Everything You Need To Know About Diosmin Powder (520-27-4)

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Diosmin Powder (520-27-4)

Diosmin (diosmetin 7-O-rutinoside), a flavone glycoside of diosmetin, is manufactured from citrus fruit peels as a non-prescription dietary supplement used to aid treatment of hemorrhoids or chronic venous diseases, mainly of the legs. Diosmin is a type of plant chemical found mainly in citrus fruits.

Diosmin powder Specifications

Name:

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Diosmin powder

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www.scienceherb.com CAS:

520-27-4

Function:

Diosmin can treat various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the legs, blood clots, and bleeding (hemorrhage) in the eye or gums.

Application:

A flavonoid glycoside that reduces venous hyperpressure

Solubility:

Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in alcohol.

It dissolves in dilute solutions of alkali hydroxides.

Storage Temp:

2-8°C

Color:

N/A

What is Diosmin powder?

Diosmin (diosmetin 7-O-rutinoside), a flavone glycoside of diosmetin, is manufactured from citrus fruit peels as a non-prescription dietary supplement used to aid treatment of hemorrhoids or chronic venous diseases, mainly of the legs. Diosmin is a type of plant chemical found mainly in citrus fruits.

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Diosmin powder uses

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Diosmin is a dietary supplement used to aid treatment of hemorrhoids and venous diseases, i.e., chronic venous insufficiency including spider and varicose veins, leg swelling (edema), stasis dermatitis and venous ulcers.The mechanism of action of Diosmin and other phlebotonics is undefined, and clinical evidence of benefit is limited. It is also used to treat swelling of the arms (lymphedema) following breast cancer surgery, to protect against liver toxicity, and a type of pain called radicular pain. It is often taken in combination with hesperidin, another plant chemical.

Diosmin is not recommended for treating the rectal mucosa, skin irritations, or wounds, and should not be used to treat dermatitis, eczema, or urticaria. Diosmin is not recommended for use in children or women during pregnancy.

Diosmin powder benefits

Diosmin is an anti-inflammatory and a flavonoid glycoside that reduces venous hyper pressure. Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). Diosmin effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.

Taking diosmin in high doses along with hesperidin seems to reduce symptoms of hemorrhoids. Taking diosmin in lower doses along with hesperidin plus troxerutin or along with bulk laxatives also seems to reduce symptoms. Taking diosmin in lower doses along with hesperidin seems to help prevent hemorrhoids from coming back.

Leg sore caused by weak blood circulation (venous leg ulcer). Taking diosmin in combination with hesperidin and compression dressing seems to help heal leg ulcers caused by poor circulation.

Diosmin powder dosage

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www.scienceherb.com Diosmin is often taken in combination with hesperidin.

The following doses have been studied in scientific research:

By mouth:

For hemorrhoids: For treating hemorrhoids, 1350 mg of diosmin plus 150 mg of hesperidin twice daily for 4 days followed by 900 mg of diosmin and 100 mg of hesperidin twice daily for 3 days has been used. Also, 300 mg of diosmin, 300 mg of troxerutin, and 300 mg of hesperidin three times daily for 3 days, followed by two times daily for 2 days, and then once daily for 7 days has been used. Thereafter, 300 mg of diosmin, 300 mg of troxerutin, and 100 mg of hesperidin has been used daily for one month. Some researchers also try 600 mg of diosmin three times daily for 4 days, followed by 300 mg twice daily for 10 days, in combination with 11 grams of psyllium daily. However, this lower diosmin dose does not seem to be as effective.

For leg ulcers caused by poor circulation (venous stasis ulcers): 900 mg of diosmin plus 100 mg of hesperidin daily has been used for up to 2 months.

Diosmin powder for sale (Where to Buy Diosmin powder)

Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time.

We also focus on value-added services. We are available for service questions and information to support your business.

We are an professional Green tea extract powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and 4

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www.scienceherb.com undergoes strict, independent testing to ensure that it is safe for consumption around the world.

References

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Diosmin reduces chronic constriction injury-induced neuropathic pain in mice.Bertozzi MM et al. Chem Biol Interact. (2017)

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The effects of diosmin on aflatoxin-induced liver and kidney damage.Eraslan G et al. Environ Sci Pollut Res Int. (2017)

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Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity.Lewinska A et al. Toxicol Lett. (2017)

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Diosmin induces caspase-dependent apoptosis in human glioblastoma cells.

Soares JM, Faria BM, Ascari LM, Souza JM, Soares AG, Cordeiro Y, Romão LF.An Acad Bras Cienc. 2019 Dec 2;91(4):e20191031. doi: 10.1590/0001-3765201920191031. eCollection 2019.

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The effect of diosmin against lead exposure in rats‡.Bozdağ M, Eraslan G. Naunyn Schmiedebergs Arch Pharmacol. 2019 Dec 3. doi: 10.1007/s00210-019-01758-4.

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