Cabrini Institute Annual Report 2014-15 by Cabrini Health

2014-15 C AB R INI IN STITUTE ANN UAL R EP ORT

EDUC ATION. RESE ARCH. HE ALTH PROMOTION.

ABOUT THE CABRINI INSTITUTE 4

Established in 1996, the Cabrini Institute supports a wide range of research and education activities across Cabrini, as well as health promotion activities on behalf of the organisation. Senior medical staff and researchers oversee a diverse research program, as well as developments in clinical education. The research program includes arthritis, back pain, cancer, care of the elderly, health literacy, medicine, nursing, patient safety and surgery. The Cabrini Institute plays a significant role in the education of our current and future health professionals.

CONTENTS 6 Chair’s message 8 Executive Director’s message 10 Monash Department of Clinical Epidemiology at Cabrini Hospital 14 Cabrini Monash University Department of Medical Oncology The Szalmuk Family Department of Medical Oncology 22 Cabrini Monash University Department of Medicine 26 Cabrini Centre for Nursing Education and Research 28 Cabrini Monash University Department of Surgery The Fröhlich West Chair of Surgery 30 Clinical education at Cabrini 34 Szalmuk Family Psycho-oncology Unit 38 Allied Health Research and Education 40 Foundation 49: Men’s Health 44 Department staff 50 Supporting ethical research 58 Publications 68 Governance – Cabrini Institute Council 73 Supporters

C H A I R â&#x20AC;&#x2122; S M E S S AG E

t is a pleasure to introduce the Cabrini Institute Annual Report 2014-15, which highlights both the scope and the achievements in education, research and health promotion across Cabrini. This report also includes the publications of our outstanding researchers and projects approved by the Cabrini Human Research Ethics Committee. I would like to acknowledge the contributions of the volunteers who serve on this committee under leadership of Chair Dr Margaret Staples.

2002, Peter worked unstintingly as Executive Director of

With the reorganisation of the Cabrini Institute, Jennifer

the Cabrini Institute, as well as continuing his practice as

Burden moved from her former role as Manager of the

a senior consultant rheumatologist. He has ably guided

Cabrini Institute to the position of Manager, Cabrini

the expansion of the Cabrini Institute establishing several

Human Research Ethics Committee and Research

new research and teaching departments within it. He also

Governance. Jennifer has worked with the Cabrini

advocated for the Cabrini Institute in the community and

Institute for a decade; her commitment and support of

Professor Lawry St Ledger retired as Chair of the Cabrini Institute Council after a decade of service. His breadth of expertise in education, administration and health promotion have been of enormous benefit to the development and evolution of the Cabrini Institute.

It has been a great pleasure to welcome the new

supported the Cabrini Institute Council for a decade;

Executive Director, Associate Professor Leanne Boyd, who

she has departed the Council in light of her new role as

has skilfully led the Cabrini Centre for Nursing Education

Executive Director of Commercial and Business Systems

and Research since July 2014. She also has executive

and Deputy Chief Executive.

responsibility for nursing at Cabrini Health. Associate

In 2014-15, Professor Gerald Farrell retired from the

As a result of a restructuring within Cabrini Health, Dr Peter Lowthian has moved to the position of Executive Director of Medical Services. Since his appointment in

Professor Boyd has already established several new and

Cabrini Institute Council, which he had served since 2007.

exciting initiatives, including a recent successful grant

His contributions, particularly in the area of academic

funding round.

nursing, have provided valuable assistance to us, as has

Above: Professor Peter Fuller, Chair of the Cabrini Institute Council

led external engagements including that with the Monash Partners Academic Health Science Centre.

the Cabrini Institute Council has been greatly valued. Judith Day, in her role as Chief Financial Officer and Chief Information Officer, served on and capably

“It is always a great privilege and pleasure to have the opportunity to interact with an outstanding group of committed researchers and educators”

Professor Robert Thomas AM, who also retired after eight years on the Cabrini Institute Council. Professor Thomas provided a broad perspective on academic surgery, as well as insights into the challenges in cancer service provision in Victoria, reflecting his role as the Chief Cancer Adviser to the Victorian Department of Health.

of the high quality researchers active within the member

In 2015, it was a great pleasure to welcome Professor Meg Morris to the Cabrini Institute Council. She is the Head of the School of Allied Health at La Trobe University. Professor Morris has a distinguished research and education career in academic physiotherapy and her appointment parallels the recent expansion of allied health research and education in the Cabrini Institute.

has recognised Cabrini as an accredited clinical trial

I would like to congratulate Professor Rachelle Buchbinder for her appointment as a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellow. She has been duly recognised as a key exemplar

practice in clinical oncology is associated with active

organisations in the successful application of the Monash Partners Academic Health Sciences Centre for recognition by the NHMRC as an advanced health research and translation centre. I wish to note that the USA Federal Drug Administration site. This is a substantial achievement, particularly in the private health setting, and reflects the very active clinical trials program that continues under the aegis of the Cabrini Monash University Department of Medical Oncology, The Salzmuk Family Department of Medical Oncology. There is compelling evidence that best

Cabrini patients with access to the latest advances in cancer therapeutics. As Chair of the Cabrini Institute Council, it is always a great privilege and pleasure to have the opportunity to interact with an outstanding group of committed researchers and educators who have continued to provide innovative approaches in a sector that has not always embraced the importance of research and education to the provision of outstanding health services. That the Cabrini Board of Directors both recognises and supports the importance of these activities makes the task of Chair fulfilling and worthwhile. I would like to mention that 2016 marks the twentieth anniversary of the Cabrini Institute and plans are well underway to celebrate this important milestone.

clinical trials programs. Also, the exciting new range of therapeutic agents becoming available, called ‘precision medicine’ makes trials an essential way of providing

Professor Peter Fuller Chair, Cabrini Institute Council

E X EC U T I V E D I R EC TO R ’ S M E S S AG E

he Cabrini Institute Annual Report 2014-15 highlights the collaborations, research projects, education and health promotion activities underway within Cabrini. Recently we have identified our Cabrini Institute research themes, which are as follows: strategically aligned clinical research; patient and family centred care; safety and quality; and Catholic healthcare. These themes align with the Cabrini Strategic Plan 2013-15 and highlight our commitment to excellence in patient and family care.

the six successful applications. Quality Improvement

and Dixie Ward, Cabrini oncology nurse – addressed

Grants of $15,000 were awarded to Camilla Radia-George

the topic ‘Incorporating interdisciplinary care in the

(Manager of Allied Health and Ambulatory Services) and

cancer patient’s journey’. The event began with a moving

Dr Michael Rose (consultant physician and geriatrician).

reflection from Sally Holmes about her experiences with

The successful recipients of $30,000 Research Project

cancer. The 2015 Peter Meese Oncology Travel Grant

Grants were Andrea Rindt (Nurse Director and Program

was awarded to Bronwyn Flanagan, breast care nurse at

Manager, Women and Children, Cabrini), Tash Brusco

Cabrini Brighton.

Cabrini Foundation grants

(consultant surgeon) and Dr Sue Burney (Head, Szalmuk

Cabrini is an inaugural member of the Monash Partners

Family Psycho-oncology Unit). Project outcomes will be

Academic Health Sciences Centre. Monash Partners was

presented at the 2016 Cabrini Research Day.

officially recognised in March 2015 by the National Health

In 2014-15, the Cabrini Foundation introduced the Cabrini Foundation Research Grant Program for a total of $150,000 with the support of the Cabrini Institute. The annual internal competitive grant round invited funding applications for quality improvement and research projects from all Cabrini staff. Eighteen high quality applications were received and a Grant Review Committee chaired by Sylvia Falzon (Chair of the Cabrini Foundation Board and a Director of the Cabrini Health Board) spent a considerable amount of time choosing

(Chief Physiotherapist and Manager of Allied Health and Ambulatory Services Education), Mr Stephen Bell

Monash Partners Collaboration

and Medical Research Council (NHMRC) as one of four Peter Meese Memorial Lecture

inaugural Advanced Health Research and Translation

The annual Peter Meese Memorial Lecture was held on

Centres in Australia, reflecting the collaboration’s

24 March 2015 at Cabrini Malvern. This was well attended

capability to improve health outcomes through high

and received. A panel of five – comprising Catherine Carr,

impact translational research. In an announcement

senior pastoral practitioner; Associate Professor Natasha

made by the Federal Minister for Health, the Hon

Michael, Director of Palliative Medicine; Tori Whitman,

Sussan Ley MP and the NHMRC, the Monash Partners

Chief Social Worker; Lisa Mahon, occupational therapist;

Academic Health Science Centre was recognised as an

Above: Associate Professor Leanne Boyd, Executive Director of the Cabrini Institute

“Monash Partners was recognised by the National Health and Medical Research Council as one of four Advanced Health Research and Translation Centres in Australia”

international leader in linking clinical practice, research translation and education.

FDA audit As mentioned by Professor Fuller, a major oncology

From Cabrini’s perspective, our partnership strengthens

trial undertaken at Cabrini was the subject of a USA

our collaborative opportunities with other Monash

Food and Drug Administration (FDA) audit this year.

Partners members such as Monash University, Monash

These are relatively rare in Australia and involve an

Health, Alfred Health, Epworth HealthCare, Baker IDI,

extensive investigation into all aspects of the clinical

Burnet Institute and the Hudson Institute.

trial. The outcome was extremely positive. Cabrini was commended for excellent preparedness, organisation

Cancer Trials Australia We are able to attract the best oncologists when we have a thriving research culture and can offer our

and transparency. Our university partnerships

patients access to treatments not otherwise available.

Our partnerships with major universities continue

The Cabrini Institute has recently partnered with

to evolve. We welcomed La Trobe University to the

Cancer Trials Australia (CTA) to ensure that we remain

Cabrini Institute through its association with our allied

competitive in the oncology research arena. CTA is a

health service. Our relationship with Monash University

clinical trial network, which is spread across multiple sites

continues to grow through our Monash Partners

and provides a comprehensive oncology clinical trials

relationship and our research department collaborations,

service that includes the conduct of single or multisite

as well as hosting undergraduate medical, nursing and

clinical trials, ethics submissions, research governance

allied health students. Cabrini also hosts undergraduate

and clinical development advisory services.

nursing students from Deakin and Australian Catholic

universities. In the past year, we welcomed our first group of medical students from the University of Notre Dame. Acknowledgements None of the excellent work that occurred over the past year would have been possible without the commitment, dedication and hard work of the Cabrini Institute staff, our Cabrini colleagues and our valued donors. During the past 12 months, our staff have worked hard to review, evaluate and develop our research and education programs and the underpinning infrastructure. We are most grateful to our wonderful Cabrini clinicians for their support of our undergraduate and postgraduate medical, nursing and allied health students. We thank all involved for their efforts and continued commitment to the mission and values of Cabrini.

Associate Professor Lee Boyd Executive Director, Nursing Executive Director, Cabrini Institute

Monash Department of Clinical Epidemiology at Cabrini Hospital

he Monash Department of Clinical Epidemiology at Cabrini Hospital focuses on performing high quality clinical research with an emphasis on answering clinically important questions that can be translated into better quality patient care and outcomes. During 2014-15, a major focus has been to set up the Australia and New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network, which has been formed to support the conduct of large-scale clinical trials designed to answer the most critical questions for common musculoskeletal conditions. By focusing on large evidence- and evidence-practice gaps, the goals are to enable better care and improved health and quality of life for people who have musculoskeletal conditions. Our first summit was held in April 2015, attended by 100 participants affiliated with 22 universities in Australia and New Zealand, various research institutes, hospitals, consumer organisations, professional societies, the National Health and Medical Research Council (NHMRC),

Above: Professor Rachelle Buchbinder

State Departments of Health (NSW and WA), Australian Commission on Safety and Quality in Health Care, Australian Clinical Trials Alliance and health insurers (Medibank Private). The summit produced an agreed vision, mission statement and set of values, as well as goals for the next 12 months. A report of summit proceedings is available online, refer www.anzmusc.org/ The final paper reporting the results from our vertebroplasty study has been accepted for publication in Archives of Osteoporosis. In this paper, the twoyear radiologic outcomes were examined. While no statistically significant between-group differences for new or progressed fracture risk at 12 and 24 months were observed between the vertebroplasty and placebo groups, we noted a consistent trend towards higher risk of any kind of fracture in the group undergoing vertebroplasty, however no firm conclusions for this outcome can be drawn. Dr Margaret Staples led the analysis and writing of the paper.

Dr Renea Johnston has the role of Managing Editor of the Cochrane Musculoskeletal Group within our department. Her role is to manage the editorial process of systematic reviews that are published within our group including liaising with potential and current authors and providing assistance to authors completing protocols, reviews and updates. A major review of vertebroplasty for osteoporotic vertebral fractures that included 11 trials was published this year. Based upon moderate quality evidence, we concluded that the evidence does not support a role for vertebroplasty for treating osteoporotic vertebral fractures in routine practice. Postdoctoral researcher Dr Susan Slade developed the Consensus for Exercise Reporting Template (CERT) planned as an addendum to the Consolidated Standards of Reporting Trials (CONSORT) Statement. This statement is an evidence-based, minimum set of recommendations for reporting randomised trials. It offers a standard way for authors to prepare reports of trial findings, facilitating

their complete and transparent reporting, and aiding their critical appraisal and interpretation. Dr Slade performed an international Delphi study involving exercise experts from 14 countries. The final template includes 16 items that should be reported in all clinical trials investigating exercise. This is expected to be an important advance, as currently exercise interventions in trials are poorly described. More complete descriptions will aid in the interpretation of trial results, enable comparison between trials and support uptake of proven effective programs in clinical practice. We continued to recruit participants for our NHMRCfunded, randomised, controlled trial in which we are comparing the effect of autologous platelet-rich plasma injection to glucocorticoid injection and placebo for lateral epicondylitis or tennis elbow (72 participants were recruited and 14 completed). Two new centres, one in Sydney and one in Adelaide, have joined and we hope to complete the trial by the end of 2016.

We are continuing the long-term observation of participants in the Australian Rheumatology Association Database (ARAD) to determine long-term outcomes of biologic therapy in people who have inflammatory arthritis. Several PhD students are now using the database for their projects and we are hoping to attract further honours students to take advantage of the rich data we have been collecting for more than ten years. The Cabrini Health Literacy Project overseen by Dr Allison Macpherson (nee Bourne) is underway with completion of the data collection phase. This involved distribution of a mail survey to more than 9000 patients who received inpatient care at Cabrini Malvern in 2014. The first 1000 responses formed the basis of Shehzaad Muhammad Peerbux’s Bachelor of Basic Medical Sciences degree, which he passed with distinction in December 2014. Also, he won the prize for best poster at 2014 Cabrini Research Day. More than 3000 responses have been received and the final analysis is being performed by Dr Margaret

Staples and colleagues at Deakin University. Our data will provide a detailed understanding of the health literacy profile of Cabrini patients and valuable insights into how we might enhance their care and health outcomes. Major projects • Is autologous platelet rich plasma injection effective for tennis elbow? • Understanding the health literacy of patients attending Cabrini Health • OPtimising Health LIterAcy (OPHELIA) Project • A standardised method for reporting exercise programs in clinical trials • The long-term outcomes of people with inflammatory arthritis in Australia (ARAD) • What is the content and quality of consumer information about arthroscopy in Australia? • The Australia and New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network

From left: Biostatistician Dr Margaret Staples works on a range of projects within the Cabrini Institute. She has a doctorate in epidemiology, which is the cornerstone of evidence based practice. Student Shehzaad Muhammed Peerbux (right) received the 2014 Cabrini Research Day Prize for Best Poster. He is pictured with Associate Professor Leanne Boyd (left).

M O N A S H D E PA R TM E N T O F C LI N I C A L E P I D E M I O LO G Y AT C A B R I N I H O S P I TA L

Grants 12

NHMRC Project Grant (2010-14) Project title: A randomised controlled trial to evaluate the efficacy of bisphosphonate therapy in patients with osteonecrosis of the hip Applicants: Sambrook P, Little D, March L, Buchbinder R. ARC Linkage Project Grant 120200111 (2013-15) Project title: Enhancing health literacy to optimise health equality across Victorian communities Applicants: Osborne R, Buchbinder R, Beauchamp A. Netherlands Organisation for Health Research and Development (2013-15) Project title: A patient and professional based multimedia campaign as innovative implementation strategy to improve low back pain guideline adherence: A cost-effectiveness evaluation Applicants: Anema JA, Boot CRL, Braspenning J, Buchbinder R, Elders P, Schaafsma FG, van Tulder MW, van der Wouden JC.

NHMRC Cochrane Funding (2013-15) Project title: Cochrane Musculoskeletal Review Group (CMSG), Australian satellite Applicants: Buchbinder R, Johnston R. NHMRC Project Grant 1062638 (2014-18) Project title: A multicentre, double blind, randomised, placebo-controlled trial of oral anticoagulation in systemic sclerosis-related pulmonary arterial hypertension Applicants: Nikpour M, Buchbinder R, Prior D, Nandurkar H, Williams T, Gabbay E, Proudman S, Nash P, Zochling J, Stevens W. Arthritis Australia Grant In Aid (2014) Project title: Standardised method for reporting exercise programs Applicants: Slade S, Buchbinder R, Underwood M. NHMRC Senior Principal Research Fellowship (2015-19) Project title: SPRF ID 1082138 (funding $911,915) Applicant: Buchbinder R.

NHMRC Centre of Research Excellence in Translation of Research (2015-19) Project title: Centre of Research Excellence in Translation of Research into Improved OUtcomes in Musculoskeletal Pain & Health (CRE TRIUMPH) ID 1079078 (funding $2.5m) Applicants: Bennell K, Hunter D, Hodges P, Buchbinder R, Pirotta M, Hinman R, Harris A, Foster N, Michie S, Vicenzino B. Patient-Centered Outcomes Research Institute (PCORI) Engagement Award (2015-17) Project title: Development of a core outcome measurement set for clinical trials in shoulder disorders (funding $US237,127) Applicants: Gagnier JJ, Buchbinder R.

Dr Allison Macpherson I M P ROV I N G H E A LT H LIT E R AC Y

n January 2013, Dr Allison Macpherson began her current role as a Research Fellow in the Monash Department of

Clinical Epidemiology at Cabrini Hospital. She was drawn to Cabrini by its reputation and that of Professor Rachelle Buchbinder, who leads the department. With a doctorate in biochemistry, Allison was previously a bench scientist based in a laboratory. “In this role, I get to talk to people, which is what I like most about it,” she says. Allison is currently overseeing the Cabrini Health Literacy Project, the first of its kind in the private health setting, and is interested in understanding how health literacy among Cabrini’s patients can be improved. She describes her work as challenging and enjoyable. “Health literacy is about how well someone is able to find and understand health information,” explains Allison. “It is important because a person’s level of health literacy influences their ability to manage their own health effectively and to navigate the healthcare system, which is becoming increasingly complex. People need to understand what they are doing and why, for example how to take their medications correctly.” On the other hand, lower levels of health literacy are associated with decline in health, more hospitalisations and higher rates of morbidity. A simple mail survey was used and a 30 per cent response rate achieved. With analysis of the data underway, the next step is preparation of a paper to be submitted to a peer-reviewed journal. The initial results indicate that Cabrini patients have a higher than average level of health literacy.

Cabrini Monash University Department of Medical Oncology The Szalmuk Family Department of Medical Oncology

his department established in 2003 aims to provide compassionate, state-of-the-art care for cancer patients and continued advancements in the prevention, diagnosis, treatment and cure of cancer via a combination of research, education and clinical practice. Research agenda During 2014-15, there has been significant reorganisation and expansion in our department. Cabrini has entered a partnership with Cancer Trials Australia (CTA), which will take over many of the administrative components of the clinical trials, including ethics submissions, research governance and budget negotiations. This will enable our staff to focus on our core business of entering patients into clinical trials. CTA has broad connections with cooperative research groups and pharmaceutical companies, which will provide the opportunity to significantly expand our clinical trial program.

Above: Associate Professor Gary Richardson

Studies with new cancer agents continue to dominate our cancer research program, although there has been a move into immunotherapy. Immunotherapies are treatments that restore or enhance the immune system’s ability to fight cancer. Studies have been completed in melanoma (skin cancer) and we are embarking on trials in lung cancer and other malignancies. We continue to have a large number of trials using targeted therapies, which block the growth and spread of cancer by interfering with specific molecules involved in the growth, progression and spread of cancer. They are a cornerstone of precision medicine, which uses information about a person’s genes and proteins to prevent, diagnose and treat disease. Research highlights Immunotherapy: Using the Immune System to Treat Cancer The immune system’s natural capacity to detect and destroy abnormal cells may prevent the development of

many cancers however, some cancers are able to avoid detection and destruction by the immune system. They may produce signals that reduce the immune system’s ability to detect and kill tumour cells or they may have changes that make it harder for the immune system to recognise and target them. Immunotherapies are treatments that restore or enhance the immune system’s ability to fight cancer. In recent years, the rapidly advancing field of cancer immunology has produced several new methods of treating cancer that increase the strength of the immune response against tumours. These therapies either stimulate the activities of specific components of the immune system or counteract signals produced by cancer cells that suppress immune responses. Research in this area is growing rapidly, and a number of different approaches are being considered to enhance the immune system’s ability to fight cancer. Agents that are currently being investigated at Cabrini include:

• Immune checkpoint inhibitors: One immunotherapy approach is to block the activity of certain proteins that limit the strength of immune responses. These proteins normally keep immune responses in check to prevent overly strong responses that might damage normal cells as well as abnormal cells. In cancer cells, these checkpoint proteins may be abnormal and may help tumours to evade the immune response. Blocking one of these checkpoint proteins could support the immune system in enabling it to destroy cancer cells. • Cancer vaccines: The use of cancer treatment (or therapeutic) vaccines is another approach to immunotherapy. These vaccines are usually made from a patient’s own tumour cells or from substances taken from tumour cells. They are designed to treat cancers by strengthening the body’s natural defences against the cancer. Treatment vaccines may act in various ways including delaying or stopping the growth of cancer cells, causing tumour shrinkage, preventing cancer

from recurring or to eliminating cancer cells that have not been killed by other forms of treatment. • Adoptive cell transfer: Cytotoxic T-cells that have invaded a patient’s tumour, called tumour-infiltrating lymphocytes (TIL), are harvested. The cells that have the greatest anti-tumour activity are selected and large populations of these cells are then grown in the laboratory and activated with cytokines. The cells are then infused into the patient. The idea is that TIL already have the ability to target tumour cells but may not be present in sufficient amounts to exert an anti-tumour effect. If the activity of the TIL is being suppressed by the tumour cells, it may be possible to overcome that suppression by exposing the tumour to large amounts of activated TIL. • Chimeric antigen receptor therapy (CAR): Patients’ T-cells are collected from their blood and genetically modified to express hybrid proteins called chimeric antigen receptors (CAR) before they are expanded

and infused into the patient. The CAR allows the cells to attach to specific proteins on the surface of cancer cells, which activates the T-cells to attack those cells. Cabrini is currently participating in research to: • Increase our understanding of what enables immunotherapy to work in some patients but not in others who have the same cancer • Expand the use of immunotherapy to more types of cancer • Better understand how to use immunotherapies in combination with targeted therapies and other standard treatments, such as chemotherapy and radiation therapy CheckMate-066 Trial – landmark study Associate Professor Ben Brady (Director of Medical Oncology and Haemotology at Cabrini) and colleagues recently published a phase 3 study comparing the anti–

From left: Dr Michelle White is an oncologist with Brightways: A Cabrini Breast Cancer Service and a Principal Investigator with the Cabrini Monash University Department of Medical Oncology. Dr David Pook, an oncologist at Cabrini, is an Associate Investigator with the department. Associate Professor Jeremy Shapiro is a Principal Investigator with the department: he is involved in teaching and clinical research and focuses on new treatment options for colon and prostate cancer.

C A B R I N I M O N A S H U N I V E R S I T Y D E PA R TM E N T O F M E D I C A L O N CO LO G Y T H E S Z A L M U K FA M I LY D E PA R TM E N T O F M E D I C A L O N CO LO G Y

programmed death 1 (PD-1) antibody nivolumab with the standard melanoma chemotherapy dacarbazine in the frontline treatment of patients who have advanced BRAF wild-type melanoma. In this study, nivolumab was shown to be better than dacarbazine in improving overall survival, progression-free survival and objective response rate. Nivolumab was also associated with a lower rate of high-grade side effects than dacarbazine. This study is the first to demonstrate that nivolumab, and any anti-PD-1 antibody, improves overall survival compared with a standard comparator in a large, well-conducted, randomised, placebo-controlled, phase 3 study. The high response rate and favourable toxicity profile of nivolumab and pembrolizumab (Keytruda), another anti– PD-1 antibody, in patients who have melanoma have been well known from large, previously published, early-phase studies. Yet how these anti–PD-1 antibodies perform in randomised studies against standard chemotherapy (dacarbazine or carboplatin/paclitaxel) has only recently

begun to emerge. Cabrini recruited the largest number of patients of any international centre. Immunology studies in non-small cell lung cancer Programmed cell death-1 (PD-1) is one of the pathways that inhibit tumour-specific T-cells. Inhibiting these T-cells reduces the body’s ability to fight cancer cells. Increased quantity of PD-1 has been demonstrated in lung cancer cells, thus protecting them from the body’s immune system. Being able to block this inhibition can allow the immune system to be freed to fight the cancer. Studies have shown that use of anti-PD-1 drugs in patients who have previously treated lung cancer can produce meaningful responses. Cabrini is embarking on an exciting research program in collaboration with Roche Australia using a new anti-PD-L1 antibody, MPDL3280A, in untreated, non-small cell lung cancer. Anti-PD-L1 antibodies act in a similar way to anti-PD-1 antibody in blocking the interaction between

the PD-1 receptor and its PD-L1 ligand, thus restoring the function of chronically exhausted tumour-specific T-cells and augment the T-cell response. Two studies will consider treatment of newly diagnosed patients with metastatic squamous cell NSCLC and metastatic nonsquamous NSCLC. A third study will consider prevention of recurrence of NSCLC in patients with high-risk disease after potentially curative surgery. New targeted therapies: PARP inhibitors Poly (ADP-ribose) polymerase (PARP) inhibitors are pharmacologic agents that inhibit the PARP enzymes within the cell. This class of agents represents an exciting potential therapy in patients who have defects in the HR repair pathway. In particular, PARP inhibitors are being developed for patients who have germline BRCA1 or BRCA2 mutations, although the spectrum of tumours that may be treated effectively by these agents may be larger.

From left: Associate Professor Lara Lipton is an Associate Investigator with the department. She has a particular interest in cancer genetics and consults at the Cabrini Family Cancer Clinic. Oncologist Dr Ben Brady is Chair of the Cabrini Medical Staff and Director of Haematology and Oncology. He is a Principal Investigator with the department.

Due to strong interest in PARP inhibitors as a class, some pharmaceutical companies have designed PARP inhibitors and have tested them in a number of clinical scenarios. Currently, olaparib, rucaparib, niraparib, velaparib and BMN673 have reached phase 3. Cabrini is participating in a worldwide access program for the first PARP-inhibitor (olaparib) to be approved by the USA Food and Drug Administration. Olaparib is a potent, orally administered PARP inhibitor tested in patients who have advanced ovarian cancer and known or suspected BRCA1 or BRCA2 mutations (about 15 to 20 per cent of ovarian cancer patients). It has excellent results among these patients. Current studies

Disease

Current trials (patient recruitment phase)

Non-recruiting trials (patients still followed)

Breast cancer

Colorectal cancer

Haemotology (cancer of the blood)

Lung cancer

Lymphoma

Multiple myeloma

Melanoma

Myelodysplastic syndrome

Pancreatic cancer

Prostate cancer

General

Total

Current drug trials There is a wide spectrum of specific disease trials currently being undertaken. These are mainly phase 2 and 3 studies.

From left: Associate Professor Ian Haines, an Associate Investigator with the department, is pictured in his oncology consulting rooms at Cabrini Malvern. Dr Kirsten Hebert is a haematologist and oncologist who practises at the Cabrini Haematology and Oncology Centre.

C A B R I N I M O N A S H U N I V E R S I T Y D E PA R TM E N T O F M E D I C A L O N CO LO G Y T H E S Z A L M U K FA M I LY D E PA R TM E N T O F M E D I C A L O N CO LO G Y

Details of studies 18

Abbreviation

Protocol number

Scientific title

Abbreviation

Protocol number

Scientific title

Cancer 2015

Ca2015 (08-05-12-11)

The Cancer 2015 Project proposes a major, Framingham-type, whole-of-system epidemiologic study that will enrol 10,000 cancer patients, drawn from all parts of Victoria, into a research program to develop, test and implement a new model of cancer diagnosis and treatment

ICECREAM

AG0112CR (03-22-10-12)

Randomised phase 2 study of cetuximab alone or in combination with irinotecan in patients who have metastatic CRC with either KRAS WT or G13D mutation

TEVA

TV1011-LC-303 (01-18-03-13)

The SUPER study is a prospective study of patients who have cancer of unknown primary to create a national information resource and improve the understanding of the molecular biology, clinical, quality of life and psychosocial characteristics

A multinational, randomised, open-label phase 3 study of custirsen (tv-1011/ogx-011) in combination with docetaxel versus docetaxel as a secondline treatment in patients who have advanced or metastatic stage 4) non-small cell lung cancer

SELECT-1

D1532C00079 (01-29-09-14)

A randomised, placebo-controlled, double-blind, phase 3 study to evaluate the safety and efficacy of the addition of veliparib plus carboplatin versus the addition of carboplatin to standard neoadjuvant chemotherapy versus standard neoadjuvant chemotherapy in subjects who have early stage, triple negative breast cancer

A phase 3, double-blind, randomised, placebocontrolled study to assess the efficacy and safety of selumetinib (AZD6244; ARRY-142886) (hyd-sulfate) in combination with docetaxel, in patients receiving second-line treatment for KRAS mutation-positive locally advanced or metastatic non-small cell lung cancer (stage 3B to 4)

SINE

KCP-330-013 (08-01-12-14)

A multicentre, phase 2, open-label study of efficacy and safety of the selective inhibitor of nuclear export (SINEâ&#x201E;˘) Selinexor (KPT-330) in patients who have relapsed or refractory peripheral T-cell lymphoma and cutaneous T-cell lymphoma

SUPER

ABBVIE

LORELEI

SUPER (06-16-06-14)

M14-011 (09-07-04-14)

GO28888/BIG-3-13/ SOLTI 1205/ABCSG 38 (05-27-10-14)

A phase 2, randomised, double-blind study of neoadjuvant letrozole plus gdc-0032 versus letrozole plus placebo in postmenopausal women who have ER-positive, HER2-negative, early stage breast cancer

Abbreviation

Protocol number

Scientific title

Abbreviation

Protocol number

Scientific title

Denosumab

20090482 (02-06-08-12)

A randomised, double-blind, multicentre study of denosumab compared with zoledronic acid (ZometaďŁ¨) in the treatment of bone disease in subjects who have newly diagnosed multiple myeloma

Prosper

MDV3100-14 (01-28-10-13)

A multinational, phase 3, randomised, double-blind, placebo-controlled, efficacy and safety study of enzalutamide in patients who have non-metastatic, castration-resistant prostate cancer

54767414MMY3003 (07-16-06-14)

Phase 3 study comparing daratumumab, lenalidomide and dexamethasone (DRd) versus lenalidomide and dexamethasone (Rd) in subjects who have relapsed or refractory multiple myeloma

CtDNA pancreatic

01-07-04-14

POLLUX

Circulating tumour DNA as a biomarker pancreatic cancer

LEAF

04-12-05-14

The lymphoma lifestyle, environment and family study

ACIS

56021927PCR3001 03-22-06-15

A phase 3, randomised, placebo-controlled, double-blind study of JNJ-56021927 in combination with abiraterone acetate and prednisone versus abiraterone acetate and prednisone in subjects who have chemotherapy-naive metastatic castrationresistant prostate cancer

Kalobios

KB004-01 (04-30-03-15)

A study of the anti-EphA3 monoclonal antibody KB004 in subjects who have EphA3expressing haematologic malignancies

MDS

AZA-MDS-003

A phase 3, multicentre, randomised, double-blind study to compare the efficacy and safety of oral azacitidine plus best supportive care versus placebo plus best supportive care in subjects who have red blood cell transfusion-dependent anaemia and thrombocytopenia due to IPSS lower-risk myelodysplastic syndromes

APACT

ABI-007-PANC-003 (03-21-07-14)

A phase 3, multicentre, open-label, randomised study of nabÂŽ-Paclitaxel plus gemcitabine versus gemcitabine alone as adjuvant therapy in subjects who have surgically resected pancreatic adenocarcinoma

C A B R I N I M O N A S H U N I V E R S I T Y D E PA R TM E N T O F M E D I C A L O N CO LO G Y T H E S Z A L M U K FA M I LY D E PA R TM E N T O F M E D I C A L O N CO LO G Y

Summary 20

A total of 17 trials are now closed to accrual and 13 new studies are to be initiated. Research grants and funding 1) Cancer Australia Grant – SUPER Study 2) VCA Grant – Cancer 2015 3) Cooperative Groups • Australasian Gastrointestinal Trials Group • Australasian Leukaemia and Lymphoma Trials Group • National Cancer Research Network (UK) 4) Pharmaceutical Industry • Allos Therapeutics • Amgen Inc • AstraZenica • Beigene • Bristol Myers Squibb • Celgene Corporation

• F. Hoffmann-La Roche Ltd • Gilead • Incyte • Janssen Asia-Pacific • Kalobios • Lilly • Medivation Inc • Novartis Oncology • Pfizer • Teva Pharmaceutical Industries Ltd 5) Ulm University (Germany) Partner organisations American Association for Cancer Research American Society of Clinical Oncology Australasian Gastro-Intestinal Trials Group Australasian Leukaemia and Lymphoma Study Group Australia and New Zealand Breast Cancer Trials Group Australia New Zealand Gynaecological Oncology Group Clinical Oncology Society of Australia

Clinical Trials Australia Gynaecology Oncology Group – USA Haematology Society of Australia International Association for the Study of Lung Cancer International Society of Gynaecologic Oncology Medical Oncology Group of Australia Monash Comprehensive Cancer Consortium Monash Partners Academic Health Sciences Centre Peter MacCallum Cancer Institute Private Cancer Physicians of Australia Southern Melbourne Integrated Cancer Service Thoracic Society of Australia Victorian Cooperative Oncology Group

Above: Dr Melita Kenealy is a haematologist and oncologist who practises at Cabrini. She is a Principal Investigator with the department and is involved with clinical trials and translational research.

Julia Carlson A I M I N G H I G H FO R PAT I E N T S

ulia Carlson is unequivocal about why she does her job as Team Leader, Oncology Research. “It’s the patients,

knowing you might be helping them when there are often no other options left,” says Julia. After completing a Bachelor of Science degree, Julia initially joined Cabrini as a pharmacy technician. After her aunt was diagnosed with colorectal cancer and joined a clinical trial, Julia became interested in clinical trial research. She applied for a Clinical Trial Study Coordinator role at the Cabrini Institute. Eight years later, Julia still loves her job in research. Julia is responsible for overseeing all aspects of clinical trial study coordination at Cabrini. She is quick to acknowledge that her role has both highs and lows. “It is very rewarding when you see a patient responding well to a new drug but just as saddening when they don’t respond as you would hope.” Things are never dull in the dynamic world of clinical research. “My job is exciting, as the environment is always changing with new drugs always coming on trial,” says Julia. Cabrini recently established a partnership with Clinical Trials Australia (CTA), which will take over many of the clinical trial administration tasks, allowing the study coordinators to focus on the patients and results from the trials. Julia’s goal for oncology research is an aspirational one. “I want Cabrini to become the biggest clinical trials research centre in Victoria, to be known for its excellence in conducting the best and newest trials,” she says. “I want to be a part of that.”

Cabrini Monash University Department of Medicine

stablished in 2006, the Cabrini Monash University Department of Medicine provides a focus for research

investigate whether there are distinctive characteristics of communicatively effective ward round interactions.

and education in medicine within Cabrini. Our emphasis is

Analysis of the data shows that the ward round

on research that can be translated into improvements in

communication is a stylised conversation with a particular

medical practice and models of care for our patients.

agreed format and rules of engagement. The thesis has

We are primarily interested in research as it relates

been completed by PhD student Alice Rouse.

to the care of older patients, our focus being particularly on end-of-life care, incorporating issues such as communication, quality of death, the role of

Long-term health outcomes in patients aged over 80 years after an intensive care admission

cardiopulmonary resuscitation and other treatments at

This prospective study examined health outcomes among

the end-of-life stage, understanding of language and

patients aged 80 and older including quality of life and

shared decision-making.

functional status up to two years after discharge from intensive care. The 24-month follow-up was completed in

Current projects Clinician patient discourse â&#x20AC;&#x201C; a multimodal investigation

October 2014 and showed that quality of life is maintained after patientsâ&#x20AC;&#x2122; admission to intensive care. We explored

Delirium is a widely encountered problem in the hospital setting and of particular concern in intensive care. Up to half of patients admitted to intensive care develop delirium while in hospital. We have examined the incidence of delirium following intensive care admission among patients aged 80 years and older and found that up to 30 per cent of them met the criteria for delirium. We also found that patients diagnosed with delirium had a longer stay in intensive care and longer hospital admissions. These results highlight the importance of accurate diagnosis and sufficient training for staff to enable them to recognise the early symptoms of delirium in older patients.

motivations, satisfaction with outcomes and factors

Staphylococcus Aureus Bacteraemia and ECG findings

affecting medical decision-making in a focus group of

This project was undertaken by Mark Lym, recipient of the inaugural summer research scholarship (2014). This was a collaborative project with researchers at Royal Melbourne

This qualitative study aims to describe how the work of

patients (80 years and older) who had undergone cardiac

the ward round is carried out communicatively and to

surgery (Oldroyd et al, 2013).

Above: Associate Professor Michele Levinson

Diagnosing delirium in older ICU patients

Hospital. The aim was to assess whether the use of

have also written on the default response to in-hospital

echocardiography in staphylococcus aureus bacteraemia

cardiac arrest, which is to attempt resuscitation except

(SAB) differed in private and public hospitals. Our results

in the presence of a do-not-resuscitate order. We argue

showed that the private hospital population with SAB

that resuscitation status for all elderly patients should be

was older with a similar risk factor profile for infective

discussed and decided at the time of admission to hospital

endocarditis. The use of echocardiography was different

(Levinson and Mills, 2014). This article prompted a debate

between the two sites. This is being further analysed.

on the Medical Journal of Australia website.

End-of-life care projects

We also conducted a multicentre point prevalence

Our work on end-of-life care is addressed in a number of different ways. We have written on attitudes towards

study to investigate the number of advance care plans and not-for-resuscitation orders across five Victorian

dying and how the concept of death has been viewed in

health services. Completion of this study revealed each

changing ways over the course of history. The continued

site had its own set of forms and policies with respect

thrust for treatment at end of life may prolong suffering

to resuscitation status, which combine to contribute

and obviate the opportunity for a peaceful and dignified

to barriers to the writing of do-not-resuscitate orders

death. Tackling changes in our perceptions can help

(Levinson et al, 2014). This article has generated

medical professionals provide patients and families with

much interest, including a letter to the editor in the

sensitive, timely guidance to help them through the end-

International Medical Journal IMJ in response. The issue

of-life process (Gellie et al, 2014 and Mills et al, 2014). We

was also covered by the Melbourne Age newspaper

following an interview with Associate Professor Michele Levinson (published 19 May 2014). A 12-month retrospective review of medical emergency team (MET) call data in 2012 illustrated the role of the MET in end-of-life care, especially with respect to writing limitations of treatment orders. This review is being extended by inclusion of more recent data. We have investigated the use and understanding of language around concepts of resuscitation. A pilot study of visitors to the Terrace CafĂŠ at Cabrini Malvern and subsequently, a group of elderly patients who were admitted to hospital were surveyed to assess understanding of terminology related to resuscitation orders. This study showed that despite familiarity, understanding of the term â&#x20AC;&#x2DC;do not resuscitateâ&#x20AC;&#x2122; was poor, which has implications for shared decision-making and conversations between doctors and their elderly patients. The next step in the project is to survey elderly people living in the community.

From left: Mark Lym, a fourth-year medical student, received the Inaugural Summer Scholarship in 2014. Chief Executive Dr Michael Walsh (second from left) and Associate Professor Lee Boyd (far right) are pictured with students of the University of Notre Dame Australia. Alice Rouse is a higher degree research student with the Cabrini Monash University Department of Medicine.

CABRINI MONASH UNIVERSIT Y D E PA R TM E N T O F M E D I C I N E

We have begun surveys of medical staff about their 24

attitudes towards, and understanding of, do-notresuscitate orders. In January 2015, we surveyed doctors at Cabrini using the online doctors’ portal on the Cabrini website. The survey revealed that a number of factors are involved in the writing of these orders, including patient and family wishes and perceived legal issues, as well as consideration of goals of care. Plans are underway to survey nursing staff and to include other hospital sites in these surveys. Awards Dr Amber Mills won Best Oral Presentation at Cabrini Research Day 2014 for her address entitled ‘Quality of life outcomes in the very elderly six and 12 months postICU admission’. She presented follow-up data from the ‘Long term health outcomes in patients over 80 years discharged from Intensive Care’ study. Preliminary results showed that the good quality of life and functional status

experienced by these patients prior to hospital admission do not deteriorate post-ICU admission. Leadership positions and appointments Associate Professor Levinson continued the following leadership positions, appointments and commitments during 2014-15: • Member of Specialist Advisory Committee for Acute and General Medicine • Co-Chair Royal Australasian College of PhysiciansCollege of Intensive Care Medicine Working Group on Joint Training (2014) • Site visit for trainee/site in trouble • Overseas Trained Physicians’ interviews for Royal Australasian College of Physicians • Examiner for Fellow of the Royal Australasian College of Physician clinical examination • Represented Specialist Advisory Committee at the Advanced Training Forum 2014

From left: The medical emergency team in action at Cabrini Malvern. Medical students perform a mock resuscitation exercise under the supervision of Associate Professor Michele Levinson.

Dr Mills continued her role as a Board Member of the Australian Patients Association, which is an independent, not-for-profit organisation dedicated to championing and protecting the rights and interests of all patients. Future projects Planning is underway for projects that will evaluate factors that contribute to the experience of patients and families when there is a death in hospital. Also, we are planning a multidisciplinary project (involving clinicians, ethicists, linguists and legal experts) to interview doctors, nurses and members of the community about issues relating to the implementation of advance care plans and do-notresuscitate orders. Our work has been accepted for a number of upcoming conferences, including a presentation at the Australasian Association of Gerontology Annual Conference. Two posters were accepted for the bi-annual International Advance Care Planning and End of Life Care Conference.

Dr Amber Mills TOWA R D S A G O O D D E AT H

t is often said that the only certainties in life are death and taxes. Yet in Australian society, many of us would be

more comfortable discussing money than death. Although death is inevitable, much of the language related to death and dying characterises death as a foe and dying as something to fight. Research Fellow Dr Amber Mills has spent much time thinking about death and dying during the past year, as she and her colleagues (including Associate Professor Michele Levinson who leads the department) have worked on multiple research projects focused on end-of-life care. Amber, who joined Cabrini in June 2012, finds this work fascinating and personally resonant. “I have always taken a strong interest in the lifespan – how we change, grow and evolve over time,” she said. “The more work we do in researching end-of-life care, the more questions we have.” End-of-life care is a complex area of research spanning shared decision-making, person-centred care and the quality of the patient experience. “It involves factors such as the capacity to make decisions, the use of language and meaning, patients’ expectations and the role of healthcare professionals,” said Amber. Amber would like to see more honest public discourse about death and dying – particularly about what community members want and how they would like the healthcare system to respond. She encourages patients to focus on the goals of care in all their healthcare interactions. “You should expect to be asked about what you want anytime you see a doctor or attend hospital.”

Cabrini Centre for Nursing Education and Research

ursing research at Cabrini is focused on the Cabrini Institute research themes: patient and family centred care, safety and quality and Catholic healthcare. We aim to continually improve and evaluate the safety and quality of our services, provide evidence for nurses to inform their clinical practice and assist our patients and their families in making informed healthcare decisions. The Cabrini Centre for Nursing Education and Research has been established at Cabrini, in order to help us achieve our goals. Progress in 2014-15 A research agenda has been established which is based on the Cabrini Strategic Plan 2013-15 and aligns with the National Safety and Quality Health Service Standards evaluation requirements. There have been two major research highlights in 2014-15: 1) Completion of the Victorian Department of Health project to develop education resources for the

National Safety and Quality Health Service Standards for public and private hospitals across Victoria 2) Commencement of a grant with the Federal Department of Health to develop an online education resource for cultural and religious elements of advance care planning High quality supervision of higher degree research students remains a priority for the Centre for Nursing Education and Research. We congratulate Dr Grainne Lowe who graduated in May 2015. In her thesis, Dr Lowe investigated the role of nurse practitioners in Australia. A Research Associate, Amanda Pereira-Salgado, who was appointed to support the Director, Associate Professor Leanne Boyd, began work at the Cabrini Institute in July 2014. Two Research Assistants have been appointed to work on funded grants.

• Research partnerships with universities and other stakeholders • Research expertise within the Cabrini workforce in leadership, patient centred care and quality and safety • Research secondments where Cabrini nurses who have an interest in research work on a project while working part-time clinically. The aim is to enhance the individuals’ research skills and embed them within the practice setting. This will increase our local research capacity and support the development of a culture of enquiry in our workforce Grants The following grant was awarded in 2014-15:

We are continuing to work towards establishment of:

Australian Government Department of Health $570,000 (2015-17) Project title: Developing online resource for religious and cultural advance care planning.

• A student support hub for nursing staff

Applicants: Boyd L, Pereira-Salgado A and Walker, H.

From left: Associate Professor Leanne Boyd Research Associate Amanda Pereira-Salgado was a member of the grant-winning team that is working on a new resource for religious and cultural advance care planning. Jovie Ann Decoyna, a nurse at Cabrini Malvern, is working toward a Master degree: she is pictured volunteering in Rwanda.

Jasmine Kopcewicz PA S S I O N FO R M E D I C A L R E S E A RC H

aving undergone a significant reorganisation since December 2014, several staff within the Cabrini Institute

have been appointed to new roles within it and some new people from other parts of the organisation have also joined. In June 2015, Jasmine Kopcewicz began work with the Cabrini Institute in the position of Research Administration Assistant. Hers is a frontline role, being first point of contact at the reception desk. She provides valuable support to Dr Emma Baker, Manager of Research Programs, and many other research staff. Previously employed in a nursing pre-admission role at Cabrini Malvern for more than six years, Jasmine brings extensive experience in medical practice administration and customer service to her new job. Jasmine says she was drawn to the Cabrini Institute because of an interest in medical research, the need for a new challenge and the desire to continue working at Cabrini. “I wanted to extend my experience in the medical field,” she said. “I’ve been interested in medical research ever since my Dad was diagnosed with cancer and was involved in a clinical trial as part of his treatment. I really enjoy working for Cabrini as an organisation and I am excited by this new challenge.” Jasmine has had a busy start at the Cabrini Institute. Key projects in her first three months have been assisting Emma in planning, organising and promoting Cabrini Research Day internally and externally and preparations for an FDA audit of a clinical trial conducted at Cabrini.

Cabrini Monash University Department of Surgery The Fröhlich West Chair of Surgery

stablished in 1998, the Chair of Surgery at Cabrini Hospital is a joint venture between the Cabrini Institute and Monash University. It was the first of its kind in the Victorian private medical sector and one of the first in Australia. The chair was endowed as the Fröhlich West Chair of Surgery in 2004. During 2014-15, the Cabrini Monash University Department of Surgery continued to expand its role in clinical research and quality assurance leadership at Cabrini and in the Australian medical community. Community engagement Through our collaboration with Let’s Beat Bowel Cancer, the Cabrini Monash University Department of Surgery continued a number of significant initiatives designed to improve the health of the Australian community, particularly in relation to bowel cancer.

Above: Associate Professor Paul McMurrick

Crawf’s Health Channel

Public presentations

Former AFL player and Brownlow medallist, Shane Crawford, through his ‘Crawf’s Health Channel’ produced two audiovisual presentations that were distributed to the Australian community, designed to increase awareness of bowel cancer and the National Bowel Cancer Screening Program. In these recordings, Associate Professor Paul McMurrick was interviewed by compere Shane Crawford.

Members of the Cabrini Monash University Department of Surgery gave several public presentations over the past year, including one at the Brighton Blue initiative of the Brighton Grammar School community.

Victorian Department of Health National Bowel Cancer Screening Program, GP Education Series Associate Professor McMurrick and the Cabrini Monash University Department of Surgery were commissioned by the Victorian Department of Health to create a series of audiovisual presentations designed to increase public uptake of bowel cancer screening through education of general practitioners. Associate Professor McMurrick was joined by broadcaster Dr Norman Swan and GP Dr Julia Sher in creating the series.

AL Polglase Visiting Professor Program The Visiting Professor Program continued in 2014 with the visit of Dr George Chang from MD Anderson (Texas, USA). He engaged in various educational initiatives during his time at Cabrini including an instructive operating theatre session and, a public lecture, as well as educational activities with a senior trainee and with Cabrini’s colorectal surgeons. The visit culminated in a dinner meeting and presentation by Dr Chang to Victorian members of the Colorectal Surgical Society of Australia and New Zealand (CSSAZ).

Professional representation Members of the department continued their important work as clinical representatives of professional bodies including: • Joint Council of Monash Partners Comprehensive Cancer Consortium: Associate Professor McMurrick • Executive Council, Victorian Clinical Oncology Group: Associate Professor McMurrick • Member of the Training Board in Colon and Rectal Surgery: Mr Stephen Bell • Cabrini Director of Surgical Training, Mr Martin Chin • Members of the Victorian Advisory Panel for the National Bowel Cancer Screening Program: Mr Stephen Bell and Associate Professor McMurrick • Member of Executive Council, CSSANZ and International Society of Digestive Surgery: Associate Professor McMurrick Leadership of the Monash Partners Comprehensive Cancer Consortium Colorectal Tumour Stream Research

Group has been maintained through the department, which also led the Victorian Cancer Agency grant application. Educational activities

stemming from the updated database. Cabrini continues to lead the extended dataset and has now passed highly detailed data entry on more than 2000 cancer treatment episodes.

In 2014-15, we continued our training posts with accredited registrars from the Royal Australasian College of Surgeons SET 1. The colorectal fellowship program continued with the appointment of Dr Raymond Yap with the annual visit to the Mayo Clinic Colorectal Surgical Service. Dr Yap was appointed to accredited training in the CSSANZ program in 2015.

Grants

Leadership in clinical research

Cabrini Foundation ($30,000) Project title: ADIPOSe – Australasian Decrease in Intra-Pelvic Obesity for Surgery trial: using VLEDs to reduce weight and improve outcomes in obese patients undertaking laparoscopic rectal cancer surgery Applicants: Bell S, Downey W, Druce J, McMurrick P and Warrier S.

The Bi-national Colorectal Cancer Audit of the CSSANZ, derived from the Cabrini colorectal neoplasia database, continued in 2014-15. It now includes data from more than 10,000 colorectal cancer treatment episodes across Australia and New Zealand, with signup from more than 70 centres. This culminated in the inaugural annual report,

Colorectal Surgical Society of Australia and New Zealand ($11,420) Project title: The effect of very low energy diets (VLED) on the preoperative reduction of mesorectal fat volume on obese individuals Applicants: Bell S and Warrier S.

From left: Visiting Professor Dr George Chang (second from left) pictured with colorectal surgeons (from left): Mr Peter Carne, Emertius Professor Adrian Polglase and Associate Professor Paul McMurrick. GP Dr Julia Sher worked with Associate Professor Paul McMurrick and Dr Norman Swan to film an educational resource aimed at GPs and designed to increase bowel cancer screening. Filming underway in the Stewardson Charitable Trusts Simulation Centre at the Cabrini Institute.

Clinical education at Cabrini

abrini is a strong supporter of education in healthcare. Cabrini is a teaching hospital and in

fulfilling this role, we participate in undergraduate and postgraduate education in allied health, medicine and nursing. The clinical education team supports the development and delivery of nursing education programs and other programs that support the continued accreditation of Cabrini. Medical education During 2014-15, Cabrini educated 29 specialist trainees across multiple specialties including colorectal surgery, emergency medicine, gastroenterology, general medicine, geriatric medicine, haematology, intensive care medicine, medical administration, medical oncology, neurology, palliative medicine, pathology and uppergastrointestinal surgery. The specialist consultants at Cabrini who supervise the trainees and offer valuable learning opportunities are commended for their

generous contributions to this program. At the time of their exit interviews, most trainees commented that they were surprised by the opportunities offered at Cabrini. Cabrini is a larger healthcare service with a wider diversity of patients and learning opportunities than trainees generally expect when they arrive.

Their learning experience involves four weeks of

Cabrini’s medical education program requires extensive logistical support and liaison with partner healthcare services: Alfred Health, Eastern Health, Monash Health, Peter MacCallum Cancer Centre and Austin Health, as well as the relevant specialist colleges, the Federal Department of Health and all the trainees involved. Training continues throughout the year – generally two incumbents during the course of a year (six monthly rotations) – but this regime varies from specialty to specialty. The specialist trainees provide teaching to the undergraduate medical education program.

and help prepare another 50 or more new Australian

During 2014-15, the first medical students from the University of Notre Dame Australia arrived at Cabrini.

As well as providing medical training for Australia’s future

work in one of the following rotations: obstetrics and gynaecology; cardiology; palliative care or neurooncology, orthopaedics or rehabilitation. The new relationship with the University of Notre Dame Australia is expected to enrich Cabrini’s clinical education program doctors each year. With clinical placements for medical students often hard to find in Australia, Cabrini is accepting four students at a time. This initiative will not impinge on our longstanding relationship with Monash University, as these new students will work in different areas and be taught by different teachers. Now, in their fourth and final year, Cabrini is providing valuable, clinicalbased learning in particular specialties. Diverse education program

doctors, Cabrini provides clinical training for other

preceptors and clinical teachers. Leading up to Cabrini’s accreditation survey against the national safety and quality health service (NSQHS) standards in August 2015, we introduced a series of interactive case studies focusing on clinical knowledge, skills and behaviours that are critical to providing safe and effective patient care. disciplines such as nursing and allied health. Providing education to more than 4000 clinical staff across a diverse

Innovation

range of clinical areas and multiple locations requires

In 2014-15, we supported the introduction of new basic life support and advanced life support programs. They are the first of their kind in Australia and provide staff with anytime access to training and skills designed to maintain their knowledge and skills. These programs are the culmination of research that identified gaps in performance and tested solutions, resulting in implementation of an organisation-wide program to improve patient safety. In 2015-16, this process will be extended to areas such as recognition and response to clinical deterioration (NSQHS standard 9) and medication safety (NSQHS standard 4).

the education department to use a range of delivery platforms. High-level clinical skills development and team training occur regularly in the Stewardson Charitable Trusts Simulation Centre located in Cabrini’s Patricia Peck Education and Research Precinct at 154 Wattletree Road, Malvern. For other courses, we make use of online learning portals. In 2015, we have a number of new clinical courses aligned to workforce planning. For example, we introduced a new course to improve the ability of clinical staff to act as

From left: Librarian Di Horrigan is pictured in the Lee & Brian Johnstone Library, an integral part of education and research at Cabrini. Matt Johnson is Director of Education at Cabrini.

Grants 31

A grant for $26,000 was awarded to Research Associate Amanda Pereira-Salgado from Deakin University for her project on strategies for increasing capacity for undergraduate nursing placements. Reorganisation of clinical education In August 2014, Cabrini’s clinical education department was reorganised. We revised the traditional delivery model for education whereby nurse educators were previously allocated to specific ward areas and were available only during day shifts on weekdays. Our new approach ensures that clinical and education expertise are available to all staff regardless of their location or hours of work. The change provided an opportunity to address issues of duplication and inconsistencies between the education received and recorded at different Cabrini locations. Our new model has required a significant change in the way education is developed and

C LI N I C A L E D U C AT I O N AT C A B R I N I

delivered, with a shift to online resources for knowledge development, the use of interactive case studies to challenge clinical decision-making and more rigorous assessments to ensure performance. The use of innovative technologies has allowed the clinical education department to reach, improve and support nursing staff who have not previously had access to Cabrini-based clinical education. This will also help the department to support the increasing number of allied health and medical staff entering the Cabrini workforce. Change in Cabrini Institute’s infrastructure In December 2014, we began a review of the structure of the Cabrini Institute and consulted our staff throughout the process. At this time, 66 staff were employed across 34 equivalent full-time positions. Within the Cabrini Institute, there are various models of employment and models of funding, providing flexibility for the people who work with us. This enables clinicians to spend some time

in research and/or educative roles and enables academics to have appointments with universities and with Cabrini. As with most research organisations, the greatest concern among staff was tenure and limited financial security due to the nature of grant funding. To address this, we restructured within the Cabrini Institute to ensure that we have skillsets that allow us to remain knowledgeable in funding opportunities and acquisitions, to promote those opportunities and to support researchers in applying for funding. New appointments include the following: • Dr Emma Baker – appointed to the position of Manager Research Programs, bringing experience and skills in funding acquisition and research promotion. For more than ten years, she worked in grant-funded medical research laboratories. • Jasmine Kopcewicz – appointed to the position of Administration Assistant Research • Michele Tonkin – appointed to the position of Scholarships, Grants and Communications Administration

Restructuring of the Cabrini Institute was undertaken with consideration given to succession planning, professional development and access to management for decisionmaking. A major realignment occurred in oncology research. The context of this change is that: • The world of international clinical trials has become increasingly competitive • Cabrini wants to be able to offer clinical trials to patients • We believe that patient care is enhanced through an active research program In order to improve opportunities for our patients to participate in oncology research trials, Cabrini will collaborate more closely with Clinical Trials Australia. This relationship will provide additional infrastructure to attract trials to Cabrini and to facilitate their start-up to recruitment stage.

From left: Anne Spence is Manager of Institute Infrastructure at Cabrini. ‘Patient’ Steve and his wife consult with medical student Thomas Ponsonby for the purpose of a new online resource designed to support clinical education.

Michele Tonkin N O S TO N E U N T U R N E D

he research environment in Australia is a competitive one and every dollar counts. Success in research requires being

aware of every funding opportunity available to researchers and having an effective grant support system in place. In recognition of these imperatives, recently the Cabrini Institute created the role of Scholarships, Grants and Communications Administration. The aim is to create the most supportive research environment possible, in order to support Cabrini’s valued research teams. In the middle of 33 2015, the Cabrini Institute welcomed Michele Tonkin to this new, part-time role. Michele brings experience in marketing communication and customer service to the Cabrini Institute, having previously worked in marketing roles in the hotel and premium golf industries. Most recently, Michele worked as a unit receptionist at Cabrini Malvern. She says she was enticed by the new role at the Cabrini Institute because it encompasses a new scope of work that that she expects will support her in her professional development. Another drawcard is that the job “provided an opportunity to work with the highly talented researchers, educators and senior staff at Cabrini Institute”. Michele’s role includes identifying funding opportunities for researchers, managing Cabrini’s internal scholarship and grant opportunities, supporting external grant applications and communicating all relevant opportunities to the research teams. “I feel that I am contributing to an important aspect of healthcare by supporting those seeking funding to carry out research programs.”

Szalmuk Family Psycho-oncology Unit

he Cabrini Monash Psycho-oncology group (now known as the Szalmuk Family Psycho-oncology Unit) was established in 2008. We strive to achieve real clinical research outcomes that can make a difference to people’s lives. We work to conduct best practice, evidence-based research, clinical interventions and education with respect and understanding. In the Szalmuk Family Psycho-oncology Unit, our research interests range from cancer screening in the general population, treatment decision making, psychosocial factors that influence adjustment to cancer, unmet needs of cancer patients and their families, psychosocial interventions for people affected by cancer and psychosocial factors in palliative care settings. In 2015, we changed our name from Cabrini Monash Psycho-oncology to the Szalmuk Family Psycho-oncology Unit to reflect our gratitude to our benefactors, the Szalmuk family of Melbourne.

Above: Dr Sue Burney

Highlights of our work in 2014-15 include: • Completion of eight research projects • Completion of postgraduate research theses by seven students • Publication of ten peer-reviewed journal articles • Presentations at 13 conferences nationally and internationally • Further six presentations to consumer, academic and clinical peer audiences • Receipt of two grants • Completion of clinical placements by six postgraduate psychology students • Delivery of 24 psycho-education sessions to cancer patients and their families • Continuation of our weekly drop-in mindfulness sessions held at our Brighton, Malvern and Prahran hospitals

In 2014-15, Dr Burney completed a policy paper on assessing and managing complicated grief in both the Cabrini Palliative Care inpatient and homecare settings. We redeveloped our content on the Cabrini website to include an online application form for students seeking placements and a general invitation for psycho-oncology researchers to collaborate in our research projects. Research grants National Health and Medical Research Council Project Grant 2015 ($749,704) Project title: ASTROID: Active Surveillance and other Treatment Options for prostate cancer. A randomised controlled trial of decision aid and DVD information support for men diagnosed with low-risk prostate cancer and their partners. Applicants: Chief Investigator: Associate Professor Penelope Schofield and Associate Investigator Dr Jo Brooker

Cabrini Institute Grant 2015 ($30,000) Project title: A pilot study of the mindful self-compassion program for cancer patients Applicants: Chief Investigator Dr Sue Burney and Associate Investigators: Dr Yoland Antill, Dr Jo Brooker, Jane Fletcher, Professor Mark Frydenberg, Associate Professor Ian Haines, Associate Professor Jeremy Millar, Professor Miles Prince, Associate Professor Gary Richardson and Associate Professor Jeremy Shapiro Education and teaching All postgraduate psychology students on placement (who are registered with AHPRA as provisional psychologists) have undertaken a two-day per week placement of durations varying from 44 days to 88 days. It estimated that in 2014-15, these students contributed 308 volunteer days of clinical psychological services and research support to Cabrini. The students have contributed to Cabrini by providing counselling to patients and family

members; developing, facilitating and evaluating our psycho-education and mindfulness sessions, as well as supporting research activities. Dr Brooker provided training in mindfulness practice and in facilitating mindfulness sessions to students on placement at Cabrini and to pastoral services staff. She also convened a facilitators’ group enabling students, staff and colleagues to obtain feedback about their mindfulness facilitation skills in a supportive, collegial environment. In 2014-15, six students completed placements at Cabrini as follows: • Rebecca Carlson, Postgraduate Diploma of Psychology, Deakin University • Dr Brindha Pillay, Doctor of Psychology (Clinical), Monash University • Dr Lyndel Shand, Doctor of Psychology (Health), Deakin University

Above: Jane Fletcher is a practising psycho-oncologist, researcher and educator.

• Gemma Stephenson, Bachelor of Psychology (Honours), University of New England • Dr Adriana Ventura, Doctor of Psychology (Health), Deakin University • Eva Yuen, PhD, Deakin University Six students were on placement at the time of writing: • Shey Cooper, Postgraduate Diploma of Psychology, Deakin University • Parris Davenport, Postgraduate Diploma of Psychology, Deakin University • Jane Hayman, PhD, Monash University • Melissa Maas, Doctor of Psychology (Health), Deakin University • Sophie Robinson, Doctor of Psychology (Clinical), Monash University • Gemma Stephenson, Master of Clinical Psychology, Victoria University

S Z A L M U K FA M I LY P S YC H O - O N CO LO G Y U N I T

Clinical and therapeutic services

Psycho-education groups

Dr Burney was employed as the first psychologist at Cabrini Palliative Care in Prahran from April 2012 until September 2014. During this period, she established and documented the: role of psychology in the palliative care multidisciplinary team and policy and procedures for the introduction of family focused therapy for all community palliative care patients and their families. Dr Burney also developed assessment and detection of complicated grief reactions in the bereaved. She served as a member of the hospital’s Patient and Family Experience Committee and worked on developing a response to the National Standards Assessment Program Guidelines with this group.

In 2014-15, our two-hour psycho-education sessions for cancer patients and their families held at our Brighton and Malvern hospitals have been offered on average every two weeks. These sessions are free for people to attend. Topics included sleep, pain management, fatigue management, coping with stress and worry, mindfulness and support for carers. Together with our staff, our postgraduate psychology placement students prepared, facilitated and evaluated these sessions.

Jane Fletcher operates a private psycho-oncology practice at our Brighton and Malvern hospitals. Her experience and knowledge in this practice has enriched the education and practice of our clinical placement students.

Drop-in mindfulness meditation sessions This successful program has been held over the past few years and is a collaboration with Cabrini’s pastoral services team. The sessions are directed to Cabrini patients, family members, visitors, and staff who wish to learn about mindfulness meditation or develop their practice. The sessions are each half an hour long and are held weekly at our Brighton, Malvern and Prahran hospitals. To facilitate

Above: Dr Jo Brooker is a Research Fellow within the Szalmuk Family Psycho-oncology Unit.

these sessions, our psychology placement students join a roster with Dr Brooker and pastoral services staff. Engagement in the professional community • Dr Burney is a member of the Australian Psychological Society College of Health Psychologists (Victoria) Committee • Dr Brooker commenced her second term as a member of the Cabrini Human Research Ethics Committee

• Dr Brooker and Ms Fletcher are founding committee members of the Mental Health Professionals Network, Psycho-oncology Interest Group and as part of their roles, they hosted a range of professional development seminars at the Cancer Council Victoria • Dr Brooker, Dr Burney and Ms Fletcher are members of the national Psycho-Oncology Co-operative Research Group (PoCoG), based at the University of Sydney, and the Cancer Council Victoria’s Clinical Network Current research projects Presently the following research projects are underway: • Meaning and Purpose (MaP) therapy in advanced cancer – a pilot, randomised controlled trial • Refinement and revalidation of the demoralisation scale • Treatment information needs of individuals diagnosed with early stage, non-small cell lung cancer

• ASTROID: active surveillance and other treatment options for prostate cancer – a randomised, controlled trial of decision aid and DVD information support for men diagnosed with low-risk prostate cancer and their partners • Finding the words: the lived experience of parents in communicating their cancer diagnosis to their children • The unmet needs of women diagnosed with ovarian cancer • Shifts in perceptions of self associated with the experience of ovarian cancer • Meaning and benefit-finding in women diagnosed with ovarian • Understanding women’s experience of ovarian cancer through the use of metaphors The latter three studies are part of a larger research project entitled Understanding the experiences and unmet needs of women diagnosed with ovarian cancer.

Completed research projects The following research projects were completed in 2014-15: • Understanding and measuring health literacy for caregivers of people with cancer • Informed choice in bowel cancer screening • Staff perceptions of the effects of a changed model of care in a palliative care service • The lived experiences of patients and carers in Cabrini’s palliative home-care service • Post-traumatic stress and post-traumatic growth in women diagnosed with ovarian cancer • The information and supportive care needs of Australian, Greek and Italian men diagnosed with early stage prostate cancer • Exploring the factors predicting psychological distress in haematopoietic stem cell transplant patients • Self-compassion and psychological health: The mediating role of emotion regulation difficulties

Above: Dr Yoland Antill is a member of the grant-winning team working on a pilot study of the mindful self-compassion program for cancer patients. Monash University student Elise Sloan worked on the study ‘Finding the words: the lived experience of parents in communicating their cancer diagnosis to their children’, which is ongoing.

Allied Health Research and Education

his is the third report of Cabrini’s Centre for Allied Health Research and Education, which was established in 2012 to build research capacity within and across each of Cabrini’s allied health professions. The unit’s activities continue to be led by Associate Professor Helena Frawley under a joint appointment with La Trobe University. In 2014-15, activity in allied health research increased significantly with greater numbers of clinicians engaged in patient-focused research activities and staff generating higher research output. Development of a strategic plan for allied health research has been a focal point for research planning and execution. This plan will serve as a roadmap to guide our activities for the next few years. Our goal is to improve the health of Cabrini patients and our local community through development and implementation of clinically-focused research, which translates into best clinical practice. We want to be the leader in allied

Above: Associate Professor Helena Frawley

health research in Australian private healthcare. We have identified three research focus areas to guide allied health research at Cabrini. Each of these areas is strongly linked to the Cabrini Institute’s four research themes, which are strategically aligned clinical research; patient and family centred care; safety and quality; and Catholic healthcare. The three research focus areas for allied health research are: • Implementation of clinical practice guidelines • Rehabilitation and self-management of chronic disease • Health economic evaluations To help us achieve our goals, we are working with our partners and colleagues to create research linkages. These include Cabrini allied health researchers and clinicians, medical, nursing and health administrative staff, staff of the Cabrini Institute, our university partners, Honorary Professors, health networks with which we have relationships and external agencies (such as professional associations, funders).

Our research staff have honorary appointments with our university partners: • Dr Helena Frawley, Honorary Senior Fellow, University of Melbourne • Dr Rosemary Higgins, Honorary Associate Professor, Deakin University • Dr Tash Brusco, Adjunct Senior Lecturer, La Trobe University Research projects During 2014-15, our primary research activity has been the allied health-led multidisciplinary rehabilitation program for patients following surgery for pelvic cancer. This project involves clinical researchers from the physiotherapy, health psychology, dietetics and exercise physiology disciplines. It is supported by urological, gynaecological and colorectal medical specialists. The project involves a nested pelvic floor muscle measurement study, which is in collaboration with the

University of Melbourne and forms part of a student’s PhD study. Currently we are recruiting patients for the project, which is due for completion by the end of the 2016 calendar year.

Publications

Thanks to the generosity of the Cabrini Foundation, in June 2015 an Allied Health Research Grant of $10,000 was made available. Targeted at novice researchers, the grant will be used to help build capacity and capability in allied health research. The team was led by Louise Tilley who is a physiotherapist at Cabrini Rehabilitation (Hopetoun Street campus) for the project: ‘My therapy: the feasibility of increasing inpatient rehabilitation intensity by implementing an additional self-directed independent exercise program’. This team will be able to implement their project in 2015-16.

has been made possible via our collaborations with

Currently several research projects are being developed and we anticipate a busy year in 2015-16 as we establish these projects.

During 2014-15, our research-active allied health staff have generated significantly more publications with a total of 16 compared with two last year. This increase our university partners, external research centres and research colleagues in other networks. As our higher degree research student supervisory activities increase, we anticipate further growth in our publications. Grants The unit’s Honorary Professor of Research from La Trobe University, Meg Morris, is a Chief Investigator for two projects funded by the National Health and Medical Research Council. The projects, which have a total grant income of $868,186, began in 2014-15. Allied health researchers have been active with grant submissions to external funders, as Chief and Associate

Above: Tash Brusco is Chief Physiotherapist at Cabrini and is an Adjunct Senior Lecturer at La Trobe University.

Investigators, in partnership with our research networks. We hope for success with these grant applications in over the next 12 months. Cabrini’s allied health research and clinical staff responded enthusiastically to the release of the Inaugural Cabrini Foundation Research Grant Round 2015-16, having entered five submissions. Of them, four were successful. Allied health staff led or significantly contributed to these submissions. This demonstrates their ability to work collaboratively in multidisciplinary teams and contribute to high quality research and high quality project designs. Grant awards totalled $90,000 for these projects, which will result in outcomes that will directly benefit Cabrini’s patients. Conference presentations In 2014-15, allied health staff gave 28 presentations with research topics covering an extensive range of healthcare areas relevant to Cabrini.

Foundation 49: Men’s Health

oundation 49: Men’s Health is Cabrini’s response to the health crisis affecting 49 per cent of the population and is dedicated to improving the health status of men across each across each decade of life. Supported by an 11-member Council and two employed staff at Cabrini, Foundation 49 continues to work toward its goal of improving the health status of men in Australia across each decade of life. Since its beginnings in Melbourne, Foundation 49: Men’s Health has achieved a great deal in the development of new approaches to men’s health and men’s health promotion. Foundation 49 was integral in the development of the National Male Health Policy 2010 and the Victorian Male Health Strategy 2010-14, which attest to its influence. Strong foundations Foundation 49: Men’s Health has been a major health promotion initiative of Cabrini for more than a decade.

Above: The late Tony Hitchin

It was created in 2001 in the name of the late Tony Hitchin, a former journalist and Chief of the Herald & Weekly Times who died from an aggressive urological cancer. Like Mr Hitchin’s family and friends, his oncologist Associate Professor Richardson wanted to acknowledge this man’s life and early death. Together, they decided to commemorate him in a way that was both significant and positive. The establishment of the Tony Hitchin Foundation – later renamed Foundation 49: Men’s Health

– focuses its efforts on the health of men, the gender comprising 49 per cent of Australia’s population. The people who were initially involved with the Tony Hitchin Foundation are acknowledged for their vision, dedication and hard work, which laid the foundations of a robust and well respected men’s health initiative, the first of its kind in Australia. They include the following: Dr Lyn Brodie, Pat Carmody, Lillian Frank, Robert Hicks, Jenny Hitchin, Ian Hollick, Associate Professor Doug Lording, Judy Mcleod, Murray McLeod, Brian Morris, Associate Professor Gary Richardson, Kim West and Tony Wiltshire. A number of these people formed the inaugural Board of the Tony Hitchin Foundation, which comprised Dr Lyn Brodie, Sylvia Bradshaw, Tom Buchan, Associate Professor Gary Richardson, Associate Professor Doug Lording, Dr Peter Lowthian, Alan Frees, Ross Fraser, Ian Hollick, Jenny Hitchin, Judy McLeod, Stephen Mead, Murray McLeod, Brian Morris, Ken Smith and Detective Inspector Kim West.

Background Foundation 49 is dedicated to improving the health status of men across each decade of life. Each year in Australia, more than four men die every hour from preventable conditions; a total of 35,000 fatalities. Through education of men, their partners, families, employers, communities and government, there is an opportunity to improve the health status of men and reduce the prevalence of the major diseases that men experience. Since inception, Foundation 49 has continued to work towards achieving our goals of encouraging men to take better care of their health and wellbeing and to have an annual health check with their GP. Foundation 49 produces significant resources to support these aims. Also, we support community organisations throughout Australia in holding men’s health awareness raising events and activities. The small team, which consists of Manager Penny Christie and Administrative

Assistant Patrick Mader, attends various men’s health events and distributes resources to many thousands of people each year. Health promotion for men is important and there remains a disparity between the genders with respect to overall health status and mortality. In 2014-15, the Foundation 49 Council met on many occasions to create a pathway for Foundation 49 in the future. At the time of writing, discussions were underway with Baker IDI Heart and Diabetes Institute, an independent, internationally renowned medical research facility with research goals of treating, managing and preventing disease at any stage. It is hoped that a partnership with Baker IDI Heart and Diabetes Institute will create an opportunity to enhance men’s health advancement. Community engagement activities During 2014-15, International Men’s Health Week (14-19 June 2015) was a focal point of activity for Foundation 49.

We were represented at five different events and hosted our key annual event. We partnered with Glaxo Smith Kline to hold an awareness raising event for benign prostate hyperplasia at Federation Square, Melbourne. We attended two events hosted by the Men of Malvern http://menofmalvern.com.au and provided resources for participants. Annual business breakfast On 17 June 2015, we held our annual men’s health business breakfast. This event encourages men to take better care of their health by having an annual health check with their GP, in order to identify any issues early. Held at Melbourne’s RACV Club, more than 210 men and women attended the event, which included an address by the Hon Jill Hennessy MP, Victorian Minister for Health. The event began with an address by keynote speaker Dr Peter Larkins (clinical specialist and former athlete) followed by interviews between MC Ian Goldsmith and

From left: Penny Christie, Manager of Foundation 49: Men’s Health, takes the microphone. Cabrini Chief Executive Dr Michael Walsh with Victorian Minister for Health Jill Hennessy MP at the 2015 Foundation 49: Men’s Health Business Breakfast. Cabrini Chief Executive Dr Michael Walsh with Peter Mahon (member, Cabrini Board) and Matt Johnston (Director of Education) at the 2015 Foundation 49: Men’s Health Business Breakfast.

FO U N DAT I O N 49: M E N ’ S H E A LT H

panel members: Marcus Padley (stock broker and author), Nik Stirzaker (Melbourne Rebels player and Foundation 49 ambassador, Justin McLean (global partner at PWC and founder of www.thrivor.org.au) and Dr Steve Ellen (psychiatrist and head of emergency psychiatry at Alfred Health). Proceeds of the event (approximately $11,000) were donated to Baker IDI Heart and Diabetes Institute. Annual GP symposium On 8 August 2015, we held our annual men’s health GP symposium in the new auditorium at Cabrini Malvern. This event designed for GPs and health professionals featured a range of contemporary topics with the following sessions: Diabestity, Dermatology, the Ageing Male Patient and the Vice of Life. Approximately 40 GPs from Victoria and interstate attended the event and we received positive feedback about the quality of the event and information provided.

Communication and education Various communication and education activities were conducted in 2014-15 under the Foundation 49 banner. They are designed to promote men’s awareness of health issues that affect them and encourage concrete actions that will help to ensure their health and wellbeing.

structured on the Decades of Life program. The booklet provides useful tips for attaining and maintaining wellness. Copies may be ordered online via the website www.49.com.au New website Our Foundation 49 website www.49.com.au has been

Whole New Ball Game magazine

redeveloped with positive feedback. The interactive

In 2014-15, three editions of the Whole New Ball Game magazine were published. A total of 26 issues have been published over the lifetime of this magazine. Approximately 5000 people subscribe with more people signing up every week.

website captures important health challenges according to each decade of a man’s life and provides high quality information and guidance for site visitors. The five-minute online health check enables users to obtain a snapshot of their current health status and an opportunity to take the next step and visit their GP for an annual check-up.

Men’s Health Toolkit With sponsorship funding provided by Glaxo Smith Kline, we updated and redesigned our popular men’s health booklet called the Men’s Health Toolkit. This booklet contains current, evidence-based health information

Above: Penny Christie is Manager of Foundation 49: Men’s Health, a Cabrini health promotion initiative.

Community Grants Program With sponsorship funding provided by Glaxo Smith Kline Glaxo Smith Kline, we conducted our 2015 Community Grants Program. Currently we are implementing 15 grants,

supporting community groups throughout Australia in holding men’s health events and activities to raise awareness of the importance of men’s health. These are due to be completed by November 2015. Male Health Victoria Foundation 49 continues to be involved with this incorporated statewide professional network and peak body aimed at improving the health and wellbeing outcomes of men and boys. Male Health Victoria advocates for a greater emphasis on men’s health and wellbeing programs. Support for new fathers In 2014-15, we have provided a men’s health kit for distribution to fathers of children born at Cabrini’s maternity service located at Cabrini Malvern. The aim is to encourage them to look after their own health to ensure they are able to support and enjoy their family in future.

Acknowledgement and recognition Foundation 49 is grateful to its valued donors, sponsors, supporters and volunteers. We are deeply indebted and grateful to the volunteer members of our Council and Medical Advisory/Scientific Committee. We thank all who have served, and continue to serve, Foundation 49 as members of these groups. Foundation 49 Council Associate Professor Gary Richardson (Chair) John Allen Robyn Charlwood Penny Christie Mr Jeremy Grummet Dr Daryl Kroschel Associate Professor Doug Lording Professor Bernie Marshall Alistair McCreadie Stephen Mead Dr Peter Wirth

Foundation 49 Medical Advisory/ Scientific Committee (past and present) Professor David Clarke Professor Gavin Davis Dr Ron Dick Dr David Fonda Mr Jeremy Grummett (current) Dr Daryl Kroschel Associate Professor Doug Lording (current) Mr Daniel Moon (current) Dr David Oberklaid Associate Prof Gary Richardson (current) Dr James Shaw Dr Peter Wirth (current) Note: In previous reports, the Let’s Beat Bowel Cancer health promotion initiative has been featured within this chapter. For information about Let’s Beat Bowel Cancer, please refer to page 28 where it appears within the chapter on the Cabrini Monash University Department of Surgery/The Fröhlich West Chair of Surgery.

From left: Former Victorian Health Minister David Davis MP (left) pictured at the last Foundation 49 gala evening (2011) with Associate Professor Gary Richardson (centre) and former Board Chair Peter Matthey (right). Cabrini Foundation Board Chair Syliva Falzon contributes to the fundraising efforts of Foundation 49 at the 2011 gala evening. Foundation 49: Men’s Health Administrative Assistant Patrick Mader is pictured delivering health promotion information.

Department staff

Monash Department of Clinical Epidemiology at Cabrini Hospital Head of Department Professor Rachelle Buchbinder Administrative Assistant Cathy Matthews Managing Editor, Cochrane Musculoskeletal Group Dr Renea Johnston ARAD State Coordinator Joan McPhee Biostatistician Dr Margaret Staples Research Fellow Dr Allison Macpherson Postdoctoral Research Fellow Dr Susan Slade PhD scholars Megan Blackburn (2010-), Deakin University, Rebecca Jessup (Deakin University, 2014-) Sarah Hosking (Deakin University 2014-) Bethan Richards (University of Sydney, 2011-)

PhD scholars Megan Blackburn (2010-), Deakin University Rebecca Jessup (2014-), Deakin University Sarah Hosking (2014-), Deakin University Dr Bethan Richards (2011-), University of Sydney Masters students Kelly Joyce (2014-), Monash University BBiomedSci student Shehzaad Muhammad Peerbux (2014), Monash University

Cabrini Monash Department of Medical Oncology The Salzmuk Family Department of Medical Oncology Head of Department Associate Professor Gary Richardson Principal Investigators Dr Yoland Antil Dr Ben Brady Dr Andrew Haydon Dr Melita Keneally Professor Miles Prince Associate Professor Jeremy Shapiro Associate Professor Gary Richardson Dr Michelle White

Associate Investigators Emma Beadsley Dr Sanjeev Gil Associate Professor Ian Haines Dr Henry Januszewicz Oliver Klein Esther Lin Dr Lara Lipton Dr Ben Markman Joanna Morgan Dr David Pook Dr Nicole Potasz Professor Max Schwarz Dr Robert Stanley Karen Taylor Associate Professor Max Wolff Team Leader Oncology Research Julia Carlson Study Coordinators Jaishri Ellengovan Kate Hurford Mary Lane Connie Louizos Jenny McIndoe (Cancer 2015) Alice Newman Rachel Osborne (Cancer 2015) Helen Smenda

Cabrini Family Cancer Clinic Dr Lynne McKay Brightways Breast Cancer Data Manager Barbara Scher

Cabrini Monash University Department of Medicine Head of Department Associate Professor Michele Levinson Research Fellow Dr Amber Mills Research Assistants Anthea Gellie Natalie Heriot Gaya Sritharan Higher Degree Research Student Alice Rouse, PhD student Inaugural Summer Scholarship Recipient Mark Lym (fourth-year medical student) Volunteers Dr Annie Walker Valerie Co (fifth-year medical student) Dr Thinn Khine Dr Scott Abbinga (intern)

Cabrini Centre for Nursing Education and Research Director Associate Professor Leanne Boyd Research Associate Amanda Pereira-Salgado Research Assistant Michelle Morgan PhD students Louise Alexander Janet Curtis Dr Grainne Lowe Tegwyn McManamny Diana Wong Masters students Kerry Bateman Elizabeth Cooch Jovie Decoyna Claire Hatherley Jane Lynch Sue Hope-Murray Jennifer MacIndoe Jo Miller Christine Moon Emma Patterson Amanda Peat

Meg Pollock Chris Quinn Toula Saltas Jo Schlieff Jennifer Soikans Tanya Warren Lauren Williams Bismi Wilson Tay Usatoff

Cabrini Monash University Department of Surgery The Frรถlich West Chair of Surgery Head Associate Professor Paul McMurrick Surgical staff Emeritus Professor Adrian Polglase Mr Stephen Bell Mr Roger Berry Mr Peter Carne Mr Martin Chin Mr Chip Farmer Mr Pravin Ranchod Dr Boris Ruggiero Mr Paul Simpson Mr Raymond Yap

D E PA R TM E N T S TA FF

MEDICAL EDUCATION TEAM Clinical Dean Associate Professor Michele Levinson

Foundation 49: Men’s Health

Administration Assistant Jennie McInerney

Administrative Assistant Patrick Mader

Clinical Education at Cabrini

Szalmuk Family Psycho-oncology Unit

Cabrini Institute Infrastructure Team

Director Matt Johnson

Head and Senior Research Fellow Dr Sue Burney

NURSING EDUCATION TEAM Agnetha Clarke Yvette Gomez Abby Hadden Claire Hatherley Nat Horvath Barb Miles Jo Miller Emma Patterson Amanda Peat Chris Quinn Jo Schlieff Libby Smith Louise Suttie Tanya Warren Geoff White Lauren Williamss

Research Fellow Dr Jo Brooker

Allied Health Research and Education

Anne Spence (Director of Institute Infrastructure) Dr Emma Baker Jennifer Burden Anne-Marie Devine Di Horrigan (Manager of Library Services) Jasmine Kopcewicz Jan Palich Sue Smith Maria Terzoglou Michele Tonkin Grace Winjen

Head Associate Professor Helena Frawley

Palliative Care

Academic staff Dr Simon Wilkins Administrative and management staff Karen Oliva – Database Manager Kirsty Poynter - Administrative Assistant

Honorary Research Fellow Jane Fletcher Research Assistant Courtney Hempton

Honourary/Advisory Dr Tash Brusco Dr Rosemary Higgins Professor Meg Morris

Manager Penny Christie

Senior Research Associate Clare O’Callaghan

Dr Emma Baker F U N D I N G A N D R E P U TAT I O N

edical research enables the high quality medical care we enjoy today. Our researchers are building the future of

medicine, improving patient outcomes and our health. Research requires money and the biggest pressure facing our researchers at Cabrini is securing enough funding to undertake their research. Funding is highly competitive, there are limited sources and it takes substantial effort and time to apply for funding; time that detracts from progressing research. Dr Emma Baker is experienced in research funding, having worked as a postdoctoral scientist investigating cancer, epigenetics and pre-clinical drug testing in medical laboratories. She understands the funding pressures that researchers face. “I have watched good research come to an end, good researchers leave the profession and good ideas be abandoned due to a lack of funding. Research is a hard career and the pressure of obtaining and maintaining funding is immense,” said Emma. During her career, Emma has secured funding from the NHMRC and others. She has promoted her research and research Institutions successfully to attract money from donors and funding bodies. In May 2015, she joined the Cabrini Institute as Manager of Research Programs. “I am passionate about research and improving patient outcomes. Research is challenging but rewarding and we need to retain researchers so we can continue improving healthcare and outcomes for patients. I want to work with our researchers and help them enhance their reputation and funding”.

Governing safe and ethical research

Supporting ethical research

he Cabrini Human Research Ethics Committee helps to protect the interests of patients, researchers and Cabrini by maintaining high ethical research standards in research projects. High quality, ethical research creates many benefits for patients, health professionals and the community. The Cabrini Health Human Research Ethics Committee reports directly to the Cabrini Board. It reviews and approves research projects conducted at Cabrini that involves human participants. It is chaired by Dr Margaret Staples and supported by Jennifer Burden as Manager. Our Human Research Ethics Committee ensures that: • Ethically sound research is promoted and supported at Cabrini • The research affirms the mission and values of Cabrini and social teaching of the Catholic Church • Ethical standards are maintained in research projects to protect the interests of the research participants, the investigator and the institution

Activity

Conduct and certification

In 2014-15, the Cabrini Human Research Ethics Committee (CHREC) worked on 94 projects covering a wide range of research areas.

The Cabrini Human Research Ethics Committee operates in accordance with the National Statement on Ethical Conduct in Research Involving Humans issued by the National Health and Medical Research Council in 2007, other relevant Commonwealth and State legislation and regulations and Catholic Health Australia’s Code of Ethical Standards for Catholic Health and Aged Care Services in Australia.

We have 1076 projects in our HRECTrack database to date. We are continuing to work on developing this database with a view to moving to electronic submission of applications for all levels of CHREC review. A highlight was our twilight seminar entitled ‘The patient experience of consenting for clinical and research procedures’ held on 2 June 2015. The seminar provided an insight into the patient perspective of consenting for clinical procedures and research trials. It was interesting to hear the value patients place on the relationship with their treating specialist when considering participation in a research study. We are grateful to the specialists Professor Rachelle Buchbinder, Dr Anna Rosamilia and Associate Professor Wilson Heriot and two patients who generously gave their time to participate.

The Cabrini Human Research Ethics Committee continues to be certified by the National Health and Medical Research Council’s (current until 31 December 2016). Changes in committee membership We welcomed new member Angela Baird in September 2014 and farewelled Dr Bronwyn Sacks who retired from the committee in June 2014.

Changes in staff

Cabrini Human Research Ethics Committee 51

In December 2014, Anne Spence became the Director of Institute Infrastructure, a new role focused on aligning the Cabrini Institute’s education and research processes with Cabrini’s strategic plan 2013-15. Prior to this role, she had managed the Human Research Ethics Committee for 12 years. In March 2015, Jennifer Burden took up the role of Manager, Human Research Ethics Committee and Research Governance. Prior to this role, she had managed the Cabrini Institute for nine years. The Cabrini Human Research Ethics Committee is now supported by three employed staff within the Cabrini Institute: • Jennifer Burden, Manager, CHREC and Research Governance • Grace Wijnen, Administrator • Sue Smith, Administrative Assistant

Name

NHMRC category

Gender

Status Began 1/9/15

Angela Baird

Nurse

Female

Beatrice Bastomsky

Lay person

Female

Michelle Britbart

Lawyer

Female

Dr Joanne Brooker

Researcher

Female

Jennifer Burden

Invitee

Female

David Curtain

Male

Associate Professor Henry Debinksi

Researcher

Male

Dr Dane Horsfall

Professional carer

Male

Revd Kevin McGovern

Pastoral carer

Male

Associate Professor Marilyn Poole

Additional

Female

John Robertson

Lay person

Male

Dr Bronwyn Sacks

Professional carer

Female

Finished 16/6/14

Anne Spence

Invitee

Female

Finished 31/3/15

Dr Margaret Staples

Chair

Female

Associate Professor Val Ustaoff

Researcher

Male

Dr Sharon Woolf

Professional carer

Female

Began 1/4/15

S U P P O R T I N G E T H I C A L R E S E A RC H

Research area

Project

Â Principal researcher

Allied health

Evidencing social work practice in health and mental health

Victoria Whitman

Laying the groundwork for great goal setting in rehabilitation

Yvette Vonier

Arthritis

Do bone marrow lesions identified by different magnetic resonance (MR) imaging sequences have different clinical correlates in people with knee osteoarthritis?

Associate Professor Anita Wluka

Auto-immune disease

A multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study of ustekinumab in subjects who have active systemic lupus erythematosus

Associate Professor Stephen Hall

Cancer

A multinational, prospective, observational study in patients who have unresectable or metastatic melanoma

Dr Ben Brady

A phase 3, multicentre, open-label, randomised study of nab-paclitaxel plus gemcitabine versus gemcitabine alone as adjuvant therapy in subjects with surgically resected pancreatic adenocarcinoma

Associate Professor Jeremy Shapiro

A phase 3, open-label, multicentre, randomised study evaluating the efficacy and safety of MPDL3280A (AntiPD-L1 Antibody) in combination with Carboplatin plus Paclitaxel or MPDL3280A in combination with Carboplatin plus Nab-Paclitaxel versus Carboplatin plus Nab-Paclitaxel in chemotherapy-naive patients with stage 4 squamous non-small cell lung cancer

Associate Professor Gary Richardson

A phase 3, randomised, placebo-controlled, double-blind study of JNJ-56021927 in combination with Abiraterone Associate Professor Jeremy Shapiro Acetate and Prednisone versus Abiraterone Acetate and Prednisone in subjects with chemotherapy-naive metastatic castration-resistant prostate cancer A phase 2, randomised, double-blind study of neoadjuvant letrozole plus GDC-0032 versus letrozole plus placebo in postmenopausal women with ER-positive/HER2-negative, early stage breast cancer

Dr Yoland Antill

A phase 2, multicentre, randomised, double-blind study to evaluate the efficacy and safety of RO5520985 plus folfox versus bevacizumab plus folfox in patients who have previously untreated metastatic colorectal cancer

Associate Professor Jeremy Shapiro

A phase 3, double-blind, randomised, placebo-controlled study to assess the efficacy and safety of Selumetinib (ADZ6244; ARRY-142886) (Hyd-Sulfate) in combination with Docetaxel, in patients receiving secondline treatment for KRAS mutation-positive locally advanced or metastatic non-small cell lung cancer (Stage 3B-4)

Associate Professor Gary Richardson

A phase 3, open-label, randomised study of MPDL3280A (Anti-PD-L1 Antibody) in combination with Carboplatin plus Paclitaxel with or without Bevacizumab compared with Carboplatin plus Paclitaxel plus Bevacizumab in chemotherapy-naive patients with stage 4 non-squamous non-small cell lung cancer

Associate Professor Gary Richardson

Research area

Project

Â Principal researcher

Cancer continued

A prospective, randomised phase 3 trial of carboplatin/gemcitabine/bevacizumab versus carboplatin/pegylated liposomal doxorubicin/bevacizumab in patients who have platinum-sensitive recurrent ovarian cancer

Associate Professor Gary Richardson

An Australian, multicentred, retrospective analysis of the efficacy of cabazitaxel post abiraterone acetate in men who have metastatic castrate resistant prostate cancer who have failed docetaxel

Dr David Pook

Annual report of the bi-national colorectal cancer audit

Associate Professor Paul McMurrick

Assessing general practitioner involvement in cancer care from diagnosis to advanced illness.

Dr Catherine Rowe

Exploring the supportive care needs of women who have advanced breast cancer prescribed Everolimus in a private oncology setting

Associate Professor Gary Richardson

Investigating the prevention of endometrial cancer with metformin (PECAM study)

Professor Susan Davis

Myeloma and related diseases registry

Professor Miles Prince

Non-interventional, retrospective tissue sample collection follow-up to Amgen study 20050244 (study of denosumab compared with zoledronic acid in the treatment of bone metastases in subjects with advanced cancer or multiple myeloma)

Associate Professor Gary Richardson

Palliative chemotherapy within the last 30 days of life: experience at a private hospital oncology unit

Dr Ian Haines

Phase 3 study evaluating palbociclib (PD-0332991), a cyclin-dependent kinase (CDK) 4/6 inhibitor in patients who have hormone-receptor positive, HER2-normal primary breast cancer with high relapse risk after neoadjuvant chemotherapy

Dr Yoland Antill

Screening for Lynch Syndrome in patients who have colorectal cancer: the Cabrini Health experience

Associate Professor Paul McMurrick

Search for a common target for metastatic disease in colorectal, ovarian and pancreatic cancer

Associate Professor Paul McMurrick

The timeline and quality of life implications of madarosis in patients undergoing cytotoxic chemotherapy for breast malignancy

Dr Yoland Antill

Use of adjuvant chemotherapy in stage 2 colorectal cancer: the Cabrini and Alfred hospital experience

Associate Professor Jeremy Shapiro

Heart failure readmissions

Lauren Barker

Cardiology

S U P P O R T I N G E T H I C A L R E S E A RC H

Research area

Project

Principal researcher

Cardiology continued

The Dormant-AF study: determining the optimal dose of adenosine for unmasking dormant pulmonary vein conduction in patients undergoing AF ablation

Professor Peter Kistler

Dietetics

Finger food menu proposal (patient satisfaction survey)

Rebekah Anderson (Scholes)

Education

An evaluation of undergraduate clinical placements in a private health care organisation

Emma Patterson

Augmented eXperience Modules (AXM) Activity

Associate Professor Michele Levinson

Extending awareness of healthcare ethics at Cabrini Health: junior clinicians’ perspectives

Julia Trimboli

Pilot study of the ‘Breast Feeding Champions’ group

Chris Quinn

Self-perceived readiness to practice of graduate and experienced nurses entering perioperative education

Matthew Johnson

The impact of an undergraduate university fellowship program on the perceptions of work-readiness among new graduate nurses: a cross-sectional study

Emma Patterson

Emergency medicine

The safety and use of intravenous Metoprolol in general hospital wards-a single centre observational study

Dr Diane Kelly

Gastroenterology

A combined phase 2/3, double-blind, randomised, placebo-controlled induction and maintenance study evaluating the safety and efficacy of GS-5745 in subjects who have moderately to severely active ulcerative colitis

Associate Professor Henry Debinski

A phase 3, randomised, double-blind, placebo-controlled, multicentre study to evaluate the efficacy and safety of Etrolizumab as an induction and maintenance treatment for patients with moderately to severely active Crohn’s disease

Associate Professor Henry Debinski

An open-label extension and safety monitoring study of moderate to severe ulcerative colitis patients previously enrolled in etrolizumab phase 3 studies

Associate Professor Henry Debinski

Phase 3, randomised, double-blind, double-dummy, placebo-controlled, muticentre study to evaluate the efficacy (induction of remission) and safety of Etrolizumab compared with Adalimumab and placebo in patients with moderate to severe ulcerative colitis who are naive to TNF inhibitors

Associate Professor Henry Debinski

A multicentre, phase 2, open-label study of efficacy and safety of the selective inhibitor of nuclear export (SINEtm) Selinexor (KPT-330) in patients who have relapsed or refractory peripheral T-cell lymphoma (PTCL) and cutaneous T-cell lymphoma

Professor Miles Prince

Characterising erythroid dysplasia by flow cytometry

Professor Miles Prince

Haematology

Research area

Project

Principal researcher

Haematology continued

Study of the Anti-EphA3 Monoclonal Antibody KB004 in subjects who have EphA3-expressing hematologic malignancies

Professor Miles Prince

To assess the efficacy and safety of dose reduced fludarabine, cyclophosphamide and rituximab (FCR) in elderly patients who have chronic lymphocyte leukaemia

Dr Melita Kenealy

Infection control

One million global catheters PIVC worldwide prevelance study (OMG PIVC study)

Phillipa Parsons

Infectious diseases

An audit of Staphylococcus aureus bacteraemia and echocardiographic findings at Cabrini – a comparison with findings at Royal Melbourne Hospital

Associate Professor Michele Levinson

Intensive care

Recovery-ICU: a multicentre cohort study in critically ill patients to determine functional recovery and quality of life

Dr Jonathan Barrett

TRICS III: Transfusion requirements in cardiac surgery – an interventional, multicentre, randomised, controlled trial to assess transfusion thresholds in patients undergoing cardiac surgery

Dr Jonathan Barrett

A non-invasive screening tool for anaemia

Associate Professor Michele Levinson

Cabrini emergency department scribe project – piloting training Australian scribes

Dr Katie Walker

Advance care planning: consumer resources

Dr Natasha Michael

Assessing the relationship between the components of the PH-FRAT and falls rates in an inpatient palliative care setting

Dr Eve Westland

Doctors’ attitudes towards not-for-CPR orders

Associate Professor Michele Levinson

Measuring the success of medical emergency teams

Dr Jonathan Barrett

Medical emergency team survey for Cabrini Health

Dr Felicity Hawker

Patient safety falls

Kirsten Seletto

RAC/RL pastoral care volunteers pilot evaluation

Anne Pate

The value of case management research

Rachel Breman

Musculoskeletal

Multidisciplinary priority setting for musculoskeletal research: ANZMUSC study

Professor Rachelle Buchbinder

Neurology

Biomarkers of efficacy of IVIg treatment for CIDP

Dr Timothy Day

Medicine

Models of care

S U P P O R T I N G E T H I C A L R E S E A RC H

Research area

Project

Â Principal researcher

Nursing

An evaluation of the purposeful hourly rounding project

Associate Professor Leanne Boyd

Evaluation of patient satisfaction and staff confidence in peripheral intravenous cannulation insertion

Georgina Wiley

Perceptions and experiences of barriers and facilitators to nurses undertaking EBP in a private hospital

Amanda Pereira-Salgado

Using an audit with feedback knowledge translation intervention to promote medication error reporting in healthcare

Associate Professor Alison Hutchinson

Evaluating the Malvern Nurse Manager orientation and induction process

Margaret Harley

What are patientsâ&#x20AC;&#x2122; perceptions of medication management during their hospitalisation?

Associate Professor Alison Hutchinson

Obstetrics

Improving postnatal care for multiparous women from hospital to home at Cabrini

Dr Danielle Wilkins

Ophthalmology

2RT laser for the fellow eye (2RT 2E)

Associate Professor Wilson Heriot

Application to become a TGA-authorised prescriber of an unapproved product under subsection 19(5)/ section 41HC of the Therapeutic Goods Act

Associate Professor Wilson Heriot

Laser intervention in age-related macular degeneration for those patients rejected from the LEAD study (LEAD-R)

Associate Professor Wilson Heriot

Retinal oxygen levels and laser therapy for central retinal vein occlusion

Associate Professor Wilson Heriot

RTA255-P001: Assessment of anatomical and functional outcomes in subjects treated with Ocriplasmin for Vitreomacular traction/symptomatic Vitreomacular adhesion (VMT/sVMA)

Associate Professor Wilson Heriot

Patient information

Written instructions to patients to confirm pathology results, how effective is this in closing the loop for transmission of information?

Associate Professor Paul McMurrick

Psychology

A pilot study of the mindful self compassion program for people who have been diagnosed with cancer or haematological malignancy

Dr Sue Burney

Evaluation of the mindfulness-based relapse prevention program at Delmont Private Hospital

Melissa Kent

Evaluation of the substance use and addiction program at Delmont Private Hospital

Melissa Kent

Large Observational study to UNderstand the Global impact of Severe Acute respiratory FailurE- LUNG-SAFE study

Dr Jonathan Barrett

Respiratory

Research area

Project

Principal researcher

Surgery

Circumferential resection margins after resections of rectal cancer

Mr Peter Carne

Colorectal cancer surgery on high risk surgical patients: a review of outcomes from a colorectal neoplasia database

Associate Professor Paul McMurrick

Diabetes: an examination of perioperative morbidity and mortality in a colorectal setting

Associate Professor Paul McMurrick

Establishment of a bariatric surgery clinical quality registry

Mr Paul Burton

Incidence of post-operative delirium at Cabrini Malvern in high risk patients

Dr Chantal McNally

Modelling human intestinal disease using in vitro organoid culture

Associate Professor Paul McMurrick

Surgery in the new extremes of age

Associate Professor Paul McMurrick

Suturing: revising Peyton’s approach for larger group settings

Associate Professor Paul McMurrick

The Australian Breast Device Registry

Gillian Farrell

The effect of upper gastro-intestinal surgery on inflammatory biomarkers

Mr Paul Burton

The predictive power of submucosal invasion in malignant colorectal polyps for lymph node metastasis

Associate Professor Paul McMurrick

The relationship between increasing BMI and surgical, pathological and oncological outcomes in the treatment of colorectal cancer

Mr Stephen Bell

Upper-gastrointenstinal surgical audit

Mr Paul Burton

A prospective, non-randomised, multi-centre, clinical investigation of the safety and performance of GT urological, LLC’s Phenix device artificial urinary sphincter

Mr Daniel Moon

A randomised, double blind, parallel-group, active-controlled, multicentre study to evaluate the long-term safety and efficacy of combinations of solifenacin succinate and mirabegron compared to solifenacin succinate and mirabegron monotherapy in subjects with over-active bladder

Dr Anna Rosamilia

An evaluation of the medium-term efficacy of the advance urethral sling in the treatment of post-prostatectomy stress urinary incontinence

Mr Daniel Moon

Early experience with Solyx single-incision mid-urethral sling

Dr Anna Rosamilia

Urology

Publications

Monash Department of Clinical Epidemiology at Cabrini Hospital

and weaknesses across socio-demographic groups: a crosssectional survey using the Health Literacy Questionnaire. BMC Public Health 15:678.

Publications Aitken D, Buchbinder R, Jones G and Winzenberg T. (2015) Interventions to improve adherence to exercise for chronic musculoskeletal pain in adults. Australian Family Physician 44(1):39-42. Andrés M, Sivera F, Falzon L, Buchbinder R and Carmona L. (2014) Dietary supplements for chronic gout. Cochrane Database of Systematic Reviews 10:CD010156. Araújo F, Cordeiro I, Ramiro S, Falzon L, Branco JC and Buchbinder R. (2015) Outcomes assessed in trials of gout and accordance with OMERACT recommendations: a systematic literature review. Journal of Rheumatology 54(6):981-93. Batterham RW, Buchbinder R, Beauchamp A, Dodson S, Elsworth GR and Osborne RH. (2014) The Optimising Health Literacy (OpHeLia) process: using health literacy profiling and community engagement to create and implement health reform. BMC Public Health 14:694. Beauchamp A, Buchbinder R, Dodson S, Batterham R, Elsworth GR, McPhee C, Sparkes L, Hawkins M and Osborne RH. (2015) Distribution of health literacy strengths

Bennell K, Buchbinder R and Hinman R. (2015) Physical therapies in the management of the osteoarthritis. Current state of the evidence. Current Opinion Rheumatology 27(3):304-11. Bennell KL, Egerton T, Martin J, Metcalf B, McManus F, Abbott H, Sims K, Pua YH, Wrigley TV, Forbes A, Smith C, Harris A and Buchbinder R. (2014) Effect of physical therapy on pain and function in patients with hip osteoarthritis: a randomised clinical trial. Journal of the American Medical Association 311(19):1987-97. Bourne A, Whittle S, Richards B, Maher C and Buchbinder R. (2014) The scope, funding and publication of musculoskeletal trials performed in Australia. Medical Journal of Australia 200(2):81-91. Brennan SL, Lane SE, Lorimer M, Buchbinder R, Wluka AE, Page RS, Osborne R, Pasco JA, Sanders KM, Cashman K, Ebeling PR, Graves SE. (2014) Associations between socioeconomic status and primary total knee joint replacements performed for osteoarthritis across Australia 2003-10: Data from the Australian Orthopaedic Association

National Joint Replacement Registry. BMC Musculoskeletal Disorders 15(1):356. Buchbinder R, Harris I and Sprowson A. (2015) Practice Pointer: Management of degenerative meniscal tears and the role of surgery. BMJ 350:h2212. Buchbinder R, Maher C and Harris I. (2015) Setting the research agenda for improving health care for musculoskeletal disorders. Nature Reviews Rheumatology 11(10):597-605. Buchbinder R, Johnston R, Golmohammadi K, Jones A, Dhillon SS, Owen R, Homik J, Kallmes DF, Crowther S, Ong K and Lambert RGW. (2015) Percutaneous vertebroplasty for osteoporotic vertebral compression fracture. Cochrane Database of Systematic Reviews 4:CD006349. Buchbinder R, Richards B and Harris I. (2014) Knee osteoarthritis and role for surgical intervention: lessons learned from randomized clinical trials and population-based cohorts. Current Opinion in Rheumatology 26(20):138-44. Chen JS, Buchbinder R, Lassere M and March L. (2014) Comparative effectiveness of anti-tumour necrosis factor (TNF) drugs on patient reported health-related quality of life among Australian Rheumatology Association Database

(ARAD) patients with inflammatory arthritis. Arthritis Care and Research 66(3):464-72. Chiarotto A, Deyo RA, Terwee CB, Boers M, Buchbinder R, Corbin T, Costa LOP, Foster NE, Grotle M, Koes, BW, Kovacs FM, Lin CWC, Maher C, Pearson AM, Peul WC, Schoene ML, Turk DC, van Tulder M and Ostelo RW. (2015) Core outcome domains for clinical trials in non-specific low back pain. European Spine Journal 24(6):1127-42. Chiarotto A, Terwee CB, Deyo RA, Boers M, Lin CWC, Buchbinder R, Corbin T, Costa LOP, Foster NE, Grotle M, Koes, BW, Kovacs FM, Maher C, Pearson AM, Peul WC, Schoene ML, Turk DC, van Tulder M and Ostelo RW. (2014) A core outcome set for clinical trials on non-specific low back pain: Study protocol for the development of a core domain set. Trials 15:511. Christensen R, Maxwell LJ, Jüni P, Tovey D, Williamson PR, Boers M, Goel N, Buchbinder R, March L, Terwee C, Singh J and Tugwell P. (2015) Consensus on the need for a hierarchical list of patient-reported pain outcomes for metaanalyses of knee osteoarthritis trials: an OMERACT objective. Journal of Rheumatology doi: 10.3899/jrheum.141384. Ciciriello S, Buchbinder R, Osborne RH and Wicks IP. (2014) Improving treatment with methotrexate in rheumatoid arthritis – development of a multimedia patient education

program and the MiRAK, a new instrument to evaluate methotrexate-related knowledge. Seminars in Arthritis and Rheumatism 43(4):437-46. Cross M, Smith E, Hoy D, Carmona L, Wolfe F, Kamalaraj N, Vos T, Williams B, Gabriel S, Lassere M, Buchbinder R, Woolf A and March L. (2014) The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study. Annals of Rheumatic Diseases 73(7):1316-22. Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Osborne R, Vos T, Buchbinder R, Woolf A and March L. (2014) The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Annals of Rheumatic Diseases 73(7): 1323-30. Ghogomu E, Maxwell LJ, Buchbinder R, Rader T, Pardo JP, Johnston R, Christensen R, Singh J, Wells GA, Tugwell P and the Editorial Board of the Cochrane Musculoskeletal Group. (2014) Updated method guidelines for Cochrane Musculoskeletal Group systematic reviews and metaanalyses. Journal of Rheumatology 41(2):194-205. French SD, Green SE, Francis JJ, Buchbinder R, O’Connor DA, Grimshaw JM and Michie S. (2015) Evaluation of the fidelity of an interactive face-to-face educational intervention to improve general practitioner management of back pain. BMJ Open 5(7):e007886.

Graf SW, Whittle SL, Wechalekar M, Moi J, Barrett C, Hill C, Littlejohn G, Lynch N, Major G, Taylor A, Buchbinder R and Zochling J. (2015) Australian and New Zealand recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion in the 3e initiative. International Journal of Rheumatic Diseases 18(3):341-51. Hadi M, Sprowson A, Bucknall T, Underwood M, Costa ML and Buchbinder R. (2014) Periarticular analgesia for postoperative pain following total hip replacement. Cochrane Database of Systematic Reviews 11:CD011327. Hoy D, March L, Woolf A, Blyth F, Brooks P, Smith E, Vos T, Barendregst J, Blore J, Murray C, Burstein R and Buchbinder R. (2014) The global burden of neck pain: estimates from the Global Burden of Disease 2010 study. Annals of Rheumatic Diseases 73:968-74. Hoy D, Smith E, Cross M, Sanchez-Riera L, Buchbinder R, Blyth F, Brooks P, Woolf A, Osborne RH, Fransen M, Driscoll T, Vos T, Blore J and March L. (2014) The global burden of musculoskeletal conditions for 2010: an overview of methods. Annals of Rheumatic Diseases 73(6):982-9. Hoy DG, Smith E, Cross M, Sanchez-Riera L, Blyth FM, Buchbinder R, Woolf AD, Driscoll T, Brooks P and March LM. (2015) Reflecting on the global burden of musculoskeletal

P U B LI C AT I O N S

conditions: lessons learnt from the Global Burden of Disease 2010 Study and the next steps forward. Annals of Rheumatic Diseases 74(1):4-7.

effects of anti-TNF treatment on health-related quality of life among Australian ankylosing spondylitis patients. Journal of Rheumatology 54(2):310-7.

Hoy D, March L, Brooks P, Blyth F, Woolf A, Bain C, Williams G, Smith E, Vos T, Barendregst J, Murray C and Buchbinder R. (2014)The global burden of low back pain: estimates from the Global Burden of Disease 2010 study. Annals of Rheumatic Diseases 73(6):968-74.

Kydd ASR, Seth R, Buchbinder R, Falzon L, Edwards C, van der Heijde D and Bombardier C. (2014) Urate-lowering therapy for the management of gout: Summary of 2 Cochrane reviews. Journal of Rheumatology 92:33-41.

Kent P, Mirkhal S, Keating J, Albert HB, Buchbinder R and Manniche C. (2014) The concurrent validity of brief screening questions for anxiety, depression, social isolation, catastrophisation and fear of movement. Clinical Journal of Pain 30:479–89. 60

Kroon F, Staples MP, Ebeling P, Wark J, Osborne R, Mitchell P, Wriedt C and Buchbinder R. (2014) Vertebroplasty for osteoporotic vertebral fractures: Two-year results from a randomised controlled trial. Journal of Bone and Mineral Research 29(6):1346-55. Kroon FPB, van der Burg L, Buchbinder R, Osborne RH, Johnston RV and Pitt V. (2014) Self-management education programmes for osteoarthritis. Cochrane Database of Systematic Reviews 1:CD008963. Kroon F, van der Burg L, Ramiro S, Landewé, Buchbinder R and van der Heijde D. (2014) Non-steroidal antiinflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis). Cochrane Database of Systematic Reviews 1:CD010952. Kroon F, van der Burg L, Ramiro S, Landewé, Buchbinder R and van der Heijde D. (2015) Non-steroidal antiinflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis).Cochrane Database of Systematic Reviews 7:CD010952. Kydd ASR, Chen JS, Makovey J, Chand V, Buchbinder R, Lassere M and March L. (2015) Smoking did not modify the

Kydd ASR, Seth R, Buchbinder R, Edwards CJ, Bombardier C. (2014) Uricosuric medications for chronic gout. Cochrane Database of Systematic Reviews 11:CD010457. Lefevre-Colau MM, Buchbinder R, Regnaux JP, Roren A, Poiraudeau S and Boutron I. (2014) Self-management education programmes for rheumatoid arthritis. Cochrane Database of Systematic Reviews 10:CD011338.

Jull J, Barnabe C, Pohl C, Duruöz T, Singh JA, Tugwell P and Guillemin F. (2015) Towards ensuring health equity: Readability and cultural equivalence of OMERACT patientreported outcome measures. Journal of Rheumatology doi: 10.3899/jrheum.141168. Rader T, Pardo JP, Stacey D, Ghogomu E, Maxwell LJ, Singh JA, Buchbinder R, Légaré F, Santesso N, Winzenberg T, Tugwell P and the Editorial Board of the Cochrane Musculoskeletal Group. (2014) Knowledge translation to clinicians and patients: Update of strategies to translate evidence from Cochrane Musculoskeletal Group systematic reviews for use by various stakeholders Journal of Rheumatology (2):206-15.

March L, Smith EU, Hoy DG, Cross MJ, Sanchez-Riera L, Blyth F, Buchbinder R, Vos T and Woolf AD. (2014) Burden of disability due to musculoskeletal (MSK) disorders. Best Practice and Research Clinical Rheumatology 28(3):353-66.

Rader T, Pardo JP, Stacey D, Ghogomu ET, Maxwell L, Buchbinder R, Légaré F, Santesso N, Winzenberg T and Tugwell P. (2014) Knowledge translation to clinicians and patients: update of strategies to translate evidence from cochrane musculoskeletal group systematic reviews for use by various stakeholders, Cochrane Library Systematic Reviews 1(2):206-215 .

Moi JHY, Sriranganathan M, Falzon L, Edwards CJ, van der Heijde DM and Buchbinder R. (2014) Lifestyle interventions for the treatment of gout – a summary of 2 Cochrane systematic reviews. Journal of Rheumatology 92:26-32.

Rankin KS, Sprowson AP, McNamara I, Akiyama T, Buchbinder R, Costa ML, Rasmussen S, Nathan SS, Kumta S and Rangan A. (2014) The orthopaedic research scene and strategies to improve it. Bone and Joint Journal 96-B:1578–85.

Page MJ, Green S, Kramer S, Johnston RV, McBain B, Chau M and Buchbinder R. (2014) Electrotherapy modalities for adhesive capsulitis (frozen shoulder). Cochrane Database of Systematic Reviews 10:CD011324.

Richards B, Whittle S, Buchbinder R, Barrett C, Lynch N, Major G, Littlejohn G, Taylor A and Zochling J. (2014) Australian and New Zealand evidencebased recommendations for pain management by pharmacotherapy in inflammatory arthritis. International Journal of Rheumatic Diseases 17(7):736-46.

Page MJ, McKenzie JE, Green SE, Beaton DE, Jain NB, Lenza M, Verhagen AP, Surace S, Deitch J and B uchbinder R. (2015) Core domain and outcome measurement sets for shoulder pain trials are needed: systematic review of physical therapy trials. Journal of Clinical Epidemiology doi: 10.1016/j.jclinepi.2015.06.006. Petkovic J, Epstein J, Buchbinder R, Welch V, Rader T, Lyddiatt A, Clerehan R, Christensen R, Boonen A, Goel N, Maxwell L, Toupin-April K, De Wit M, Barton J, Flurey C,

Segan J, Staples M, March L, Lassere M, Chakravarty E and Buchbinder R. (2015) Risk factors for herpes zoster in rheumatoid arthritis patients: The role of tumour necrosis factor alpha inhibitors. Internal Medicine Journal 45(3):310-8. Seth R, Kydd ASR, Buchbinder R, Bombardier C and Edwards CJ. (2014) Allopurinol for chronic gout. Cochrane Database of Systematic Reviews 10:CD006077.

Silagy M, O’Bryan E, Johnston R and Buchbinder R. (2014) Autologous whole blood and platelet rich plasma injection for tennis elbow (Protocol) Cochrane Database of Systematic Reviews 2:CD010951. Sim IE, Buchbinder R and Ebeling P. (2014) Bisphosphonates for preventing and treating osteoporosis in men.Cochrane Database of Systematic Reviews 4:CD011074. Singh J, Dohm M, Sprowson A, Wall P, Richards B, Gossec L, Hawker G and Buchbinder R. (2015) Outcome domains and measures in total joint replacement clinical trials: Can we harmonize them? An OMERACT Collaborative Initiative Journal of Rheumatology doi: 10.3899/jrheum.141201 Sivera F, Wechalekar MD, Andrés M, Buchbinder R and Carmona L. (2014) Interleukin-1 inhibitors for acute gout. Cochrane Database of Systematic Reviews 9:CD009993. Sivera F, Andrés M, Carmona L, Kydd A, Moi J, Seth R, Sriranganathan M, van Durme C, van Echteld I, Vinik O, Wechalekar M, Aletaha D, Bombardier C, Buchbinder R, Edwards CJ, Landewé RB, Bijlsma JW, Branco JC, Vargas RB, Catrina AI, Elewaut D, Ferrari AJL, Kiely P, Leeb BF, Montecucco C, Müller-Ladner U, Østergaard M, Zochling J, Falzon L and van der Heijde DM. (2014) Multinational evidence-based recommendations for the diagnosis and management of gout: Integrating systematic literature search and expert opinion of a broad panel of rheumatologists in the 3e initiative. Annals of Rheumatic Diseases 73 (2):328-35. Slade S, Dionne C, Underwood M and Buchbinder R. (2014) Standardised method for reporting exercise programs: Protocol for a Modified Delphi study. BMJ Open 4:e006682. Slade S, Kent P, Bucknall T and Buchbinder R. (2015) Barriers to primary care clinician adherence to clinical guidelines for the management of low back pain: Protocol of a systematic review and meta-synthesis of qualitative studies. BMJ Open 5(4):e007265. Smith E, Hoy D, Cross M, Merriman TR, Vos T, Buchbinder R, Woolf A and March L. (2014) The global

burden of gout: estimates from the Global Burden of Disease 2010 study. Annals of Rheumatic Diseases 73(8):1470-6. Smith E, Hoy D, Cross M, Naghavi M, Vos T, Buchbinder R, Woolf A and March L. (2014) The global burden of other musculoskeletal disorders: estimates from the Global Burden of Disease 2010 study. Annals of Rheumatic Diseases 73 (8):1462-9.

Wechalekar MD, Vinik O, Mio JHY, Sivera F, van Echteld IAAM, can Durme C, Falzon L, Bombardier C, Carmona L, Aletaha D, Landewé, van der Heijde DM and Buchbinder R. (2014) The efficacy and safety of treatments for acute gout: Results from a series of systematic literature reviews Including Cochrane reviews on intraarticular glucocorticoids, colchicine, non-steroidal anti-inflammatory drugs and interleukin-1 inhibitors. Journal of Rheumatology 92:15-25.

Sprowson A, Hadi M, Underwood M, Parsons N, Bucknall T, Costa ML and Buchbinder R. (2014) Periarticular analgesia for postoperative pain following total knee replacement. Cochrane Database of Systematic Reviews 11:CD011328.

Whittle S, Buchbinder R. (2015) In the Clinic: Rotator cuff disease. Annals of Internal Medicine 162(1):ITC1.

van Durme CMPG, Wechalekar MD, Buchbinder R, Schlesinger N, van der Heijde D and Landewé RBM. (2014) Non-steroidal anti-inflammatory drugs for acute gout. Cochrane Database of Systematic Reviews 9:CD010120.

Farrell M, Buchbinder R and Hall W. (2014) Should doctors prescribe cannabinoids? BMJ 348:g2737.

van der Heijde DMFM and Buchbinder R. (2014) Introduction: Diagnosis and management of gout. Systematic literature reviews of the 3e Initiative, 2011–2012. Journal of Rheumatology 92:1-2. van Echteld I, Wechalekar MD, Schlesinger N, Buchbinder R, Aletaha D. (2014) Colchicine for acute gout. Cochrane Database of Systematic Reviews 8: CD006190. Page MJ, Green S, Kramer S, Johnston RV, McBain B, Chau M, Buchbinder R. (2014) Manual therapy and exercise for adhesive capsulitis (frozen shoulder). Cochrane Database of Systematic Reviews 8:CD011275. Vinik O, Wechalekar M, Falzon L, Buchbinder R, van der Heijde D and Bombardier C. (2014) Treatment of asymptomatic hyperuricaemia for the prevention of gouty arthritis, renal disease and cardiovascular events: A systematic literature review. Journal of Rheumatology 92:70-4.

Editorials

Hinman RS, Buchbinder R, Craik R, George S, Maher CG and Riddle D. (2015) Is this a clinical trial? And should it be registered? Physical Therapy 95:810-814.

Book chapters French S, Green S, Buchbinder R and Grimshaw J. (2014) Implementation Research. Grieve’s Modern Musculoskeletal Physiotherapy, 4th edition. Elsevier Limited, Oxford UK.

Reports Buchbinder R, Haines T, Ebeling PR, Day L, Maher C, Lord S, Barker A, Findlay D. (2015) Case for Action – Proposal to NHMRC: Falls and fracture prevention. https://www.nhmrc. gov.au/research/research-translation/research-translationfaculty/ideas-research-translation-faculty-cases.

Cabrini Monash Department of Medical Oncology The Szalmuk Family Department of Medical Oncology Publications

Wall PDH, Brown JS, Parsons N, Buchbinder R, Costa ML and Griffin D. (2014) Surgery for treating hip impingement (femoroacetabular impingement). Cochrane Database of Systematic Reviews 9:CD010796.

Ackerman A, Klein O, McDermott DF, Wang W, Ibrahim N, Lawrence DP, Gunturi A, Flaherty KT, Hodi FS, Kefford R, Menzies AM, Atkins MB, Long GV and Sullivan RJ. (2014)

P U B LI C AT I O N S

Outcomes of patients with metastatic melanoma treated with immunotherapy prior to or after BRAF inhibitors. Cancer 120(11):1695-701. André F, O’Regan R, Ozguroglu M, Toi M, Xu B, Jerusalem G, Masuda N, Wilks S, Arena F, Isaacs C, Yap YS, Papai Z, Lang I, Armstrong A, Lerzo G, White M, Shen K, Litton J, Chen D, Zhang Y, Ali S, Taran T and Gianni L. (2014) Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncology 15(6): 580-91.

Antill YC, Dowty JG, Win AK, Thompson T, Walsh MD, Cummings MC, Gallinger S, Lindor NM, Le Marchand L, Hopper JL, Newcomb PA, Haile RW, Church J, Tucker KM, Buchanan DD, Young JP, Winship IM and Jenkins MA. (2015) Lynch syndrome and cervical cancer. International Journal of Cancer June 137(11):2757-61. Azad AA, Beardsley EK, Hotte SJ, Ellard SL, Klotz L, Chin J, Kollmannsberger C, Mukherjee SD, Chi KN. (2014) A randomised, phase 2 efficacy and safety study of vandetanib (ZD6474) in combination with bicalutamide versus bicalutamide alone in patients with chemotherapy naïve castration-resistant prostate cancer. Investigational New Drugs 32(4):746-52.. Chan MM, Haydu LE, Menzies AM, Azer MW, Klein O, Lyle M, Clements A, Guminski A, Kefford RF and Long GV. (2014) The nature and management of metastatic melanoma after progression on BRAF inhibitors: effects of extended BRAF inhibition. Cancer 120(20):3142-53. Cheah CY, Herbert KE, O’Rourke K, Kennedy GA, George A, Fedele PL, Gilbertson M, Tan SY, Ritchie DS, Opat SS, Prince HM, Dickinson M, Burbury K, Wolf M, Januszewicz EH, Tam CS, Westerman DA, Carney DA, Harrison SJ and Seymour JF. (2014) A multicentre retrospective comparison of central nervous system prophylaxis strategies among patients with high-risk diffuse large B-cell lymphoma. British Journal of Cancer 111(6):1072-9.

Cheah CY, Dickinson M, Hofman MS, George A, Ritchie DS, Prince HM, Westerman D, Harrison SJ, Burbury K, Wolf M, Januszewicz H, Herbert KE, Carney DA, Tam C and Seymour JF. (2014) Limited clinical benefit for surveillance PET-CT scanning in patients with histologically transformed lymphoma in complete metabolic remission following primary therapy. Annals of Hematology 93(7):1193-1200.

Ikeda M, Melichar B, Nemecek R, Ohkawa S, ŚwiebodaSadlej A, Tjulandin SA, Van Cutsem E, Loberg R, Haddad V, Gansert JL, Bach BA and Carrato A. (2015) A phase 3 randomised, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial. Annals of Oncology 26(5):921-7.

Davis ID, Long a, Yip S, Espinoza D, Thompson JF, Kichenadasse G, Harrison M, Lowenthal RM, Pavlakis N, Azad A, Kannourakis G, Steer C, Goldstein D, Shapiro J, Harvie R, Jovanovic L, Hudson AL, Nelson CC, Stockler MR and Martin A. (2015) EVERSUN: A phase 2 trial of alternating sunitinib and everolimus as first line therapy for advanced renal cell carcinoma. Annals of Oncology 26(6):1118-23.

Harrison SJ, Hsu AK, Neeson P, Younes A, Sureda A, Engert A, Prince HM, Li M, Savage P, Bugarini R, Williams D, Squier M and Ritchie DS. (2014) Early thymus and activationregulated chemokine (TARC) reduction and response following panobinostat treatment in patients with relapsed/ refractory Hodgkin lymphoma following autologous stem cell transplant. Leukemia and Lymphoma 55(5):1053-60.

Dickinson M and Prince HM. (2014) Emerging drugs for T-cell lymphoma. Expert Opinion on Emerging Drugs 19(2):201-13.

Harrison SJ, Quach H, Link E, Feng H, Dean J, Copeman M, Van De Velde H, Schwarer A, Baker B, Spencer A, Catalano J, Campbell P, Augustson B, Romeril K and Prince HM. (2015) The addition of dexamethasone to bortezomib for patients with relapsed multiple myeloma improves outcome but ongoing maintenance therapy has minimal benefit. American Journal of Hematology 90(5):E86-91.

Ellem SJ, Taylor RA, Furic L, Larsson O, Frydenberg M, Pook D, Pedersen J, Cawsey B, Trotta A, Need E, Buchanan G and Risbridger GP. (2014) A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment. Journal of Pathology 234(1):86-98. Field K, Shapiro J, Wong HL, Tacey M, Nott L, Tran B, Turner N, Ananda S, Richardson G, Jennens R, Wong R, Power J, Burge M and Peter Gibbs. (2014) Treatment and outcomes of metastatic colorectal cancer in Australia: Defining differences between public and private practice. Internal Medicine Journal 45(3):267-74. Fleming S, Harrison SJ, Blombery P, Joyce T, Stokes K, Seymour JF, Prince HM and Ritchie D. (2014) The choice of multiple myeloma induction therapy affects the frequency and severity of oral mucositis after melphalanbased autologous stem cell transplantation. Clinical Lymphoma, Myeloma and Leukemia 14(4):291-6. Fuchs CS, Azevedo S, Okusaka T, Van Laethem JL, Lipton L, Riess H, Szczylik C, Moore MJ, Peeters M, Bodoky G,

Herbert KE, Demosthenous L, Wiesner G, Link E, Westerman DA, Came N, Ritchie DS, Harrison S, Seymour JF and Prince HM. (2014) Plerixafor plus pegfilgrastim is a safe, effective mobilization regimen for poor or adequate mobilizers of hematopoietic stem and progenitor cells: a phase I clinical trial. Bone Marrow Transplant 49(8):1056-62. Hughes CF, Khot A, McCormack C, Lade S, Westerman DA, Twigger R, Buelens O, Newland K, Tam C, Dickinson M, Ryan G, Ritchie D, Wood C and Prince HM. (2015) Lack of durable disease control with chemotherapy for mycosis fungoides and Sézary syndrome: a comparative study of systemic therapy. Blood 125(1):71-81. Klein O, Davis ID, McArthur GA, Chen L, Haydon A, Parente P, Dimopoulos N, Jackson H, Xiao K, Maraskovsky E, Hopkins W, Stan R, Chen W and Cebon J. (2015) Lowdose cyclophosphamide enhances antigen-specific CD4(+) T cell responses to NY-ESO-1/ISCOMATRIX™

vaccine in patients with advanced melanoma. Cancer Immunology, Immunotherapy 64(4):507-18. Kothari N, Kim R, Jorissen RN, Desai J, Tie J, Wong HL, Farragher I, Jones I, Day FL, Li S, Sakthinandeswaren A, Palmieri M, Lipton L, Schell M, Teer JK, Shibata D, Yeatman T, Sieber OM, Gibbs P and Tran B. (2015) Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation. Acta Oncologica 54(4):487-92. Lung MS, Trainer AH, Campbell I and Lipton L. (2015) Familial colorectal cancer. Internal Medicine Journal 45(5):482-91. Monk BJ, Poveda A, Vergote I, Raspagliesi F, Fujiwara K, Bae DS, Oaknin A, Ray-Coquard I, Provencher DM, Karlan BY, Lhommé C, Richardson G, Rincón DG, Coleman RL, Herzog TJ, Marth C, Brize A, Fabbro M, Redondo A, Bamias A, Tassoudji M, Navale L, Warner DJ and Oza AM. (2014) Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial. Lancet Oncology 15(8):799-808. Parakh S, Wong H, Rai R, Ali S, Field K, Shapiro J, Wong R, Nott L, Gibbs P and Yip D. (2015) Patterns of care and outcomes for elderly patients with metastatic colorectal cancer in Australia. Journal of Geriatric Oncology doi:10.1016/j.jgo.2015.06.001. Price TJ, Segelov E, Burge M, Haller DG, Tebbutt NC, Karapetis CS, Punt CJ, Pavlakis N, Arnold D, Gibbs P and Shapiro JD. (2014) Current opinion on optimal systemic treatment for metastatic colorectal cancer: outcome of the ACTG/AGITG expert meeting ECCO 2013. Expert Review of Anticancer Therapy 14(12):1477-93. Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbé C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Arance A, Schmidt H, Schadendorf D, Gogas H, Lundgren-Eriksson L, Horak C,

Sharkey B, Waxman IM, Atkinson V and Ascierto PA. (2015) Nivolumab in previously untreated melanoma without BRAF mutation. New England Journal of Medicine 372(4):320-30. Roohullah A, Wong HL, Sjoquist KM, Gibbs p, Field K, Tran b, Shapiro j, Mckendrick J, Yip D, Nott L, Gebski V, Ng W, Chua W, Price T, Tebbutt N and Chantrill L. (2015) Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab. World Journal of Gastroenterology 21(17):5352-8. Segelov E, Chan D, Shapiro J, Price TJ, Karapetis CS, Tebbutt NC and Pavlakis N. (2014) The role of biological therapy in metastatic colorectal cancer after first-line treatment: a meta-analysis of randomised trials. British Journal of Cancer 111(6):1122-31.

forms across five Victorian health services. Internal Medicine Journal 44(7):671-675. Levinson M and Mills A. (2015) Letter to the Editor: Cardiopulmonary arrest and mortality trends, and their association with rapid response system expansion. Medical Journal of Australia 202(1):19. Mills A, Gellie A and Levinson MR. (2014) A changing view of death. Hektoen International: A Journal of Medical Humanities 7(4). Rose M, Pan HM, Levinson MR, Staples M, Stephenson G. (2014) Can frailty predict complicated care needs and length of stay? Internal Medicine Journal 44(8):800-5.

Conference presentations Stirling RG, Evans SM, McLaughlin P, Senthuren M, Millar J, Gooi J, Irving L, Mitchell P, Haydon A, Ruben J, Conron M, Leong T, Watkins N and McNeil JJ. (2014) The Victorian Lung Cancer Registry pilot: improving the quality of lung cancer care through the use of a disease quality registry. Lung 192(5):749-58. Wong HL, Field K, Harol M, Tran B, Tie J, Shapiro J, Wong R, Yip D, Nott L, Richardson G, McKendrick J and Gibbs P. (2014) Resection of colorectal cancer metastases in routine practice. European Journal of Cancer 50:e62.

Cabrini Monash University Department of Medicine Publications Gellie A, Mills A, Levinson MR, Stephenson G and Flynn E. (2015) Death: A foe to be conquered? Questioning the paradigm? Age and Ageing 44(1):7-10. Levinson MR and Mills A. (2014) Cardiopulmonary resuscitation – time for a change in the paradigm? Medical Journal of Australia 201(3):152-154. Levinson MR, Mills A, Hutchinson AM, Heriot, G and Gellie A. (2014) Comparison of not for resuscitation (NFR)

Gellie A, Mills A, Levinson M, Stephenson G and Flynn E. Death: A foe to be conquered? Questioning the paradigm. Presented at Cabrini Research Day, Melbourne, October 2014. Khine T, Mills, A, Levinson M, Abbinga, S. Diagnosing Delirium in very Elderly ICU Patients. Presented at Australian and New Zealand Society for Geriatric Medicine (ANZSGM) Conference, Perth, May 2015. Levinson M. Advance care plans and resuscitation orders: A multicentred point prevalence review in five Victorian health services. Presented at Royal Melbourne Hospital Grand Round, Melbourne, November 2014. Levinson M, Mills A, Stephenson G, Gellie A, Heriot G and Hutchinson A. Comparison of not-for-resuscitation (NFR) forms across five Victorian health Services. Presented at Internal Medicine Society of Australia and New Zealand (IMSANZ) Annual Conference, Adelaide, September 2014. Levinson M, Mills A, Sritharan G and Gellie A. Doctors attitudes towards not for resuscitation orders. Presented at Royal Australasian College of Physicians (RACP) Annual Conference, Cairns, May 2015.

P U B LI C AT I O N S

Mills A, Gellie A, Heriot G, Hutchinson A, Levinson M, Newnham H, Robertson M, Stephenson G and Walker A. Standard 9: Advanced Care Plans and Resuscitation Orders. How do we rate? Presented at Australian Association of Gerontology (AAG) National Conference, Adelaide, November 2014. Rouse A and Levinson MR. How are you? Questions at the bedside. Presented at the International Conference on Conversational Analysis, University of California, Los Angeles, Los Angeles, June 2014.

Cabrini Centre for Nursing Education and Research Publications 64

Johnson M, Boyd L, Grantham H and Eastwood K. (2015) Paramedic principles and practice ANZ: A clinical reasoning approach, Elsevier, New South Wales.

Gheradin E. Improving recognition and response to patient deterioration: an educational model for ward nurses. Presented at Australia and New Zealand Intensive Care Society (ANZICS) Safety and Quality Conference, Melbourne, July 2014. Gomez Y, Seletto K, Wong E, O’Reilly M, Wilke A and McGinness, C. Documentation of antimicrobial therapy in haematology and oncology – A nursing-led antimicrobial stewardship intervention pilot project.Presented at Clinical Oncology Society of Australia’s (COSA) 41st Annual Scientific Meeting, Melbourne, December 2014. Johnson M, Miller J and Boyd L. Improving CPR performance using in-situ simulation. Presented at SimHealth, Adelaide, August 2014.

Quinn C and King R. (2015) Developing a Professional Development PLAN. Australian Midwifery News 15(1):24-25.

Johnson M, Warren T, Peat A and Boyd L. Patient Safety: Utility of simulation to prepare undergraduate nurses for clinical placements. Presented at SimHealth, Adelaide, August 2014.

Sheen J, McGillivray J, Gurtman C and Boyd L. (2015) Assessing the clinical competence of psychology students through Objective Structured Clinical Examinations (OSCEs): student and staff views. Australian Psychologist 50:51-59.

Johnson M, Miller J and Boyd L. Big data, lower costs, better outcomes. A review of a patient safety implementation at a large private hospital. Presented at Users Network Conference, Gold Coast, May 2015.

Conference presentations

Johnson M, Miller J and Boyd, L. Self-directed CPR program leads to improved outcomes for lower cost. Presented at NZ Association of Simulation in Health Care, Auckland, June 2015.

Clarke A. Collaboration and development of simulation resources between healthcare and education providers in the Southern Metropolitan and Mornington Peninsula regions. Presented at Sim Health, Adelaide, August 2014. Driver A, Schlieff J and Boyd L. Using the quality cycle to enhance patient centred care. Presented at 20th WCET (World Council of Enterostomal Therapists) Conference, Gothenburg, Sweden, June 2014.

Patterson E, Boyd L and Mnatzaganian G. The impact of undergraduate University Fellowship Programs on the perceptions of work readiness among new graduate nurses: A systematic review. Presented at Cabrini Research Day, Melbourne, October 2014.

Durston V, Flanagan, B Murphy and Connolly L. Cabrini Breast Cancer Service: Evaluation of a best practice model in a private hospital setting. Presented at 18th Cancer Nurses Society of Australia Winter Congress, Perth, June 2015.

Peat A, Johnson M and Warren T. Man versus Machine: A comparison of assessment of chest compressions by trained assessors compared with mannequin recording. Presented at Sim Health, Adelaide, August 2014.

Peat A, Johnson M and Warren T. CPR performance of accredited nurses at the end of the 12-month training cycle. December 2014. Peat A, Johnson M and Warren T. Accuracy of trained assessors in determining CPR quality. Presented at Catholic Health Australia, Melbourne, November 2014. Peat A, Johnson M and Warren T. Man vs. Machine: A comparison of assessment of chest compressions by trained assessors compared with mannequin recording. Presented at 15th International Meeting on Simulation in Healthcare, New Orleans, January 2015. Schlieff J, Peat A, Johnson M and Boyd, L. “You Had Me at Hello”. A Patient Centric Approach to Teaching IV Cannulation Using Hybrid Simulation – A pilot study. Presented at Sim Health, Adelaide, August 2014. Schlieff J, Peat A, Johnson M and Boyd L. A patient centred approach to teaching clinical skills – A pilot study. Presented at ACU Simulation Showcase, Brisbane, December 2014. Sherman K. From Chaos to Calm: A new model of care for Children’sPre/Post. Presented at Cabrini Research Day, Melbourne, October 2014. Sherman K. The CNS model in the Children’s Centre. Presented at Clinical Nurse Specialist Planning Day, Melbourne, November 2014. Sherman K. From Chaos to Calm: A new model of care for Children’s Pre/Post. Presented at Catholic Health Australia Symposium, November 2014.

Cabrini Monash University Department of Surgery The Frölich West Chair of Surgery Publications Bell S, Carne P, Chin M and Farmer C. (2014) Establishing a robotic colorectal surgery programme. ANZ Journal of Surgery 85(4):214-216.

Buxey KN, Sia C, Bell S, Wale R, Wein D and Warrier S. (2014) Clostridium colitis : challenges in diagnosis and treatment. ANZ Journal of Surgery doi: 10.1111/ans.12840.

Szalmuk Family Psycho-oncology Unit

Buxey K and Ranchod P. (2015) Transrectal negative pressure sponge treatment of full-thickness rectal perforation. ANZ Journal of Surgery 85(9):691-692.

Beasley E, Brooker J, Warren N, Fletcher J, Boyle C, Ventura A and Burney S. (2015) The lived experience of volunteering in a palliative care biography service. Palliative and Supportive Care 13(5):1417-1425.

McMurrick PJ, Oliva K, Carne P, Reid C, Polglase A, Bell S, Farmer KC and Ranchod P. (2014) The first 1000 patients on an internet-based colorectal neoplasia database across private and public medicine in Australia: development of a Binational model for the Colorectal Surgical Society of Australia and New Zealand. Dis Colon Rectum 2014 Feb; 57(2) :167 -173 Hall DJ, Farmer KC, Roth HS and Warrier SK (2014) Transanal endoscopic microsurgery colorectal anastomosis : a critical step to natural orifice colorectal surgery in humans. Dis Colon Rectum April 57(4): 549 -52 Loon K, Wilkins S, Oliva K, Carne P, Fock A, Frawley G, Polglase A and McMurrick P. (2014) Hyperbaric oxygen for anastomotic complications following low anterior resection: A report of five cases. International Journal of Colorectal Disease 29:1579-1581. Fung KYC, Tabor B, Buckley MJ, Priebe IK, Purins L, Pompeia C, Brierley GV, Lockett T, Gibbs P, Tie J, McMurrick P, Moore J, Ruszkiewicz A, Nice E, Adams TE, Burgess A and Cosgrove LJ. (2015) Blood based protein biomarker panel for the detection of colorectal cancer. PLOS One 10(3):e0120425. Jarde T, Kass L, Staples M, Lescesen H, Carne P, Oliva K, McMurrick P and Abud H. (2015) ERBB3 positively correlates with intestinal stem cell markers but marks a distinct non proliferative cell population in colorectal cancer. PLOS One 10(9):e0138336.

Publications

Brooker J, Webber L, Julian J, Shawyer F, Graham A, Chan J and Meadows G. (2014) Mindfulness-based training shows promise in assisting staff to reduce their use of restrictive interventions in residential services. Mindfulness, 5(5), 598-603. Chirayil E, Thompson C and Burney S. (2014) Predicting human papilloma virus vaccination and pap smear screening intentions among young Singaporean women using the theory of planned behaviour. SAGE Open 4(4):2158244014554961. Kearns N, Shawyer F, Brooker J, Graham A, Enticott J, Martin P and Meadows G. (2015) Does rumination mediate the relationship between mindfulness and depressive relapse? Psychology and Psychotherapy: Theory, Research and Practice. doi:10.1111/papt.12064. O’Callaghan C, Michael N, Brooker J, Walker H, Hiscock R and Phillips D. (2015)Introducing a model incorporating early integration of specialist palliative care: A qualitative study of staff’s perspectives. Palliative Medicine doi: 0269216315598069. Robinson S, Kissane D, Brooker J and Burney S. (2014). A review of the construct of demoralization: History, definitions, and future directions for palliative care. American Journal of Hospice and Palliative Medicine doi: 1049909114553461 Robinson S, Kissane D, Brooker J and Burney S. (2015). A systematic review of the demoralization syndrome in individuals with progressive disease and cancer: A decade of research. Journal of Pain and Symptom Management 49(3):595-610.

Shand LK, Brooker J, Burney S, Fletcher J and Ricciardelli LA. (2015) Symptoms of posttraumatic stress in Australian women with ovarian cancer. Psycho-Oncology 24(2):190-196. Shand LK, Cowlishaw S, Brooker J, Ricciardelli LA and Burney S. (2015). Correlates of posttraumatic stress disorder symptoms and posttraumatic growth in cancer patients: A systematic review and meta-analysis. Psycho-Oncology 24(6):624-634.doi: Yuen E, Knight T, Dodson S, Ricciardelli L, Burney S and Livingston P. (2014). Development of the Health Literacy of Caregivers Scale - Cancer (HLCS-C): Item generation and content validity testing. BMC Family Practice 15:202.

Other publications Brooker J. (2015) Mindfulness and wellbeing: An introduction. Acoustic Neuroma Association Australia newsletter. Burney S. (2014) Grief and loss − Losing a limb (Part 1). Limbs4 Life newsletter.

Conference presentations Thirteen presentations were given at a diverse range of local and overseas conferences including the Australian Psychological Society Health Psychology Conference, Cabrini Research Day, Asia Pacific Hospice Conference, World Congress of Psycho-oncology, Clinical Oncology Society of Australia Annual Scientific Meeting and Palliative Care Victoria Conference.

Allied Health Research Publications Brusco NK, Taylor NF, Watts JJ and Shields N. (2014) Does additional acute phase inpatient rehabilitation help people return to work? A subgroup analysis from a randomized controlled trial. Clinical Rehabilitation 28(8):754-761.

P U B LI C AT I O N S

Brusco NK, Watts JJ, Shields N and Taylor NF. (2015) Is cost effectiveness sustained after weekend inpatient rehabilitation? 12 month follow up from a randomized controlled trial. BMC health services research, 15(1), 165. Brusco NK, Watts JJ, Shields N and Taylor NF. (2014) Are weekend inpatient rehabilitation services value for money? An economic evaluation alongside a randomized controlled trial with a 30 day follow up. BMC Medicine 12:89.

Dumoulin C, Alewijnse D, Bo K, Hagen S, Stark D, van Kampen M, Herbert J, Hay-Smith J, Frawley HC, McClug D and Dean S. (2015) Pelvic-Floor-Muscle Training Adherence: Tools, Measurements and Strategies - 2011 ICS State-of-the-Science Seminar Research Paper II of IV. Neurology and Urodynamics 34(7):615-621. Dumoulin C, Hay-Smith J, Frawley HC, McClurg D, Alewijnse D, Bo K, Burgio K, Chen SY, Chiarelli P, Dean S, Hagen S, Herbert J, Mahfooza A, Mair F, Stark D and van Kampen M. (2015) 2014 consensus statement on improving pelvic floor muscle training adherence: International Continence Society 2011 State-of-the-Science Seminar. Neurology and Urodynamics 34(7):600-605. Ferreira C, Dwyer P, Davidson M, de Souza A, Ugarte J and Frawley HC. (2015) Does pelvic floor muscle training improve female sexual function? A systematic review International Urogynecology Journal doi: 10.1007/s00192-015-2749-y. Jackson A, Frydenberg E, Liang R, Higgins RO and Murphy B. (2015) Familial impact and coping with child heart disease: A systematic review. Pediatric Cardiology 36(4):695-712. Frawley HC, McClurg D, Mahfooza A, Hay-Smith J and Dumoulin C. (2015) Health professionals’ and patients’ perspectives on pelvic floor muscle training adherence - 2011 ICS State-of-the-Science Seminar research paper IV of IV. Neurology and Urodynamics 34(7):632-639.

ICS State-of-the-Science Seminar research paper III of IV. Neurology and Urodynamics 34(7):622-631.

Australasian Rehabilitation Conference, Adelaide, September 2014.

Jackson A, Frydenberg E, Liang R, Higgins RO and Murphy B. (2015) Familial impact and coping with child heart disease: A systematic review. Pediatric Cardiology 36(4):696-712.

Davidson MJ, Bryant AL and Frawley HC. Muscle stiffness and pain in women with vulvodynia. Presented at International Association for the Study of Pain, Buenos Aires, Argentina, October 2014.

Lin KY, Granger C, Denehy L and Frawley HC. (2014) Pelvic floor muscle training for bowel dysfunction following colorectal cancer surgery: a systematic review. Neurourology and Urodynamics doi: 10.1002/nau.22654.

Davidson MJ, Bryant AL and Frawley HC. Muscle stiffness and pain in women with vulvodynia. Presented at World Confederation of Physical Therapy Congress, Singapore, May 2015.

McClurg D, Frawley HC, Hay-Smith J, Dean S, Chen SY, Chiarelli P, Mair F and Dumoulin C. (2015) Scoping review of adherence promotion theories in pelvic floor muscle training - 2011 ICS State-of-the-Science Seminar research paper I of IV. Neurourology and Urodynamics 34(7):606-614.

Davidson MJ, Bryant AL and Frawley HC. Perineal muscle stiffness in women with and without vulvodynia: Reliability of measurement. Presented at International Continence Society, Rio de Janeiro, Brazil, October 2014.

Radia-George C, Imms C and Taylor N. (2014) Interrater reliability and clinical utility of the Personal Care Participation Assessment and Resource Tool (PC-PART) in an inpatient rehabilitation setting. American Journal of Occupational Therapy 68(3):334-343.

Book chapters Bo K and Frawley HC. (2015) Pelvic floor muscle training for pelvic organ prolapse. Evidence based physical therapy for the pelvic floor, 2nd edition. Elsevier, London UK. Frawley HC. (2015) Pelvic Floor Muscle Pain. Abdominal and Pelvic Pain: From Definition to Best Practice. Wolters Kluwer Health, Philadelphia USA. Frawley HC. (2015) Pelvic pain. Evidence based physical therapy for the pelvic floor, 2nd edition. Elsevier, London UK.

Ferreira CH, Dwyer PL, Davidson M, De Souza A, Ugarte JA and Frawley HC. The effect of pelvic floor muscle training on female sexual function: A systematic review. Presented at World Confederation of Physical Therapy Congress, Singapore, May 2015. Frawley HC. An update on pelvic organ prolapse management: Physiotherapy perspective. Presented at Australian Physiotherapy Association Continence and Women’s Health Group Victorian Brach Annual Seminar, Melbourne, November 2014. Frawley HC. Physiotherapy perspective of pelvic pain following mesh. Presented at Joint meeting: Continence Foundation of Australia and Urogynaecological Society of Australasia, Cairns, September 2014. Frawley HC. POPPY (Pelvic Organ Prolapse Physiotherapy) UK & Australia: Results from the multi-centre trials. Presented at International Symposium of Physiotherapy in Women’s Health, São Paulo, Brazil, October 2014.

Conference presentations Hay-Smith J, Dean S, Burgio K, McClurg D, Frawley HC and Dumoulin C. (2015) Pelvic-floor-muscle-training adherence “modifiers”: A review of primary qualitative studies - 2011

Brusco T, Taylor N, Watts J and Shields N. Are weekend rehabilitation services value for money? Presented at

Frawley HC. Uptake of antepartum continence screening and pelvic floor muscle exercise instruction by maternity care providers: an implementation project. Presented at

International Symposium of Physiotherapy in Women’s Health, São Paulo, Brazil, October 2014. Frawley HC, Chiarelli P and Gunn J. Uptake of antepartum continence screening and pelvic floor muscle exercise instruction by maternity care providers: an implementation project. Presented at International Continence Society, Rio de Janeiro, Brazil, October 2014. Frawley HC, McClurg D and Dumoulin C. Consensus statement of improving pelvic-floor-muscle-training adherence. Presented at International Continence Society, Rio de Janeiro, Brazil, October 2014. Gojanovic M. Malnutrition in Victorian Cancer Services Phase II study: To identify the risk and prevalence of malnutrition in colorectal cancer patients from diagnosis to 30 days postsurgical intervention. Presented at Cabrini Research Day, Melbourne, October 2014. Hay-Smith EJ, Dean S, Frawley HC and McClurg D. Exercise adherence: Integrating theory, evidence and behaviour change techniques. Presented at World Confederation of Physical Therapy Congress, Singapore, May 2015.

Higgins R, Murphy B, Page K, Holloway E and Jackson A. Cardiac blues: A translational research project to support emotional recovery after a cardiac event. Presented at Australian Psychological Society, College of Health Psychologists Scientific conference, Sydney, April 2015. Higgins R, Murphy B and Jackson A. The “Beatings Heart Problems Program”: from evidence to practice: a translational research project. Presented at Australian Disease Management Association, Melbourne, March 2015. Higgins R, Murphy B and Jackson A. Cardiac rehabilitation programs, a closer look: A national survey of cardiac rehabilitation coordinators. Presented at Australian Cardiovascular Health and Rehabilitation Conference, Sydney, August 2014. Ludwik C, Mills T and Frawley HC. The prevalence of bladder and bowel symptoms experienced by men and women seeking treatment for general chronic pain. Presented at World Confederation of Physical Therapy Congress, Singapore, May 2015.

Higgins H. Self-management: Evidence to practice. Presented at Westmead Hospital Week Allied Health Conference, Sydney, August 2014.

McClurg D, Frawley HC, Hay-Smith J, Dean S, Chen SY, Chiarelli P and Dumoulin C. Limited effects from limited adherence: Using behavioural therapy to underpin pelvic floor muscle training programs and outcomes. Presented at World Confederation of Physical Therapy Congress, Singapore, May 2015.

Higgins H. Supporting self-management in patients with heart disease. Presented at Heartbeat Cabrini Annual General Meeting, Melbourne, October 2014.

Morris M. Large randomised controlled trials on Parkinson’s disease. Presented at International Society of Posture & Gait Research, Seville, Spain, July 2015.

Higgins H. Doing self-management better: Evidence to practice. Presented at Victorian Association of Cardiac Rehabilitation State Conference, Melbourne, October 2014.

Raymond J. Communication and speech in Parkinson’s Disease. Presented at Parkinson’s Victoria Living Well Seminar, Melbourne, September 2014.

Higgins R and Holloway E. Improving heart failure services in Victoria: A capacity-building initiative. Presented at Australian Cardiovascular Health and Rehabilitation Conference, Sydney, August 2014.

DEVELOPING RESEARCH UNITS Publications Michael N, O’Callaghan C, Baird A, Gough K, Krishnasamy M, Hiscock N and Clayton J. (2015) A mixed methods feasibility study of a patient- and family-centred advance care planning intervention for cancer patients. BMC Palliative Care 14:27. Michael N, O’Callaghan C, Brooker JE, Walker H, Hiscock R and Phillips D. (2015) Introducing a model incorporating early integration of specialist palliative care: A qualitative research study of staff’s perspectives. Palliative Medicine, doi: 0269216315598069. O’Callaghan C, Schofield P, Butow P, Nolte L, Price M, Tsintziras S, Sze M, Thein T, Yiu D, Mireskandari S, Goldstein D and Jefford M. (2015) “I might not have cancer if you didn’t mention it”: a qualitative study on information needed by culturally diverse cancer survivors. Support Cancer Care doi: 10.1007/s00520-015-2811-9. Sulistio M, Franco M, Vo A, Poon P and William L. (2015) Hospital rapid response team and patients with life-limiting illness: A multicentre retrospective cohort study. Palliative Medicine, 29(4):302-309.

Cabrini Institute Council The Cabrini Institute Council is responsible for developing, supporting and promoting the clinical education and research activities of Cabrini. The group brings a broad range of clinical and managerial experience to the Cabrini Institute Council’s governance role.

Professor Peter Fuller AM Member since June 2005, Chair from May 2014 Peter is National Health and Medical Research Council Senior Principal Research Fellow at Prince Henry’s Institute of Medical Research in Melbourne where is Associate Director and Head of the Steroid Receptor Biology Group. He is Director of the Endocrinology Unit at Southern Health and Adjunct Professor in Medicine and Biochemistry and Molecular Biology at Monash University. Peter’s research interests include understanding the molecular mechanisms of adrenal steroid hormone action and the molecular pathogenesis of endocrine tumours.

Associate Professor Leanne Boyd Invitee from September 2014, Member since September 2015 Leanne leads the Cabrini Institute, having joined the Executive Committee in August 2014 as Executive Director of Nursing and Cabrini Institute. She has a clinical background in critical care and began working at Cabrini in 2012 as Director of Education and Staff Development. Leanne has more than 20 years’ experience in health professional education. Previously, she worked at Monash University as Director of Academic Programs (Middle East) and Head of Department Community Emergency Health and Paramedic Practice. Leanne holds postgraduate qualifications in education and critical care from Monash University and a Master of Tertiary Education Management from the University of Melbourne.

Jennifer Burden Invitee since November 2005, retired March 2015 Jennifer, who has a background in medical research and clinical science, joined Cabrini in 2005 and was Manager of the Cabrini Institute for nine years. This role included organising the annual Cabrini Research Day and liaising with donors who support the research work of Cabrini Institute and fund education scholarships for Cabrini staff. In March 2015, she took up the role of Manager, Human Research Ethics Committee and Research Governance. Jennifer has a Bachelor of Science from Deakin University.

Judith Day Member since January 2006, retired May 2015 Judith is a Certified Practising Accountant and has a Master of Business Administration from the University of Adelaide. Judith has 17 years’ experience in the health sector. Previously, she was Director of Finance and Administration at St Andrew’s Hospital in Adelaide. Prior to that, she worked in various roles at Faulding Healthcare, Flinders Medical Centre and Ashford Community Hospital.

Sue James Invitee from July 2010, retired March 2015 Sue is responsible for the strategic development of the Cabrini Foundation’s philanthropic fundraising to support the work of Cabrini. Sue has worked in the not-for-profit sector in fundraising, marketing and communication roles. Sue is committed to the ongoing professional development of fundraisers and has presented at both national and state professional development conferences. She is a Fellow of the Fundraising Institute of Australia.

Sam Low Invitee from May 2015 As Cabrini’s Finance and Treasury Manager, Sam is responsible for Cabrini’s financial accounting, compliance and treasury. He has been a Chartered Accountant for 12 years and has a Graduate Diploma in Applied Finance from the Financial Services Institute of Australasia. Previously, he was the Corporate Finance Manager at a national logistics company jointly owned by Australia Post and Qantas. Prior to that, he worked at Deloitte, a professional services firm.

C A B R I N I I N S T IT U T E CO U N C I L

Kellie-Ann Jolly Member since September 2012 Kellie-Ann Jolly began her professional career as a dental therapist in the School Dental Service. A Post Graduate Diploma in Health Promotion followed by Masters in Health Sciences (Health Promotion) led to her move into health promotion where she remained for over 18 years. Her health promotion roles have included senior policy advisor with the Victorian Department of Health, tertiary lecturer in health promotion, and Director Physical Activity and Healthy Eating at the Victorian Health Promotion Foundation (VicHealth). Since August 2008, Kellie-Ann has been the Director Cardiovascular Health at the Heart Foundation (Victoria) where she manages the health programs which aim to prevent death and disability from heart disease.

Associate Professor Doug Lording Member since September 2008 Doug is an endocrinologist and andrologist in private practice at Cabrini. From 1992-2007, he was Medical Director at Cabrini. His specialities include diabetes, general endocrinology and male reproductive medicine. Doug has extensive clinical trial experience and is an Honorary Clinical Associate Professor of Medicine at Monash University. He is a Fellow of the Royal Australasian College of Physicians, a Board member of Andrology Australia and a member of the scientific advisory committee for Foundation 49: Menâ&#x20AC;&#x2122;s Health.

Dr Peter Lowthian Invitee since February 2002, retired September 2014 Peter was Executive Director of the Cabrini Institute from 2002 until 2014 when he was appointed Executive Director of Medical Services. He is a practising rheumatologist and a graduate of Monash University. Peter is a Fellow of the Royal Australasian College of Physicians, of the Australian Faculty of Rehabilitation Medicine, of the Royal College of Physicians London and of the Royal Australian College of Medical Administrators.

Jeremy McCarthy Member since February 2007 Jeremy is a partner at national law firm, HWL Ebsworth in its mergers and acquisitions group in Melbourne. He has extensive experience in corporate governance and general commercial matters and has drafted a broad range of commercial contracts. Jeremy advises clients in a range of industries, in particular the health sector.

Professor Meg Morris Member since February 2015 Professor Meg Morris is a physiotherapist and fellow of the Australian College of Physiotherapists. She is Head of the School of Allied Health at La Trobe University, an Honorary Professor at Cabrini and an Honorary Professor at Melbourne Health. She is an international expert in ageing and neurological conditions such as Parkinson’s disease and is widely published. Professor Morris is known for her work on physical activity, exercise and dancing for people with Parkinson’s disease, as well as physical activities and strength training. She has strong international research collaborations in Italy, Ireland and Singapore.

Professor Robyn O’Hehir Member since November 2010 Robyn is Professor and Director of Allergy, Immunology and Respiratory Medicine, the Alfred and Central Clinical School, Monash University. She is Deputy Head (Clinical), Central Clinical School, Monash University and Deputy Head Research, Alfred Health. Robyn is a consultant physician, educator and researcher in allergy and antiinflammatory therapies and has won continuous grant support from the National Health and Medical Research Council. Robyn is editor Clinical and Experimental Allergy, Life Governor of Asthma Victoria and a member of Council of the Sir Robert Menzies Memorial Foundation.

C A B R I N I I N S T IT U T E CO U N C I L

Associate Professor John Santamaria Member since August 1996 John is the Director of St Vincent’s Hospital Melbourne’s intensive care unit. He is National and State President of the Australian and New Zealand Intensive Care Society. John is Chair of the Cabrini Health Ethics Committee and is a member of the Cabrini Patient Experience and Clinical Governance Committee. John was a member of the Cabrini Board of Directors for many years and served as Vice Chairman from September 2005 until October 2009.

Dr Michael Walsh Member since December 2008 Michael has more than 25 years’ experience in hospital and health administration in Australia, the UK and the Middle East. He is a medical graduate of Monash University and holds a Master of Public Administration from the Kennedy School of Government, Harvard University. Michael is a Fellow and current Vice President of the Royal Australasian College of Medical Administrators and a Fellow of the Australasian College of Health Service Managers. He is a member of the Catholic Health Australia Stewardship Board and chairs the Health Policy Sub-Committee. Michael serves on the Federal Government to Australia’s Independent Hospital Pricing Authority Board.

Professor Neville Yeomans Member since February 2010 Neville is Director of Research at Austin Health and Emeritus Professor of Medicine (previously Foundation Dean) in the School of Medicine, University of Western Sydney. He is a gastroenterologist and a fellow of the Royal Australasian College of Physicians, American College of Gastroenterology and American Gastroenterological Association. Neville’s research has been mainly into the biology and pathology of the gastric mucosa, pharmacology of acid-related diseases and recently, medical education.

C A BR I NI S U P P ORTE R S Founding Institute Donors

Heartbeat Cabrini Inc.

Mr Angus Mackay

Cabrini Hospital

Mr Alan Jackson AO & Mrs Esme Jackson

Mr Louis Mangan AO & Cecile Mangan

Cabrini Hospital Medical Staff

Alan Jackson Nursing Research Fellow

The McMurrick Family

Cabrini Pharmacy

Mr John Laidlaw OAM & Mrs Betty Laidlaw

Mr & Mrs Mark Newman

Construction Engineering (Aust) Pty Ltd

Mr David Mandie AM OBE

Richard & Dorothea Nossbaum

Corrs Chambers Westgarth

Pfizer Australia Pty Ltd

Ostomy Association of Melbourne Inc

CWB Australia Ltd

The Sambor Family

Nigel Peck AM & Patricia Peck

The Gandel Charitable Trust

The Moniek Sambor Family Memorial Research Fund

Alan, Ahda & Evi Selwyn Family

Dr Romayne Holmes

The Simonds Family

Richard Smith

The Lording Family

The Stewardson Charitable Trusts

Melbourne Pathology

Mr George & Mrs Mira Szalmuk

Dr Frank Panetta

Szalmuk Family Department of Medical Oncology

Mr Denzil & Mrs Sylvia Pinto

Mrs Anne Wollach-Szalmuk

The Polglase Family

Mr Geoff Szalmuk

Radclin Medical Imaging

Mrs Simone Singer-Szalmuk

Safetell International

Dr David & Mrs Lisa Thurin

Schering Australia Pty Ltd

Mr & Mrs Joseph & Helena Fröhlich West

Tattersall’s, The Estate of the Late George Adams

Fröhlich West Chair of Surgery

Drs Victor & Karen Wayne

Fellows Associated Retailers Limited The Bachrach Charitable Trust In Memory of Jan Bucknall Charter Security Group The Alfred & Jean Dickson Foundation The Fryer Family Brian H Gillies Travel Scholarship for Palliative Care Nurses Prue Gillies

Partners

Geoff and Helen Handbury Foundation

The Michael & Andrew Buxton Foundation

Mr & Mrs Higgins

Bensons Group of Companies

Mrs Kerrie Hunter & Family

Cabrini Medical Staff

Susan Kavals Memorial

Construction Engineering (Aust) Pty Ltd

Mrs Dinah Krongold & Family

Companions

Marc & Bev Fookes

Dr Laurence LeWinn Foundation

Aventis Pharma Pty Ltd

Charles Holckner & Family − In Memory Of Lily

Kylie Minogue OBE

Mr John Gandel AO & Mrs Pauline Gandel

HD & KM Johnston

Richard & Susan Mizgala

Mr Ian & Mrs Linda Gandel

Jreissati Foundation

Frank O’Shea OAM

Ms Michelle Gandel

Peter Meese Cancer Nursing Fund

Mayer Page Research Fellow

Mr Tony & Mrs Helen Gandel

Mr David & Mrs Barbara MacDonald

The Family of Duncan Powers

In Memory of Sir Edward Hughes In Memory of Mavis Lord In Memory of Esther Barouh The Judy Reddoch Breast Cancer Fund

In Memory of Marlene Regan

Eleanor Keamy & George Tate

Smith & Nephew Pty Limited

The Sasse Family

Mrs Judith Lang & The Gideon Lang Foundation

Margery E Snowball

Mr & Mrs P Selzer & Family

Helen Macpherson Smith Trust

Sotheby’s Australia

Signorino Family

Mr Colin & Mrs Jannene Madden

Spooner Family

Victor Smorgon Charitable Fund

The Matthey Family

G & K Stansen

David & Chasya Tamir

Alison McElroy

Bib Stillwell BMW

Michael & Donna Tricarico & Family

Ron & Valerie McLaughlan

Mr Brian J Sutton FRCNA

Cheryl M Windsor

Men of Malvern

Tattersall’s, The Estate of The Late George Adams

Merrin Foundation Benefactors

Mr Stewart & Mrs Ingrid Webster

MIA Victoria

Amgen Australia Pty Ltd

Dr Charles William (Bill) Edgar Wilson

Doris Mohl OAM

Windemere Foundation

AMP Foundation

John Allison Monkhouse

Yarra Valley Travel

AON Risk Services Australia

John Allison Monkhouse Palliative Care Scholarship

Anthony & May Barry

Mr Hugh Morgan AC & Mrs Elizabeth Morgan

Patrons

Beaconsfield & de Winter Families

Mr Patrick Nalty

Aquanita Racing

W & G Bradshaw Trust

The O’Donohue Family

Pat & Sheril Aughterson

Chris Chadwick

Pharmacia Australia Pty Limited

Mr Nick & Miss Angela Baldi

Collier Charitable Fund

Prostate Cancer Foundation of Australia

Bagot Gjerja Foundation

Commonwealth Bank of Australia − Corporate Financial Services Vic & Tas

Elinor Rabinov

Theodore (Ted) & Miriam Berman

Gary Richardson

Ron Bunker & Evelyn Abaya

Roche Products Pty Ltd

Reginald & Audrey Campbell

The De Luca Family

Irvin Rockman CBE

Caravan Industry Australia Victoria Trades Division

David & Kristene Deague

Rotary Club of Brighton

John Christopherson

Mr Andrew C Facey

Rotary Club of Malvern

Estate of Mrs Margaret Cochrane OAM

Mr Geoff & Mrs Lesley Freeman

The Sanford Partnership

Naja David & Family

Brian Goddard

Sanofi-Sythelabo Australia Pty Ltd

In Memory of Nereo Dizane

Mr John Grossi

The Late John Saunders AO

Downie Family

Herschel Asset Management Limited

Margaret Savill

Mr & Mrs Wal Edgar & Family

Mr Russell Hutchinson

Mr Richard John Savill

Eric Ormond Baker Charitable Fund

Des & Cheri Jackson

Alexander Slade

The Marian & E H Flack Trust

Jack & Sheila Jenner

The Brian Smith Endowment

Fried & Sable Families

Kay & Burton Pty Ltd

June F.M. Smith

Mr Michael & Mrs Helen Gannon

Maureen Coomber

Mrs Jenny Gold and Family In Memory of Dr Norman Gold

Sarah Miskin Palliative Care Nursing Scholarship

The Wallis Family

Eli & Kerry Goldfinger

Barry & Beatrice Moignard Charitable Trust

Marie & John Warnock

Grenda Foundation

Montague Group

Drs Victor & Karen Wayne

Ken & Margaret Grenda

Moore Stephens Melbourne Pty Ltd

The Werled Foundation

Dorothy Haines

R M Morgan AM

The Hall Family

Paul Mullaly QC

P & M Harbig (Holdings) Pty Ltd

Mr John & Mrs Pamela Murphy

The George Hicks Foundation

In Memory of Mary Nesbitt

In Memory of Jade Howell

In memory of Mr Chor-Kim Ng

In Memory of Kerrie Hunter

Novartis Pharmaceuticals Pty Ltd

The Irvine Club Inc

Richard (Frederick) O’Brien

Jacobs Thomas & Associates

Bruce Parncutt & Robin Campbell

Dr Sharon Keeling

Paulusz Family Foundation

Mr Doug Kefford AO

Proclaim Management Solutions Pty Ltd

Cobram Barooga Golf Club Veterans Club

In Memory of Dorothy Keyte

Ramler Family

In Memory of Graham Coningsby

The Valda Klaric Foundation

Mr & Mrs Anthony Reeves

Mrs Margaret Coningsby

Langton’s Pty Ltd

John Reeves

In Memory of Ron & Joan Davies

Gailey Lazarus Foundation

Mr Benedict J Roche

Brian Davis

Lynette & Kevin Lee

Denis Roche

Barbara Dicker

Mrs Barbara J Lewis

Drs Sue & Phil Ronaldson

Mary Drenen

The Lochtenberg Family

Rotary Club of Chadstone/East Malvern

Mrs Susie Edwards & Family

Jeff Loewenstein

Rotary Club of Brighton Charitable Foundation

Sylvia Falzon

Lord Mayor’s Charitable Fund

Peter & Barbara Shearer

John Graham

Joan Loton

Mrs Maggie Christin Shipp

Mr & Mrs Geoffrey A Grant

The Lowthian Family

Mr John Sircom & Mrs Helen Sircom

Edward Hauser OBE

Andy Lyas

In Memory of Marjorie Smith

Jean & Ern Ireland − Sea Bee Pty Ltd

In Memory of Dr Ann Marks

Mr Daryl Somers OAM & Mrs Julie Somers OAM

In memory of George Karpathiou

Christopher Marriott

In Memory of Margaret Roff Sutton

Jack & Karen Joel & Family

Men of Malvern

Mrs Valma Truin

The Jonson Family

Medtronic Australasia Pty Ltd

Barbara Tucker

Mr Andrew Lindsay

The Mezo Family

In Memory of Suzanne Vass

Mr & Mrs Simon & June Lubansky

Associates Georgina Barraclough John & Liz Bate Mr & Mrs Jack & Meg Bowen The Sir Wilfred Brookes Charitable Foundation Mr & Mrs G & J Brown The Hon Stephen Charles QC Nelson & Julie Cheung In memory of Ignatius Paul Cini

Douglas Mackenzie

Mr Choo Keng Wee & Mrs Beverley Anne Wee

Estate of Robert Mackey

Ron & Fay Malouf

In Memory of Mr John Whitbread

In Memory of Mrs Katherine Jane Mactier

In Memory Of Leigh Masel In Memory of Stewart Maxted Allan McNicol Desmond W Milner Gordon Moffatt AM In Memory of Judith Moir Richard Mole E. Morris Vincenzo Paoletta Pellicano Group Mrs Christine Potts 76

Bequests In Memory of Claire Abrahams Estate of Ellen M Balderstone Estate of Carmel Mary Blanton Mrs Ann Brewer Estate of Rosina Violet Brown Estate of Nance Nevasa Buchanan Estate of Agnes Ferguson Clark Estate of Annie Marjorie May Clarke Roger John Cleary Estate of Joyce Mena Coxall

Rita Anversa Magris Estate of Katherine Mander Estate of Brian Charles Mander Estate of June Masson Estate of Marita Therese Mulcahy Estate of Marjorie May Murdoch Estate of Rex Oxnam Estate of Leslie Charles Parkinson Estate of Russell Pitt Estate AV Powers Estate of Lindsay G Quinn Estate of William Clifford (Peter) Rawlins

Mrs Irene Reich

The Estate of David Roy Cross

Ralph & Ruth Renard

Rino Della Bosca

Richard & Ros Rogers

Estate of John Robert Edwards

The Russell Foundation

Estate of Barbara Feil

William Sexton

In Memory of Hubert Frances & Margaret Mary McCarthy

Yvonne Spencer

Estate of Harold Francis

The Springwaters Foundation

Estate of U M Frawley

Jean St Leger Educational Scholarship

Estate of Dorothy Cecelia Garbutt

Mr & Mrs Frank & Heather Stewart

Estate of John Sutherland Hamling

The Strachan Family

Estate of Pamela Mary Harper

Mr Bernard Sweeney

Estate of Noel Arthur Hatherly

In Memory of Mrs Pamela Tax

Estate of Mary Kathleen Hauser

Geoffrey H Thomas

Estate of Doris Mary Hawkless

In Memoriam

Joan & Roderick Thomson

Estate of Rita Mae Hunt

Mr Christopher Bedelis

Leonie Thompson

Estate of Doreen Johnson

Patricia Boxall

B & A Wain

Estate of Valda Irene Keil

John William Clapham

Peter Wain & Family

Estate of Irene Kozica

Kevin Elias

Mr Max Walters

Estate of Dr Betty Laidlaw

Walter Lyle Fish

Estate of Alexander Graeme Robertson The Estate of Anthony Carmel Saccasan Estate of Grace Saunders Mrs E C Seccull Estate of Leslie Alfred Shapland Estate of Maria (Lina) Concetta Sinelli Bella Taft Estate of Hugh L Wallace Estate of Wilma Elsa White Estate of Betty Geddes Wood The Estate of Vica Vitea Yavitch

Amelia Fuller

C ABRI NI I NSTI T UTE AC ADE MI C DEPARTMENT S

Margaret Goddard Mrs Jenny Gold and Family In Memory of Dr Norman Gold The Tom Hafey Memorial Fund Jade Howell Kerrie Hunter Patricia Janes

Cabrini Monash University Department of Surgery The Fröhlich West Chair of Surgery Head: Associate Professor Paul McMurrick Monash Department of Clinical Epidemiology at Cabrini Hospital Head: Professor Rachelle Buchbinder

Mr Stephen Kelly In Memory of Dorothy Keyte In memory of Tuen Yee Lucy Lao In Memory of Mrs Patsy Littlejohn In Memory of Dr Ann Marks In Memory of Stewart Maxted

Cabrini Monash University Department of Medical Oncology The Szalmuk Family Department of Medical Oncology Head: Associate Professor Gary Richardson Cabrini Monash University Department of Medicine Head: Associate Professor Michele Levinson

Mr Brian O’Sullivan In Memory of Maxwell Charles Parsons Mrs Christine Potts

Cabrini Centre for Nursing Research and Education Head: Associate Professor Leanne Boyd

Mr Harry M Ramler Joyce Reed In Memory of Mrs Bella Rogers

S P ONS OR RECO GNI TI ON

In Memory of Timothy Russell

Research Day 2014

In Memory of Ann Ryan In Memory of Mr Richard John Savill Kevin & Patricia Speer In Memory of Diane Spielvogel In Memory of George & Mira Szalmuk – The Szalmuk Family Miss Charlotte Tait Mrs Pamela Tan Dr Charles William (Bill) Edgar Wilson Geoffrey Robin Westacott

C A BR I NI M I S S I ON

TH E C ABRI NI I NSTI T UTE MI S S I ON

Who we are: We are a Catholic healthcare service inspired by the spirit and vision of Saint Frances Xavier Cabrini and the Missionary Sisters of the Sacred Heart of Jesus.

The Cabrini Institute is committed to improving the clinical outcomes of patients of Cabrini. It embraces the mission, values and vision of Cabrini and works within an ethical framework. The Cabrini Institute has a vital role in helping Cabrini to achieve its vision – that is:

What we believe: We are a community of care, reaching out with compassion, integrity, courage and respect to all we serve. What we do: We provide excellence in all of our services and work to identify and meet unmet needs. C A BR I NI VA LUE S

Our values form the base of our mission, are built around what we believe and drive how we act. They are drawn from Saint Frances Xavier Cabrini’s life and reflect her heart, her spirit, her conviction and her approach. Compassion: Our drive to care is not just a professional duty to provide excellent quality care but is born of a heartfelt compassion for those in need, motivated by God’s love for all people. Integrity: We believe in the power of hope to transform people’s lives and remain faithful to the bold healing mission and legacy of Saint Frances Xavier Cabrini. Courage: We have the strength, determination, vision and conviction to continue the work of Saint Frances Xavier Cabrini and the Missionary Sisters. Respect: We believe that every person is worthy of the utmost respect and the best possible healthcare. We know that our resources are entrusted to us to use for the benefit of others.

“By understanding and addressing the needs of our community, we will grow by learning – by researching and continuously improving the quality of our care and by motivating staff committed to our healthcare mission to provide excellence in all of our services . . . we will enhance health and quality of life by working with our patients and their families to anticipate, prevent and ease suffering.”

Published October 2015. Designed by Motion Advertising & Design Pty Ltd. Printed by Adams Printers Pty Ltd. Printed on Grange Laser/Offset, which is PEFC certified and manufactured in a facility with ISO 14001 EMS accreditation. Made elemental chlorine free.

C ABRINI INSTIT UTE 154 Wattletree Road Malvern Victoria 3144 Australia email: institute@cabrini.com.au www.cabrini.com.au