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EXEMESTANE (107868-30-4) Exemestane,brand name Aromasin. It is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.It is a steroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after resection and after failure of tamoxifen.
Status:
In Mass Production
Unit:
25kg/Drum
Capacity: 1390kg/month
Exemestane (107868-30-4) video Exemestane (107868-30-4) Description Exemestane,brand name Aromasin. It is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.It is a steroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after resection and after failure of tamoxifen. Exemestane has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Breast cancer cell growth may be estrogen-dependent. Aromatase (exemestane) is the principal enzyme that converts androgens to estrogens both in pre- and postmenopausal women. While the main source of estrogen (primarily estradiol) is the ovary in premenopausal women, the principal source of circulating estrogens in postmenopausal women is from conversion of adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) by the aromatase enzyme in peripheral tissues. Estrogen deprivation through aromatase 1
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