Cabrini Institute Annual Report 2019-20

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Cabrini Monash University Department of Surgery, The Frรถhlich West Chair of Surgery Head: Professor Paul McMurrick Safety in Surgery through research: The cornerstone of all our research is the colorectal neoplasia database allowing us to carry out a large number of clinical research projects. For example, research projects investigate which patients are at most risk of developing complications after surgery, which patients might have a recurrence of their cancer, and how we can improve cancer care for improved patient outcomes.

Head of Department Frรถhlich West Chair of Surgery Professor Paul McMurrick Consulting Surgeons Mr Stephen Bell, Colorectal surgeon, Senior Lecturer Mr Peter Carne, Colorectal surgeon, Senior Lecturer Mr Martin Chin, Colorectal surgeon and

Director of Colorectal Fellowship Program Mr Chip Farmer, Colorectal surgeon, Senior Lecturer Emeritus Professor Adrian Polglase Mr Pravin Ranchod, Colorectal surgeon, Lecturer Mr Paul Simpson, Colorectal surgeon

Mr Raymond Yap, Colorectal and Academic surgeon, Research Fellow Dr Evan Williams, Colorectal Fellow Dr Gemma Solon, Colorectal Fellow Senior Research Fellows Dr Simon Wilkins

Dr Rebekah Engel Dr Christine Koulis Database Manager Karen Oliva PhD Students Stephen Bell, Monash University Sara Hlavca, Monash University Honours Student Claudia Corrente

In conjunction with clinical governance at Cabrini Hospital, we have a quarterly quality assurance loop to ensure that not only are the overall results for the treatment of bowel cancer at Cabrini at an international standard but also that the individual outcomes of every surgeon are scrutinised and reported.

Personalised medicine tissue platform Through our three main collaborative projects with Monash University, namely organoids, tissue microarray and the new tissue-slice assay, we are able to match individual tumour responses to drug treatments, gene expression, and immune responses in the laboratory to clinical data in the colorectal neoplasia database on patient outcomes and the success of their treatment. When combined, these three major projects will have the potential to personalise treatment for each bowel cancer patient in the future.

Highlights 1. Colorectal Cancer organoid program Our program is developing a high throughput screening platform to test known and

C A B R I N I I N S T I T U T E A N N U A L R E P O RT 2 0 1 9 -2 0

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