http://www.folio.ualberta.ca/pdfs/100163

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Storytelling in the theatre of surgery

Putting a face to the shine

The complex relationship between St. Joseph’s College and the U of A

Teaching & Learning

Staff Spotlight

Is that so, Joe?

Volume 47 Issue 22 | August 13, 2010 | www.ualberta.ca/folio

Researcher says BMI thin on accuracy in heart-failure patients

Flocking together Michael Holly I Creative Services

Carmen Leibel

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ifty-five-year-old Evan Chan is one of 400,000 Canadians living with heart disease. Chan’s enlarged heart causes him to be short of breath and sometimes have dizzy spells, but being a part of a University of Alberta study is his way of helping find out more about the disease. “I wanted to contribute to society in hopes that this research might find something,” said Chan. Chan was one of Antigone Oreopoulos’ study participants in a research project that found body mass index, or BMI, is an inaccurate way to test the body fat status of heart-failure patients. Oreopoulos, from the U of A’s School of Public Health, also found heartfailure patients with more muscle may have a better chance at survival. Oreopoulos studied 140 patients with heart failure. Study participants underwent a special scan to measure their muscle mass and body fat.

A flock of pigeons take flight on the South Campus.

CIHR grant will fund research into link between physical activity and breast cancer

This grant gives his team the opportunity to take their work down new paths and use different approaches ver the next five years, thanks to a large, diverse research a diverse, multidisciI think it is important plinary team of research- cohort. “The really novel aspect of to note that we cannot this study is the link between physiers led by Kerry Courneya of the cal activity and fitness, and disease rely on BMI alone as a University of Alberta and Christine outcomes,” says Courneya. “There has Friedenreich of Alberta Health Sermeasure of obesity and vices will conduct a series of five large been limited research examining those risk in patients with research projects to probe the impacts outcomes. Women who survive breast cancer are at greater risk heart failure.” of physical activity on for breast cancer recurbreast cancer. Antigone Oreopoulos rence, second cancers, Courneya’s team is cardiac dysfunction, one of just four across weight gain, bone loss, “I wanted to explore something Canada to be awarded a lymphedema and joint called the ‘obesity paradox,’ whereby $2.5 million team grant pain; they complain of once heart failure is established, over five years from the cognitive dysfunction, patients with a higher body-mass index Canadian Institutes of menopausal symptoms, who are considered obese live longer, Health Research, and fatigue; [and] some which is opposite of what occurs the only team from the report psychosocial in people without the disease,” said University of Alberta to distress.” Oreopoulos. do so. The grants were Kerry Courneya The five research Oreopoulos’ research found that recently announced by projects will focus on having more muscle was associated the federal minister of the potential role of physical activity with better nutritional status and health, Leona Alukkaq. and health-related fitness in facilitatlower severity of heart failure, while A Canada Research Chair in ing treatment completion, alleviathigher body fat was associated with Physical Activity and Cancer since ing treatment side effects, hastening increased inflammation and reduced 2004, Courneya has been making exercise capacity. breakthroughs in the fields of physical recovery after treatments, improving long term quality of life and reduccontinued on page 2 activity and cancer for over a decade.

Jane Hurly

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ing the risks of disease recurrence, other chronic diseases, and premature death. “Our team will look at breast cancer recurrence, death from breast cancer as well as overall survival and whether physical activity and healthrelated fitness—cardio-respiratory fitness, muscular strength and body composition—are independent predictors of recurrence of the disease and survival,” says Courneya. For the five-year study, researchers will be recruiting 1,500 women newly-diagnosed with breast cancer through the Tom Baker Cancer Centre in Calgary and the Cross Cancer Institute in Edmonton. The study is set to begin early in 2011. “We have a system set up with the medical oncologists at these centres and all women eligible for the study, up to age 75, will be approached to see if they want to participate,” said Courneya. Besides the major studies, Courneya says there are opportunities for sub-group analysis, with a large research cohort. “These analyses might include looking at the link between

fitness and disease outcomes based on disease stage, or we could look at some of the molecular markers in the cancer cells such as estrogen receptor positive or estrogen receptor negative cancer, for example. “We can look at and determine what role exercise is playing depending on other medical co-morbidities or depending on your fitness level at the time of diagnosis and those types of things. Then you can give more targeted recommendation about what the best bang for the buck might be in terms of an exercise prescription.” Courneya says the true value of the team grant is the legacy of research projects it will spawn. “The real goal of our CIHR team grant is to build this cohort so we have a beautiful resource, a living laboratory, of 1,500 women with all the gold-standard assessments of exercise and health-related fitness tracked over many years and followed for all these disease outcomes. And once you establish that, there are an endless number of questions future students and academics could potentially look at.”

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