate our educational resources. For instance, a large fraction of the engineering student population resides outside the US. Nationally, this has been the case at the graduate level for years, with more than half of engineering PhDs and nearly half of all master’s degree graduates hailing from overseas. This is a good thing from a global perspective as foreign countries and economies stand to benefit more, and an educated society is generally a more civilized and constructive one. While the proportion of non-resident bachelor’s degree graduates is comparatively low (around 8 percent), it is rising. The rise is all too often driven by financial forces, and soon US engineering schools will need to address the challenge of recruiting more American students, especially a diverse set of US citizens. Domestically, there is a large imbalance in engineering student demographics. Women make up less than a quarter of the student population, and the proportion of underrepresented minorities— defined as African American, Hispanic, American Indian and Pacific Islander—is much smaller. Among those, only the number of Hispanic engineering students is rising, and that is probably due to a rising

Hispanic population nationally. We need to find a way to attract more women and underrepresented minorities to engineering, beginning at the bachelor’s degree level, and make their education financially viable for both the student and US institutions. We need to develop interest and passion starting at the elementary and middle school levels and then work with high schools to nourish this passion. While these challenges face us in the near and middle term, there are long-range issues we need to consider as well. For many years, the undergraduate engineering curriculum—largely dictated by accreditation organizations—has been fairly rigid. Strong technical foundations are obviously essential, but today’s engineers need more. Increasingly, engineers interact with other professionals in business, law, medicine and other fields, and many engineering graduates go on to pursue careers in those fields. We need a more flexible curriculum that exposes our students to other disciplines and to the processes that make organizations and society function. While rising enrollments—and the revenue they generate—bring smiles to the faces of university presidents, they bring challenges on the other side of the ledger. A larger faculty is required to keep class sizes reasonable. Engineering students need laboratories, which are expensive to build and equip and must be regularly updated to keep education in a rapidly advancing field relevant. For many years, engineering schools have found it challenging to sustain sufficient resources—not because engineering is not valued, but because it costs more to maintain relative to other disciplines. But savvy leaders everywhere are aware that one of the biggest dangers to any organization is to grow at a rate far in excess of its resources. Quality can drop as quickly as enrollment increases, threatening long-term survival. Given society’s increasing reliance on engineering, it is time for universities to consider reallocating resources as enrollments become more disproportionate in favor of engineering. Such reallocations are often complex and eventually will require difficult decisions made by the leadership. Success always brings challenges, and these are problems engineering educators are happy to have. But a careful, reasoned assessment of where this success has brought us, and where it is likely to lead, will ensure that our profession continues to produce leaders who make great strides in advancing our society.

CONTENTS • FALL 2014

< ATTAWAY WINS TEACHING AWARD

> KLAMKIN WINS NASA AWARD

THE NEW

TRANSFORMERS ENG LEADING THE WAY IN SYNTHETIC BIOLOGY INNOVATION

Managing Type 1 Diabetes

ENG-developed bionic pancreas found effective

Illness Prevention

Fearless Displays

Improving food safety through synthetic biology

Advancing leading-edge video walls

3 | inENG 26 | Faculty News

NEW TRANSFORMERS: DAN AGUIRRE

30 | Alumni News

E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

Richard Lally

Michael Seele

Gretchen Fougere

Mark Dwortzan

associate dean for administration associate dean for outreach & diversity

Bruce Jordan Kenneth R. Lutchen dean

assistant dean for development & alumni relations

Solomon R. Eisenberg

ENGineer is produced for the alumni

editor

managing editor

Kathrin Havrilla staff writer

contributors

Rich Barlow, BU Global Programs, Rachel Harrington, Chelsea Hermond, Gabriella McNevin, Paloma Parikh and Cheryl Stewart

Stay Connected to the College of Engineering Join the ENG online community! Post, tag, tweet, ask questions, reconnect with alumni and learn about networking opportunities, job fairs, seminars and other news and events.

senior associate dean for academic programs

and friends of the Boston University College of Engineering.

Selim Ünlü

Please direct any questions or comments to Michael Seele, Boston University College of Engineering, 44 Cummington Mall, Boston, MA 02215. Phone: 617-353-2800 Email: engalum@bu.edu Website: www.bu.edu/eng

design & production

Roger A. Dorf ’70 Former Vice President, Wireless Group, Cisco Systems

Dean L. Kamen, Hon.’06 President & Founder, DEKA Research & Development

Stephen N. Oesterle, MD Senior Vice President—Medicine & Technology, Medtronic, Inc.

Ronald G. Garriques ’86 CEO and Chairman, Gee Holdings LLC

Peter Levine General Partner, Andreesen Horowitz

Adel Al-Saleh ’87 Group Chief Executive, Northgate Information Solutions

Joseph Healey ’88 Senior Managing Director, HealthCor Management LP

Nick Lippis ’84, ’89 President, Lippis Enterprises

Anton Papp ’90 Vice President, Corporate Development, Teradata Inc.

Alan Auerbach ’91 CEO, President and Chairman, Puma Biotechnology, Inc.

Jon Hirschtick Founder & Chairman, OnShape Inc.

associate dean for research & technology development

Thomas D. C. Little

associate dean for educational initiatives

Boston University Creative Services photography

College of Engineering, except where indicated

www.facebook.com/BUCollegeofENG www.twitter.com/BUCollegeofENG www.youtube.com/BUCollegeofENG

Engineering Leadership Advisory Board John E. Abele Founder & Director, Boston Scientific Gregg Adkin ’86 Managing Director, EMC Ventures, EMC Corporation

Adam Crescenzi ’64 Founding Partner/Owner, TELOS Partners

William I. Huyett Director, McKinsey & Company, Inc. Amit Jain ’85, ’88 President and CEO, Prysm Inc.

Venkatesh Narayanamurti Benjamin Peirce Professor of Technology & Public Policy; Former Dean, School of Eng. & Appl. Sciences, Harvard University Girish Navani CEO, eClinicalWorks

Richard Reidy, SMG’82 Former President and CEO, Progress Software Corp. Binoy K. Singh ’89 Associate Chief of Cardiology, Lenox Hill Hospital, North Shore LIJ John Tegan ’88 President and CEO, Communication Technology Services

ENG West Coast Alumni Leadership Council Bettina Briz Himes ’86 Principal, ValuQuest International Christopher Brousseau ’91 Global Commercial Director, Accenture Inc.— Spend Management Services Gregory Cordrey ’88 Partner, Jeffer Mangles Butler & Mitchell, LLP Gregory Courand ’79 President, Founder and Chief Methodologist, Synergia LLC Mark Deem ’88 Partner, The Foundry Inc. Richard Fuller ’88 Associate Business Development Director, Broadcom Corp.

Please recycle 0914

Timothy Gardner ’00 Director, Research Programs & Operations, Amyris Biotechnologies Roger Hajjar ’88 Chief Technical Officer, Prysm Inc. Kent Hughes ’79 Distinguished Member of the Technical Staff, Verizon Wireless Michele Iacovone ’89, CGS ’86 Vice President, Chief Architect, Intuit Inc. Martin Lynch ’82 Executive Vice President, Operations, Xicato Inc. Daniel Maneval ’82 Vice President, Pharmacology & Safety Assessment, Halozyme Therapeutics

Rao Mulpuri ’92, ’96 CEO, Viewglass Inc. Sandip Patidar ’90 Managing Partner, Titanium Capital Partners Sanjay Prasad ’86, ’87 Head of Acquisitions & Strategy, Software and Communications Business Unit, Intellectual Ventures

Dylan Steeg ’95 Director of Business Development, Skytree Inc. Francis Tiernan ’70 President, Anritsu Company Joseph Winograd ’95, ’97 Executive Vice President, Chief Technology Officer and Co-Founder, Verance Corp

Sharad Rastogi ’91 Vice President, Strategy and Marketing, Cisco Systems

Jamshaud Zovein ’95, GSM ’99 Chief Operating Officer, Algert Coldiron Investors

George Savage ’81 Co-Founder and Chief Medical Officer, Proteus Biomedical

Ex-officio, from Dean’s Advisory Board:

Gregory Seiden ’80 Vice President, Applications Integration, Oracle Systems

Anton Papp, Vice President, Corporate Development, Teradata Inc.

Amit Jain, President, CEO, Prysm Inc.

SAVING LIVES AT BIRTH

TRACKING OSTEOARTHRITIS

WRITTEN + EDITED BY MARK DWORTZAN

Ed Damiano, Firas El-Khatib, and research fellow Katherine McKeon calibrate iPhones for a test of a bionic pancreas.

Damiano’s Bionic Pancreas Takes a Big Step Forward

CYDNEY SCOTT

STUDY FINDS SYSTEM WORKS AS WELL AS CONVENTIONAL TREATMENTS

wearable artificial pancreas co-developed by Associate Professor Edward Damiano (BME) and Research Assistant Firas El-Khatib (BME) has been shown to automatically manage type 1 diabetes, for which patients currently check their own blood sugar levels and determine the amount of insulin needed. In two five-day trials, one involving 32 adolescents and one involving 20 adults, the device performed better than conventional pumps on several measures, including the average blood sugar levels over the five-day period in

both adults and adolescents, the average number of interventions among adolescents, and the amount of time that glucose levels fell too low among adults. The so-called bionic pancreas consists of a glucose monitor, a pump for insulin and another for glucagon, and an iPhone that runs an algorithm that autonomously computes how much insulin or glucagon to administer at a given time. The results of the studies, which Damiano and El-Khatib conducted under the direction of endocrinologist Steven Russell at Massachusetts General Hospital (MGH), were published in the New England Journal of Medicine and reported at a meeting of the American Diabetes Association in San Francisco. “This was a very ambitious study,” said Damiano. “It was the first test of our mobile device, and it allowed subjects to walk around Boston. They could visit restaurants, museums and shops. It really let people be themselves.” Damiano, whose 15-year-old son was diagnosed with type 1 diabetes at the age of 11 months, was first motivated to build a bionic pancreas by the fear that the child’s blood sugar would dive while he was sleeping, a potentially fatal event known as dead-in-bed syndrome. He made it his goal to get his device through Food and Drug Administration (FDA) E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

c learance around the time his son leaves for college in 2017. Type 1 diabetes, which affects about two million people in the United States, is an autoimmune disease that destroys the pancreatic cells that normally produce insulin, a hormone that allows the body to convert carbohydrates to energy. Instead of being put to work by muscles, the sugars build up in the blood, creating a toxic combination that, if treated poorly over many years, is almost certain to damage organs such as the kidneys and eyes, as well as blood vessels and nerves. Damiano and El-Khatib first began testing their invention in pigs in 2005, carefully finetuning the algorithm to churn out immediate and precise responses to the wild fluctuations in the pigs’ blood sugar. In 2008, with assistance from the Wallace H. Coulter Foundation, the Frederick Banting Foundation, the Juvenile Diabetes Research Foundation, the Helmsley Charitable

Trust and the National Institutes of Health, Damiano, El-Khatib and Russell began a series of three inpatient human trials to test increasingly sophisticated versions of their system. In 2013 they went on to conduct the first outpatient studies of the bionic pancreas, which was now a mobile device. In an adult outpatient study, the subjects were monitored by nurses, lived in a hotel for five days and were free to roam during the daytime. In an adolescent outpatient study, patients attended a summer camp, where, Damiano said, “they were integrated into all of the usual activities of the other campers.” Damiano, El-Khatib and Russell subsequently initiated a second summer camp study, this one with pre-adolescents 6 to 11 years old. Over the course of the next year, they will also conduct an even more ambitious study involving 40 adults at four different sites: MGH, the University of Massachusetts Medical

College to Launch Charles DeLisi Distinguished Lecture Series Thanks to a generous gift by Professor and Dean Emeritus Charles DeLisi, the College has established the Charles DeLisi Award Lecture Metcalf Professor of and Ceremony. Set to launch in 2015, this annual Science and Engineering event will feature a lecture by a College of and Dean Emeritus Engineering faculty member or alumnus who has Charles DeLisi made outstanding contributions to engineering and society. Charles DeLisi Distinguished Lecturers may include researchers who have contributed significantly to the advancement of their field, executives who have helped shape their industry and/or entrepreneurs who have invented or mentored transformative technologies that have enhanced our quality of life. The lectures will be open to the entire Boston University community and the general public. Widely considered the father of the Human Genome Project, DeLisi was an early pioneer in computational molecular biology and also made seminal contributions to theoretical and mathematical immunology. He currently serves as Metcalf Professor of Science and Engineering. As Dean of the College of Engineering from 1990 to 2000, he recruited leading researchers in biomedical, manufacturing, aerospace, mechanical, photonics and other engineering fields, establishing a research infrastructure that ultimately propelled the College to its ranking in U.S. News & World Report’s top 40 engineering graduate schools. In 1999 he founded— and chaired for more than a decade—BU’s Bioinformatics Program, the first such program in the nation. 4

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Center, Stanford University and the University of North Carolina at Chapel Hill. That study, a series of eight-week trials at each site, will allow participants to live at home, go to work and travel up to one hour from the testing sites. Damiano said the coming “home” study will mark the end of the useful life of the current iteration of their mobile device. The research team is planning a final, pivotal study, which will involve several hundred subjects who will use a new version of the bionic pancreas for several months. The new version of the device will integrate the three components of the current system into a single apparatus. And no, he said, he is not backing off the deadline he set for himself several years ago. “We hope to complete the study of the integrated device in 2016, and apply to the FDA for premarket approval early in 2017,” he said. “We are still hoping for FDA clearance by the second half of 2017.”

College Expands Master’s Options The College of Engineering is expanding its suite of master’s degree programs to give students more flexibility in choosing a program best suited to their career aspirations. Requiring one to two years of study, these programs emphasize advanced technical coursework and include an individual or teambased practicum design project. Students will be able to choose among Master of Science and Master of Engineering programs in Biomedical, Computer, Electrical, Mechanical or Manufacturing Engineering; Photonics; Materials Science & Engineering; and Global Manufacturing (MS only). “We’ve added new dimensions to our master’s degree programs that speak to the career paths of prospective graduate students,” said College of Engineering Dean Kenneth R. Lutchen. “Whether students want a strictly technical program, one that includes some leadership training or one that prepares them for doctoral work, all options will be available to them.” Master of Science programs emphasize advanced technical coursework and include an individual or team-based practicum design project, as well as a range of opportunities to gain practical experience, including company or research internships. Master of Engineering programs include advanced technical coursework, a practicum requirement and the option to take elective courses in Project Management and Product Design, some of which are offered in the School of Management.

Zaman Receives $2 Million “Saving Lives at Birth” Grant FUNDING TO ENABLE SCALE-UP OF COUNTERFEIT DRUG DETECTOR

The portable PharmaChk can verify a drug’s safety in a matter of minutes.

Up to 50 percent of medicines distributed in developing countries are either counterfeit or significantly substandard, and procedures used to check their quality are largely inaccurate, not to mention slow, expensive and complicated. The result: hundreds of thousands of preventable deaths each year. To address the problem, a research team led by Associate Professor Muhammad Zaman (BME, MSE) has spent the past four years developing and field-testing PharmaChk, a user-friendly, low-cost, portable, fast and accurate detector for screening counterfeit and substandard medicines. Once deployed on a large scale, the technology could substantially improve fragile health systems and save countless lives—including those of mothers and newborns suffering from malaria, sepsis and other diseases—in many developing nations. Recognizing the potential of PharmaChk to vastly improve health outcomes for this population, the Saving Lives at Birth: A Grand Challenge for Development program awarded Zaman’s team a $2 million “transition-to-scale” grant to demonstrate the impact of its tech-

nology at scale—one of only four such awards among 30 announced at the Saving Lives at Birth’s annual DevelopmentXChange conference in Washington, DC.

“THIS IS A HUGE HONOR NOT ONLY FOR OUR TEAM BUT ALSO FOR BOSTON UNIVERSITY, AND UNDERSCORES THE UNIVERSITY’S LEADERSHIP AND STRONG COMMITMENT TO TECHNOLOGICAL INNOVATION AND GLOBAL HEALTH,” SAID ZAMAN. The PharmaChk team, which includes graduate students Darash Desai (BME), Nga Ho (BME) and Andrea Fernandes (SMG, SPH), and research scientist Atena Irani Shemirani (BME), was among 52 finalists at the conference (winnowed down from an original field of 550 teams from dozens of countries) competing for funding to realize and scale disruptive

technologies and other innovative ideas to save the lives of mothers and newborns in the poorest places on the planet. Zaman’s team was the only engineering group to receive a transition-to-scale grant and one of a select few to do so within two years of receiving a $250,000 seed grant from the program. “This is a huge honor not only for our team but also for Boston University, and underscores the University’s leadership and strong commitment to technological innovation and global health,” said Zaman. “We are deeply honored to be the first team at BU to be awarded the transition-to-scale grant and are eager to work with our partners in Boston and around the world to address this huge global challenge.” Those partners include the US Pharma copeial (USP) Convention under the Promoting the Quality of Medicines (PQM) program funded by USAID, the Wallace H. Coulter Foundation, the Center for Integration of Medicine and Innovative Technology (CIMIT) (including critical assistance from CIMIT Accelerator Program Executive Wolfgang Krull) and the National Collegiate Inventors and Innovators Alliance. E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

BU Grant Funds Digital Learning Technology in ENG Classrooms In an emerging education approach called the flipped classroom, students view lectures online while at home, and spend classroom time applying what they learned both individually and in small group exercises. Collaborating with their peers at round tables in a revamped “learning studio” and guided by the faculty member and a team of teaching assistants moving from table to table, they solve problems that reflect the scope of the lecture material. And the difficulty: some problems are chosen based on trouble spots identified via mandatory quizzes that accompany the online lectures to assess student comprehension. This is where engineering education is heading, and Boston University, which

launched its Digital Learning Initiative (DLI) last year to spearhead innovative projects in online learning at all of its schools and colleges, is fully on board. The DLI recently awarded $80,000 to fund a College of Engineering proposal to enhance two core undergraduate engineering courses, EK127 (Introduction to Engineering Computation) and EK307 (Electric Circuits), with a suite of classroomflipping, studio-based educational technologies and techniques. The College also hopes to use information gleaned from this pilot program to upgrade the learning experience in other engineering courses. Course content will be hosted on the edX platform.

In the flipped classroom, students solve problems that reflect the scope of lecture material viewed online.

Imaging Method Promises to Upgrade Remote Sensing and Microscopy Imagine two hiring managers sizing up an applicant. The first gathers all the information she can before forming a first impression. The second collects the bare minimum but does so strategically, arriving at virtually the same impression with far less effort and in far less time. It turns out that the latter approach can be taken to produce reasonably accurate photos of objects under low lighting conditions using a remote sensing technology such as LIDAR, which bounces pulsed laser light off of a targeted object to form an image. Rather than waiting to collect and compare hundreds of reflected photons to generate each pixel of the image, as is typically done, you can instead count the number of laser pulses it takes to detect the first photon at each pixel. The lower the number, the greater the intensity of the light reflected off the object’s surface—and thus, the brighter the pixel. Assistant Professor Vivek Goyal (ECE), who, along with former colleagues at MIT’s Research Laboratory of Electronics, demonstrated the concept in the journal Science, calls his method “first-photon imaging.” “We wondered what we could infer about a scene from detecting only one photon from each pixel location, and eventually realized that when the intensity of light is very low, the 6

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amount of time until you detect the photon gives you information about the intensity of the light at each pixel,” said Goyal, whose research was funded by the Defense Advanced Research Projects Agency and the National Science Foundation. To produce a high-quality image from the raw, single-photon-per-pixel data, Goyal’s method applies a computer model of surfaces and edges typically encountered in threedimensional, real-world objects, correcting the intensity and depth of neighboring pixels as needed to fit the model, and filters out noise coming from ambient light sources.

Emulating a conventional LIDAR system, Assistant Professor Vivek Goyal’s (ECE) team uses pulses from a focused laser source to illuminate one scene patch at a time. (Image courtesy of Dheera Venkatraman, MIT Research Laboratory of Electronics)

First-photon imaging may ultimately improve night vision and low-light remote sensing technologies by extending the distance at which images may be taken. The new method may also dramatically increase the speed of biological imaging and the variety of samples—many of which degrade when subjected to higher-intensity lighting—that can be photographed.

New Study Probes Mechanics of Blood Vessel Formation

CHITOSE SUZUKI

FINDINGS COULD OPEN UP NEW AVENUE FOR DISEASE TREATMENT Angiogenesis, the sprouting of new blood vessels from pre-existing ones, is essential to fuel human growth and development but also plays a critical role in the onset and progression of some major diseases. While the process accelerates in cancerous tumors as they grow, it can’t go fast enough in the most common form of heart disease and in engineered tissue implants, where the growth of new vessels is critical to providing organs and tissues with a sufficient oxygen Christopher Chen (BME) supply. Drugs that either inhibit or accelerate the creation of new blood vessels could play a significant role in treating certain diseases, but their effectiveness will depend on a more complete understanding of how those vessels form. Building on research pinpointing various biochemical factors involved in angiogenesis, Professor Christopher Chen (BME), one of the world’s leading tissue engineering researchers and an associate faculty member at the Wyss Institute for Biologically Inspired Engineering at Harvard University, has sought to shed light on the mechanics underlying the process. Since 2011, he and postdoctoral fellow Peter Galie have led a team of researchers at Boston University and the University of Pennsylvania to investigate why fluid filtering through blood vessel walls triggers the sprouting of new blood vessels. Conducting experiments with artificial “blood vessel-on-a-chip” devices that they engineered using a design inspired by microfluidic technology developed by Associate Professor Joe Tien (BME, MSE), the researchers discovered that cells lining each artificial vessel sprouted to form new vessels once the force exerted by fluid leaking through the original vessel wall exceeded a certain threshold. They also determined they could induce sprouting of a new vessel by boosting the force exerted by fluid flowing inside the original vessel to match this same threshold, challenging a widely held

Cells sprouting from the end of an artificial blood vessel engineered by Professor Christopher Chen (BME) and his team. (Photo courtesy of the University of Pennsylvania’s Center for Engineering Cells and Regeneration)

DRUGS THAT EITHER INHIBIT OR ACCELERATE THE CREATION OF NEW BLOOD VESSELS COULD PLAY A SIGNIFICANT ROLE IN TREATING CERTAIN DISEASES, BUT THEIR EFFECTIVENESS WILL DEPEND ON A MORE COMPLETE UNDERSTANDING OF HOW THOSE VESSELS FORM. notion that flow within blood vessels always prevents sprouting. “These findings suggest that our blood vessels can sense when blood flow exceeds their carrying capacity and respond by producing

additional vessels on demand,” Chen explained. “Perhaps we could one day take advantage of this response to enhance vessel regrowth where the need is critical, such as after a heart attack.” Chen and his collaborators reported their findings in Proceedings of the National Academy of Sciences (PNAS). Their work was funded by the National Institutes of Health and the University of Pennsylvania’s Center for Engineering Cells and Regeneration, where Chen was a founding director. “The logical next step is to determine the molecular mechanism behind this phenomenon,” said Galie. “What proteins are involved and how might they be targeted in new drug therapies?” E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

Tracking Osteoarthritis with Nanoparticles NEW IMAGING METHOD PROMISES EARLIER, MORE PRECISE DETECTION

The new osteoarthritis diagnostic method exploits tantalum oxide nanoparticles as contrast agents to image surface and interior regions of cartilage coating the joints.

A chronic disease afflicting more than 27 million Americans and 630 million worldwide, osteoarthritis occurs as the protective cartilage coating on joints in the knees, hips and other parts of the body degrades. No cure for osteoarthritis exists, but treatments can slow its progression, reduce pain and restore joint functioning. Now a team of researchers led by Professor Mark Grinstaff (BME, Chemistry, MSE) has developed a sensitive imaging method that promises to enhance diagnosis of osteoarthritis and enable improved care through earlier detection and more targeted treatments. Funded by the National Institutes of Health and described in the journal Angewandte Chemie, the method exploits new, biocompatible nanoparticles as contrast agents to image surface and interior regions of articular cartilage (the smooth, water-rich tissue that lines the ends of bones in loadbearing joints)—regions that traditional X-ray illumination cannot detect. In the short term, these contrast agents could be used to image cartilage over time to monitor the efficacy of proposed osteoarthritis drugs; with continued development, they may enable clinicians to diagnose and stage the disease so that the most appropriate course of treatment could be followed. 8

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“Today we have very poor capability to detect early stage osteoarthritis,” said Grinstaff. “Most patients come into the clinic at stage three when the pain becomes significant, but if diagnostics based on our method is done proactively, many patients could get the treatment they need much earlier and avoid a lot of discomfort.” In the past five years alone, Grinstaff has produced more high-impact inventions than many researchers do in an entire career, from the new osteoarthritis detection method to a hydrogel wound sealant that can later be dissolved and gently removed. In addition, he has co-founded four companies to translate some of his ideas into clinical products. In recognition of his ability to advance engineering and scientific principles to invent and translate new technologies to impact society, Grinstaff was named as the inaugural College of Engineering Distinguished Professor of Translational Research last June, and awarded an annual discretionary fund of $20,000. The professorship came on the heels of his April appointment as director of the Center for Nanoscience & Nanobiotechnology, which combines BU’s strengths in nanotechnology, engineering and medicine to improve our understanding of subcellular processes, biomolecular function and human physiology, and to apply that knowledge to clinical challenges.

Tweet Your Reaction THE FUTURE OF DRUG MONITORING

Social media is often associated with trivial pursuits, but recent research at the Boston University College of Engineering has harnessed Twitter’s massive reach to improve a critical aspect of health care: how doctors and patients report adverse side effects of prescription drugs, vaccines and medical devices to regulators. Clark Freifeld, a newly minted BME PhD and founder of the startup Epidemico, has leveraged the company’s expertise in public health and computer science to explore how the explosive growth of social media posts on adverse side effects could be exploited to replace or enhance

The MedWatcher app automates and streamlines reporting and analysis of adverse side effects from drugs, vaccines and medical devices. (Photo courtesy of Epidemico)

the current paper-based reporting process and boost the volume of data that gets sent to the Food and Drug Administration. Moving more of the reporting process online could enable regulators and drug manufacturers to spot patterns of adverse side effects sooner and address them more quickly. Under the traditional system, doctors must fill out a four-page form reporting a negative drug reaction and then send it in to the FDA. Not surprisingly, researchers estimate that only 10 percent of such reactions ever get reported. Freifeld’s project, funded by the FDA and described in a study published in the journal Drug Safety, could lead to significant improvements in prescription drug monitoring and safety.

In continuously monitoring all tweets (about 500 million per day) over a sevenmonth period with the aid of online dictionaries for drug product names and common symptoms, Freifeld and collaborators from Boston University, Boston Children’s Hospital, Harvard Medical School, the FDA and other research institutions found that for the most part, tweets of side effects matched up with reports collected the old-fashioned way. For each of 23 drugs examined, the most frequently mentioned adverse effects of that drug—from

fatigue to stomach aches—were similar to those found in data manually reported to the FDA MedWatch drug monitoring system. “We found about a 70 percent correlation between symptoms reported on MedWatch and those posted on Twitter,” said Freifeld, who has since automated the process with a machine learning program. “We also saw many more mild side effects in the Twitter data, as most patients and doctors wouldn’t fill out an extensive form just to report a headache, itch or other mild reaction.”

In addition to monitoring social media for patterns in adverse side effect reporting, Epidemico is also advancing a user-friendly, iPhone and Android-compatible app called MedWatcher that enables patients and physicians to upload a more streamlined version of the information that they’d normally mail or fax to the FDA’s MedWatch system. Users choose from a list of more than 10,000 drugs, vaccines and medical devices, indicate problematic symptoms, and then submit.

Mobile App Developers Win College’s Third Imagineering Competition Developers of Downtyme, an app that makes it easier for college students and other overscheduled people to get together offline, won the $2,500 first prize at the College of Engineering’s third annual Imagineering Competition. Held in April at Ingalls Engineering Resource Center, the competition fielded entries from nine undergraduate engineering students or student teams that applied their creativity and entrepreneurial skills to build working prototypes of technologies aimed at improving the quality of life. Competitors presented prototypes developed in the Singh Imagineering Lab and other on-campus facilities before a four-judge panel of ENG faculty and administrators, who assessed them for originality, ingenuity and creativity, quality of design and prototype, functionality, and potential to positively impact society. Scoring high marks in all four categories, Downtyme enables Facebook friends with free time to find each other by uploading their calendars, selecting a friend (or group of friends) who is free and close by during a specified window of time, and inviting them to share a meal, study, play basketball, hang out and more. Incorporating more than 25,000 lines of code, the app displays friends on your screen in order of proximity and closeness of their relationship to you. “We think there’s a discrepancy between the time people spend on social media and the time they’d like to spend interacting in the real world,” said Luke Sorenson (CE/ EE’16), who transformed Downtyme from a

The winning team includes (from left) Timothy Chong (BME/ CE’16), Luke Sorenson (CE/EE’16), John Moore (CE’16), Nick Sorenson (SMG’14) and Barron Roth (CE’16) (not pictured).

final project in Assistant Professor Douglas Densmore’s Introduction to Software Engineering course into an app and startup in four months with teammates John Moore (CE’16), Timothy Chong (BME/CE’16) and Barron Roth (CE’16). The second prize winner, Konstantinos Oikonomopoulos (ME’14), received $1,500 for a robotic manipulator that can translate and rotate objects about three axes with three sets of software-controlled, carbon-fiber arms that move in parallel. Potential applications include affordable, desktop 3D printing on curved surfaces, multi-axis machining and multi-axis robotic assembly. Adrian Tanner (ME’15) and Rhonda Silva (BME’15) won the $1,000 third place prize for a low-cost device designed to support animal studies of addictive behaviors towards food including obesity and compulsive eating disorders.

“The Downtyme mobile app shows a highly developed awareness of how important personal contact is in an increasingly digital world,” said Jonathan Rosen, director of Technology Innovation Programs for the College and one of the competition’s judges. ”All three winning projects show how our students are becoming Societal Engineers as they apply their engineering skills, creativity and entrepreneurship to improve the quality of life.” Sponsored by John Maccarone (ENG’66), the competition was designed to reinforce the ideal of creating the Societal Engineer by spotlighting student efforts to design, build and test new technologies that promise to positively impact society. Imagineering Lab programming is supported by the Kern Family Foundation and alumni contributions to the ENG Annual Fund. E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

THE NEW TRA ENG LEADING THE WAY IN SYNTHETIC BIOLOGY INNOVATION

ANSFORMERS BU synthetic biology core faculty (from left): Assistant Professor Douglas Densmore (ECE, BME, Bioinformatics); Assistant Professor Ahmad (Mo) Khalil (BME, Bioinformatics); and Assistant Professor Wilson Wong (BME)

BY MARK DWORTZAN E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

A COVER STORY: THE NEW TRANSFORMERS

SSISTANT PROFESSOR WILSON WONG (BME) IS ATTEMPTING TO DEVELOP THE NEXT GENERATION

of personalized smart cancer therapy by taking a cancer patient’s immune system cells and installing novel genetic programs to control when, where and how strongly the engineered cells should respond to cancer cells. To rapidly and predictably engineer desired properties in human immune cells to treat leukemia and other cancers, Wong is applying sophisticated techniques from a rapidly growing and highly promising field that was pioneered at the College of Engineering: synthetic biology. Synthetic biology brings together engineers, molecular biologists, physicists and chemists who apply engineering principles to conceive, design and build molecular biological systems that effectively rewire and reprogram cells, microbes and other living organisms to perform specified tasks. They achieve this by using molecular biology and computational tools to make strategic modifications to genetic “circuits,” networks and pathways that perform logical functions akin to those observed in electrical circuits. Through such modifications, synthetic biologists promise to improve both our understanding of the inner workings of life and the quality of our lives as they advance novel solutions to critical challenges in health care, energy, the environment, global security, food production and safety, and other domains.

ENG and Synthetic Biology: Right There From the Start

Since the early 1960s, scientists and engineers have sought to engineer microorganisms to perform tasks that address such challenges. It wasn’t until the 1990s, however, that the enabling technology would emerge with major advances in genomic sequencing and the rise of systems biology, which combines experimental techniques with computational approaches to reverse engineer cellular networks and pathways. By the end of the decade, researchers who recognized the cellular network as a hierarchy of modular molecular components—proteins, genes and other bits of DNA—began to tune and rearrange these components, thereby changing the behavior of the network as a whole. Rather than reverse engineering the genome, they attempted to forward engineer it to enable living organisms to perform a variety of functions. One of the first two attempts to perform such forward-engineering took place at Boston University in 1999, when Professor James J.

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Collins (BME, MSE, SE) and his graduate student Timothy Gardner (BME’00) tweaked E. coli bacterial genes so they could be induced to either make or not make certain proteins. This two-gene on/off switch for a biological circuit—together with a similar breakthrough at Princeton University around the same time—were ultimately hailed in the journal Nature as the “defining pair of experiments” marking the birth of synthetic biology. Since then, the field dramatically expanded its capabilities as practitioners developed more complex biological circuits and an increasingly diverse array of well-characterized genetic components from which to assemble them. These developments, coupled with significant gains in the past five years in computational power and DNA assembly capabilities, have accelerated efforts to reengineer living organisms to produce clean energy, kill cancer cells, remediate oil spills, detect weapons and perform other tasks that move society forward.

ENG Emerges as a Leader in Synthetic Biology

Carving out renovated space at 36 Cummington Mall, the College created a world-class facility to provide a platform for synthetic biology innovation and train its next generation of researchers. This platform serves ENG synthetic biology core faculty assistant professors Douglas Densmore (ECE, BME, Bioinformatics), Ahmad (Mo) Khalil (BME, Bioinformatics) and Wilson Wong (BME). Together, they are reinforcing BU’s place among the preeminent synthetic biology institutions in the nation. Drawing on non-biology backgrounds emphasizing electrical engineering (Densmore), mechanical engineering (Khalil) and chemical engineering (Wong), the core faculty are joined by 11 associate faculty members from the College of Engineering, College of Arts & Sciences and School of Medicine whose work relates to synthetic and systems biology. “A central goal of our synthetic biology faculty will be to prepare the next generation of synthetic biologists for this multidisciplinary type of research at an early stage, and to challenge them to think conceptually and creatively about how engineering can help in understanding life,” says Khalil. The facility—slated for eventual relocation to a new Center for Integrated Life Science & Engineering building nearby—includes newly renovated wet and dry labs and computational space. To advance its research agenda, the faculty plan to develop and support large-scale, collaborative projects, and organize a seminar series and annual symposium on synthetic biology [see sidebar, p. 16]. The faculty will also support research training, education and outreach activities to ensure that students of all levels can learn about the fundamentals and practice of synthetic biology, As the core faculty members advance tools and techniques to create genetic parts and circuits to reprogram bacterial and mammalian cells more efficiently, cheaply and precisely, they are also applying these approaches to better understand biological systems and improve the quality of life, with a primary focus on medical diagnostics and treatments.

Assistant Professor Wilson Wong (BME) aims to engineer “smart” therapeutic agents that can adapt to different patients and eradicate a wide range of cancer cells while avoiding side effects.

Wilson Wong: Engineering Smart Cancer Therapies

Formerly a postdoctoral scholar in cellular and molecular pharmacology at UC-San Francisco, Wilson Wong joined the BU faculty in 2012 and a year later won the National Institutes of Health Director’s New Innovator Award, which provides up to $1.5 million in research funding for five years. The award supports exceptionally creative, early-career researchers pursuing highly innovative projects with the potential to transform their field of endeavor and bring about improved health outcomes. Wong’s research on personalized smart cancer therapy more than qualifies. He is currently working to engineer genetic circuits to improve the efficacy and safety of adoptive T cell therapy, a treatment for leukemia and related blood cancers—and potentially other tumors—in which a patient’s immune system is reprogrammed. This entails removing millions of a patient’s T cells (a kind of white blood cell) and inserting new genes that make it possible for the T cells to kill cancer cells. When the modified T cells are returned to the patient’s veins, they ideally kill the cancer. One major challenge in developing a curative therapy like this one is that a tumor is composed of diverse sets of cancerous and noncancerous cells expressing different biomarkers at varying levels— within and among patients. Current therapeutic agents that target specific cellular processes or signaling pathways are not effective against such diverse cell populations, and those that target cancer-

Below: a. A tumor is composed of diverse sets of cancerous and non-cancerous cells expressing different biomarkers at varying levels, and tumors from different patients are also very different. One reason why many cancer therapies ultimately fail is that current therapeutic agents were never designed to combat such diversity. b. In adoptive immunotherapy, a tumor-specific receptor is introduced to patients’ T cells, enabling the T cells to find tumors and destroy them. A tumor-specific receptor called chimeric antigen receptor (CAR) has shown phenomenal clinical results in treating leukemia. c. Wong aims to engineer smart cancer therapies that kill a wide variety of cancer cell types without introducing side effects. He will apply synthetic biology technologies to develop genetic circuits that can control when, where and how the T cells are activated.

Smart therapy to combat cancer heterogeneity a

Inter-patient heterogeneity

Intra-patient heterogeneity

scFv

tumor different cancerous cells

tumor antigen

genetic engineering

MIKE PECCI

ONE MAJOR CHALLENGE IN DEVELOPING A CURATIVE THERAPY LIKE THIS ONE IS THAT A TUMOR IS COMPOSED OF DIVERSE SETS OF CANCEROUS AND NONCANCEROUS CELLS.

co-activator domains CD3ζ

Chimeric Antigen Receptor (CAR)

collect T cells

ex vivo expansion and adoptive transfer

Input

None

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THE NEW TRANSFORMERS

specific mutations or markers miss many of the different cancerous cells found in a tumor. In addition, drugs that are effective for some patients may be ineffective or have severe side effects for others. So Wong aims to engineer “smart” therapeutic agents that can adapt to different patients and eradicate a wide range of tumor cells while avoiding systematic side effects. “We will leverage our expertise in synthetic gene circuits, T cell engineering and computational modeling to develop novel gene networks in T cells that control when, where and which cancer-specific receptors are being expressed, thus reprogramming the spatial and temporal activity of cancer-killing T cells,” he explains. The resulting engineered T cells would be the most sophisticated therapeutic agents ever developed, providing an unprecedented level of flexibility, precision and personalization. The genetic circuits and design principles developed through this research could serve as a general platform that could be applied and have immediate and broad impact on many cancers. “By bringing two emerging fields of science—cell-based immunotherapy and synthetic biology—to cancer research, we hope to fundamentally change cancer treatment,” says Wong.

Douglas Densmore: Automating Synthetic Biology

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Assistant Professor Douglas Densmore’s (ECE, BME, Bioinformatics) work focuses on automating processes to increase efficiency, remove errors and improve reproducibility. Liquid handling robots and microfluidic devices are part of this ecosystem.

“My goal is to develop several simple biological parts and package them in electronics,” Densmore explains. “The hybrid systems would be built automatically with software.” For example, a bacterium might be engineered to react to light by producing a change in the pH of a liquid in a microfluidic chamber. Electronics surrounding the chamber would sense the pH change and tweet a message indicating that the bacteria has detected light. One might place the bioelectronics device inside concrete pillars holding up a bridge, where it could report cracks at the first sign of light. “People have done this before, but our hook will be to combine synthetic biology-designed organisms with electronics using software tools,” says Densmore. “For this to work on an industrial scale, the systems we make will have to be cheap enough to throw away and operate autonomously for at least 24 hours, which is about how long bacteria can survive.”

HIS ELEVATOR SPEECH BOILS DOWN TO THIS: “I MAKE THE SPECIFICATION, DESIGN AND PHYSICAL ASSEMBLY OF SYNTHETIC BIOLOGY SYSTEMS EASIER WITH THE USE OF COMPUTATIONAL TOOLS.”

MIKE PECCI

Three years before joining BU’s faculty in 2010 and while completing his PhD in electrical engineering at UC-Berkeley, Douglas Densmore was surprised that genetic circuits presented in a talk by a bioengineering expert were described much like electrical circuits. Densmore has been working ever since to streamline the process of producing novel genetic circuits by extending the analogy to their design process. He may be the only person in the world whose entire research agenda is devoted to automating synthetic biology, moving it from an art form to a more rigorous, standardized discipline. His elevator speech boils down to this: “I make the specification, design and physical assembly of synthetic biology systems easier with the use of computational tools.” Specifying a synthetic biology system is akin to laying out a blueprint for a new building, he says, one that’s comprehensive and detailed enough so that there’s no ambiguity about what the final structure should look like. Designing a specified system entails transforming that blueprint into the biological components, or parts, needed to build it. The final step, assembly, is done not by hand, but with robots or microfluidic chips that move liquids and DNA around. Densmore developed one software tool for each stage of the process, complete with a colorful name: Eugene for specification, Clotho for design and Puppeteer for assembly. Since joining the BU faculty, he has upgraded these technologies while creating seven additional specification, design and assembly tools. Funded by a $1.1 million grant from the National Science Foundation, Densmore is now working to transform Clotho into commercially viable software via a University spinoff called Lattice Automation. Meanwhile, he is beginning to fuse his original and current fields, electrical engineering and synthetic biology, with a long-term focus on hybrid bioelectronics.

THE NEW TRANSFORMERS

Dashboard for Clotho, a tool developed by Assistant Professor Douglas Densmore (ECE, BME, Bioinformatics) to design synthetic biology systems. Funded by a $1.1 million grant from the National Science Foundation, Densmore is now working to transform Clotho into commercially viable software.

Toward that end, Densmore and Khalil are working to combine microfluidics and synthetic biology approaches to construct a programmable, bioelectronic device that could be used in bioremediation, biosensing and other applications.

Ahmad (Mo) Khalil: New Parts and Pathways to Reprogram Cells

A former postdoctoral fellow in Collins’ lab and BU faculty member since 2012, Mo Khalil became interested in synthetic biology as a PhD student at MIT. Named one of the 20 most promising early-career genomics researchers around the world in 2013 by GenomeWeb, Khalil has developed a new, reliable and expanded toolkit of genetic circuit components and microfluidic devices that synthetic biologists can use to program novel behaviors in living cells. For example, working with colleagues at BU, Harvard Medical School, Massachusetts General Hospital and MIT, he has advanced a new method for constructing and analyzing genetic circuits in eukaryotes—organisms whose cells contain nuclei. Instead of constructing these circuits with off-the-shelf parts from bacteria and

porting them into eukaryotes, as most synthetic biologists do, Khalil and his collaborators have engineered these circuits using modular, functional parts from the eukaryotes themselves. Potential applications range from stem cell therapeutics to in-cell diagnosis of cancer and other diseases. In addition to advancing the state of the art of synthetic biology, Khalil is applying its techniques to improve our understanding of biological organisms and devise new ways to treat disease. With the support of a National Science Foundation CAREER award in 2014, he is working to better understand the mechanisms underlying how organisms adapt to changing environments, a classic problem in evolutionary biology. He’s testing a theory that prions—proteins that can cause neurodegenerative diseases in mammals—equip microbes with an enhanced capability to survive under fluctuating environmental conditions. “This work will have broad implications for our basic understanding of evolution and development, and could provide us with interesting new strategies for engineering and evolving cellular systems for application,” says Khalil. In another project that promises to directly improve the effectiveness of health care, Khalil is helping to spearhead a method that could accelerate diagnosis and treatment of bacterial infections, a growing public health problem. Continued on page 17 E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

THE NEW TRANSFORMERS

ON JUNE 9, THE COLLEGE OF ENGINEERING convened its first annual conference, Synthetic Biology Boston (SB2), a one-day workshop bringing together Boston and Cambridge-area researchers in synthetic biology. Participants at the workshop included experts from a variety of life sciences and engineering disciplines, software developers from academic and industrial labs and regional industrial and startup company representatives. SB2 focused on leading-edge research that’s advancing and harnessing synthetic biology approaches, and sought to foster new collaborations and partnerships among academic and industrial researchers. “We talked about creating a pivotal event that would bring together Boston-area researchers in synthetic biology, further strengthen what’s becoming a vibrant community here in Boston, showcase some of the novel synthetic biology approaches being developed and used and highlight talks by world-renowned researchers,” said Khalil as he kicked off the conference. SB2 featured two keynote speakers: the inaugural Charles Cantor Lecturer, Jack W. Szostak, 2009 Nobel Laureate in Physiology or Medicine; and renowned stem cell biologist George Daly. It included a presentation by industry speaker and “organism engineer” Patrick Boyle from Ginkgo BioWorks, and a dozen talks delivered by graduate students and postdocs representing established synthetic biology labs in the Boston area. More than four hours were set aside for networking and discussion. Postdocs and graduate students from the College of Engineering presented advances ranging from a technique to produce synthetic transcription factors, or proteins that turn genes on and off, to a new method to produce synthetic genetic circuits in mammalian cells that can receive and transmit multiple signals. Researchers from MIT Lincoln Laboratory, MIT’s Synthetic Biology Center and Harvard’s Wyss Institute for Biologically Inspired Engineering shared innovations emerging from their labs, including efforts to streamline the assembly of genetic circuits; engineer bacteria to detect gastrointestinal disease markers or convert biomass into biofuels, pharmaceuticals and other useful products; reprogram stem cells to grow into specific tissues and organs; and assemble DNA nanostructures that can be used to reprogram biological processes for imaging and therapeutic applications. “I’m excited to see this community come together,” said Densmore. “This workshop shows that this community exists, that it’s diverse yet collaborative, experienced yet young and excitable. I take this as a charge to follow up on these collaborations and make some of the vision we saw today a reality.”

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MIKE PECCI

ENG HOLDS FIRST SYNTHETIC BIOLOGY BOSTON CONFERENCE

Assistant Professor Ahmad (Mo) Khalil’s (BME, Bioinformatics) lab focuses on advancing synthetic biology approaches to provide a better understanding of the design principles of complex biological systems, and to engineer cells for useful applications in medicine, energy and the environment.

Below: Top: (left) Nobel Laureate Professor Jack W. Szostak, Harvard Medical School; (middle) Evan Appleton, graduate student, BU, talking to Michael Smanski, postdoctoral fellow, MIT; (right) Irene Brockman, graduate student, MIT Bottom: (left) Professor Emeritus Charles Cantor (BME, MED), BU; (middle) Jessica Polka, postdoctoral fellow, Harvard Medical School; (right) David Kong, MIT Lincoln Laboratory

THE NEW TRANSFORMERS

SCHEMATIC OF PROGRAMMABLE MICROFLUIDIC DEVICE

PHOTOGRAPH OF DEVICE

pneumatic valving OPEN

outlet

cell growth chambers

Pinpointing the most effective treatment for a bacterial infection can take several days as clinicians culture bacteria and select the most effective antibiotic. Meanwhile, patients receive broadspectrum antibiotics that could be far less effective, leaving them prone to spreading the infection and generating antibiotic-resistant bacteria. But a new, culture-free diagnostic approach that Khalil and Collins are exploring could identify the most suitable antibiotic in just a few hours, leading to rapid treatment and infection containment. The researchers are developing systems to detect early cellular changes that occur in susceptible bacterial cells when treated with antibiotics. “Our goal is to create a universal diagnostic platform that can perform antibiotic susceptibility testing across a full spectrum of antibiotics,” says Khalil. “And to do this as rapidly as possible.”

“OUR GOAL IS TO CREATE A UNIVERSAL DIAGNOSTIC PLATFORM THAT CAN PERFORM ANTIBIOTIC SUSCEPTIBILITY TESTING ACROSS A FULL SPECTRUM OF ANTIBIOTICS,” SAYS KHALIL. “AND TO DO THIS AS RAPIDLY AS POSSIBLE.”

GROWTH AND ANALYSIS OF ENGINEERED CELLS cell live cell segmentation microscopy

inlets

CLOSED

The Khalil lab designs and fabricates microfluidic systems for studying and characterizing engineered cells. The schematic and photograph show a device used to study the behavior of engineered cells, consisting of miniaturized channels (black channels) and pneumatic valves (red channels) to precisely control the flow of liquids and biological content. Engineered cells are placed in growth chambers (grey), and then microscopically imaged in real time as they grow, respond to environmental perturbations and execute engineered functions. The devices enable highresolution studies with cells, including single-cell analysis of yeast cells (bottom right panel). Software is used to program device operations with simple logical commands, making it straightforward to automate highthroughput and complex experimental routines.

The Future of Synthetic Biology

In the coming decades, synthetic biology is likely to generate many more new insights about the genetic circuitry and behavior of biological organisms and sophisticated devices that exploit that circuitry to diagnose and treat disease, produce renewable biofuels and meet other societal challenges. The wellspring of innovation in the field will be in today’s living organisms, which embody a “knowledgebase” of genetic circuits, networks and pathways that have evolved over countless millennia to perform complex functions in a wide range of environments. Leading the way in translating information from life’s knowledgebase into synthetic biology techniques and applications from the very beginning, the College of Engineering is poised to continue shaping the field and advancing life-enhancing solutions for many years to come. E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

ILLUMINATING BACTERIA, PREVENTING ILLNESS BME ALUM APPLIES SYNTHETIC BIOLOGY TO IMPROVE FOOD SAFETY BY MARK DWORTZAN

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Michael Koeris (BME, PhDâ&#x20AC;&#x2DC;09), co-founder and COO of Sample6

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BOUT 12 HOURS AFTER EATING a meal at this year’s

national Food Safety Summit at the Baltimore Convention Center, more than 100 food safety professionals reported symptoms associated with food poisoning. Outside of the irony, that’s not big news, considering countless reports over the past decade of foodborne illness outbreaks ranging from salmonellatainted peanut butter to Listeria-infected cantaloupes. According to the Centers for Disease Control, these illnesses remain stubbornly common: one in six Americans get sick from food poisoning each year, resulting in an estimated 128,000 hospitalizations and 3,000 deaths. The main causes of foodborne illness are producers, retailers and restaurants improperly handling, preparing and storing food. Reducing the incidence of outbreaks will require not only more stringent food management procedures but also more rapid and affordable methods to detect foodborne pathogens and microbial toxins. At most testing sites, it typically takes a minimum of two days and $30 to detect a single pathogenic bacterium in a food sample culture. Enter Michael Koeris (BME, PhD’09), who is spearheading a new method that promises to significantly reduce the time, cost and complexity of food safety testing. Koeris is a co-founder and chief operating officer of Sample6, a startup in Boston’s Innovation District that’s using synthetic biology techniques to develop the first enrichment-free technology platform for the rapid detection of pathogens in the food industry and hospitals. The platform provides quick results in a user-friendly kit with two components—Detect and Control. Detect is a suite of enrichment-free diagnostics for harmful bacteria in food industry environments that delivers results within one eight-hour shift rather than days. Control is a web-based software tool enabling users to schedule, monitor and analyze their food safety efforts. Since 20

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launching in April, Sample6 has beta-tested its first product, a Listeria detection system that tests different spots in a facility for $10 to $15 a spot, with 35 food industry partners across the US. “When you are in the business of perishable foods with limited shelf life, time is a huge factor,” says John Ciarametaro, a quality assurance specialist who worked at Legal Sea Foods, one of Sample6’s pilot partners in 2014. “The Sample6 swabs were able to detect Listeria in areas that traditional enrichment methods couldn’t, and with no interruption to the flow of the operation.” Now 25 employees strong in a well-lit, open-landscaped office peppered by multiple yellow dry-erase boards displaying complex calculations and random doodles, Sample6 is a spinoff of the Collins Lab. Back in 2009, under the guidance of Professor James J. Collins (BME, MSE, SE) and funded by the National Institutes of Health and National Science Foundation, Koeris and then-postdoc Timothy Lu (presently an associate professor of biological engineering and electrical engineering & computer science at MIT and board member of Sample6) engineered bacteriophages, or bacteria-specific viruses that reside in the small intestine, to both detect and treat bacteria. “We conceptualized a new way of using bacteriophages as delivery vehicles to detect the presence of bacteria, instead of as antibiotics to attack it,” says Koeris. Collins, a co-founder of Sample6 who continues to support the company as chair of its scientific advisory board, encouraged Koeris and Lu to commercialize the technology they had co-invented. “Jim encourages you to think about what it is you can be great at, and if he sees potential in you, he’ll push you in that direction,” says Koeris. “In my case, that’s commercialization.” A German-born graduate of the University of Berlin and MIT where he studied biochemistry and biophysics, Koeris came to BU in 2006 to study systems and synthetic biology under Collins but also

PREVIOUS PAGE AND ALL PHOTOS: DAN AGUIRRE

ILLUMINATING BACTERIA

Sample6 scientists and engineers employ leading-edge synthetic biology techniques and tools to provide a state-of-the-art solution that enables a step change in food safety diagnostic performance.

REDUCING THE INCIDENCE OF OUTBREAKS WILL REQUIRE NOT ONLY MORE STRINGENT FOOD MANAGEMENT PROCEDURES BUT ALSO MORE RAPID AND AFFORDABLE METHODS TO DETECT FOODBORNE PATHOGENS AND MICROBIAL TOXINS. maintained a strong interest in business. Before entering the PhD program, he had worked for management consulting firms in Germany; during the program, he co-founded an on-campus health care consulting and entrepreneurship organization. United by a passion for entrepreneurship and biotechnology, Koeris and Lu entered several business plan competitions to drum up seed funding to move their technology platform into the market. They came away with $100,000, but when they sought to raise more for their fledgling company, Novophage Therapeutics, they ran into a number of speed bumps. “We started out with the idea of using the platform to produce a new kind of antibiotic to treat resistant infections, but we received no funding,” Koeris recalls, noting the company couldn’t afford to pay for clinical trials that would take five years to complete, and so went on hiatus for several months. “We next thought of focusing the platform on industrial uses, such as engineering phages to remove biofilms in oil and gas pipelines, but the timeline for Environmental Protection Agency approval was uncertain, introducing potential delays that would be difficult to sustain as a startup. Finally, we pivoted from industrial remediation to industrial diagnostic activities, which were more fundable, easier to develop technically and posed no difficult regulatory hurdles. Now all we needed was a good first application.” While the company went on hiatus, Lu joined the MIT faculty and Koeris signed on with a venture capital firm named Flagship

Ventures and got married. After regrouping to focus Novophage on biofilm remediation, they obtained an additional $150,000 investment from BU, ramped up hiring and recruited an early-stage business developer, Micah Rosenbloom. Together the team quickly raised $6 million (and eventually an additional $11 million), and Koeris decided to transition the CEO spot to Rosenbloom in the summer of 2011. That fall, after searching for something they could produce with their phage-engineering platform with a low barrier to entry and sufficiently large market, they found their application: food safety microbial diagnostics. Rather than immerse a food sample in an enrichment medium to enable the detection of target bacteria within days, Sample6’s Bioillumination Platform™ reprograms the genetic circuits of phages with an enzyme that induces the bacteria to emit photons that can be detected within hours using off-the-shelf technology. Derived from a deep-sea shrimp, the enzyme is related to the same protein that makes fireflies glow. During the company’s initial experiments, the platform detected six bacterial cells from a food sample, leading to its current name, Sample6. The name has stuck, even though the platform subsequently proved its ability to detect a single bacterial cell. Koeris relishes his current role as chief operating officer at Sample6, where he can direct much of what goes on at the company on a daily basis—a far cry from his work as an associate at management consulting and venture capital firms. “I’m really bad at following orders, and it’s this stubbornness that’s been essential in starting the company, which is the best decision I’ve made outside of marrying my wife,” he says. “It suits my temperament and enables me to have a positive impact on society.” More information about Sample6 is available at sample6.com. E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

FEARLESS DISPLAYS

EE ALUM ADVANCES LEADING-EDGE VIDEO WALLS FTER AMIT JAIN (EE’85, ’88) received his first bach-

elor’s degree in physics, chemistry and math in India, an older brother invited him to help out at the audiotape manufacturing company that he owned in Kolkata. Having no prior knowledge of how to assemble audiotapes, Jain jumped right in, and was soon running the factory floor. Three years later, during his senior year as an electrical engineering student at the College of Engineering, an ENG professor offered to hire him as a research assistant and teach him everything he knew about optics if he decided to pursue his graduate studies at the College. Jain went on to become one of the first ENG students to graduate with an MS degree in EE with a focus on optics. Fast forward to 2005. When investors asked Jain and his business partner Roger Hajjar (EE’88) to shift from optical networking to large displays, they came up with a new display technology that ultimately transformed the industry. As you may have guessed by now, neither Jain nor Hajjar had prior knowledge of the field. Their new display technology laid the foundation for Prysm, Inc., a Silicon Valley-based designer and manufacturer of video wall systems now used across the globe by leading technology, retail, financial services and media companies, governments and universities, including Beijing TV, CNBC, General Electric and, most recently, BU’s College of Engineering. “I have learned to never be afraid of trying new things, and to go with my gut,” says Jain, 53, CEO and co-founder with Hajjar (now CTO) of Prysm. “When we started Prysm, Roger and I had no fear of entering a new industry, and no baggage from previous companies on what couldn’t be done—just ideas that could be applied in a new context. Within 18 months we came up with the concept for a new display technology, built a prototype and shipped our first product.” 22

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Today Prysm designs, assembles, installs and provides software support for large, modular, interactive video walls of nearly any size, brightness or resolution, customized to users’ needs, as well as 117-inch and 190-inch standard video walls used in collaboration rooms. The custom video walls enable architects, designers and brand managers to provide unique, engaging, immersive experiences in lobbies, conference centers, control rooms, stores and other environments. The collaborative walls empower teams in multiple locations to boost their productivity through real-time interactions, whether through touch or gesture, or by posting, sharing and editing content uploaded from smartphones, tablets or other mobile devices. At the heart of Prysm’s video walls is the company’s proprietary Laser Phosphor Display (LPD) technology, which features a solidstate, ultraviolet laser engine, phosphor panel and advanced optics. Mirrors direct beams from the laser engine across the phosphor panel, which, in turn, emits red, green or blue light to form image pixels. The process occurs on multiple, 25-inch tiles that fit together to make up a single, integrated wall. Compared to conventional LED- and LCD-based technologies, LPD video walls deliver superior image quality, viewing angles, energy efficiency and environmental impact—resulting in a lower cost of ownership. Manufactured in an eco-friendly way with nontoxic materials and requiring no consum-

THROUGHOUT HIS CAREER, JAIN HAS DRAWN ON HIS EXPERTISE IN BOTH ENGINEERING AND BUSINESS, AND LESSONS LEARNED FROM AN EXTENDED FAMILY, MANY OF WHOM WERE ALSO ENTREPRENEURS.

DAVE GREEN

BY MARK DWORTZAN

Amit Jain (EEâ&#x20AC;&#x2122;85, â&#x20AC;&#x2122;88) beside Prysm video wall installed in the 44 Cummington Mall lobby

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LEFT: DAVE GREEN. THIS PAGE: PHOTOS COURTESY OF PRYSM

< The back of the video wall at 44 Cummington Mall

PRYSM VIDEO WALLS USE UP TO 75 PERCENT LESS ENERGY THAN COMPETING LARGEFORMAT DISPLAY TECHNOLOGIES.

ables, they use up to 75 percent less energy than competing large format display technologies and give off far less heat, eliminating the need for electrical system or HVAC upgrades. “The Prysm video wall . . . delivers astounding image quality and ultra-wide 178-degree viewing angles,” says Yao Hong, a sales director at the State Grid Corporation of China, which uses a curved, 80-foot-wide by 11-foot-high wall to monitor the electrical grid system of China’s Jiangsu province. “These attributes combined with the tremendous scalability of LPD technology provide an ideal display solution for the command and control environment.” Chris Van Name, a regional vice president at Time Warner Cable, chose Prysm in order to impress customers and minimize environmental impact. “Prysm’s video wall creates a significant ‘wow’ factor for any customer visiting our store and enables us to showcase our technologies in TV, broadband Internet and digital phone in a brilliant and beautiful fashion,” he says. For Jain, Prysm represents the pinnacle of a 20-year career of growing successful technology-related businesses. Before founding Prysm, he served as CEO of Bigbear Network and cofounder and CEO of Versatile Optical Networks, which was acquired by Vitesse Semiconductor Corporation, where he led the Optical Systems

“Because I already had a bachelor’s degree, Ken gave me the opportunity to teach classes while still an undergraduate,” recalls Jain. “As I faced up to 40 friends and peers, I learned how to explain complex ideas clearly and concisely.” Fortunately, he had already developed a penetrating voice that now came in handy. “My projectile voice comes from survival of the fittest,” he says. “I have 48 cousins and am second from the bottom in age, so one needed a powerful voice to get your point across.” Subsequently earning his bachelor’s and master’s degrees in electrical engineering at BU (where he met Hajjar in Professors Mike Ruane and Masud Mansuripur’s Optical Data Storage Lab) as well as an MBA at the University of Maryland, Jain became well-versed in the technological, communications, entrepreneurial and other skills that are the hallmark of the Societal Engineer, a concept he embraces both as CEO of Prysm and as a member of the Dean’s Leadership Advisory Board.

Division as vice president and general manager. Previously, he held several management positions in startups and large companies including Terastor, Optex Communications and Digital Equipment Corporation. Throughout his career, Jain has drawn on his expertise in both engineering and business, and lessons learned from an extended family, many of whom were also entrepreneurs. While working for his brother in the audiotape business, he imagined inventing technologies rather than just assembling them on the factory floor, and ultimately applied to the College of Engineering in 1983 to earn a second bachelor’s degree in electrical engineering. There he not only learned engineering but also how to communicate effectively to large groups as Professor (now Dean) Kenneth R. Lutchen’s first undergraduate teaching assistant.

Olympic video walls allow architects, designers and brand managers to create and customize unique, immersive experiences, engaging digital signage and unrivaled audience engagement in any number of environments.

While pleased with Prysm’s achievements and outlook, Jain views the close relationships he has maintained with his wife, son (Ayush (BME’13)) and daughter, and with his 200-plus employees, as critical to his success. Anchoring those relationships is his religion, Jainism, some of whose tenets—Don’t kill. Ask forgiveness. Respect different views.—appear on a card he carries in his pocket. “Everyone has a viewpoint,” he observes. “The important thing is to listen to all views in order to make the right decisions.” More information about Prysm is available at prysm.com. E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

faculty

< HAN AND CASSANDRAS WIN FACULTY AWARDS

ENG WELCOMES NEW FACULTY >

Dean Lutchen Honored with Biomedical Society’s Highest Award Dean Kenneth R. Lutchen received the American Institute for Medical and Biological Engineering’s (AIMBE) highest honor, the Pierre Galletti Award, in recognition of his contributions to the public awareness of medical and biological engineering, and to the promotion of the national interest in science, engineering and education. AIMBE selected Lutchen based on his “seminal contributions to quantitative understanding and treatment of respiratory disease, providing a role model for national growth of the biomedical engineering discipline, mentoring a generation of students, elevating the stature and visibility of AIMBE with key federal agencies and lawmakers, and promoting public awareness of the field through a national engineering school and professional society leadership,” according to the award citation. He received the award and presented a lecture at AIMBE’s annual meeting in March in Washington, DC. “This award from my peers is a great personal honor,” said Lutchen, “but I hope that it can also serve to raise awareness among

Klamkin Receives NASA Early Career Faculty Award RECOGNIZED FOR EFFORTS TO IMPROVE DEEP SPACE COMMUNICATION Assistant Professor Jonathan Klamkin (ECE, MSE) is one of seven university researchers nationwide to receive the 2014 NASA Early Career Faculty Award, which honors early career faculty focused on space technology addressing critical needs in the US space program. Klamkin caught NASA’s attention with a proposal to develop integrated laser transmitter technology for deep space 26

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AIMBE President William Hawkins presents Dean Kenneth Lutchen with the Pierre Galletti Award.

policymakers and future engineers about the importance of biomedical engineering in our health care and our economy.”

AIMBE represents approximately 50,000 individuals, of which only 2 percent are admitted to the organization as fellows. —By Michael Seele

communication, as the space agency had recently completed a mission that demonstrated high-rate laser communication between Earth and the Moon. As NASA prepares future missions to Mars, the award provides Klamkin with a grant of up to $600,000 over three years to further develop the technology to allow for deep space communication. High-rate space communication is made possible through laser communication transmitters that send data to Earth through space similar to how ground-based lasers send data over fiber-optic cables to the Internet. With funding from the NASA grant and partnerships with MIT Lincoln Laboratory and the Jet Propulsion Laboratory, Klamkin aims to apply photonic integrated circuit technology

to reduce the size, weight and power of space laser transmitters—and ultimately inspire new design methodologies for space laser transmitter hardware. —By Gabriella McNevin Assistant Professor Jonathan Klamkin (ECE, MSE) at a photonic integration training workshop at the Boston University Photonics Center.

Zaman Receives Howard Hughes Medical Institute Professorship

Bird, Khalil and Schwager Net NSF CAREER Awards

ALSO ELECTED TO BOARD OF PREEMINENT GLOBAL HEALTH ORGANIZATION

Assistant professors James C. Bird (ME, MSE), Ahmad (Mo) Khalil (BME, Bioinformatics) and Mac Schwager (ME, SE) each received the National Science Foundation’s prestigious Faculty Early Career Development (CAREER) Award in recognition of their outstanding research and teaching capabilities. Collectively, they will receive more than $1.5 million over the next five years to pursue high-impact projects combining research and educational objectives. Bird intends to apply his CAREER award to explore how submicron aerosol droplets are formed from small bursting bubbles. Using direct, high-speed observations, numerical simulations and experimental models, he will seek out the primary mechanism behind this phenomenon. Pinpointing this mechanism is important in engineering applications ranging from turbine corrosion to the dispersion of respiratory diseases, and may also improve models used to predict the progression of global climate change. Khalil will use his award to develop microfluidic systems and synthetic biology methods to better understand the mechanisms underlying how organisms adapt to changing

ZAMAN: CYDNEY SCOTT. ATTAWAY: MIKE SPENCER

Associate Professor Muhammad Zaman (BME, MSE) will teach students about challenges to global health as a Howard Hughes Professor.

Associate Professor Muhammad Zaman (BME, MSE) became one of the first two Boston University faculty members to receive a Howard Hughes Medical Institute (HHMI) Professorship, awarded to researchers who demonstrate innovative techniques in undergraduate science education. In awarding its 2014 professorships, which confer a five-year, $1 million grant, the HHMI whittled down a field of 173 applicants to 15. Zaman will use his professorship to design ways of incorporating global health issues, including engineering challenges in resourcelimited settings, into the curriculum. He and his students have worked on various technologies to improve developing world medical care, including a detector for counterfeit and defective drugs flooding into poorer countries. [See p. 5.] In addition, the Consortium of Universities of Global Health (CUGH), the most prestigious professional organization in global health, elected Zaman to its Board of Directors. Zaman is one of a small but growing number of nonphysicians—and only the second engineer—to achieve this status. Founded by leading North American university global health programs, CUGH sets standards for global health curricula, competencies and field placements, and coordinates collaborative global health projects among resource-rich universities and resource-limited nations and institutions. “Historically, undergrad engineering students have not been a part of the activities in global health, but there is tremendous interest amongst them,” said Zaman. “This opportunity will allow me to get them more engaged and provide a platform for them to make an impact on the world.”— By Rich Barlow and Mark Dwortzan

Metcalf Cup and Prize Winner: Stormy Attaway TEACHING THAT ALWAYS EVOLVES, LIKE TECHNOLOGY Assistant Professor Stormy Attaway (ME) was this year’s winner of the Metcalf Cup and Prize, the University’s highest teaching honor. Working since 1986 both as a teacher and director of curricular assessment and improvement to help ENG students thrive, Attaway has deliberately evolved her teaching style to incorporate new approaches to better reach students. “One of my main concerns is evidencebased teaching,” she says, “trying things in a systematic way to find out what works and what doesn’t.” For example, she has shifted in recent years to brief talks of no more than 10 minutes, fol-

Top left: Assistant Professor James C. Bird (ME, MSE) Top right: Assistant Professor Ahmad (Mo) Khalil (BME, Bioinformatics) Bottom: Assistant Professor Mac Schwager (ME, SE)

environments—knowledge that could inform new approaches for engineering cellular functions. [See p. 15.] Schwager’s award will support his research efforts to develop algorithms enabling groups of robots to control harmful ecological phenomena such as forest fires, oil spills and agricultural pest infestations. He aims to use a group of robots not only to sense an environment but also to control the evolution of processes in the environment.

HER DEVOTION TO STUDENTS AND EVER-IMPROVING TEACHING HAS EARNED STORMY ATTAWAY THE 2014 METCALF CUP AND PRIZE.

lowed by practice problems that students tackle in teams for a more active learning approach. Last year she abolished lectures outright in one of her classes; instead, students now receive lecture videos online, complete with embedded quiz questions. Dispensing with traditional lectures makes it easier to assess how she’s doing as a teacher, since “I can walk around the room and engage the students one-on-one.” “I can think of no one who has touched more BU engineering students during the last 30 years,” one colleague wrote to the Metcalf selection committee. Attaway (GRS’84, ’88) has also written a textbook about a sophisticated programming language called MATLAB used in research labs, and worked to develop online education through BU’s Digital Learning Initiative. —By Rich Barlow, BU Today E N G I N E E R FA L L 2 0 1 4 W W W. B U . E D U / E N G

ENG Welcomes New Tenure-Track Faculty

NEW FACULTY Formerly a systems scientist at Carnegie Mellon University, Manuel Egele (ECE) develops methods and tools to assess and improve security and privacy on mobile devices, web browsers and social networks. For example, he has devised a novel approach and tool that analyzes iOS programs (apps) for potential leaks of sensitive information from a mobile device to third parties—work that won the Distinguished Paper Award at a top international conference in computer security. He received his PhD in computer science from Vienna University of Technology.

Vivek Goyal (ECE) hails from MIT, where he was a faculty member in the Electrical Engineering and Computer Science Department. An expert in signal processing and imaging systems, he published a paper in the journal Science this year on a new method to boost remote sensing and microscopy capabilities [see p. 6]. Prior to joining the MIT faculty, he was a member of the technical staffs at Bell Labs and Digital Fountain. A recipient of a National Science Foundation CAREER Award and multiple IEEE awards, an IEEE Fellow, and

Manuel Egele (ECE)

Vivek Goyal (ECE)

technical program committee co-chair for the 2016 IEEE International Conference on Image Processing, Goyal earned his PhD in electrical engineering from the University of California, Berkeley. Previously an assistant professor of engineering science and mechanics at Virginia Tech, Douglas Holmes (ME) investigates the mechanics and control of thin structures, with an eye toward designing advanced materials with novel properties, from flexible microneedles to artificial muscles. For example, his observations on how polymer surfaces fold, crumple and snap could lead to the development of materials that can dynamically change in the presence of different environmental conditions. A 2013 ASEE Outstanding New Mechanics Educator and Oxford University visiting scholar, Holmes earned his PhD in polymer science and engineering from the University of Massachusetts, Amherst. Sahar Sharifzadeh (ECE) joins the faculty from the Lawrence Berkeley National Laboratory, where she served as a project scientist. Her research focuses on the application of the latest electronic structure

Cassandras, Han Win Faculty Awards

Professor Christos Cassandras (ECE, SE) delivered the 2014 Distinguished Scholar Lecture, where he highlighted methods he’s developed to solve difficult problems by exploiting their specific structure and asking the “right” questions. His approach has resulted in time and cost savings, enhanced security and other benefits. Assistant Professor Xue Han (BME) won the College’s Early Career Research Excellence Award. 28

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Douglas Holmes (ME)

Sahar Sharifzadeh (ECE)

theories to better understand optical and electronic properties of complex materials. She plans to use this theoretical approach to design novel solar energy conversion materials. Sharifzadeh received her PhD in electrical engineering from Princeton University. PROMOTIONS Paul Barbone (ME) and Joshua Semeter (ECE; ENG’92, ’97) were promoted to Professor, and James Galagan (BME, Microbiology) and Michael Smith (BME) were promoted to tenured Associate Professor.

Klapperich Selected as First Dorf-Ebner Distinguished Faculty Fellow Associate Professor Catherine Klapperich (BME, MSE) was selected as the inaugural recipient of the Dorf-Ebner Distinguished Faculty Fellow Award, which honors a mid-career ENG faculty member who has demonstrated exceptional performance and impact in research, teaching and service to the College, and who is on track to become an outstanding senior leader in his or her field. Issued once every five years, the award provides each recipient with $100,000 for discretionary initiatives in research and/or education over a five-year period. The award is made possible by the generous philanthropy of Roger Dorf (MS, MFG’70)—a former vice president of Cisco Systems who serves on the ENG Dean’s Leadership Advisory Board—and was named in memory of Professor Merrill Ebner (MFG), who served as a mentor to both Dorf and Klapperich.

KLAPPERICH: MIKE SPENCER

The College of Engineering welcomed four new faculty members this year as assistant professors. Experts in a wide range of fields, they are expected to bring innovative ideas into the College’s classrooms and research labs. In addition, four ENG faculty members were promoted.

NEWS BYTES FACULTY › Professor Enrico Bellotti’s (ECE, MSE) Computational Electronics Group received a $336,000 grant from the NSF for research that could improve utility pole efficiency and reduce developmental costs of electric trains. The group also received a $150,000 grant from the Army Research Office to evaluate heterogeneous computer architectures to simulate advanced materials and devices.

› The American Cancer Society

granted Assistant Professor Darren Roblyer (BME) a Research Scholar Award of $776,000 over four years to develop a noninvasive, wearable imaging device he invented that promises to ensure that cancer patients receive chemotherapy drugs that work effectively throughout the course of treatment.

› The Department of Energy awarded

$800,000 to an ENG team—Associate Professor Srikanth Gopalan, Professors Soumendra Basu and Uday Pal, and Assistant Professor Emily Ryan (all ME, MSE)—and industry partner, Fuel Cell Energy, to extend the lifetimes of solid oxide fuel cells, which are suitable for applications ranging from electric power stations to longhaul transportation.

› Assistant Professor Xue Han (BME) received a Presidential Early Career Award for Scientists and Engineers at the White House in April.

A prototype system the Roblyer Lab plans to clinically test to improve cancer treatment (Photo by Connor Gleason)

› Professor Barbara Shinn-

Cunningham (BME) was elected as vice president of the Acoustical Society of America.

Professor Barbara Shinn-Cunningham (BME) with outgoing Vice President Peter Dahl at the Acoustical Society of America conference.

› Associate Professor Muhammad Zaman (BME, MSE) addressed the “Showcasing the Bioeconomy—The Future Is Now” conference at the US State Department in March.

STUDENTS & ALUMNI › Three BU students—Winston Chen (ECE’16), Dean Shi (ECE’16) and Huy Le (CAS’16)—and a UMass Lowell student, Corey Prak (’15) were named the winners of HackBostonStrong, a 26.2hour event organized by mobile app development firm Intrepid Pursuits to encourage technological advancements to solve marathon-related issues. Winning $2,000 for their efforts, the team developed the “Echo Can,” a green bin that sorts recyclable and unrecyclable waste. › Competing with about 500 other

student groups, ENG’s Global App Initiative received two student group awards from BU’s Student Activities Office: Best in Category: Service and Justice; and Excellence in Individual Programming, for its GAI App Fair.

› Andrew Kelley (CE’14), who has started his career at SpaceX, received the BU Center for Space Physics Undergraduate Research Award. Kelley was selected for his contribution to the BU Satellite Program and the BU Rocket Propulsion Group.

started 17 websites or mobile apps from scratch within 24 hours. BU clubs BUILDS, Digital Media Club and Open Web also helped plan the event.

› A $1,000 prototype of AutoScan, a vehicle-mounted pothole detection system developed by graduating EE students Austen Schmidt, Nandheesh Prasad, Charlie Vincent, Vinny DeGenova and Stuart Minshull as part of their senior design project, won first prize in a video contest organized by GizmoSphere. Coupled with tracking and scheduling software and incorporating a low-cost, embedded technology development platform called a Gizmo board, the system could provide a comprehensive and economical road repair solution. › A team of MSE grad students (PhD

students Shizhao Su, Yihong Jiang and Yiwen Gong, and MEng student Xiao Han) from Professor Uday Pal’s (ME, MSE) research group won the silver medal and an $8,000 cash prize at the TECO Green Tech Contest in Taiwan in August for their project, “Innovative Green Technology for CostEffective Metals Production.” The BU team placed second among 19 teams representing universities from China, Japan, Russia, Singapore and the US.

› A paper by Assistant Professor President Barack Obama talks with PECASE recipients in the East Room of the White House, April 14, 2014 (Official White House Photo by Pete Souza). Han is in the second row (from top), fourth from left.

› Professor Yannis Paschalidis (ECE, SE) is editor-in-chief of the new IEEE journal Transactions on Control of Network Systems, which released its inaugural issue in April on the IEEE Xplore site.

Yannis Paschalidis

Matthias Schneider (ME) and Research Associate Shamit Shrivastava that appeared in June in Journal of the Royal Society Interface provides new evidence suggesting that cells can signal each other via sound waves, and potentially leading to fundamentally new drug targets and approaches for treating neurological disease and engineering artificial organs.

› An interdisciplinary team consisting

of Professor Sandor Vajda (BME, SE), Research Assistant Professor Dima Kozakov (BME), Professor Yannis Paschalidis (ECE, SE) and Associate Professor Pirooz Vakili (ME, SE) has discovered new computational methods to boost the speed and accuracy of software that predicts the structures of complexes that form when two proteins bind together. Described in the journal eLife, these new methods could help researchers quickly discover both healthy protein pairs and disease-causing pairs that may serve as drug targets.

Associate Professor Joshua Semeter (ECE), Andrew Kelley (CE’14) and ECE Department Chair Professor David Castañón (ECE, SE). Photo by Chitose Suzuki

› Annie Lane and Maya Saint Germain (both CE’16) and Kathleen Lewis and Rebecca Thompson (both BME) received Clare Boothe Luce Scholar Awards, which support undergraduate summer research projects undertaken by female US citizens. › Connor McEwen (ECE’14) and a planning team called Make_BU organized the first overnight hackathon, or collaborative computer programming event, at BU’s Engineering Product Innovation Center. In groups of two to four people, more than 120 hackers

Yihong Jiang, Shizhao Su and Yiwen Gong with their silver medal at the Green Tech Contest. (Xiao Han was unable to attend.)

› Senior design teammates Poling Yeung, Michaelina Dupnik and William Moik (all BME’14) took second place in the National Institute of Biomedical Imaging and Bioengineering’s Design by Undergraduate Biomedical Engineering Teams (DEBUT) competition. The team, which created a high-tech glove to enhance the capabilities of the traditional white cane used by people with visual impairments, will receive $15,000 at a ceremony at the Biomedical Engineering Society (BMES) conference in October. —Mark Dwortzan, Gabriella McNevin, Chelsea Hermond (SMG’15) and Paloma Parikh (COM’15)

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alumni

WE WANT TO HEAR FROM YOU! SEND YOUR CLASS NOTES SUBMISSIONS TO ENGALUM@ BU.EDU OR VISIT WWW.BU.EDU/ENG/ALUMNI.

ENG Graduates Urged to Use Their Societal Engineer Skills

t convocation ceremonies on May 17, the College of Engineering’s Class of 2014 was reminded of the impact a Societal Engineer can make in improving our quality of life.

Dean Kenneth R. Lutchen congratulated the 336 undergraduates for having completed what he contended was one of the most difficult degrees to earn from BU. “What you’ve done by getting an education at Boston University is really understand the extraordinary importance of learning how to create, design and interact with other disciplines, and how to move organizations forward by integrating with a complex social economic system,” he said. Student speaker Shana Blumenthal (ME’14, Aero), now working at

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Pratt and Whitney, told her fellow graduates, “Great engineering feats of the past century were not developed by those who solved the easy problems, but by those risk-takers who attempted the impossible. It is our time to find solutions for new challenges. It is our responsibility to seek out opportunities to allow us to grow and develop.” Kevin Kit Parker (ENG’89), a professor of bioengineering and applied physics at Harvard University and leader of a research team that in 2011 upended the conventional wisdom about the cause of traumatic brain injury, was Commencement speaker. Parker emphasized strength and perseverance, qualities that served him well as a US Army paratrooper when he completed two tours of duty in Afghanistan. “I’m a BU-trained Societal Engineer,” he said. “My job isn’t always technical, but it always involves solving problems.”

CLASS NOTES Want to earn an ENG T-shirt? Send your class notes submissions to engalum@bu.edu or visit www.bu.edu/eng/alumni. Contributors of all published notes receive a red BU Engineering T-shirt!

1999

Alex Poon, BS, White Plains, New York • Alex’s new venture,

x.ai, an artificial intelligence-powered personal assistant that lets you use email to schedule meetings, closed a $2 million seed round. “You talk to Amy as you would to any other person,” he writes. “Once tasked, she’ll do all the tedious email ping-pong that comes along with scheduling a meeting.”

2000 Student speaker Shana Blumenthal (ME’14) (above left), encouraged her fellow graduates to be risk-takers who find solutions for new challenges. Kevin Kit Parker (ENG’89) (above), Tarr Family Professor of Bioengineering and Applied Physics at Harvard University, addressed bachelor’s degree recipients at Commencement Exercises.

COMMENCEMENT PHOTOS COURTESY OF COMMENCEMENT PHOTOS, INC.

Girish Navani (ENG’91) (left), CEO and co-founder of eClinicalWorks, addressed graduate students at their ceremony later in the afternoon.

Lutchen also gave out the Department Awards for Teaching Excellence, which went to Associate Professor Michael Smith (BME), Assistant Professor Ajay Joshi (ECE) and Associate Professor of the Practice William Hauser (ME). Outstanding Professor of the Year went to Professor James J. Collins (BME, MSE, SE), and the Faculty Service Award to Associate Professor Elise Morgan (ME, BME). He also noted that Assistant Professor Stormy Attaway (GRS’84, ’88) would receive the Metcalf Cup and Prize [see p. 27], the University’s highest teaching honor, at the University Commencement ceremony the following day. The graduating seniors received several honors, including the Societal Impact Capstone Project Awards. In that category, Yash Adhikari, Angela Lai, Timothy Mon and Leslie Nordstrom (all BME) won first place for their project, “An Integrated Microfluidic Device for Diagnosing Neisseria gonorrhea;” Ian Cohen and Zachary Herbert (both ME) placed second for “MicroDiagnostics Device Innovation;” and Elvin Cako, Anne DuBois, Benjamin Nichols, Evan Praetorius and Heather Towey (all ECE) placed third for “EPIC/EpiPen® Calls.” Later in the day, Girish Navani (MS, MFG’91), CEO and co-founder of eClinicalWorks, a leader in ambulatory health care IT solutions, delivered the speech at the master’s and PhD hooding ceremony in which 86 master’s students, 150 MEng students and 53 PhD students were recognized for successfully completing the requirements for graduating. Navani, who was named a 2010 Mass High Tech All-Stars honoree and received the Ernst & Young Entrepreneur Of The Year® 2009 Award in the Healthcare Technology category in New England, commended the graduate students on their success. “Milestones like the one you are experiencing right now remind us of the paths we have taken, and present us with a road for the future,” he said. “Today is full of promise; full of opportunity for what lies ahead.”—Kathrin Havrilla

Loretta (Hawkes) McHugh, BS, Thompson, Connecticut •

Loretta has worked for 11 years at Henke Sass Wolf of America, a medical device company in central Massachusetts, and is currently director of quality. She had her third child in March, Adeline Hannah. Big sister Maggie, 7, and big brother James, 3, are loving their new baby sister. Look for the McHugh family in their season ticket seats for BU Men’s Hockey.

2003

Josh Gepner, BS, Chicago, Illinois • Environmental Systems

Design Inc. (ESD) has promoted Josh to vice president. He joined ESD in 2009 with a background in designing electrical systems for commercial, residential and industrial facilities, and now specializes in commissioning projects for mission-critical facilities.

Earl Valencia, BS, Muntinlupa, Philippines • President/cofounder of the IdeaSpace Foundation Inc., the largest privately backed, multi-industry incubator in the Philippines, Earl is one of four Filipinos named Young Global Leaders of 2014 by the World Economic Forum.

PASSINGS James D. Moriarty (’55) Dante V. Asci (’56), Senoia, GA William F. Keene (‘56), Hampton, NH John C. King (’56), Lyndon Center, VT Richard D. Little (’56, SED’65), Tucson, AZ Allen P. Wiley (’56), Warrenton, MO William E. Brennan (’58), Southfield, MI Lawrence M. Theriault (’58), Elkton, FL Trygve M. Blix (’61), St. Mary’s City, MD Philip A. MacVicar (’64), Enfield, NH Edward J. Trainor (’66), New Castle, NH Laura L. Reid (‘77), Chilmark, MA William E. Klein (’86), Poolesville, MD James A. Vachon (’91), Rowley, MA Christopher J. Miller (‘95), Los Angeles, CA Eric S. Munsell (’12), Manalapan, NJ David M. D’Alessandro (‘13), Brookline, MA Kevin Lee (’16), Brooklyn, NY CORRECTION: ENGineer regrets the erroneous inclusion of Patrick J. Callery (’94) in this list in the Spring 2014 issue. Mr. Callery lives in Goleta, CA.

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ENG 50th Anniversary Celebration

Alumni Lunch Panel

Speaking before an audience packed with ENG students, alumni and faculty at the BU Photonics Center Colloquium Room on September 19, six exemplary alumni highlighted their career paths, how they’ve impacted society and how their engineering education has contributed to their success. Joined by Dean Kenneth R. Lutchen (third from left) were panelists (from left) Kevin Kit Parker (BME’89), Kathleen McLaughlin (ECE’87), Amit Jain (ECE’85, ’88), Jennifer Gruber (AME’99), Kevin Knopp (ECE’94) and George Savage (BME’81).

Hovering over a cluttered table in the BU Photonics Center Colloquium Room, John Folloni (ENG’60, ’72) (from left), Gregg Fischer (ENG’07), Abena Kwakyi (ENG’11), Associate Professor Daniel C. Cole (ME), Ian Leatherman (ENG’11) and Ben Graham (ENG’16) collaborated on their vehicle. Supplied with a bag of popsicle sticks, duct tape, straws, plastic wheels, balloons, batteries, circuit boards and other small parts, they vied with three other teams of alumni, students and faculty to design and build a small vehicle that could travel across four long tables under its own power. 32

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ENG on the Green

ENG golf outing at Knollwood Country Club in Elmsford, New York, hosted by Dr. Binoy K. Singh (ENG’89) in July. Ritesh Singh (‘16), Assistant Dean for Development & Alumni Relations Bruce Jordan, Jordan S. Orlins (‘89), David I. Herman (’70), Binoy K. Singh (‘89), Dean Kenneth R. Lutchen, Min Ki “Mitchell” Kim (’86), Jarl Jensen (’94), Gordon Walsh (’67, ’68, GSM’71) and Ryan Smedley.

BOTTOM RIGHT: CYDNEY SCOTT. TOP: NATALIA BOLTUKHOVA

Student-Alumni Team Design Challenge

Dear Friends, The College’s 50th Anniversary Celebration year is here, and you have already started it with record-setting generosity in annual giving and in the ENG Capital Campaign! California Chrome may have fallen short of the Triple Crown, but not you. Your generosity this year broke ENG records in every category: annual giving dollars, annual giving donors and leadership donors. And not by a nose, but by a furlong. Leadership donors—those who give $1,000 or more to the ENG Annual Fund or Societal Engineering Fund—grew by 15 percent to 156—a seventh consecutive record. Annual Giving grew by more than $200,000 to $626,000, also a seventh consecutive new record, and annual giving donors were up by almost five percent. That’s what I call the “Triple Crown of Generosity.” Once again our senior class led the way: Almost 60 percent gave to the Senior Class Gift, far and away the most generous class in ENG history. Thank you, seniors, for showing your leadership! It gets even better. By July, the College’s Capital Campaign had surpassed $55,800,000—93 percent of the way to its goal, and well ahead of the other major BU schools. Not one but four new professorships, a new distinguished faculty fellowship, two new lectureships and two new scholarships were pledged, as more than $11,000,000 was raised in FY’14. Breathtaking! Savor the impact your generosity is having on College of Engineering students, like these: • STARS fellows, like Maria Barrios, whose summer research in Professor Joyce Wong’s lab is helping to develop chemo-attractant molecules that will ultimately be used to predict the migration of cancer cells in the human body; • F ive EE seniors—Austen Schmidt, Nandheesh Prasad, Charlie Vincent, Vinnie DeGenova and Stuart Minshul—whose AutoScan device, using sensors mounted on the undercarriage of Boston cars to identify and pinpoint potholes, won a GizmoSphere video contest; • I nspiration Ambassadors, like Frances Bravo (ME’16) and Kevin Mannix (CE’15), who have traveled the US infusing middle and high school students with excitement over how they can impact the world through careers in engineering; • T erriergami—Prakash Iyer, Aditya Sengupta and Haravin Vallabhaneni (BME’14) and Sageeta Satish (BME’16)—whose method of delivering DNA origami to neurons won gold at the national BIOMOD competition; •N athaniel Lee (BME’15) and Dan Sade (ME‘14) who, with their Engineers Without Borders mentors, developed cell phone reception booster antennas in Naluja, Zambia, allowing medical personnel to transmit and receive critical test results from areas with limited network access; and •D oug Roth, Luke Sorenson, Timothy Chong (all CE’16) and John Moore (CE’15), whose app, Downtyme, won first prize at the Third Imagineering Competition. Now a startup, Downtyme enables college students to locate and meet up with friends nearby. Generosity like yours not only makes a huge difference in the lives of undergraduates, but also enables the quantum leap in excellence the College is making, from the dramatic growth in our number of applicants (which has doubled in three years) to the international awards and honors the faculty is winning, to top-40 recognition in surveys appearing in U.S. News & World Report and other widely read publications. Thanks for jumping aboard and joining this adventure—I promise you will enjoy it! My warmest thanks,

Bruce Jordan, Assistant Dean for Development & Alumni Relations P.S. I look forward to seeing you at our 50th Anniversary events this year!

Honor Roll of Supporters $100,000–$249,000

Anonymous ■ ■ Joseph P. Healey (ENG’88) ■ Steven M. Tadler and Joyce E. Tadler ■ ■

$50,000–$99,999

Roger A. Dorf (ENG’70) and Sandra M. Dorf ■ ■ David E. Hollowell (ENG’69, ’72; GSM’74) and Kathleen A. Hollowell (GRS’71, SED’77) ■ ■ ■ David F. Kiersznowski (ENG’85) and Demi D. Lloyd ■ ■ John Tegan (ENG’88) ■ ■

$25,000–$49,999

Charles R. Cantor ■ Michael B. Gordon ■ ■ Tsong-Hour Chen and Yu-Hsing Jao ■ ■ Peter J. Levine (ENG’83) and Martha Levine ■ John A. Maccarone (ENG’66) and Young O. Maccarone ■ ■

$10,000–$24,999

Anonymous ■ ■ ■ Mary S. Abele (CAS’60) and John E. Abele ■ ■ Professor Stormy Attaway (GRS’84, ’88) and Theo A. De Winter ■ ■ ■ Frederick G. Bargoot ■ ■ Edward S. W. Boesel (ENG’70) ■ ■ Wayne Cheung (ENG’99) ■ ■ Christopher H. Brousseau (ENG’91) and Mary Lou K. Cronin ■ ■ Hanna G. Evans ■ ■ William D. Felder and Katharine C. Felder ■ ■ Joan Ingalls ■ Nicholas J. Lippis (ENG’84, ’89) and Lillian A. Lippis ■ ■ ■ Girish M. Navani (ENG’91) and Radhi Navani ■ ■ ■ Richard D. Reidy (SMG’82) and Minda G. Reidy (SMG’82, GSM’84) ■ ■ ■ Binoy K. Singh (ENG’89) ■ ■ Philip Taymor and Kathleen Taymor ■ ■ ■ Christine Trainor ■ ■ Edward J. Trainor (ENG’66) ■ ■ Gordon R. Walsh (ENG’67, ’68; GSM’71) and Irene S. Walsh ■ ■

$5,000–$9,999

Anonymous ■ ■ ■ Saad N. Buisier (ENG’03) and Rita M. Buisier ■ ■ Leonard W. Ely ■ ■ Tony L. Fant and Sheila M. Fant ■ ■ Michele J. Iacovone (CGS’86, ENG’89) and Lisa Hu (CGS’86, COM’88) ■ Dean L. Kamen (Hon.’06) ■ ■ Ezra D. Kucharz (ENG’90) and Jennifer M. Kucharz ■ ■ Andrew J. Marsh (ENG’83) and Heather J. Marsh (CAS’83) ■ ■ Eric J. Meltzer (ENG’82) and Brooke Meltzer (CGS’80, MET’82) ■ ■ Sanjay Patel (ENG’87) and Falguni S. Patel ■ ■ ■ Glenn J. Riedman (ENG’90) and Jill Riedman ■ Yannis Skoufalos and Maria Kalomenidou ■ ■ ■ Jennifer R. Gruber (ENG’99, ’99) and Ron Sostaric ■ ■ Mark R. Templeton (ENG’11) and Betsy Templeton ■ ■ Francis J. Troise (ENG’87) ■ ■ Brendon J. Howe (ENG’84) and Lynne M. Wadman-Howe (SED’87) ■ ■

$2,500–$4,999

Gregg Adkin (ENG’86) and Kim A. Adkin ■ ■ Charles E. Bascom (ENG’64) and Christina M. Bascom ■ ■ Bettina Briz Himes (ENG’86) and Peter G. Himes ■ ■ Peter K. Cocolis (ENG’64) and Lorraine P. Cocolis (SAR’63) ■ ■ ■ M. John DeMatteo ■ ■ Patrick J. Foley (ENG’91, ’94) and Kerry C. Foley (ENG’91) ■ ■ Alireza Hakimi (ENG’82, ’86) and Nazila Bidabadi (CAS’82, SDM’87) ■ ■ Kenneth E. Hancock (ENG’92, ’01) and Hsi Pin Chen (CAS’89, SPH’91; MED’96, ’96) ■ ■ Ruth A. Hunter (ENG’64, GSM’86) ■ ■ Amit Jain (ENG’85, ’88) and Rachana Jain ■ ■ ■ Larry Leszczynski (ENG’85) and Anne E. Hines (ENG’87) ■ ■ Gayle W. Lutchen (SED’93) and Kenneth R. Lutchen ■ ■ ■ ■ David W. Maruska (ENG’82) and Dorothy J. Maruska ■ ■ ■ Carl L. Myers (ENG’65) and Jane S. Myers ■ ■ Jason R. Light (ENG’02, ’04) and Samantha Nagle-Light ■ Steve N. Oesterle ■ Taki G. Pantazopoulos (CGS’80, ENG’83) and Elaine V. Pantazopoulos ■ ■ Sanjay Prasad (ENG’86, ’87) and Suman V. Prasad (SMG’89) ■ Guy Rodgers ■ ■ ■ Michael L. Salamone (ENG’84) and Pamela E. Salamone ■ ■ H. T. Than (ENG’85, LAW’93) and Kim Quyen V. Pham (ENG’91) ■

$1,000–$2,499

Mr. Husain M. Al-Bustan (ENG’89, ’91) ■ ■ Robert F. Allen and Gayle H. Allen ■ ■ Santiago Beltran Miranda ■ ■ David J. Bishop ■ ■ Charles Bragdon ■ ■ ■ David J. Brand (ENG’83) and Deborah P. Brand ■ ■ Regina G. Carolan (ENG’97, ’03) ■ ■ Li-Yang Chen ■ ■ Jason P. Colacchio (ENG’90) and Tracy L. Colacchio ■ ■ Gregory S. Cordrey (ENG’88) and Stephanie K. Cordrey ■ ■ Nirav A. Dagli (ENG’92, ’96) and Juhi G. Dagli (UNI’99) ■ Abdulrasul A. Damji (ENG’85, ’90) and Amina A. Damji ■ ■ ■ Lawrence F. DePaulis (ENG’99) and Debra DePaulis ■ Thomas M. DiCicco (ENG’01) ■ ■ Robert T. Eberhardt and Margaret M. Eberhardt ■ ■ ■ ■ Howard C. Ehrlich (ENG’60) and Nina W. Ehrlich ■ ■ Solomon R. Eisenberg and Terri B. Eisenberg ■ ■ ■ Tahsin M. Ergin (ENG’81) and Colleen P. Ergin ■ ■ Peter C. Fang (ENG’75) and Josephine T. Fang ■ Debra Feldman ■ ■ Edwin J. Fitzpatrick (CGS’70, CAS’72) ■ ■ ■ Janet A. Fraser (ENG’81) and Gregory B. Fraser ■ ■ Ronald G. Garriques (ENG’86) and Karena Garriques ■ ■ John M. Garvey (ENG’86) and Kimberly J. Garvey ■ ■

HONOR ROLL Lisa W. Gill ■ ■ Muckai K. Girish (ENG’94, ’97) and Sandhya R. Girish ■ ■ Steven J. Goldman (ENG’91) ■ ■ Warren M. Grill (ENG’89) and Julia Grill ■ ■ Paul W. Gross (ENG’93, ’98) and Tanya Gross ■ Roger A. Hajjar (ENG’88) and Jeannette Hajjar ■ William T. Hathaway (ENG’65) and Joan L. Hathaway ■ ■ William M. Hauser ■ ■ ■ Bader M. Hawary (ENG’01, ’02) ■ Mark G. Hilderbrand (ENG’87) and Rebecca J. Hilderbrand ■ Ralph Holmberg (ENG’66, ’70) and Carolyn Murphy ■ ■ Robert H. Howland (ENG’82) and Michele H. Howland ■ ■ Marjorie F. Hsu (ENG’86, GSM’93) and David R. Buckler ■ Kent W. Hughes (ENG’79) and Debra S. Hughes ■ ■ William I. Huyett and Lauren M. Huyett ■ ■ Min Ki M. Kim (ENG’86) and Michelle Kim ■ Tyler D. Kohn (ENG’98) ■ ■ Scott Kyllo ■ ■ David W. Lacey (ENG’65) and Andrea L. Lacey ■ ■ Manuel A. Landa (ENG’66) ■ ■ Min-Chang Lee ■ ■ ■ ■ Thomas P. Lisowski (ENG’95) ■ ■ Curt Lomax ■ ■ Jeanne M. Mathews (LAW’84) ■ ■ Marguerite P. Matson ■ William N. McClelland (ENG’84) ■ Robert C. McKinstry (ENG’84) ■ ■ ■ Shaun P. McManimon (ENG’83) ■ Jeffrey M. Melzak (CAS’84) and Julie S. Melzak (ENG’87) ■ ■ Richard J. Mendes (ENG’86) and Catherine Mendes ■ Pamela L. Metz (ENG’81) ■ ■ David S. Miller (ENG’91, ’94) and Barbara Miller ■ Dale T. Moorman and Mildred R. Moorman ■ ■ ■ Matthias F. Moran and Clare A. Moran ■ ■ ■ Theodore D. Moustakas and Elena Moustakas ■ ■ ■ ■ Rao P. Mulpuri (ENG’92, ’96) and Rohini D. Mulpuri ■ Frances A. Murphy ■ Kurukundi R. Murthy (ENG’90) and Barbara A. Kowack-Murthy (ENG’90) ■ ■ John D. Nachmann (CAS’89) ■ Karen E. Kullas (ENG’77) and Bruce Newcomb ■ ■ Richard A. Ng-Yow (SMG’85, GSM’88) and Tamara S. Ng-Yow (ENG’87, GSM’88) ■ John D. O’Neil (ENG’62) and Mary L. O’Neil ■ Justine Osage-Laugharn (ENG’83) and James A. Laugharn ■ ■ Osman Oueida (ENG’01) ■ ■ George S. Ouellette (ENG’81) ■ ■ Anton T. Papp (ENG’90) and Susan Papp ■ ■ Kevin K. Parker (ENG’89) ■ ■ Kimberly G. Parker ■ ■ James S. Paulsen (ENG’69, ’72) and Susan C. Paulsen ■ ■ Joseph A. Pellegrino (LAW’78) and Kathleen B. Pellegrino (ENG’62) ■ ■ Michael P. Platt (ENG’13) ■ ■ ■ Dennis S. Poe and Milja R. Poe ■ ■ ■

B U CO L L EG E O F E N G I N E E R I N G

Michael D. Poling and MaryJane J. Poling ■ ■ ■ Andrew P. Quick (ENG’92, ’95) and Tracy M. Quick (SED’93) ■ ■ David Dean (ENG’73) and Deborah P. Rata ■ ■ Kyle Richard (ENG’86) and Kristin Richard ■ ■ Sandra L. Rivas-Hall (ENG’81) and William C. Hall ■ ■ Alan G. Rottman ■ ■ ■ Robert F. Sabia (ENG’87) and Kathy Sabia ■ Frank N. Salamone (ENG’94) ■ ■ George M. Savage (ENG’81) and Nancy K. Savage (COM’80) ■ ■ Yuval V. Scarlat ■ ■ Jennifer S. Schneider ■ Cheri Schumann ■ ■ Richard C. Scully (SMG’78, ENG’81) and Deborah L. Cobb (SAR’77) ■ ■ Gregory D. Seiden (ENG’80) and Robin K. Seiden ■ ■ Ushir N. Shah (ENG’98) and Susan R. Shah ■ ■ Philippe Sikias (ENG’99, ’00) and Sima Sikias ■ Benjamin D. Sullivan (ENG’97) ■ ■ Frederic J. Syrjala (ENG’58, ’60) and Mary E. Syrjala ■ ■ David H. Johnson (ENG’65, ’66) and Rebecca G. Thompson ■ ■ Francis A. Tiernan (ENG’70) and Barbara H. Tiernan ■ ■ Mark A. Tubinis (ENG’81) and Martha Tubinis ■ ■ ■ Selim M. Unlu and Nese Lortlar ■ ■ ■ Berl P. Winston (ENG’64) and Alice J. Winston (SED’65) ■ ■ Robert P. Wotiz (ENG’99, ’05, ’06) ■ ■ Janice K. Zika (ENG’84) ■ ■ Bernardo J. Zubillaga and Susana Herrera ■ ■ ■

$500–$999

Alexander Adam (ENG’92, ’95, ’03) and Davina D. Wong (GSM’02) ■ Mark A. Allen (ENG’87) and Phyllis J. Allen Lawrence J. Aube (ENG’84) and Bernadette M. Aube ■ Joseph M. Basile (ENG’82) James Bethune (ENG’64, GSM’74, SED’91) ■ ■ ■ Thomas G. Bifano ■ ■ Sarah H. Brukilacchio (ENG’89) and Thomas J. Brukilacchio ■ Daniel J. Burke (ENG’92) and Kelly A. Musick (CAS’92) James J. Byrne (ENG’93) and Sarah M. Byrne (SAR’93) ■ Stephen M. Campbell (ENG’97) ■ James H. Caplan (ENG’79, GSM’83) and Heather C. Caplan (GSM’94) ■ Frederic D. Carter (ENG’97) ■ Chun-Wei Chan (ENG’06) ■ Wesley R. Chedister (ENG’00) ■ Lou Chitkushev (ENG’96) and Irena Vodenska (UNI’09) ■ Daniel J. Clancy (ENG’91) ■ Susan L. Crockett (ENG’84) and David Crockett ■ Thyagaraju Damarla (GRS’87, ENG’93) and Bai K. Damarla ■ Hemang D. Dave and Theresa Dave ■ ■ Martin DeMatteo ■ Alexander C. Demusz (ENG’08) ■ ■ Stephanie A. Dines (ENG’94)

Lawrence S. Drasner (ENG’89) and Dawn M. Drasner ■ Martha E. Ferris (ENG’82) ■ Christopher A. Frail (ENG’97) and Melissa Frail (ENG’97) Timothy S. Gardner (ENG’00) and Wendy C. Gardner (CGS’95, SAR’97) ■ Patrick Gillooly (ENG’87) and Christin L. Gillooly (SAR’92) Steven D. Girouard (ENG’89) and Cynthia L. Keim Girouard (SAR’89) ■ ■ Richard G. Gould (CGS’85, ENG’90) and Diana Stilwell ■ George C. Guerra (ENG’84) ■ Russell W. Wolf (CAS’97, MET’01) and Tara L. Heath (ENG’96, GSM’02) ■ Sui C. Heier (ENG’89) ■ ■ Jody L. Hoppe (ENG’82) Iftekhar Hossain and Feroza K. Hossain ■ ■ Hui Huang (ENG’98) Jim Huang (ENG’95) and Christine A. Huang ■ Ronald H. Johnson (ENG’59) and Mary J. Johnson ■ Bruce C. Jordan ■ ■ William J. Karlon (ENG’88, ’91) Nikesh Kotecha (ENG’99) and Masumi P. Patel (SMG’99, MET’02) ■ Robert B. Leonard (ENG’84) and Ilene H. Leonard ■ Kimchi Mai (ENG’93) and Thien P. Le ■ John H. McIver (ENG’81, GRS’90) ■ David A. Castanon and Brenda Metzler Luke E. Nelson (ENG’88) Umur Ozal (ENG’96) ■ Luis A. Pagan-Carlo (ENG’85) ■ Brant A. Cheikes (ENG’84) and Janine Papesh ■ Devang K. Parikh (ENG’99) ■ Jay B. Penafiel (ENG’90) and Elise G. Penafiel ■ Jeffrey T. Roy (ENG’95) and Whitney J. Roy ■ David Royce (ENG’65) and Mary L. Royce ■ Neil D. Beneck (SPH’94) and Marie-Helene Saint-Hilaire ■ ■ ■ William L. Salzer (ENG’72) ■ John A. Scaramuzzo (ENG’87) and Yolanda Scaramuzzo Maria A. Scardera (ENG’84) and Michael P. Scardera ■ Monica L. Slegar (ENG’02, GSM’05) ■ Greg Slyngstad and Mimi Slyngstad ■ ■ Dylan P. Steeg (ENG’95) and Mu-En Steeg (CAS’94) ■ Qun Sun and Hangchun Hu ■ Ann L. Tedford (ENG’78) ■ Michelle F. Tortolani (ENG’82, ’89) ■ Daniel A. Tyszka (ENG’94) and Gloria L. Sherman-Tyszka (GSM’89) ■ Henry Ubik and Sally Tuma ■ ■ Jason M. Ulberg (ENG’98) and Jaime Ulberg (SMG’98) ■ Dinesh Venkatesh (ENG’92, ’98) and Sowmya Manjanatha Daniel S. Hagg (ENG’95) and Jennifer Watters ■ Thomas G. Westbrook (ENG’91) and Mary D. Gibbs-Westbrook ■ Kevin Wong (ENG’12) ■ ■ Siavash Yazdanfar (ENG’96) ■ Matthew A. Zahn (ENG’94) Richard J. Moyse and Beth A. Zeranski ■ ■ Jamshaud Zovein (ENG’95, GSM’99) and Ann C. Zovein (ENG’95, MED’99)

$250–$499

Kurt L. Adams and Nancy J. Adams ■

Omar Ali (ENG’96) ■ Jae W. An (ENG’95) Rohan M. Arun (ENG’10) ■ Ryan T. Bach ■ Edward M. Ballanco (ENG’91) and Eileen M. Ballanco ■ Mark R. Bassotti (ENG’03, ’05) and Kimberly L. Bassotti (CAS’04, GRS’04) Michael D. Belmarsh (ENG’95, MET’00) Peter H. Belmonte (ENG’10) ■ Christopher Benoit (ENG’88) ■ Paul A. Bierden (ENG’92, ’94) and Sheryl C. Bierden (SAR’95, ’97) ■ Anastacia M. Bilek (ENG’96) Laurie A. Blanchard (ENG’89) and Maria C. Dunn (CAS’88) John J. Bolton (ENG’89) and Colleen R. Bolton ■ Jeffrey S. Bowen (ENG’93) ■ Jeffrey S. Brinker (ENG’96) and Stephanie Brinker Laura C. Brutman (ENG’89) and Len B. Brutman ■ Kevin H. Burek (ENG’08) ■ Ezra B. Caplan (ENG’04) ■ Albert S. Chang and Siu F. Chang ■ ■ Kenneth T. Cheng (ENG’84) ■ Jerry Chew (ENG’70) ■ Howard T. Chun (ENG’83) ■ Joseph E. Coffey (ENG’72) and Sharon R. Coffey ■ Louise R. Corman ■ ■ Steven Covert and Diane M. Covert Chenhuan Cui (ENG’07) Daniel C. Cullinane (ENG’63) ■ Brittany C. Culpepper ■ Michael J. Cunha (ENG’04, ’06) ■ Anthony Cuomo (ENG’93) and Gina Johnson-Cuomo ■ Lisa C. DeVine (ENG’87, MET’91) and Thomas J. DeVine ■ Raymond Diaz (ENG’84) and Virginia C. Diaz ■ Peter M. Dichiara (ENG’85, LAW’93) and Liz DiChiara ■ Allan J. Dolinski and Claudette C. Dolinski Sheila J. Dooley (ENG’91) ■ Michael Duchnowski (ENG’91, ’93) and Magda Duchnowski ■ Brian J. Dunkin (ENG’85) David R. Ely ■ Jose R. Esquivel (ENG’88) and Cecilia Esquivel ■ James Ferguson (ENG’61) and Patricia Ferguson Edgar Fernandes and Penny Fernandes ■ ■ Sharon Kaiser Fincher (ENG’82) and Thomas G. Fincher ■ James Y. Fong (ENG’71, ’74) and Margaret Y. Fong ■ Richard A. Fuller (ENG’88) and Tiffany Fuller ■ Roger D. Beaulieu and Jane P. Gagne ■ ■ Mary A. Garrett (ENG’80) Raymond M. Govotski (ENG’95) ■ Robert C. Harrington (ENG’00) Richard L. Heilman (ENG’72) and Carole A. Heilman (CAS’72) ■ Charles T. Hickson (ENG’88) and Susanne Paullin ■ Yue-shun E. Ho (ENG’89) ■ Glenn D. House (ENG’90) and Teresa G. House ■ Nahum Jimenez and Gladys Jimenez ■ Yuan Jing (ENG’02, ’05) ■ Daniel R. Kallman (ENG’94) ■ Paul Karger (ENG’00)

Elaine R. Kasparian ■ Nicholas K. Katzenberger (ENG’94) and Gretchen B. Katzenberger (COM’92) ■ Yuriy I. Kaufman and Irina Kaufman ■ ■ Thomas Keegan (ENG’94) Megan Kenney ■ Boissevain Kwan (ENG’83) ■ Alyssa Kyllo ■ Chad Kyllo ■ Robert Lacy and Adene B. Lacy ■ ■ Alan A. LaRocque (ENG’72, GRS’79, MED’80) and Kathleen A. LaRocque (CAS’74) ■ Chak S. Lau and Sui C. Lau ■ ■ Andrew E. Lazar (ENG’89) and Chrisanna K. Lazar Wei Dai (ENG’99) and Sau Sim Lee ■ Robert C. Levin (ENG’87, ’88) Michael U. Liebsch (ENG’83) To Chan and Hiu Ling Lo ■ ■ Ray Lundquist and Carol Lundquist Heather N. Macken (ENG’10) ■ Thomas F. Mahan (ENG’78, ’80) ■ Patrick S. Markel (ENG’97) and Jennifer Mack (COM’97) Eric Maxwell (ENG’98) ■ Michael H. Palumbo (COM’95) and Cristina M. Mazzoni Palumbo (ENG’95, MED’99) ■ Kathleen L. McLaughlin (ENG’87) and Timothy J. Costigan ■ Scott E. Meninger (ENG’96) Brett J. Meyer (ENG’10) ■ Eric K. Millard (ENG’07) ■ Robert D. Miller (ENG’00) ■ Jeffrey W. Moore (ENG’89) ■ Carlos Moreira (ENG’99, MET’03) ■ ■ Robert A. Morse (ENG’63) ■ William E. Neifert (ENG’90, ’92) ■ Michael J. Norris (ENG’07) ■ Chinonso C. Okparanta (ENG’93) and Constance E. Okparanta Francisco Ortiz and Edith Ortiz ■ ■ Christos I. Panidis (ENG’07) ■ Kirsten H. Paulson (ENG’82) and Mark A. Paulson Javier J. Perez-Andreu (ENG’80) and Marta J. Perez (SMG’80) ■ Herbert S. Plovnick (CAS’67, MED’71) and Kathleen R. Plovnick (CAS’68, ENG’89) ■ Anna M. Popke (CAS’96, ENG’96) ■ Peter I. Presel (ENG’61) ■ James D. Quinty (ENG’86) and Elizabeth Quinty William G. Quirk (ENG’62) ■ Huajun Liu (ENG’98, ’99, ’04) and Zhe Ren ■ Jinara D. Reyes (CAS’88, GSM’99) ■ ■ Ethan F. Robbins (ENG’04) Ignacio Rodriguez (ENG’02) and Nayra Romera ■ Paul C. Rohr and Rita Rohr ■ ■ Carey S. Roseman (SED’76) and Robert M. Roseman Andre Sharon and Judit Sharon ■ Eric J. Sheppard (ENG’83) and Veronica M. Sheppard ■ Robert J. Shimkus (ENG’68) and Linda R. Shimkus ■ ■ R. Paul Aftring and Margaret O. Sowell ■ Patricia N. Speelman (ENG’74) ■ Vadim Y. Spektor (ENG’95, MED’00) and Natalia Levina (CAS’94, GRS’94) Mark D. Spoto (ENG’90) and Elizabeth M. Spoto David W. Streem (ENG’91) Henry B. Stueber and Deanna G. Stueber ■ Eric R. Stutman (ENG’93) and Andrea L. Stutman Todd M. Sukolsky (ENG’13) ■ ■ Neelam M. Thacker (ENG’00, MED’04) ■ Fernando Trindade (ENG’06) ■ Viktor Vajda (ENG’02, ’04; MET’06) ■

Johanna T. Fifi (ENG’96, MED’00) and Rachel Ventura Paul J. Vizzio (ENG’10) ■ ■ Matthew J. Walker Thomas W. Warzeka (ENG’91) ■ Albert C. Williams (ENG’89) ■ Philip T. Winterson (ENG’62) and Barbara A. Winterson ■ Hasting S. Wong (ENG’67, ’68) and Josephine N. Wong (GRS’68) ■ Victor K. Tan (ENG’85) and Toreh Wong Allan M. Workman ■ Bryan Wong and Yvonne Yeung ■ ■ Xianfeng Zhao (ENG’04) ■ Todd E. Zive (ENG’98) ■

$1–$249

Ryan D. Aaron (ENG’95) and Sarah B. Aaron (COM’95) Neil Aaronson Eric Acheampong and Beatrice A. Acheampong ■ Gemma Y. Acheampong ■ Rommel Acuna (ENG’93) and Jennifer M. Acuna Oluwatosin E. Adedokun (ENG’12) Tunde M. Agboola (ENG’10) Qaasim H. Ahmed (SMG’13) ■ Temitayo O. Akinsanya (ENG’11) Farah A. Alabdulrazzaq (ENG’97) ■ William T. Alex (ENG’89) ■ Mahmood I. Alhusseini (ENG’11) ■ Syed A. Ali ■ David P. Allen (CAS’85, GRS’87, ENG’90) and Sheila L. Allen (SAR’88) ■ James D. Alman (ENG’87) ■ Yusef Al-Ojeiri (ENG’14) ■ Rana A. Alrabeh ■ Monal A. Amin (ENG’14) ■ Brian C. Anderson (ENG’95) and Angelique L. Anderson (SED’96, CAS’96) Robert J. Andrews (ENG’14) ■ Cheryl L. Armstrong (ENG’70) Martin D. Arrick and Linda K. Arrick ■ ■ Gregory T. Arzoomanian (ENG’84) ■ Michael O. Ashenuga (ENG’92) and Elizabeth M. Vondrak ■ Elisabeth A. Ashforth (ENG’97, GSM’08) ■ Russell C. Ashley Charles S. Asmar (ENG’55, ’58) and Mary M. Asmar ■ Ben Athanasiou (ENG’67, ’69) and Linda M. Athanasiou Maythaporn Auapinyakul (ENG’14) ■ Jeffrey M. Auerbach (ENG’97) ■ Aleksei M. Austin (ENG’07) ■ Kellen K. Axten (ENG’09) ■ Ashley T. Ayers (CAS’14) ■ Nidhi B. Azar (ENG’00, GRS’01) ■ Ahmar Aziz ■ Christopher S. Babinec Albert Backus and Kimberly K. Backus ■ ■ Roberta Bailey Roberts (ENG’87) Norman L. Bailis (ENG’65) and Joyce M. Bailis ■ Karen T. Bain (ENG’87) and Harold R. Bain Alejandro A. Bancalari (ENG’13) Eric M. Bancroft (ENG’14) ■ Jared M. Bancroft (ENG’06, MET’14) ■ Cris Banson (ENG’89) Nuno M. Barbosa (ENG’04) James M. Bargoot (ENG’00) ■ Max Barrasso and Anamaria Barrasso ■ ■ Beverly A. Barrett (ENG’78) and Richard M. Barrett Ruya Barrett (ENG’91) and Michael J. Barrett ■ Soumendra N. Basu and Alokparna S. Basu ■ ■ ■ Rebecca A. Bates (ENG’90, ’96) Beatrice M. Baumberger ■

Arnold H. Bearak (ENG’80) and Adena Cohen-Bearak (SPH’99) ■ George A. Beaupre ■ ■ Tami J. Beaupre ■ ■ Gerald L. Beauregard (ENG’96) ■ Andrew B. Beck (ENG’14) ■ Christian D. Becker (ENG’87) and Laurel Becker ■ Mia I. Becker ■ Ali Behnia (ENG’92) ■ Thomas M. Behrendt (ENG’84) Constance Beliveau (ENG’89) and Paul Beliveau ■ Stephen M. Bell (GSM’90) and Jill Bell (MET’93) ■ Blerinda Beluli-McCaleb ■ Marc Beneck (ENG’14) ■ Kenneth B. Benson (ENG’63) and Janet G. Benson ■ Samuel E. Bentson (ENG’09) Stanislav Beran (ENG’69) and Virginia A. Beran ■ William Bergersen and Gail L. Bergersen ■ ■ Robert J. Berkovitz (ENG’77) and Patricia M. Berkovitz Nathan S. Berkowitz (ENG’14) ■ Jordana B. Bernard (ENG’82) Benjamin E. Bernays (ENG’14) ■ Les Bernstein Susan J. Berry (ENG’11) ■ Cecile Beyh (ENG’87, ’87) and Yehia Beyh Marko Z. Bezbradica (CAS’13) ■ Robert G. Bill and Susan A. Bill ■ Kayla P. Binggeli (ENG’12) ■ Robert Binggeli and Dale E. Binggeli ■ ■ Daniel H. Black and Deborah A. Black ■ ■ Nicole L. Black (ENG’14) ■ Kim L. Blackwell (ENG’81) and Mont M. Blackwell ■ Gregory E. Blanchard (ENG’96) and Melissa L. Jendzejec-Blanchard ■ Jose L. Blanco (GSM’76, ENG’76) and Tania Blanco Daniel L. Blum (ENG’95, GSM’95) Shana C. Blumenthal (ENG’14) ■ Jeffrey C. Bogoian (ENG’10) ■ Andrew D. Bolton (ENG’04) David E. Borchardt (CGS’80, ENG’83) and Priscillla W. Borchardt ■ Dennis L. Bougher (ENG’87) and Genei Bougher Suzanne Boule ■ Timothy P. Bouvier (CAS’14) Marc Bowen and Janet Bowen ■ ■ Nicholas J. Bowen ■ Leonard W. Boyle (ENG’61) and Kathleen A. Boyle ■ Thomas P. Boyle and Anita Boyle ■ ■ Jonas Braasch ■ Kevin C. Brandenburg and Karen Brandenburg ■ ■ Patrick J. Brandenburg (ENG’12) ■ Wesley J. Branham (ENG’80) ■ Thomas P. Brashears and Julie Brashears Scott C. Bressler (CAS’94, ENG’07) ■ Andrew J. Breuder (ENG’68, MED’77) and Elizabeth A. Breuder ■ John C. Broderick (ENG’70, ’77) ■ Sean P. Broderick (ENG’89) ■ Maureen K. Brodeur (ENG’14) ■ Abraham Bromberg (ENG’61) and Barbara C. Bromberg ■ Alfred S. Brothers (ENG’64) and Sandra J. Brothers ■ Kara A. Brotman (ENG’00) ■ Andrew D. Brown ■ Charles A. Brown (ENG’68) and Martha A. Brown ■ Darryl W. Brown (ENG’78) and Kimberly S. Brown Michael G. Brown and Yvena Brown ■ ■

William W. Brown (ENG’65) ■ Andrew R. Brughera (ENG’95) ■ ■ Nicholas E. Brusco and Lucy A. Brusco ■ ■ Kim E. Bryant (ENG’87) and George G. Bryant Keith P. Buday (MET’85) and Teresa H. Buday (ENG’86) ■ ■ Christopher H. Buder (ENG’99) and Heather A. Buder (SMG’98) ■ Stella M. Buenviaje ■ Cyrus F. Buhari (ENG’96) Adam Bulakowski (ENG’99) and Lauren Bulakowski ■ Marina B. Burkatovskaya ■ ■ Chandler W. Burke ■ Edward F. Burke (ENG’68) and Donna R. Burke Francis X. Burke and Kathleen Burke ■ ■ Jessica R. Burke (SAR’14) ■ Andrea Burns (CAS’83; ENG’83, ’88) and Kenneth Burns ■ Donna M. Busa ■ ■ Albert C. Busk and Gayle Busk ■ Denis C. Bustin and Ana G. Bustin ■ Robert C. Butler and Susan A. Butler ■ ■ Charlene E. Cain (SON’68) and Michael P. Cain Luan Cako and Vilma Cako ■ ■ James Caldwell and Elizabeth Caldwell ■ ■ Vito Calefato and Maria Calefato ■ Gian D. Calvesbert (ENG’06, GSM’14) Amber N. Campa (ENG’14) ■ Lisa M. Campana (ENG’10, ’12) Nell Cant ■ Cara T. Cantwell (ENG’04, CAS’04) and Patrick R. Cantwell ■ Francis J. Capone (ENG’59) and Diane M. Capone ■ Gerard L. Carges (ENG’83) and Pamela J. Carges (SAR’83) ■ Eric R. Carlson (ENG’12) ■ Lindsay E. Carlson (ENG’11) ■ Gina M. Carrillo (ENG’97) John G. Carson and Anne H. Carson ■ ■ Douglas B. Carssow (ENG’06, ’10) Kenneth B. Rice (ENG’84, MET’96) and Christine Carter ■ Audrey B. Casavant (ENG’79) and Richard Casavant Nicholas L. Casciani (ENG’10) Thomas A. Casciani and Noreen L. Casciani Domenico Casolari (ENG’91) and Laurie A. Casolari (SAR’92) ■ ■ Steven M. Cassell and Concepcion G. Cassell ■ Maria T. Castro (ENG’12) ■ Ronald J. Cavalieri (ENG’79) and Deborah J. Cavalieri ■ James R. Cavanaugh (ENG’88) and Lisa Cavanaugh ■ John Cerini and Grace M. Cerini ■ ■ Victor Cervantes (ENG’14) ■ Christian M. Chabaneix (ENG’14) ■ Jeffrey T. Chagnon (ENG’10, ’14) ■ Srini Chakravarthi (ENG’01) ■ Richard J. Chalifoux and Julie R. Chalifoux ■ ■ Samantha J. Chan (ENG’14) ■ William L. Chan (ENG’79, ’85) and Pearl C. Chan ■ ■ Heidi D. Chang (ENG’14) ■ Wei-Hsiang Chang (ENG’12) Tatiana Chapsky (ENG’81, ’83) Ashley M. Chassar (ENG’06) Bokai Chen and Danyang Chen ■ ■ Jing Chen (ENG’04) Jong H. Chen (ENG’96) Xiaoyan Chen (ENG’07) Xudong Chen (ENG’12) Yuan Cheng (MET’02, ENG’05) ■ Peter K. Cherry and Brenda M. Cherry ■ ■ Chun Ming Cheung and Sau Yi Kimberly Cheng ■ ■ Honchun Cheung (ENG’86, ’88)

Boosting Bandwidth, Enhancing Lives IN RECENT YEARS, wireless data traffic has proliferated as more and more people access the Internet on the go and around the clock. Network traffic is particularly congested at large, densely populated venues such as sports arenas and college campuses, where thousands of people are using their mobile devices at the same time and exceeding the capacity of in-range cell sites. To boost network capacity at these high-demand locations, wireless network providers are increasingly turning to distributed antenna systems (DAS), collections of small antennas that span a designated geographic area and are linked via fiber to a central power source. The leading design, engineering and installation firm for distributed antenna systems is Communication Technology Services (CTS) based in Marlboro, Massachusetts. For more than two decades, CEO John Tegan (MFG’88) has helped transform CTS from a small, family business providing voice/data/video cable services to a national telecommunications services corporation with more than 500 employees. Since 2004, when CTS began its evolution into wireless networking, the firm has designed, engineered and installed more than 5,000 DAS networks at hospitals, hotels,

Edmond W. Chin (ENG’74, GSM’75) and Susan Y. Chin (SED’75) ■ Robert Chin (ENG’70) and Diana H. Chin ■ Kyoung-Won S. Cho (ENG’88) ■ Inyong Choi ■ ■ Yoojin Chung (ENG’10) ■ Steven J. Cicoria (ENG’65) ■ Sarah M. Clark (ENG’14) ■ Richard M. Clemence (ENG’84) Joshua M. Cochin (ENG’90) Steven L. Cockrell and Mary F. Cockrell ■ ■ Richard H. Coco (ENG’62) ■ Terrence A. Colbert (ENG’93) Richard A. Colby ■ Paul J. Collegio (ENG’82) and Susan M. Collegio (ENG’81, ’88) ■ Keith A. Collins (ENG’91) and Jennifer A. Collins ■ Michael J. Colman (ENG’88) Brian G. Colozzi (ENG’77) and Susan R. Colozzi ■ Elizabeth G. Condliffe (ENG’04) Max R. Condren (ENG’10) ■ Danielle M. Conneely ■ Thomas J. Conneely and Siobhan M. Conneely ■ David A. Cook (ENG’96) Thomas K. Cooney (ENG’89, ’91) ■ Benjamin S. Corman (ENG’14) ■

B U CO L L EG E O F E N G I N E E R I N G

college campuses, stadiums and theme parks, government buildings, airports and other venues. CTS customers range from the Orange Bowl in Miami to Petco Park in San Diego to the University of North Carolina. Today, Tegan concentrates most of his efforts on strategic planning as CTS continues to expand its clientele, diversify its service offerings and plan for the next evolution of wireless networking. He attributes his powers of concentration and planning to spending four years as a College of Engineering undergraduate in a city with diversions far more tempting than those available in his high school town of Durham, New Hampshire. “Balancing the rigors of the program with a desire to take advantage of Boston’s many attractions led me to become disciplined about setting priorities, defining a path to achieve goals and following through,” he says. Computer-aided design (CAD) and artificial intelligence courses at the College sparked his interest in information technology, leading to a job as an IT consultant where he became familiar with computer networks and distributed systems. This expertise came in handy as he joined forces with his father at CTS in the early 1990s. By 2002, he received the College of Engineering’s Distinguished Alumni Award for Service to Profession. A longtime ENG Annual Fund contributor, Tegan is a founding member of the Dean’s Society, launched in 2001 to recognize

Bryan Carl N. Cosca (ENG’14) ■ Mariano M. Cosca and Rosana N. Cosca ■ Manuel J. Costa (ENG’84) and Cheryl A. Costa (GSM’92) ■ Paul K. Costello (ENG’05) ■ Peter J. Costigan (ENG’14) Rachel J. Covert ■ Kevin Cowen (ENG’84) Kenneth E. Coyle and Janice L. Coyle ■ ■ Michael J. Cozza (ENG’92) Mark A. Cramer and Debra G. Cramer ■ Carleton W. Crockett (ENG’80) and Maureen Crockett ■ Thomas R. Cross (ENG’65) and Dayle N. Cross Jeffrey A. Crowell (ENG’13) ■ Thomas Crozier and Gayle Robin W. Crozier ■ ■ Brian J. Cruise (ENG’97) ■ Marta Cruz Christopher J. Csencsits (ENG’87) ■ Hengdong Cui (ENG’06, ’07) ■ Robyn Curtis ■ Charles H. Cynamon (ENG’87) and Dawn C. Cynamon ■ Sanjeev Daftari and Archana Daftari ■ ■ Shuangxing Dai (ENG’13) ■ Robert A. Dalgarno (ENG’13) ■

JACKIE RICCIARDI

HONOR ROLL

John Tegan (MFG’88) looks on as a College of Engineering student demonstrates equipment at the Engineering Product Innovation Center.

donors of significant annual gifts to the College and outstanding alumni, and established the Tegan Family Scholarship Fund in 2003. Currently a member of the Engineering Leadership Advisory Board, Tegan has contributed significantly to the College’s Capital Campaign, earmarking funds for the Engineering Product Innovation Center—including a CAD studio—and for a Distinguished Faculty Fellow Award. Tegan sees these investments as a vote for the core competencies—science, technology, engineering and mathematics—that will be critical to the nation’s future. “I believe in Dean Lutchen’s vision of the Societal Engineer and want to ensure that BU engineering students have the opportunity to develop those core competencies and learn how to use them to impact society,” he says.

Angelo R. D’Amato (GSM’03) and Tara D’Amato ■ Alexandra M. Damiano (ENG’14) ■ H. Alan Daniels (ENG’59) and Barbara J. Daniels ■ Jacob E. Dansey Dennis J. D’Antona (ENG’73) and Janet M. D’Antona ■ Paige W. Darby ■ Veera Raghava S. Darisi (MET’14) ■ Melissa M. Dascoli (ENG’87) and Joseph A. Dascoli ■ Howard M. Dashefsky and Sabrina C. Dashefsky ■ ■ Michael J. Datta (ENG’05, ’07) ■ Neha H. Dave (ENG’11) Robert D. David and Wendy A. David ■ Benjamin N. Davies (ENG’65) and Judith N. Davies ■ Jeffrey B. Davis (ENG’85) Kevin S. Davis (ENG’09) ■ Gregory C. DeAngelis (ENG’87) and Karen J. DeAngelis ■ J. Evan Deardorff (ENG’93) ■ Paul L. DeBeasi (ENG’79) and Linda C. DeBeasi (SON’80) ■ Foster J. DeGiacomo (SMG’51, ENG’61) and Nancy C. DeGiacomo ■ Alyson M. Deleeuw (ENG’14) ■

Sean M. DeLeo (ENG’11) ■ Bertrand Delgutte Alexander M. DelMonaco (ENG’14) ■ Julia L. Delogu (ENG’09) ■ Daniel C. DeLuca (ENG’87, SED’96) and Emily A. Lowell Andre DeNardo (ENG’08) Wenpan Deng (ENG’13) ■ James Dennison ■ Robert J. D’Entremont (ENG’62) and Ruth M. D’Entremont Devina H. Desai (ENG’14) ■ Kevan S. Desai (ENG’09) ■ Aaron M. DesRosiers (ENG’08) Robert L. DesRosiers (ENG’84) and Julieta A. DesRosiers Raghunathan Dhananjay Vinjamur (ENG’02, ’11) ■ Ali-Zain Dhukka (ENG’12) ■ Austin B. Dickey ■ Mathias Dietz ■ Gabriel V. DiFilippo (ENG’58) and Mary E. DiFilippo ■ Mark J. DiFilippo (ENG’12) ■ Russell G. DiMicco (ENG’84) Shaobin Ding (ENG’14) ■ Maria A. DiPasquantonio (ENG’83) Pierre Divenyi W. J. Dolan (ENG’65) and Carol F. Dolan

David Domenick and Patricia Domenick ■ ■ Patrik J. Donahue (ENG’14) ■ Weina F. Dorsky (ENG’03) and Jason M. Dorsky ■ Viral Doshi (ENG’10) ■ Scott A. Dow and Karen C. Dow ■ Timothy E. Dowling (ENG’82) and Marylynne E. Dowling ■ Andrew E. Dudek (ENG’03) Shannon H. Duffy and Paul J. Duffy ■ Deborah T. Dunklee ■ Kenneth J. Dunn (ENG’67) and Debra L. Dunn Michaelina C. Dupnik (ENG’14) ■ Douglas M. Duritza and Angela M. Duritza ■ Timothy M. Durkin (ENG’09) ■ John A. Duval (ENG’89) and Kathleen R. Duval ■ Hildy G. Dvorak (CFA’69) Patrick T. Easter (ENG’87) and Kristin E. Easter (SAR’87) ■ ■ Vicky Ebersole ■ ■ Richard B. Egan (ENG’78) and Jeannie Egan ■ David Ehrlicher and Maureen O. Ehrlicher ■ Patrick M. Ehrlicher (ENG’12) ■ Gerald R. Eisler (ENG’72) and Rosemarie Eisler ■ Caroline M. Ekchian (ENG’14) ■ David K. Elder (ENG’88) and Patricia A. Elder Reem S. Elderiny (ENG’02, ’05) John Eldridge ■ Charles C. Eliot (ENG’58) and Nancy G. Eliot ■ Antonio J. Encarnacao and Katherine A. Encarnacao ■ ■ Monica L. Eng (ENG’11) Eric H. Engberg (ENG’73) and Nancy L. Engberg Ryan S. Eriksen (CAS’10) Andres Escallon (ENG’81) and Margarita Duque ■ Rachel-Marie L. Esguerra (ENG’14) ■ Alfred W. Everest (ENG’59) and Christine A. Everest ■ Aristides E. Exarchos (SDM’90) and Angela L. Exarchos ■ ■ ■ Manuel N. Fagundes and Maria F. Fagundes ■ ■ Joshua A. Falkson (SMG’14) ■ Qun Fan (ENG’95) ■ Nikolaos Farmakidis Caleb H. Farny (ENG’04, ’07) and Natalie G. Farny ■ John J. Farrell (ENG’14, ’14) and Andrea F. Farrell ■ ■ ■ ■ Paul M. Faustin (ENG’85, ’88) ■ Donna M. Fedor (ENG’88) and Dan Brann ■ Timothy Feeney and Martha Feeney ■ ■ Shelli D. Feigenbaum (ENG’83) David L. Feldman (ENG’66) and Patricia A. Feldman ■ Maya Feldman (ENG’14) ■ Marc J. Albanese (ENG’99, ’03) and Rosanne E. Felicello (UNI’99, LAW’02) ■ Sarah H. Felix (ENG’00) Derek C. Felschow (ENG’06) ■ Keng Feng (ENG’14) ■ Anthony V. Ferraro (ENG’90) and Kelly A. Ferraro (CAS’90, GRS’93) Maria A. Ferreira-Cesar (ENG’14) ■ John B. Ferreri and Sharon Ferreri ■ Yevgeniy Finegold (ENG’04, MET’10) ■ Dennis M. Finnance (ENG’65) and Mary A. Finnance ■ Andrew M. Fisher (ENG’10) ■

Matthew Fitzgerald and Sheryl Fitzgerald ■ ■ Ian M. Flaherty (ENG’11) Justin Flammia (ENG’06) James P. Flanigon (ENG’09, GRS’09) and Michelene Flanigon ■ Kevin S. Flynn (CAS’14) ■ Reilly J. Flynn and Heather T. Flynn ■ ■ Howard N. Forbes (ENG’81) and Digna M. Forbes (CAS’82) ■ Bryan R. Foster (MED’05) and Sarah P. Foster (ENG’05) ■ Maurice H. Foster (ENG’53) and Nan J. Foster Mary Louise Fowler (ENG’11, ’14) ■ William Fox and Delcy Fox ■ Robert E. Frazee (ENG’14) ■ Robert F. Frechette (ENG’93) and Claire K. Frechette (CAS’93) ■ Darryl O. Freeman (ENG’87, ’88) Rosemarie Freeman ■ ■ Clark C. Freifeld (ENG’14) ■ David W. Freitag (ENG’91) and Patricia K. Freitag (CAS’84, SED’91) ■ John F. French (ENG’96) Richard L. Freyman Stephen P. Fricke (ENG’91) and Amy L. Brenner-Fricke (COM’89) Isaak Friedman and Ella Friedman ■ ■ John S. Fullford (ENG’91) and Deborah A. Fullford (ENG’89) Michael G. Furlong and JoAnn Furlong ■ John-Nicholas A. Furst (ENG’13) Paul Couto (ENG’94) and Kim W. Fusaris ■ Roger J. Gagnon (ENG’68) and Christine C. Gagnon ■ Pratik Jayeshbhai Gajjar (ENG’14) ■ Christine A. Galica (GSM’79) and Michael A. Galica Paul D. Gallagher (ENG’13) Frederick J. Gallun William M. Ganger and Jennifer B. Ganger ■ ■ Sharon B. Garde (ENG’86) and Cesar A. Garde Rebecca Gardy ■ Najyah A. Garoot (ENG’08, GRS’08) ■ Austin J. Gates (ENG’14) ■ Donald Gates and Gale Gates ■ James W. Geiger (ENG’93) Thomas R. Gennaro and Julie D. Gennaro ■ George L. Getchell (ENG’54) and Veronica G. Getchell ■ Oded Ghitza ■ Suvomita H. Ghosh (ENG’13, CAS’13) Irving S. Giller (ENG’07) ■ Yevgeniy Gindin (ENG’14) ■ Nicholas J. Giordano (ENG’11, MED’13) ■ Peter D. Girouard (ENG’12, ’12) ■ Mary Ann Givens (ENG’92) Ryan E. Gleason (ENG’08) Frederick G. Gleitsmann (ENG’61) and Michele E. Gleitsmann ■ Christopher D. Glenn (ENG’04; GSM’12, ’12) Steven M. Goetz (ENG’11) Louisa M. Going (ENG’12) Aysun Gokoglu (ENG’14) ■ Bryan H. Benesch (ENG’78) and Nancy S. Goldberg ■ Josh Goldwyn ■ Enrique Gomez (ENG’81, GSM’81) and Liliana Gutierrez Daniel G. Goncalves (CAS’05, SED’10) ■ George M. Gonzalez (ENG’14) ■ Rodrigo A. Gonzalez Alonso ■ Dan Goodman ■ Kumarapuram A. Gopalakrishnan (ENG’12)

Paul N. Goransson (ENG’81) and Helen Goransson ■ Gregg S. Gordon (GSM’96) Robert A. Gordon (ENG’59) and Jean L. Gordon Douglas W. Graham (ENG’86) and Janine Graham Ian Graham (ENG’87) Jeffrey K. Graves (ENG’02) Alison R. Graves-Calhoun (ENG’91) and W. Byron Calhoun Charles J. Green (ENG’79) and Kerin L. Green ■ Daniel P. Greenberg (ENG’01) David B. Greenstein (ENG’84) and Sandra S. Greenstein (ENG’86) Harriet Ely Griesinger (CAS’62, GRS’66) and David Griesinger ■ William M. Griffin (ENG’04) ■ William W. Grigsby and Janace G. Grigsby ■ Beatrice G. Grinius ■ Frederick K. Groll (ENG’82) and Claire C. Groll (SAR’84) ■ Matti D. Groll ■ Gregory G. Grozdits (ENG’99, MET’09) Robert D. Gunnels and Terry Gunnels ■ ■ Naman Gupta (ENG’07) Naveen Gupta (ENG’14) ■ Ege Gurocak (ENG’11) ■ Spencer R. Haas ■ Karim Habibi and Salam Habibi ■ Wilrogtric B. Hackett (ENG’00) Joseph E. Hale (ENG’83) and Lori B. Hale ■ Robert C. Haley ■ ■ Roswell G. Hall (ENG’72) and Gretchen O. Hall ■ Thomas R. Hall (ENG’12) ■ Michael E. Hamilton and Karen Hamilton ■ ■ Michael S. Hamilton (ENG’05) and Melissa L. Dubowski (ENG’05) Mark G. Hanson (LAW’81) ■ Kathryn M. Hardin ■ Juan Haro and Claudia Haro ■ ■ Brian Harris and Coleen Harris ■ ■ Casey A. Harris (ENG’12) ■ Julian I. Hart (ENG’12) ■ William M. Hartmann and Christine Hartmann Christopher S. Hatem (ENG’12) ■ Arthur R. Hathaway (ENG’59) and Marilyn D. Hathaway ■ Brendan M. Hathaway (ENG’14) ■ Meredith C. Baker-Hayes (CAS’83) and Brion Hayes ■ ■ David J. Bernays and Wendy J. Heiger-Bernays ■ ■ Dionte O. Henderson (ENG’09) ■ Glenn Herbert and Nancy Herbert ■ Zachary Herbert (ENG’14) ■ Martin C. Herbordt ■ ■ David I. Herman (ENG’70) and Lori M. Herman (GRS’78) ■ Arcadio Hernandez Butler (ENG’96) Alfred O. Hero (CAS’76; ENG’77, ’80) and Therese M. Hero ■ Raymond A. Herzog (ENG’96) and Lancia A. Herzog (ENG’96) Mary J. Hester ■ James V. Hickey (ENG’57) and Jean C. Hickey ■ Caeleigh J. Higgins ■ Michael Hille and Heather Hille ■ ■ Darin C. Hitchings (ENG’02, ’10) Shyi-Tai Jan (GRS’91) and I-Ran Ho (ENG’90) ■ ■

Loc T. Hoang (ENG’92) and Trang Nguyen ■ ■ Ian A. Hobbs and Nancy K. Hobbs ■ ■ Stuart Hochwert and Barbara B. Hochwert ■ Mark F. Hodge (ENG’99, GSM’99) ■ Samuel M. Hoffman (ENG’12) ■ Ernest M. Hoffmann (ENG’87) Spencer J. Hogan (ENG’98) ■ Lawrence L. Hoh (ENG’88) and Susan P. Hoh (ENG’88) Conor C. Holland (ENG’14) ■ Joan M. Holman (ENG’82) Carly Holstein (ENG’08) and Tyler Holstein ■ Kristina M. Holton ■ Tong Hong ■ Susan Hopkins ■ Peter T. Houston (ENG’58) and Ann B. Houston ■ Steven Houttuijn Bloemendaal and Myriam Gonzalez Calzia ■ Alexandra M. Howton (ENG’14) ■ Kujtim Hoxha and Nezihat Hoxha ■ ■ Hengyu Hu ■ Xia Hua (ENG’14) ■ David A. Hubbard (ENG’09, LAW’14) ■ Thomas G. Hubschman (ENG’14) ■ Emily K. Hudson (ENG’14) ■ C. Arthur Hughes (ENG’62) and Pearline E. Hughes ■ Mary L. Hughes (CAS’81) and Christopher Donovan ■ ■ Nina L. Hughes (ENG’94) Jessica V. Hum (ENG’14) ■ Vanessa S. Hummel (ENG’83) and Dana C. Hummel ■ Joseph Hurwitz (CFA’58, ENG’69) and Sandra F. Hurwitz (SAR’59) ■ Tanvir Hussain and Aysha Hussain ■ ■ Long T. Huynh (ENG’05) Vu Q. Huynh (ENG’99) ■ Sharon Hyzy (ENG’06) Hany N. Ibrahim (ENG’93) Massnoon Ifaz (ENG’11) Antje Ihlefeld (GRS’02, ’07) ■ Majid M. Ikhwan (ENG’03) Ryoshin L. Imai (ENG’90, ’91, ’93) and Yoko Imai ■ Anthony J. Indelicato (ENG’95) and Bina M. Indelicato Antonio T. Infante and Victoria Infante ■ ■ Gerard D. Irmer (CGS’63, ENG’64) and Lois J. Irmer Scott K. Isabelle (ENG’88, ’95) and Karen H. Isabelle Michael Isaza ■ Joseph S. Iskandar (ENG’13) ■ Raeef E. Istfan (ENG’12) Brandon D. Itkowitz (ENG’99, ’08) Prakash S. Iyer (ENG’14, CAS’14) ■ Anna Jablonka (ENG’94) and Rafal M. Jablonka Brian S. Jackson (ENG’91) and Cathy T. Jackson Joseph C. Jacobs (ENG’51, ’60) ■ Micah A. Jacobs (ENG’99) and Beth Jacobs ■ Raymond L. Jalette (ENG’71, MET’74) and Shaolin Pan ■ ■ ■ Cary G. James (ENG’10) Richard S. Jamieson (ENG’62) and Jeanine M. Jamieson ■ Paul A. Janson (ENG’69, MED’73) and Mary B. Janson ■ Theresa R. Jay (ENG’87) and John H. Jay ■ Vianney C. Jayasinha (ENG’09) and Ashley A. Jayasinha (COM’06, ENG’10)

HONOR ROLL Anjana Jeyaram (ENG’14) ■ Rubing Jin (ENG’14) ■ Rishi Jolly (CAS’14) ■ Aleksander J. Jonca (ENG’10) ■ Justin Jones (ENG’98) Kyle T. Jones (ENG’13) ■ David Jordan ■ ■ Natalie L. Jordan (ENG’14) ■ Philip Joris Susan A. Jreige (ENG’90) and George A. Jreige ■ ■ Frank Juhn (ENG’06) ■ Shirley S. Justin David W. Kaczka (ENG’90, ’93, ’00; MED’00) and Monica L. Hawley-Kaczka (ENG’90, ’94, ’00) Gary Kaftan (ENG’60) and Frizelle S. Kaftan ■ Jason R. Kait (ENG’95) Lauren N. Kalfin (ENG’14) ■ Michael S. Kalfin and Carol A. Kalfin ■ ■ Lisha M. Kaluza (ENG’14) Khaled T. Kanaan (ENG’85) Ita C. Kane (ENG’12) ■ Iris Kao (ENG’13) ■ Kavon M. Karrobi (ENG’14) ■ Siavash Karrobi and Syng Karrobi ■ ■ Walter S. Katuschenko (ENG’60) and Jacquelynn S. Katuschenko ■ Lev Katz (ENG’04) and Orah Katz Daniel J. Kazanjian (ENG’12) John D. Kazantzidis (ENG’06) John Kazarosian (ENG’68) Michael P. Kazenel (ENG’80) and Susan P. Caplan ■ Michael N. Keefe (ENG’89) and Ana C. Keefe ■ Raymond A. Keffer (ENG’09) Timothy F. Kelleher (ENG’85) and Susan M. Kelleher Robert E. Kelley (ENG’58) and Rita M. Kelley ■ Thomas F. Kelly (ENG’89) A. Rayner Kenison (ENG’65) and Donna M. Kenison ■ Kerry E. Kennedy (SAR’14) ■ Ricardo L. Kenny (ENG’83) ■ Traci M. Kent (ENG’14) ■ Eleonora Kentlier ■ ■ Holden A. Kepecs and Cindy B. Cutler ■ Jeffrey S. Keyak (MET’79) and Vicki F. Coffey-Keyak Habib M. Khan (ENG’14) ■ Michael S. Khang (SAR’14) ■ Michael I. Kim (ENG’12) Mi-Ran Kim (SAR’89) and Changsu Kim ■ Myung-Chan Kim (ENG’99, ’01) ■ Simon H. Kim (ENG’14) ■ Alexander G. Kithes (ENG’14) ■ Gary C. Kline (ENG’84, ’87) and Lauri Kline ■ Joshua C. Kline (ENG’09, ’14) ■ Jonathan W. Knapp (CAS’14) ■ Ronald W. Knepper and Helen A. Knepper ■ ■ Ethan C. Knight Michael Koan (ENG’09) ■ Paul B. Kocincki (ENG’66) ■ Frederick W. Koehler (ENG’81) and Linda T. Koehler (SAR’82) Michael S. Koeris (ENG’10) ■ Barbara Kolmansberger ■ Yevgeniy Kolodenker (ENG’12) ■ Ying-Yee Kong Benjamin Z. Kooy (ENG’06) ■ Matt D. Kopser (ENG’86) and Julie A. Kopser (CAS’87, GRS’88)

B U CO L L EG E O F E N G I N E E R I N G

Georgi Korobanov (ENG’06) ■ Denise F. Kosciusko (SED’14) ■ Shaman S. Kothari (SMG’14) ■ Roy A. Kraus and Nancy E. Kraus ■ Scott R. Kreamer (ENG’01) and Jennifer L. Kreamer (ENG’00) ■ Thea E. Kreinik (ENG’87) David P. Krinjak (ENG’13) Rajesh Krishnan (ENG’96, ’04) and Srividya Shankar ■ Peter T. Kuchler (ENG’92) James W. Kugler ■ ■ Subi Kulla and Olimpiada Kulla ■ Cathy M. Kurata (ENG’06) ■ Nicholas Kurkjy (ENG’10) William Kurtz (ENG’60) ■ Steven B. Kushnick (ENG’80) and Debra Kushnick ■ Abena N. Kwakyi (ENG’11) John T. Kyne ■ ■ Richard T. La Brecque (SED’59, ’71) ■ ■ Daniel G. LaCroix and Diane LaCroix ■ ■ Rebecca M. LaCroix (ENG’13) Ryan J. Lacy (ENG’12) Isis S. Laham (ENG’87) Angela Lai (ENG’14) ■ Kam H. Lai (ENG’12, CAS’12) ■ Michael L. Laiman (ENG’86) ■ Ronnie M. Lajoie (ENG’84) Lester D. Lakin and Kimberly A. Lakin ■ ■ Richard W. Lally (MET’99) and Regina M. Lally ■ ■ Francine Lalooses (ENG’02, ’03) ■ Stephen P. Lalooses (ENG’99) ■ Emily W. Lam (ENG’14) ■ Merrill B. Lamont (ENG’05) Wendy M. Lance (ENG’85) Li Lang (ENG’01) ■ David J. Languedoc (ENG’87) and Catherine L. Languedoc ■ Luke E. Lanoue (ENG’14) ■ Jesadang Laohaprasit (ENG’97) Stephanie Lapham ■ Juan J. Lara ■ Ronnie Lau ■ ■ Yonatan D. Laurence (ENG’14) ■ Kelly A. Lavin (SAR’08) ■ ■ Michael Le Vangie and Pollyanna S. Cooper-Le Vangie ■ Ian A. Leatherman (ENG’11) ■ Jim J. Lee (ENG’12) ■ Kristen L. Lee (ENG’11) Michelle Lee (ENG’14) ■ Yuk Lee ■ Agnes Leger ■ Martin Leibold (ENG’89) and Kathleen D. Leibold ■ Leah M. Lemont (ENG’10) ■ Peter E. Lenk (ENG’78) and Jean N. Lenk ■ Brian M. Leonard (CAS’14) John F. Leonard (ENG’83) and Anne M. Leonard Daniel J. Leonardis (ENG’04) ■ Max J. Lerman (ENG’12) ■ Douglas O. Lethin (ENG’90) ■ Ron O. Lewis (ENG’80) ■ Binbin Li (ENG’10, ’11) De Huan Li and Yu Ci Li ■ ■ Jeffrey P. Li (ENG’09, GRS’09) ■ Liang Li ■ Xiangyu Li (ENG’14) ■ Robin Liebowitz and Fred Liebowitz ■ Ben-Da Lin and Chien Fong Lin ■ ■ David B. Lindquist (ENG’82) ■ Bradley Lister and Debora Lister ■ Lena Liu (ENG’13) Lu Liu (ENG’14) ■

Victor Liu (ENG’10) Brian Lo (ENG’13) ■ Robert W. Locke (ENG’61) and Marjorie A. Locke ■ Christopher M. Lomenzo (ENG’14) ■ James Lomenzo and Maureen R. Lomenzo ■ ■ Daniel T. Louzeiro (ENG’14) ■ Kai L. Low and Lai C. Low ■ ■ Jeannie J. Lu (ENG’95, ’96; MET’00) ■ Li Y. Lu ■ ■ Qing Lu ■ James E. Luck (ENG’93, CAS’94) ■ David Ludlow and Mary Ludlow Niyom Luepongsak (ENG’95) Margaret Lundin (ENG’73) ■ Jackson Luo (ENG’12) Nicholas Lyford (ENG’08) ■ Barbara F. Lynch (ENG’82) and Greg Sprunger Eric J. Lynch (ENG’00, ’05) and Amanda S. Lynch (CAS’00, COM’00, SED’04) Dean L. Lyons and Allison S. Lyons ■ ■ Xiaohui Ma (ENG’12) ■ David L. Mabius (ENG’07, ’09) Lawrence E. Mabius and Kathy L. Mabius ■ ■ Richard S. Maccabe (ENG’58) and Noreen Maccabe Robert MacDonald and Patricia Haggerty ■ Aubrey J. MacGill (CAS’13) ■ Harrison J. Macris (ENG’09, MET’11) ■ Ross K. Maddox (ENG’11) Nicole A. Madonna (ENG’14) ■ Henry A. Magnuson (ENG’78) and Ann M. Magnuson ■ Kenneth S. Maguire (ENG’68) Agnes D. Malaret-Collazo (ENG’87) and Ernesto C. Batista ■ Jean B. Malenfant (ENG’60) and Jeanne R. Malenfant ■ Adam P. Malone (ENG’14) ■ Giovanni Mancini and Maria Contardi ■ Jonathan A. Mancini (ENG’14) ■ Jaquelyn Byrne and Michael Manes Charles R. Manning (ENG’12) Andrea J. Mannix ■ ■ Edward Mannix ■ ■ Berj M. Manoushagian (ENG’76, ’82) and Anie Manoushagian ■ Edward S. Mansfield (ENG’64, ’68) and Dolores L. Mansfield ■ Fahim Manzur (ENG’08) ■ Michel Maraney ■ ■ Bryan M. Marazzi (ENG’12) ■ Pier Marchese ■ ■ Matthew J. Marone (ENG’90; GSM’03, ’03) Meredith E. Marshall (ENG’87) and Yolanda B. Marshall Justin M. Martin (ENG’09) ■ Kyle T. Martin (ENG’07) Karla Martinez ■ ■ Jeffrey A. Marx (ENG’01) ■ Gregory J. Mascoli (ENG’88) and Maria D. Mascoli (CAS’88) ■ Gerald D. Kidd and Christine R. Mason ■ Sherrill I. Burgess (SMG’84) and John E. Massidda Steven I. Master (CAS’00) and Michelle M. Master (ENG’98) Peter F. Masucci (ENG’70) and Kathy E. Masucci (CAS’71) ■ Salwa F. Masud (ENG’11, ’14)■ Angel Mata (ENG’03) ■ Connor F. Mathews (ENG’14) ■ Robert H. Mathews (ENG’65) and Kathleen M. Mathews ■ Samuel Mathias ■ ■

Patrick Maung (ENG’94, ’96, ’02) Ronald S. Maxwell (ENG’78) ■ Rachel Mayover ■ David J. McAlpine Sharon McBride (ENG’84) Stephen A. McBride (ENG’71, ’72; GSM’73) and Christine M. McBride Conor R. Mccarron (ENG’14) ■ Steven J. McCarthy (ENG’85) and Miriam McCarthy Justin A. McClellan (ENG’04, GSM’12) Jean McCoy ■ Michael J. McCullough (ENG’03) and Lindsey McCullough ■ Francis P. McDermott (ENG’62) ■ Alison W. McDonough ■ ■ Edward R. McDonough (ENG’14) ■ Roger M. McDowell (ENG’69) and Elizabeth A. McDowell Connor C. McEwen (ENG’14) ■ Ryan M. McGovern (ENG’12) Loretta C. McHugh (ENG’00) and Evan McHugh Seth A. McKeen (ENG’10) ■ John L. McKeon ■ Hilarie B. McKinstry ■ ■ Jody E. McLean (ENG’04, SPH’08) ■ ■ Joseph P. McMahon (ENG’13) Neil P. McManus (ENG’59) and Judith A. McManus ■ Lexyne L. McNealy Jackson (ENG’02) ■ Doris McQuaid (ENG’84) Eugene Y. Mei and Grace Y. Gao ■ ■ Philip J. Melchiorre (ENG’84) ■ John Memme and Pauline Memme ■ Lynn Mendenhall (ENG’85) Andrew M. Mento (ENG’95) and Jennifer K. Mento (SAR’97, ’99; GSM’04) Yaina M. Mercado (ENG’14) ■ Carolina Mesa ■ Gene C. Messercola (ENG’14) Johan E. Mickos (ENG’14) ■ Jason Mikiel-Hunter ■ Jacob I. Miller (ENG’08) ■ James G. Miller (ENG’84) Kai A. Miller Sara T. Miller ■ ■ Steven M. Miller (ENG’87) ■ Arthur R. Milley (ENG’60) and Constance H. Milley Nancy H. Millstrom (ENG’89) and Karl Millstrom ■ Samuel A. Minkoff (ENG’10) ■ Luis A. Beltran Acosta and Yomaira Miranda Leon ■ ■ Evan G. Mislick ■ John F. Mistretta (ENG’65) and Josephine D. Mistretta ■ Kristina K. Mistry (ENG’95) and Nicholas N. Mistry Brian J. Mitchell (ENG’02, ’06) and Alma R. Mitchell (SED’02, CAS’02) ■ John N. Mitropoulos (ENG’56, ’59) and Venetia S. Mitropoulos ■ Andy Mo (ENG’14) ■ Devas J. Modi (ENG’14) ■ Jitendra V. Modi and Rita J. Modi ■ David Moghavem ■ Andrew D. Mohn (CAS’14) ■ William K. Moik (ENG’14) ■ Timothy Mon (ENG’14) ■ Maura C. Monahan ■ ■ Sean C. Montgomery (ENG’14) ■ Ryan P. Moody (ENG’13) ■ Gunnar A. Moore (ENG’14) ■ John Erik Moore (ENG’89, ’92) and Deborah J. Moore (ENG’89)

John Moore and Barbara Moore ■ ■ John O. Moore (ENG’00, MED’05) Paul F. Moore ■ ■ Peter M. Moore and Lorraine O. Moore ■ ■ Rosemary Moore ■ Jonathan R. Mooty (ENG’90) ■ David Moran and Catherine Moran ■ ■ Meagan K. Moran (ENG’14) ■ Edwin R. More (ENG’63) ■ Kirsti V. More Mark S. Moreira (ENG’84) and Gina M. Moreira ■ Yosuke Mori (ENG’87) and Chiharu Mori ■ Fred Morrison (ENG’62) and Barbara M. Morrison (CAS’64) ■ Ronald P. Morrissey (ENG’92, ’01) Demetri T. Moustakas (ENG’98) and Kathleen Moustakas ■ John W. Mroszczyk (ENG’77) and Jean Mroszczyk ■ Mitra A. Mujica-Margolis (CGS’95, ENG’99) and Michael A. Margolis ■ Tanvir A. Muktadir (ENG’11) John F. Mullett (ENG’74) and Anne B. Mullett ■ Abhishek Mundra (ENG’14) ■ Kamlesh Mundra and Deepika Mundra ■ ■ Amanda G. Munoz ■ Edward Murphy and Mary A. Murphy ■ ■ Kevin F. Murphy (ENG’09) and Meghan T. Murphy (CAS’10) ■ Matthew F. Murphy (ENG’85) and Teresa Murphy ■ William J. Murray (ENG’81) and Denise R. Murray ■ Christopher M. Myers (ENG’11) Adam M. Nadeau (ENG’08) ■ Michael M. Nadeau and Sylvie M. Nadeau ■ Amos Nascimento and Margaret A. Griesse ■ ■ Neesha J. Nathwani (ENG’11) Akshay Navaladi (ENG’09) Dylan J. Neidorff (ENG’09, MET’12) ■ ■ ■ Kevin E. Nerheim (ENG’14) ■ Varouj S. Nersesian (ENG’70, ’73) and Ingrid W. Nersesian (SED’70, ’81) ■ Charles J. Newfell (ENG’79, ’82) and Christine S. Newfell ■ Carl J. Newhouse (ENG’84) ■ Amaya O. Ngu (CGS’13) ■ Anh T. Nguyen ■ Kenneth K. Nguyen (ENG’89) ■ Tai H. Nguyen (ENG’13) ■ Thanh Huynh and Hang Nguyen ■ ■ Haifeng Ni (ENG’14) ■ Re-Jey Ni ■ Stephen J. Niemi (ENG’68, ’80, ’82) Nicole Niemiec ■ Olga S. Nikolayeva (ENG’05) ■ Xu Ning (ENG’08, ’09) ■ Victor A. Noel Leslie K. Nordstrom (ENG’14) ■ Carol W. Nung (ENG’93, MET’00) ■ George O’Brien Nicholas A. O’Connor (ENG’14) ■ Eogan C. O’Donnell (ENG’90) and Kellie M. O’Donnell (CAS’89) ■ Jon P. Olafsson (ENG’01) and Brooke Olafsson Isabella Olivares ■ John Y. Oliver (ENG’98) Andrew H. Olney (ENG’90) and Katharine S. Olney (SSW’89) ■ Craig S. Olson (ENG’90) and Dayna L. Olson ■ David A. Oluwadara ■ Jacob O. Ondeck (ENG’14) ■

Joseph B. O’Neill and Miriam O’Neill ■ ■ Shannon A. O’Neill (ENG’13) ■ Nelson E. Ortega and Fernanda T. Ortega ■ Susan M. O’Sullivan (ENG’03) ■ Oliver D. Ousterhout (ENG’07) Sean M. Packard (ENG’10) ■ Juliet A. Page (ENG’86) and Gregory S. Page Robert W. Paglierani (ENG’66) and Susan D. Paglierani ■ Richard L. Paine (ENG’88, GSM’95) Wesley Pak (ENG’13) Songeeta Palchaudhuri (ENG’03) Michael Paley (ENG’95) and Janice S. Paley (CGS’90, COM’92) Carl Eric Palme (ENG’04; GSM’12, ’12) ■ Michael R. Palmiere (ENG’14) ■ Alexander C. Paloranta (ENG’12) Haidong Pan (ENG’04) ■ John Papadopoulos (ENG’60) and Mahi A. Papadopoulos Michael D. Paquette (ENG’84) and Mary T. Paquette ■ ■ Edward M. Pardi (ENG’85) and Kathleen R. Pardi Joon B. Park (ENG’67) and Hyonsook Y. Park ■ Savan Parker (ENG’14) ■ Liakot A. Khan and Mosammat R. Parvin ■ ■ Joseph H. Passarelli (ENG’88) Wesley R. Pate (ENG’14) ■ Felicia A. Patel (ENG’14) ■ Shahil D. Patel (ENG’14) ■ Shivani H. Patel (ENG’14) ■ Shrinesh N. Patel (ENG’14, CAS’14) ■ Vidhi M. Patel (ENG’14) ■ John H. Paul (CAS’90) and Chrysanthea K. Paul (ENG’90) ■ Leonard H. Pauze (ENG’57) and Joan C. Pauze ■ Dean C. Pavlick (ENG’14) ■ Maria F. Payan ■ ■ Kylie J. Pedersen (ENG’13) Bradley Pederson and Mary Jayne Pederson ■ ■ Paul O. Pederson (ENG’90) and Martha C. Pederson ■ Marco M. Castelli (ENG’82) and Elvira S. Perez ■ Richard L. Perkins (ENG’89) David J. Perreault (ENG’89) Matthew J. Petersile (CAS’12) Erik R. Peterson (ENG’88) and Deborah A. Peterson (SMG’87) John Peterson and Victoria Peterson ■ Michael T. Pettit (ENG’14) ■ Thomas S. Pettit and Mary Pettit ■ Jeffery Pettway ■ ■ Han T. Phan (ENG’90) Brent C. Phillips (ENG’05) and Polly Jewett ■ Brittany O. Phillips (ENG’11) Karl W. Pilz (ENG’00) and Heather R. Pilz Errol W. Pinkney (ENG’02, ’04) Anthony C. Pippo (ENG’67) and Joyce P. Pippo ■ Anthony N. Pirri (ENG’64) and Catherine H. Pirri ■ Ian C. Pitcairn (ENG’79) Cameron A. Pizzo ■ Edward A. Pohl (ENG’84) and Letitia M. Pohl ■ Michael J. Poling (ENG’13) Matthew D. Pollack (ENG’14) ■ Robert J. Pomarico (ENG’07) ■ Iris Posner John J. Post (ENG’64) and Judith S. Post Claus Pramer (ENG’88) and Patricia M. Pramer (CAS’90) ■

Kushal Prasad (ENG’14) ■ Mahalingiah Prasad ■ ■ Bruce G. Pratt (ENG’69) and Maureen S. Pratt Luke J. Preisner (ENG’00) M. Gail Preslar ■ Cheryl L. Pritchard (ENG’86) ■ Benjamin W. Pritz (ENG’14) ■ George Pronesti and Jennifer Pronesti ■ Edgar A. Puesan (ENG’14) Manuel Berroa and Tomasa Pujol ■ Michael J. Pulliam (ENG’83) and Jacquett Pulliam Stephen B. Qually (ENG’72, GSM’73) and Linda A. Qually (SED’70) ■ Tahir Qureshi and Farhana Qureshi ■ ■ Eduardo Ragolta and Carolina T. Ragolta ■ ■ Khandker A. Rahman and Asma Arif ■ Ajay Rajshekar (ENG’14) ■ Bryant A. Ramon ■ Elizabeth Rantissi ■ Ram Das Rao (ENG’88) ■ Gerardo J. Ravago and Maria L. Ravago ■ Amit Raybardhan (ENG’05) Sarah M. Raymond (ENG’04, GSM’13) ■ Christopher J. Reaney (ENG’87) and Susan K. Reaney ■ Ellen E. Reavey (ENG’11) Herbert P. Redman (ENG’63) and Joan E. Redman ■ ■ James L. Reed (CGS’85, ENG’88) ■ Andre Joseph M. Reid (ENG’02) Roberto Reif (ENG’08) and Kathy B. Reif (LAW’09) ■ Donald C. Reny (ENG’88) and Jennifer R. Reny ■ Dorie A. Resnik (ENG’92) ■ Sandra D. Reulet (ENG’86) Jessica A. Reyes (ENG’14) ■ Jorge D. Reyes and Gina M. Reyes ■ ■ Adam S. Riley (ENG’07) Corey M. Ringhisen (ENG’01) ■ John Rinzel ■ Eric J. Risley and Rhonda M. Risley ■ ■ John W. Ritz (ENG’80) Raquel Rivera (ENG’96) Mary B. Roane (ENG’88) and Kevin Roane Beth P. Robert (ENG’89, ’04; GSM’04) Michael Robichaud (ENG’11) ■ Stephen L. Rodi (ENG’07, ’08) Peter C. Rodrigues ■ Luis G. Carrasquillo-Egea and Icelsa Rodriguez ■ Robert G. Rogers (CAS’00) and Lisa W. Rogers (ENG’00) Joseph K. Rollin (ENG’05) ■ Nikolaus J. Roman (ENG’14) ■ Lisa A. Rooker (ENG’13) Robert H. Ropp (GSM’74, ’80; ENG’79) and Alexia L. Jacobs ■ David C. Ross (MET’87) and Emily B. Ross Kenneth N. Ross (ENG’95) Giovannibattista Rossi (ENG’02, GRS’05) Glen E. Rothenberg and Stefanie Rothenberg ■ ■ Michael A. Rothman (ENG’64) Brian F. Rowan (ENG’14) ■ Andrew M. Roy (ENG’87) ■ Ronald A. Roy and Nancy S. Roy ■ ■ ■ Robert S. Rubery (ENG’63) Rochelle E. Rucinski (ENG’98) and David E. Rucinski ■ Gary S. Rudman (ENG’88) and Robin Rudman Donald A. Ruffle (ENG’83, ’83) and Betty L. Ruffle ■ Meir Ruhman (ENG’59, ’60, ’61) and Emma Y. Ruhman (CAS’60) ■

Edward A. Runci (CAS’69) Morgan F. Rushing (ENG’10) ■ Jesse L. Rusk (ENG’04) ■ Jeffrey H. Sakai (ENG’11) Tashfiq Salam (ENG’10) Hugo D. Salazar (ENG’83) and Mariaelena Salazar ■ Karen Sanchez (SMG’14) ■ Dawn Marie D. Sanok (ENG’83) Mark Santora and Ling C. Santora ■ Thomas A. Santoro (ENG’91) and Susan E. Santoro Peter B. Santos and Cheryl L. Santos ■ ■ Christopher J. Sanzo (ENG’87) and Roberta Groch (CAS’87) ■ Modur L. Sathyendra and Leelavathy Sathyendra ■ Bradley W. Sauln (ENG’14) ■ Steven G. Saunders (ENG’89) and Susan Saunders ■ Onur Savas (ENG’07, ’09) Arpan P. Savla (ENG’05) Paul H. Scannell (ENG’59) ■ Perry M. Schein (ENG’12) ■ Denise M. Schier (ENG’81) and Karl A. Schier ■ Charles B. Schilling and Laura L. Giddings ■ William J. Schineller (ENG’89) Thomas G. Schlatter (ENG’94) and Tania A. Schlatter (CFA’90) ■ Andrew Schmidt and Jamie Lohr ■ ■ Austen P. Schmidt (ENG’14) ■ Matthew P. Schmidt (ENG’10) ■ Michael A. Schmidt (ENG’14) ■ Bertram J. Schmitz (ENG’62) and Lizabeth M. Schmitz ■ Robert E. Schneider (ENG’79) ■ Gregory M. Schneiter ■ Lisa Robinson Schoeller (ENG’82, GSM’98) and Richard J. Schoeller ■ Christiaan W. Schoemakers (ENG’11) Brian L. Schulz (ENG’82) ■ Steven J. Scott (ENG’86) and Gayle Scott Adil M. Seddiq (ENG’02) Albert R. Seeley (ENG’85, MET’95) and Lauren M. Seeley ■ Carlos A. Segura Michael L. Sehn (ENG’12) ■ Christopher M. Sek ■ ■ Rajendranath R. Selagamsetty (ENG’14) ■ Thomas J. Chapasko and Kathleen A. Sell ■ ■ Matthew N. Seminerio (ENG’08) ■ Rachel Seraspe (ENG’04) ■ Huseyin R. Seren ■ ■ Patrick J. Sexton (ENG’04, ’07) and Rebecca M. Sexton (MET’05) ■ Trevor Shackleton ■ Brian M. Shaeffer ■ Daniel Shaffer (CAS’14, ENG’14) ■ Karan J. Shah (ENG’14) ■ Nishant K. Shah (ENG’14) ■ Pooja D. Shah (ENG’14) ■ Ronak R. Shah (ENG’99) and Angela Shah ■ Michael S. Shanler (ENG’97) and Amy R. Shanler (CAS’96; COM’96, ’04) Issam A. Sharabati (ENG’63) and Doreen A. Sharabati (SON’61) Gopesh C. Sharma (ENG’09) ■ Mala K. Sharma (ENG’07) Neal K. Sharma (ENG’01) and Logan Sharma (SAR’02) ■ John H. Sheffield (ENG’91) ■ Dazhong Shen and Bei Liu ■ ■ Yuankai Shen (ENG’14) ■ Ananth Shenoy (ENG’01)

HONOR ROLL Panayiotis S. Shiakolas and Susan W. Shiakolas ■ ■ Steve Shin (ENG’89) Robert K. Cunningham (ENG’88, GRS’98) and Barbara G. Shinn-Cunningham ■ ■ Syed Shafqat Husain Shirazi ■ ■ Gordon A. Shogren (ENG’59) and Frances K. Shogren ■ Koreen J. Shoham (ENG’14) ■ Spencer W. Shore (ENG’11) Shamit Shrivastava (ENG’14, ’14) Emily A. Shugarman (SED’03) Prachi Shukla ■ John J. Shynk (ENG’79) and Tokie L. Shynk (SON’79) Fouad A. Siddiqi (GRS’04) Mahmud A. Siddiqi and Rehana I. Siddiqi ■ Milton R. Sigelmann (ENG’92) Mohinder S. Sikka (ENG’97) Eden Silva and Benita Silva ■ Travis Silver and Evionne Silver ■ Elena B. Simoncini (ENG’10) Brittany A. Simone (ENG’09) ■ John Simons and Michelle Simons ■ ■ Dennis W. Sindel and Amy C. Sindel ■ ■ Matthew M. Geary (ENG’81, GSM’84) and Dawn M. Sinnigen ■ Mark F. Cardono (ENG’91) and Tracy M. Sioussat ■ Elie A. Sirotta (ENG’01, GSM’08) and Stacey L. Sirotta (SAR’01, ’03, ’08) ■ ■ George Skandalakis (ENG’97) David T. Skodje (ENG’14) ■ Jonathan A. Slager ■ Thomas S. Slinker (ENG’81) Theodore J. Smigelski (ENG’14) ■ Peter M. Smillie (ENG’70) Bradley J. Smith (ENG’93) and Lisa G. Smith ■ John F. Smith (ENG’63) ■ Marlene S. Smith (ENG’83) John K. Smrstik (ENG’91, GSM’00) and Carren L. Smrstik (SAR’94, SED’99) Michael A. Snyder (ENG’14) ■ Kelvin So and Lay-Pin So ■ ■ Michelle W. So (ENG’14) ■ Richard Soohoo (ENG’08, MET’11) ■ David Soong and Libby Soong ■ Jeffrey L. Soong (ENG’14) ■ Luke A. Sorenson ■ Stephen H. Southworth and Miroslava Protic ■ ■ Tarik P. Soydan (ENG’82, ’85) and Anne P. Sullivan-Soydan (SAR’87, ’99) Cheryl J. Mills (STH’92) and Carey G. Spain ■ Megan E. Spangler (ENG’95) ■ Martin Spencer ■ Katherine E. Spignese (ENG’85) ■ Peter F. Staats (GSM’76) Stacey K. Stanton (ENG’10) ■ Theodore R. Staplin (ENG’92) Chris Stecker Laura M. Stefanski ■ ■ Stephanie D. Steichen (ENG’11) Katrina A. Steiling (MED’02, GRS’10, ENG’10) ■ Bessie G. Steinberg (ENG’14) ■ Jane D. Stepak (ENG’78, CAS’78) ■ Tamara Stephen (ENG’92) ■ Richard M. Stern Stephen T. Stetak (ENG’11) Christina A. Stevens (ENG’14) ■ Justin O’Connor and Heidi Stevens ■ Daniel Stewart (ENG’13) Jerome Stidham (ENG’84) Norman Stolack (ENG’62) ■ ■ Paul S. Strati (ENG’52) Tucker M. Strzempko (ENG’14) ■ John F. Studley (ENG’65) and Grayce E. Studley Gabriella R. Stueber (ENG’14) ■

Timothy F. Styslinger (ENG’90, ’92) ■ Michael J. Sugar (ENG’06) Kornkrit Suksangium (CAS’86, MET’87) ■ Lori L. Sulmasy ■ ■ Koki Sunagawa (ENG’14) ■ Pichuraman Sundaram and Rajeswari Sundaram ■ ■ Frank O. Sunderland (ENG’72, GSM’74) and Margaret S. Sunderland ■ Karin P. Sung (ENG’12) ■ Jayaganesh Swaminathy ■ Priya Swamy (ENG’96) and Prithvi Sankar Anna K. Swan (GRS’94) and Jim Kaufman ■ Gary T. Sweed (ENG’96) and Christine M. Sweed (MET’91) ■ Charles M. Sweet (ENG’91) and Julia P. Sweet ■ Natalie A. Swenson (ENG’11) ■ Edward L. Symonds (ENG’87) and Cathy J. Symonds ■ John Szczypien (ENG’66) and Diane Szczypien ■ Terri A. Taglianetti ■ ■ Carlos C. Talavera (ENG’90) and Laura I. Talavera (CAS’90) De Tan and Jie W. Meng ■ Lu Quan Tan (ENG’14) ■ Robert R. Tang Him (CAS’14) ■ Darrell J. Tanno (ENG’80) and Deborah Tanno (GSM’81) ■ Koonlawat Tantiponganant (ENG’88) ■ Robert P. Tassinari (ENG’88) and Karen N. Tassinari ■ David J. Tasto (ENG’00) and Urszula B. Tasto (ENG’00, ’00) Daniel B. Taylor (ENG’12) ■ Francis M. Taylor (ENG’57) and Audrey W. Taylor ■ Raymond S. Taylor (ENG’08) ■ Gaukhar Tergemessova (ENG’14) ■ Gabriel M. Terrenzio (ENG’56, ’57) and Maria A. Terrenzio ■ Tansukh M. Thanki (ENG’71) and Hema T. Thanki Robert J. Theer and Sharon Theer ■ ■ Herbert D. Thompson (ENG’66) and Barbara B. Thompson ■ Alexander W. Thomson (ENG’85) ■ Brian E. Newman (CAS’95, ’99) and Lisa D. Tilley-Newman (ENG’98) Ike C. Tingos (ENG’91, ’94) and Artemis Tingos Bruce P. Tis (ENG’95) and Marjorie R. Tis ■ Joanne Liang and Ho Kai To ■ ■ Michael G. Field (ENG’95, GSM’95) and Robin L. Tobin Daniel Tokar (ENG’62, ’64; GSM’64) and Taffy J. Pettit Daniel J. Tollin (ENG’95) Robert M. Tona (ENG’13) Richard W. Tong (ENG’06) ■ Alfredo L. Torrejon (ENG’80) Emanuel D. Torti (ENG’79) ■ Heather T. Towey (ENG’14) ■ Heather J. Tracey (ENG’91) ■ Michael I. Trachtman (ENG’94) Michael Trager and Cara Trager ■ Tino Trahiotis Ronald A. Tremper (ENG’87) and Vicki Tremper Micaela A. Trexler ■ Robert L. Trottier (ENG’88) and Robyn M. Trottier ■ Aleksey Trubitsyn (ENG’08) ■ Ryan C. Tsang (ENG’14) ■ Kadin Tseng (ENG’74) ■ ■ Kevin R. Tseng (ENG’91) ■ Robert R. Tucci (ENG’85) ■ Michele C. Tudor (ENG’80, ’81) and Timothy R. Tudor ■ Jillian N. Tullo (ENG’13)

Lukasz Turolski (ENG’07) John F. Twomey (ENG’79) and Jean A. Sculati ■ ■ Tuula M. Tyry ■ ■ Marc C. Ubaldino (ENG’95) and Jennifer C. Ubaldino (SSW’03, SED’03) Giorgio A. Ungarelli (ENG’87) David I. Utain and Marion B. Utain ■ ■ Peter L. Uy and Estrella Uy ■ Armaan Vachani (ENG’14) ■ Juliana C. Valentin (ENG’14) ■ Alexander D. Valentine (ENG’14) ■ Robert E. Valicenti (ENG’82) ■ Harvin Vallabhaneni (ENG’14) ■ Guy Vandevoordt and Mady F. Vandevoordt ■ Natalia Vargas Montoya (ENG’14) ■ Lauren E. Varona (ENG’08) ■ Rahul S. Veetekat (ENG’14) ■ Samantha H. Velasquez (ENG’14) ■ Anjanesh Venkatesh (ENG’13) Glenda A. Ventura (ENG’90) and Vicente A. Ventura ■ Peter J. Vergados (ENG’64) and Angelica D. Vergados ■ Christopher Verplaetse (ENG’94) and Michelle D. Kemper (SAR’01) Natalia M. Vieira (ENG’12) ■ Joshua T. Villanueva (ENG’11) ■ Carrie A. Vinch (ENG’88) Jim Schmidt and Pamela Vlahakis ■ ■ Zachary D. Voltz (ENG’13) Gregory J. Wagner (ENG’96) and Lisa D. Wilsbacher ■ Edmund J. Walsh (ENG’83, ’83) and Jane M. Walsh ■ Gary F. Walsh (ENG’11, ’13) ■ ■ Wendy Wan (ENG’89) ■ Grace E. Wang (ENG’14) ■ Hao Wang ■ Jeffrey Wang (ENG’14) ■ Le Wang (ENG’13) ■ Le Wang (ENG’14) ■ Xiaorong Wang (ENG’04) and Henan Cheng (SED’03) Yunxiang Wang and Yingchun Chen ■ ■ Jerel S. Ward (ENG’14) Michael S. Ward ■ Patrick J. Ward (ENG’05) ■ David A. Warner (ENG’60) and Philippa Warner Sandra D. Shanaberger (ENG’82) and William T. Warner ■ Peter G. Warren (ENG’73) and Pamela S. Warren ■ Mary Anne Wassenberg (ENG’90) and Michael W. Wassenberg ■ Josephine Wasserman Ann B. Weeks (ENG’80) and Eric A. Lustig Jason A. Weiner (ENG’02) ■ Gabrielle E. Weinreich ■ ■ Howard Weinreich ■ ■ ■ Joel F. West (ENG’57) and Elizabeth S. West ■ Rogelio Careaga and Rebecca Westwood ■ ■ Brian J. Wherry (ENG’98) Alice E. White ■ ■ Daniel J. White ■ Fabio D. White (ENG’95) and Theresa White ■ Heather B. White (ENG’92) and Darwin White Norman L. Whitley (ENG’75) Pamela A. Oliver (ENG’84) and Mark R. Whittaker ■ Alexander M. Whittemore (ENG’12) Nicole J. Wiart (ENG’09) ■ John A. McNeill (ENG’94) and Kristina Wile ■ Roger D. Williams (ENG’68)

Ross S. Williamson ■ ■ Dawn J. Wilson (ENG’92) Everton Wilson and Dianne Wilson ■ Richard Wilson ■ Robert M. Wilson and Maria T. Wilson ■ Troy A. Wilson (ENG’14) ■ Joyce M. Wilt (ENG’86) and Michael J. Wilt Vicki Winstead ■ Thomas C. Wojtkowski (LAW’57) and Anne E. Wojtkowski (ENG’56) ■ John D. Wolff (ENG’99) and Kimberly M. Wolff (SMG’99) Jennifer B. Wolfrum Alexander J. Wong ■ Chak H. Wong and Monica Lee ■ Stella M. Wong ■ ■ Sui Kong Wong and Fong Heng Lain ■ ■ Yin Kay Wong (ENG’14) ■ Sarah C. Wrenn (ENG’07) and John M. Wrenn ■ John W. Wright ■ ■ Nicholas G. Wright (ENG’00) ■ Barry Q. Wu (ENG’86, ’92) ■ Candong Wu (ENG’95) and Jinjin Gu I-Hsien Wu (ENG’05) ■ Xiao Hong Wu and Zhi Wei Luo ■ Zhen Wu and Di Jin ■ ■ Kuangzhong Xu (ENG’14) ■ Yu-Xin Xu and Li Liu ■ Ayah H. Yamani ■ Scott Yamashita (ENG’93, ’96) Lucy T. Yan (ENG’14) ■ Youngkuk Yang and Hansik Park ■ ■ Martin R. Yates (ENG’08) Rachel E. Yates-Berg (ENG’14) ■ Robert Q. Yee (ENG’85) Allen Yen (ENG’13) ■ Chaoyang Yen and Chiungyao L. Yen ■ ■ Jessica R. Yen (ENG’10) Patrick H. Yen (ENG’08) Poling Yeung (ENG’14) ■ Kin K. Yim (ENG’87, ’88) and Iwey Y. Wang ■ Tong Yin (ENG’07) ■ Anthony M. Yitts (ENG’88, ’92) and Lisa J. Yitts (MET’93, ’95) William Yost Kelly E. Young (ENG’00) and Corey J. Young Michael S. Young (ENG’85, ’89; MED’91) and Ellen T. Young ■ ■ Gary G. Yu (ENG’95) and Hui Chen ■ Jeeyuen Yu (ENG’95; MET’00, ’01) and Michelle L. Yu ■ Jeffrey M. Yu (ENG’14) ■ Xinke Yu (ENG’14) ■ Kang Yuan (ENG’13) ■ Ofer Zaarur and Nava Zaarur ■ ■ ■ Jeffrey P. Frick and Angelica A. Zachara ■ ■ Samir A. Zahine (ENG’99) Robert S. Zak (ENG’81) and Theresa Zak Ross H. Zamparelli ■ ■ Diane F. Zanca (ENG’85) Guylherme Zaniratto (ENG’98) ■ Anastasios S. Ioannidis (ENG’87) and Margarita Zega ■ Joshua S. Zeisel (ENG’07) ■ Bing Hou (ENG’95) and Gui-Hua Zhang ■ Hansen Zhang (ENG’14) ■ Jiang Zhang (ENG’12) Naizhao Zhang (ENG’14) ■ Yuanyuan Zhang (SMG’14) ■ Yi Zhou (ENG’05) ■ Yifan Zhu (ENG’14) ■ Weiping Wang and Yulan Zhou ■ ■ Run Zhuang (ENG’14) ■ Gaukhar S. Zhurgenbayeva (ENG’14) ■ Peter A. Zink (ENG’10) ■ Robert A. Beach and Patricia A. Zipf-Beach ■ ■ Edith A. Zive ■ ■

B U CO L L EG E O F E N G I N E E R I N G

Stanley Zoll (CAS’65) and Robin G. Zoll (CAS’75) ■ Kimberly A. Zubris (ENG’11) ■ Jeffrey R. Zuccaro (ENG’05) and Rebecca K. Zuccaro (COM’05) ■ Zamir Zulkefli (ENG’05, ’05) Patrick M. Zurek and Charlotte M. Reed Steven H. Zysman (ENG’85)

CORPORATIONS & FOUNDATIONS $1M–$4.9M

Anonymous Leona M. and Harry B. Helmsley Charitable Trust

$500,000–$999,999

Wallace H. Coulter Foundation

$250,000–$499,999 S. D. Bechtel Jr. Foundation

$100,000–$249,999

The Charles Stark Draper Laboratory Inc. General Motors Global Research & Development Grand Marquis Charitable Trust Institut Merieux Kern Family Foundation Mass Eye and Ear (Michael J Fox Fo.) Michael J. Fox Foundation The Steven M. & Joyce E. Tadler Charitable Trust

$50,000–$99,999

APIC Corporation Communication Technology Services LLC Dorf Revocable Trust Massachusetts Institute of Technology (Weatherford International) Osram Sylvania Inc. The Pew Charitable Trusts The Procter & Gamble Company Samsung Electronics (US) Schlumberger Technology Corporation superDimension, Inc. Weatherford International Ltd. Weatherford U.S., L.P.

$25,000–$49,999

American Diabetes Association American Heart Association Brain & Behavior Research Foundation Burroughs Wellcome Fund Charles R. Cantor Trust Electronics and Telecommunications Research Institute GE Aviation The Maccarone Family Fund of Goldman Sachs Massachusetts General Hospital (American Diabetes Assoc.) The National Academies Keck Futures Initiative National Christian Foundation Portland Osteosynthesis and Trauma Care Foundation Princeton University (National Academies Keck Futures Initiative) University of Cyprus

$10,000–$24,999

Accio Energy The Argosy Foundation Artech Associates Capella Photonics Inc. The GJW LLC Invuity Inc. National Collegiate Inventors and Innovators Alliance Silicon Lightwave Services, LLC

Standex Intenational Corp Stanley Black & Decker, Inc. The W. Bradford Ingalls Charitable Foundation Trust

$5,000–$9,999

AL Prime Energy Consultant, Inc. eM-Tech Fidelity Charitable Gift Fund The Leonard Wheeler Ely III Trust

The Engineering Annual Fund

Impacting the Engineers of the Future

$2,500–$4,999

American Rhinologic Society The Elizabeth Bascom Charitable Lead UniTrust General Motors Corporation H.T. Than Law Group Mass Eye and Ear (American Rhinologic Society) Medtronic, Inc.

$1,000–$2,499

Children With Diabetes Foundation The George Savage and Nancy Savage Living Trust Lisa W. Gill Trust Moran 2006 Trust Starkey Hearing Technologies, Inc. Whitney Place

$250–$499

MSI Foundation Scopus Consulting, LLC

$1–$249

Crockett and Associates Fallsgrove Endodontics Just Give Nokia Northeast Consulting Engineers, Inc. R. H. Mathews Trust Verrill Dana LLP The William T. Warner 2006 Rev. Trust

MATCHING GIFTS

AbbVie, Inc. Aetna Inc. Air Products and Chemicals, Inc. Alliance Data Analog Devices Inc. BAE Systems Bank of America, N.A. Barclays Capital Barclays Capital, Inc. Bard The Boeing Company Consolidated Edison, Inc. Fidelity Investments General Electric Company General Electric Credit Corp. Houghton Mifflin IBM Intel Corporation Johnson & Johnson Medtronic, Inc. Microsoft Corporation Motorola, Inc. Northrop Grumman Corporation Nuveen Investments, LLC Pfizer, Inc. Pitney Bowes Inc. Raytheon Company Truist United Technologies United Technologies Corporation Varian Semiconductor Equipment Associates, Inc. Verizon Communications

Relying on gifts from generous alumni and parents, the Engineering Annual Fund (EAF) impacts the educational experience of ENG undergraduates by supporting essential programs and activities that extend beyond what tuition and external research funding can provide. Gifts of any size to the EAF are immediately used to benefit these undergraduates through programs like the Summer Term Alumni Research Scholars (STARS). “Thanks to generous contributions to the EAF, I have been developing engineering curricula for middle and high school students, which is strengthening my entrepreneurial and societal engineering skillset.” —Janessa Pettway (California, ME’16)

“Through STARS I have gained my first laboratory experience. I believe that my research on accurately predicting where a cancer will metastasize will help clarify the underlying processes involved in modeling cancer cell migration.” —Maria Barrios (Colombia, BME’15)

“STARS has brought me in contact with a wonderful group of bright and inquisitive students pursuing vastly different lines of research while striving to make an impact before even entering the professional realm.” —Benjamin Moll (New Hampshire, EE’16)

You can help shape future alumni into well-rounded Societal Engineers who have a lasting impact on the world by giving to the Engineering Annual Fund today.

Visit bu.edu/eng/alumni to make your gift. Connect with the ENG Alumni Facebook Group at facebook.com/BUEngineeringAlumni.

NONPROFIT US POSTAGE PAID BOSTON MA PERMIT NO. 1839

Alice White PhD, Harvard University Chair and Professor, Department of Mechanical Engineering Former Chief Scientist, Bell Labs In the Mechanical Engineering (ME) Department, our researchers are doing everything from advancing greener manufacturing methods to developing more targeted cancer therapies. But their teaching is no less critical to society, as it equips the next generation of researchers and practitioners with the knowledge and skills to improve our quality of life. Tapping into my experience at Bell Labs, I’m working not only to build clusters of research strength and industrial partnerships, but also to remodel traditional theater-style classrooms into hands-on, interactive, café-style learning environments where students and faculty can share and implement ideas.

To learn learn more, more,visit visitwww.bu.edu www.bu.edu/eng. /eng. 4

B U CO L L EG E O F E N G I N E E R I N G

JESSICA SCRANTON

Encompassing exciting new areas, such as robotics, energy and sustainability, and nanotechnology, the department’s diverse research portfolio presents many opportunities for interdisciplinary collaboration. Another departmental strength is expertise in manufacturing, a topic that’s particularly timely as the US seeks to stem the flow of manufacturing jobs offshore. My own research will follow this path as I develop a capability to perform rapid prototyping at nanoscale resolution—an essential step in the manufacturing of a variety of high-tech products.