The MareLife News | November 2012 by http://obm.no

Newsletter from Marelife • November • 2012 NASF PRE-CONFERENCE • March 6 • 2012

Tanya Hoel.

BERGEN VISION! NASFDayZEROreadyfor

theWorldSeafoodCapital, March2013!

The MareLife News

BIG SCALE CHILE R&D

AquaGenin USD17M "BlueGenomics Chile"

"BioVerdi" is hosted at Oslo Science Center. This picture is taken when Minister of Trade and Industry, Trond Giske (center), inaugurated the new StartupLab, September 2012. Karl Christian Agerup, CEO Forskningsparken (left) and Ole Petter Ottersen, rektor, University of Oslo (right). Photo: Gorm K. Gaare.

THE BIO COMMITMENT!

THE MARELIFE NEWS • NOVEMBER • 2012

Ole Petter Ottersen, Rektor, University of Oslo.

Runar Larsen, CEO, Nortura.

Mariann Ødegaard, CEO, Innovation Kjeller.

Carl Seip Hanevold, COB, Marelife.

Øyvind Fylling Jensen, CEO, Nofima.

Arne Handeland, partner, Verdane Capital.

Hilde Steinegger, VP, Pronova Biopharma.

Gudbrand Rødsrud, CTO, Borregaard.

Gudmund Holstad, CEO, Veterinærinstituttet.

Hans Fredrik Hoen, Rektor, UMB.

Jon Hindar, CEO, Cermaq.

Yngvild Wasteson, Rektor, NVH.

Frank Larsen, CEO, Hedmark Kunnskapspark.

Greta Bentzen, CEO, NIVA.

Knut T. Traaseth, Secr. Gen., Norsk Venturekapitalforening.

Øystien Lie, Project Manager. Bio Verdi

Karl Christian Agerup, CEO, Forskningsparken.

Ole Kristian Hjelstuen, CEO, Inven2.

Sigbjørn Gregusson, CEO, BioBank.

Odd Magne Rødseth, CEO, AquaGen

Tom Colbjørnsen, Rektor, Handelshøys kolen BI.

Idun Christie, CEO, Graminor.

Sverre Bjørnstad, CEO, Geno.

Ove Lerdahl, CEO, Agroplas.

23Leaders SIGNATURES committed to bio cooperation

Norwegian bioeconomy is behind the pioneering «BioVerdi» project, based at Oslo Innovation Center. 23 top executives have signed the partnership declaration. The project picks up the results from recent large report made by Oslo Business School, «Et kunnskapsbasert Norge» (A knowledge based Norway), wich reflects the status of the most important Norwegian industry sectors. "Bio Verdi" aims at adressing the challenges and opportunities of the bio sector part of these industries, and to provide recommandations to enhance innovation. The project has been well received in all environments, from universities and industry to venture capital sector. The analytical approach is robust: experts from all bio economy sectors; medicine, marine, agro and industry together with Academia and capital owners have formed working groups, the main delivery from which is to propose on important measures to be implemented for the purpose to foster enhanced innovation in the Norwegian bioeconomy sectors. The recommendation short list will be substantiated by mobilizing adequate analyses, statistics to support the proposals. “BioVerdi” is a cross field and trans boundary initiative to develop a stronger "ecosystem" of innovation. The project is established in partnership between leading R&D units, industry representatives from bio production and pharma, capital owners and with support

from public policy system and authorities. The partners commitment and ownership to the project are based on a planning document written by Øystein Lie. “Bio Verdi” seeks to establish an International Advisory Board, represented by the Nordics, UK, USA and Singapore. “BioVerdi” intends to try to connect to “The Norwegian Industrial Biotechnology Network”, as a possible pilot or demonstration project. In essence the Norwegian bioeconomy sector is behind the project since top excecutives of the leading players of all four major branches: Marine, agri, health and process industry together with R&D organisations have endorsed its ideas and goals.

The partners

These executives has signed the document: Ole Petter Ottersen (Rektor UiO), Hans Fredrik Hoen (Rektor UMB), Yngvild Wasteson (Rektor NVH), Øyvind Fylling Jensen (Adm. dir. Nofima), Greta Bentzen (NIVA), Gudmund Holstad (Adm. dir. Veterinærinstituttet), Ole Kristian Hjelstuen (Adm. dir. Inven2), Tom Colbjørnsen (Rektor BI), Frank Larsen (Adm. dir. Hedmark Kunnskapspark), Mariann Ødegaard (Adm. dir. Kjeller Innovasjon), Karl Christian Agerup (Adm. dir. Forskningsparken), Hilde Steineger (Vice president Pronova Biopharma), Odd Magne Rødseth (Adm. dir. AquaGen), Jon Hindar (Adm. dir. Cermaq), Idun Christie (Adm. dir. Graminor), Runar Larsen (Adm. Dir. Nortura), Sverre Bjørnstad (Adm. dir. Geno), Ove Lerdahl (Adm. dir. Agroplas), Knut Thomas Traaseth (Generalsekretær Norsk Venturekapitalforening), Arne Handeland (Partner Verdane Capital), Sigbjørn Gregusson (BioBank AS), Carl Seip Hanevold (Styreleder MareLife), Gudbrand Rødsrud (CTO Borregaard). In fact, the spirit and cross sector engagements behind the Norwegian aquaculture industrial revolution is again reflected in

THE MARELIFE NEWS • NOVEMBER • 2012

BioVerdi. This is one major motif why MareLife chair, Carl Seip Hanevold and many of MareLife members involve in BioVerdi. They foresee new synergistic powers to be tapped for the blue sector through this project.

cure a sustainable expansion of the global aquaculture business. According to Øystein Lie and Tanja Hoel the seminar is designed in these days, and it will consist of chapters on aquaculture in temperate, tropical and cold water. Solutions in critical fields like the below listed will be highlighted: o Complete genome based breeding regimes o Novel vaccination strategies for sustainable fish farming o Revealing new insight to fight viral, bacterial and parasite infections o New feed resources and technologies (algae etc) o Gear and engineering solutions o Sustainable catch of wild resources and maximized utilization of corresponding byproducts for aquafeeds and ingredients o Solutions for space and water o Necessary legislations, standards of quality and best practices

More about NASF 2013: http://www.nor-seafood.com/

FINALIZING BLUEBIO Greatinterregionalmarineresearchprojectconcluded

Tanya Hoel, CEO, Fiskeriforum Vest.

BERGEN THINK TANK Visionpaperto beconludedat NASFDayZero 2013

A think tank aiming at producing a vision paper with working title: “Solutions needed to expand global aquaculture substantially to meet with future food demands” is to be in action in advance of and ready to present short list action points at the NASF Day Zero in Bergen. This is one of many new features at the popular innovation seminar warming up the North Atlantic Seafood Forum. When the very first NASF makes its takeoff in the “world marine?(seafood) capital” Bergen on Tuesday March 5h, the focus will be on global aquaculture solutions (GAS), how to innovate new solutions to advance the aquaculture sector. Day Zero will be chaired by Karl Almås, CEO SINTEF Fishery & Aquaculture, and moderated by Jostein Refsnes (Chair Norlaks). The seminar is hosted by MareLife, manager Øystein Lie, and Fiskeriforum Vest, manager Tanja Hoel. The main NASF Day Zero Partner is The Norwegian Seafood Research Fund. Minister of Fisheries and Coastal Affairs, Lisbeth Berg-Hansen will be invited to give the opening address, and opening keynote speech will be delivered by George Chamberlain, president of Global Aquaculture Alliance. Themes to be focused are the feed capacity and a series of other important issues and the search for corresponding solutions to se-

The interreg project BlueBio, where MareLife has been an active partner, was concluded at a conference at Marstrand Havshotell, Thursday November 29. Blue Bio has brought about active networking between academy, industry and society, to promote sustainable marine innovations. “Blue Biotech for sustainable innovations” (Blue Bio) is a crossborder project in the Kattegatt-Skagerack region, and it has been working towards knowledge-based development and integration of research and industry. The goal is to find sustainable ways of exploiting the marine environment and resources. Blue Bio has been working towards expanding the potential for the industrial use of microalgae. With relevant research, industrial collaborations and development of the marine innovation platform, Blue Bio reinforces microalgae as a valuable resource for industries working with foodstuffs, feeds, nutrition, pharma and bioenergy.

A new area of competence

At the end 2012 the project group of Blue Bio will hand over suggestions and tools for further development of marine biotechnology in the KASK-region to the intrinsic innovation system. This includes a handbook of innovation in the marine environment, an analysis of the current state and future potential for industrial use of microalgae, and a marine biotechnology platform of relevant researchers, companies and new innovation cases, which have been knitted together through several workshops and conferences. Project members in Sweden and Norway: University of Gothenburg (Lead Partner), Innovationskontor Väst, Chalmers University of Technology, MareLife (Norwegian project owner), Norwegian University of Life Sciences (UMB), Kjeller Innovasjon Concrete core deliverables from the project are: Microalgae market and technology analysis, Development of manual for commercialization/startups for the universities, Assisting in commercialization of a series of R&D cases, Running relevant marine biotech workshops, Communication.

THE MARELIFE NEWS • NOVEMBER • 2012

DNA VACCINE Comingup: Theimpactonfish

farmingandregulatoryissues infocus - Dec. 11-2012

What is the impact of DNA vaccines on fish farming, and how should it be regulated in the future? This topics will be focused at at seminar orgainzed by Bioteknologinemnda/The Norwegian Biotechnology Advisory Board, and MareLife.

Representatives from research institutions and government will participate at the lunch seminar Tuesday, December 11, at Rica Victoria Hotel in central Oslo. Professor Espen Rimstad, National Veterinary Institute, researcher Paul Midtlyng, Novartis, researcher Helena Hauge, National Veterinary Institute and senior advisor Casper Linnestad, Department of Environment. They will give key-note speaches, followed by debate coached by Director general Sissel Rogne, Bioteknologinemnda. Main topics are the developing of DNA vaccines and the impact on fish farming industry, and how it should be regulated by the authorities. Check out more about the seminar and register your participation here:

http://bit.ly/Ta6rvb

R&D Innovationactivities with MareLifeinvolved

“AlgInnova”: a series of workshops, market analyses and projects together with the Storby Marin network, the BlueBio consortium, UNI Research Bergen, Innovation Norway and commercial members of MareLife “Green Fishing Vessel”: a multi component project aiming at developing a fishing vessel with lowest possible carbon foot print and at the same time equipped with sensors to monitor ocean environments. Liegruppen, Rolls Royce, Telenor, Det norske veritas, NIVA, SINTEF Fishery and aquaculture, Institute of marine research “GenTrack”: reports, verifications and R&D projects aiming at developing a system for full fledge DNA tracing of nation wide salmon biomass. AquaGen, GenoMar, Akva Group, BioBank, UMB/Cigene, Norwegian School of Veterenary Science, Nofima, Norw. Seafood Research Fund, The Norwegian Seafood Federation and its new environment fund. “AquaGenome”: complete genome sequence assisted R&D approaches to optimize breeding operations and enhance insight into marine resource structures and dynamics. University of Oslo (CEES) together with national and international academic alliances and leading aqua genetics and breeding companies like AquaGen. “NOR-Openscreen”: the Norwegian EU-OpenScreen Node at the Biotechnology Center, University of Oslo, employing chemical space and bio assays (chemBio) for high throughput drug discovery. Also linked with marine bioprospecting efforts in Tromsø, Trondheim and Bergen. “AquaFarmControl”: an intelligent capsule based system under development to prevent escapees from the farm. Seafood Security AS together with Norwegian and EU allies. “Protective immune responses in Atlantic salmon”: an immunome (translated immune genes) based R&D approach to provide new knowledge base on immune gene functions as a mean for improved vaccine development and other disease control measures in salmon.

Blue Bio Project Manager Camilla Petterson (left), University of Gothenburg, and Prof. Øystein Lie, Executive Manager, MareLife. Photo: Erik Lopez Fedde University of Oslo, Norwegian School of veterinary medicine together with commercial players in the vaccine and aquaculture sector.

ESCAPEES ON THE AGENDA Aquacultureenvironmentalis-

sues withemphasis ontracing andpreventingescapees

The MareLife miniseminar concept was again a great success, Sept. 19-2012. This time featuring one of the outmost important issues for the sector reputation: Environmental issues with emphasis on tracing and preventing escapees in aquaculture. This is likely the reason for the success of this seminar concept: always sector important issues on the agenda and it attracts a diverse array of players again which foster vibrant cross talk. Around 40 people covering producers, technical solution providers, R&D entities, sector umbrella organizations, fishery authorities, NGOs and press gathered at Oslo Innovation center. The presentations were chaired by Øystein Lie and the subsequent discussion by Jostein Refsnes. The agenda was set and presentations were opened by the Norwegian Seafood Federation (FHL) director on environmental issues: Aina Valland with an overview of their new enforced emphasis on environmental issues: sealice, fish health, escapees, feed resources, installment of a new fund etc. This main talk was followed by a series of technical solutions for tracing (DNA based tracing by Sisse Kjøglum AquaGen and Matthew Baranski Nofima, , physical tagging by Pål Chr Kruger Europharma and preventing escapees by Håvard Haraldsen Havtek and Carl Ivar Holmen, Seafood Security. A vibrant discussion took place chaired by Jostein Refsnes. Although there was quite a distance in the position of the NGOs present and the aquaculture sector people as of the reality picture of the threats and impact of cultured on wild salmon, there was a consensus that more knowledge was needed. The ongoing DNA projects would assist on advancing our knowledge about these interactions

THE MARELIFE NEWS - NEWSLETTER TO MARELIFE MEMBERS EDITOR-IN-CHIEF: Øystein Lie | oystein.lie@marelife.org PRODUCED BY: Oslo Business Memo | post@oslobusinessmemo.no

THE MARELIFE NEWS • NOVEMBER • 2012

and thus also advance our dialogue in addition to the cost efficient tracing power of these. Also it was emphasized the need of instantly knowing wild or escaped and from where, at the moment too challenging to the DNAmethod but also here there is a continuous development in speed of analysis. It was also suggested that the one method did not exclude the other but rather could mutually strengthen. Hence, also a physical tagging method was presented by Europharma. Overall there was also a consensus that the ultimate goal is to prevent most and ideally all escapees and this vision was addressed by two concepts: the intelligent electronic net by Havtek and the responder tag by Seafood Security. The presentations can be retrieved from the download section together with program and participant list.

Blue Frontier Magazine No 2, printed in London and Bangkok.

http://bit.ly/QswQXK

FOOD FROM THE OCEAN AcademyofSciencesymposium inJanuary2013

The future of Norwegian and International aquaculture are focused at a symposium in The Norwegian Academy of Science and Letters, Wednesday, January 30. Minister of Fisheries and Coastal Affairs, Lisbeth Berg-Hansen, is the first in the row of top key-note speakers at the symposium with topics ranging from the general picture and overview to technological challenges and innovation. Director Christina Abildgaard, Director Karl A. Almås, Professor Roy H. Gabrielsen, Professor John Grue and Director Fridtjof Unander is in the advisory board preparing the symposium. Key-notes will be held by Karl A. Almås, SINTEF, Lasse Taranger, Havforskningsinstituttet, Yngvar Olsen, NTNU, Ragnar Tveterås, University of Stavanger and Liv Monica Subholt, Kvaerner ASA. More information closer to January 30, on the web:

http://www.dnva.no

ADVANCING COOPERATION Alliances shapingthemarine world– globally...

MareLife is in the process of formalizing strategic collaborative constructions with Biomarine Business Convention, Global Aquaculture Alliance (GAA) and Iceland Ocean Cluster. Recently the North Atlantic Ocean Cluster Alliance was founded with representatives from Norway, Iceland, Greenland, the Faroe Islands, Denmark and Newsfoundland Canada. This cooperation is sponsored by NORA and Nordic Innovation and will be lead by Iceland. One focus area where MareLife will be involved is to work together to enhance to competence for better utilization of byproducts form wild catch.

http://www.gaalliance.org

ANALYSED Recentimportantreports and

http://www.biomarine.org http://www.sjavarklasinn.in/en/

whitepapers forthesector.

… andnationally

The Government launched recently its major long term marine R&D and innovation strategy for Norway: HAV21. Research Council of Norway acted as sectretariat for the report. MareLife and allies, especially through the Storby Marin-network has been a bottom up driving force to realize this report not least through its Havlandet Norge report 2010. Read the report here: SINTEF together with DKNVS and NTVA recently presented a holistic analysis of the marine capacity of Norway in a global context. Read the SINTEF report here:

MareLife fosters innovation through facilitating cross talk between the private sector, the public sector and the R&D entities forming a triple helix. Our organisation is receiving critical important grants from The Research Council of Norway, Oslo Municipality and Akershus County Council through the VRI program to supoort this way of advancing innovation in the marine sector. Our strategic collaboration with Innovation Norway both nationally, through the biotech industrial network, and abroad is an important part of the MareLife activities. Noteably The Norwegian Industrial Biotechnology Network, with several MareLife members participating.

http://bit.ly/Ya1pGa

http://www.innovasjonnorge.no

Both above reports together with EU and international reports from FAO etc will act as very useful back drops for MareLife and allies innovation session NASF Day Zero, Bergen March 5, where Global Aquaculture solutions will be put on the agenda as a main topic.

http://www.forskningsradet.no/en/Home_page/1177315753906

http://bit.ly/Ya1EB9

http://bit.ly/zBHdCT

THE MARELIFE NEWS • NOVEMBER • 2012

SALMON GENOME PAVING THE WAY FOR NEW BUSINESS

AquaGenASA keypartnerinthe newconsortiumBlueGenomic Chile In several projects the Salmon, Trout and Cod Genome research has brought new, significant steps forward, and will in the coming years form the basis for development and commercialization of new products and services in the aquaculture sector according to the Aqua Gene management.

- Aqua Gens early investments in the dual platforms of biotechnology and breeding has already led to new products that give the aquaculture sector more choices for improving productivity and sustainability. The completion of the salmon genome, combined with the Biotech 2021 program in Norway and Blue Genomics consortiumin Chile will build a solid fundament for new innovative products and services that will reach the marketplace in near future, says Odd Magne Rødseth, CEO, Aqua Gen. Head of research at AquaGen, Nina Santi, says the company now exploits the knowledge from the Salmon Genome Project to improve the farmed salmons survival and quality.

Research in Salmon Genome has led to several new projects and business cases. Photo: Aqua Gen - Through focused product development, ourt products with increased IPN and PD resistance are already in the market, and with markers for fillet colour coming to market soon, says Santi. She reveals other tools to be used in further research: Three new SNP chips developed by Aqua Gen in collaboration with CIGENE/UMB, two for salmon and one for trout. The first salmon chip will contain some 950 000 SNP, which is a giant leap forward compared to what is available today. The best chip at the moment contain some 6 000 SNP. These chips represents total new powerful tools for identifying industrial important genes, the information of which will advance salmonid genetic enhancements to new levels. According to Nina Santi, AquaGen puts great effort in collaboration with researchers both in Norway and internationally, and to enhance the knowledge regarding the salmon genome and methods of selection. In the RCN BIOTEK2021 program, AquaGen - together with three partners - will contribute through the recently granted AQUAGENOME project under the supervision of CEES, University of Oslo. - We will bring the work with the salmon and cod genomes into the next phase, Santi says. In the project 1000 genomes of each species shall be sequenced, mapping the geneti variation within the species. The genetic variation is the main basis for any breeding progress. New methods to develop sterile salmon, SALMOSTERILE managed by HI, is another research project with which AquaGene is

Odd Magne Rødseth, CEO, Aqua Gen: A solid fundament for new innovative products and services that will reach the marketplace in near future. Photo: Gorm K. Gaare.

THE MARELIFE NEWS • NOVEMBER • 2012

Researchers both in Norway and internationally works to enhance the knowledge regarding the salmon genome. involved in collaboration with three industrial partners. This research can help to solve the problems concerning potential adverse genetic interaction between escaped farmed salmon and wild salmon. Finally Nina Santi says the new Chilean consortium Blue Genomics Chile, will be an important platform to address issues as SRS and Caligus. The consortium consisting of Aqua Gen ASA, Aqua Gen Chile SA, Vaxxinova and Biobank has been supported by Corfo to establish a marine biotech innovation center in Puerto Varas in Chile. The new center, named "Blue Genomics Chile" has a total budget of 17 million USD. The objective is to make use of new knowledge and technologies developed in the wake of the Salmon Genome Project to identify genetic markers and mapping mechanisms specifically related to disease resistance. The development will form the basis for commercialization of new products and services that contribute to a sustainable and profitable development of the aquaculture sector. Priorities for Blue Genomics Chile are rickettsiosis (SRS) and salmon lice (Caligus) that represents the largest risk factors in the industry. The new center will also include other areas such as functional genomics and genomic related services such as biobanking services

Nina Santi, Head of Research at AquaGen.

Ambassador Juan Aníbal Barría, Embassy of Chile in Norway. We are very pleased with this investment in “Blue Genomics Chile” and it is an important contribution to the fish farming industry in Chile, not least because it will introduce even more cutting edge technology to the industry in Chile. I am impressed with the research conducted in this field here in Norway, and with Aqua Gen, which I had the pleasure of visiting, says the Chilean ambassador to Norway, Juan Aníbal Barría. We also believe the Blue Genomics Chile consortium provides a very good opportunity for an even closer cooperation between the Chilean industry and the Norwegian fish farming industry and Norwegian capital, he says. There is an increased interest for investing in Chile, and Norway is moving up on the rankings of foreign investment in Chile. Norway`s importance is growing in comparison to other countries, says Ambassador Barría. Carl Seip Hanevold, Chair of MareLife, geneticist by graduation and heavily involved in the Norwegian and international industrial aquaculture revolution over 4 decades, states: - The described new aqua genomics efforts between Norway and Chile with AquaGen and allies in pivotal roles, represent a paradigm shift in genetic enhancement of farmed fish.

THE MARELIFE NEWS • NOVEMBER • 2012

MareLife, the independent sciencebased marine innovation network, has reinforced its staff and put in operation R&D projects initiated by experienced working groups covering key areas in marine innovation. A strong and committed staff combined Carl Seip Hanevold with highly experienced people in our Board and core working groups, provides Marelife with a solid foundation for moving forward, says Marelife executive manager Øystein Lie. He also extends his acknowledgements to the resigning Board members and Chair who helped developing the current MareLife platform and he welcomes onboard the new ones.

Staff The staff now consists of Øystein Lie (Executive Manager), Carl Seip Hanevold (Cermaq) (Working Chairperson), Jon Aulie (The Norwegian Seafood Federation, Marine Ingredients), Paul J. Midtlyng (Aquamedic AS, Aquaculture disease control),Sytse Ybema (Sustainovate, Ocean Resources) and Erik Fedde Lopez, Fedde Consulting (Administrative matters)

Our five working groups. Marelife has five working groups in the core areas fisheries, aquaculture, ingredients industry, commercialization and reputation. These working groups have been initiating our R&D projects and strategic efforts like the Havlandet Norge report and are chaired by the following people: Fisheries: Lars Olav Lie (Liegruppen AS), Aquaculture: Petter Arnesen (Marine Harvest ASA Ingredients Industry: Jon Aulie (MARING Forum, the Norwegian Seafood Federation, FHL) Commercialization: Knut Traaseth (Norwegian Venture capital Association) Reputation building: Geir Myrold (TraceTracker AS)

Board of directors * Carl Seip Hanevold (Cermaq), Chairperon * Live Haukvik Aker (Considium Consulting), deputy chairperon * Kjetil Jakobsen, University of Oslo * Odd Magne Rødseth, AquaGen * Dag Knappskog, MSD Animal Health * Ørjan Olsvik, University of Tromsø * Torstein Steine, Norwegian University of Life Sciences, UMB * Espen Rimstad, Norwegian School of Veterinary Science, NVH * Kristine Naterstad, Nofima * Jon Aulie, The Norwegian Seafood Federation (FHL) MARING

The Nomination Committee Sissel Rogne, CEO, The Norwegian Biotechnology Advisory Board (Committee chairperson) Director General Arne Benjaminsen, Ministry of fisheries and coastal affairs (FKD) Geir Andreassen, CEO, The Norwegian Seafood Federation (FHL)

Far-reaching network

Jacobsen

Marelife has grown its membership base from 17 founding members to currently 48 members and has a strong international network. See the member list here:

http://www.marelife.org/our-network/our-members.html

| Øystein Lie | Jon Aulie | Erik Fedde Lopez

KEY PEOPLE Doers intheMareLifenetwork!