Rare Tumours Online Course (30 Sept)

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5TH ESO-ESMO-RCE CLINICAL UPDATE ON RARE ADULT SOLID CANCERS Held in collaboration with

PRE-RECORDED SESSIONS: from 1 December 2020 LIVE SESSIONS: 16-17 January 2021 Chairs: J.Y. Blay, FR - P.G. Casali, IT R.A. Stahel, CH

In the framework of

ONLINE EVENT

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The “ESO-ESMO-RCE Clinical Update on Rare Adult Solid Cancers� is an educational effort held on an annual basis and conceived to strengthen the education of medical professionals willing to devote their career to rare cancers.

It is conceived in the context of, and supported by, EURACAN, the European Reference Network on rare adult solid cancers. The Faculty has been largely selected from EURACAN, also with the aim of letting this educational effort closely interact with its networking activities.

Optimal management of rare adult solid cancers poses specific diagnostic and therapeutic challenges. The sessions of the course have been designed to address the needs of clinical oncologists wanting an update on recent advancements on these tumours.

The global health crisis caused by the Covid-19 pandemic has forced us to turn the in-person 5TH ADVANCED COURSE ESO-ESMO-RCE CLINICAL UPDATE ON RARE ADULT SOLID CANCERS into a virtual event.

We have done our best to design an online course enabling participants to attend according to their own schedule. There will be a mixture of Pre-recorded sessions and Live sessions for Q &A and clinical case discussions with faculty members and moderators.

INFORMATION ON THE COURSE STRUCTURE The course will be carried out in two different steps.

Step 1: Pre-recorded sessions will be made available from 1st December 2020 and will remain on the e-eso website. You will be able to see all the sessions in your own time and send questions that will be selected for discussion during Step 2 of the course. Please remember that registration to the full course is free but mandatory in order to gain access to the sessions.

Step 2: Live sessions with an introductory round table on rare cancers in general, clinical case presentations and Q&A discussions with moderators and speakers will be held on 16 and 17 January 2021 (please see the detailed programme). During the Q&A sessions, speakers will answer and discuss a number of selected questions received in advance via email (see below for instructions) and/or during the live streaming via chat.

Q&A sessions: Participants are encouraged to send questions in advance, as long as they listen to the recorded sessions. The moderators will select questions to be answered during the live streaming. Questions should be sent to raretumours@eso.net, no later than 4 January 2021. Please indicate the session title and speaker your question refers to.

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INVITED FACULTy T. Albreht, National Institute of Public Health, Ljubljana, SI M. Angi, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT J. Balmana, Vall d'Hebron Institute of Oncology, Medical Oncology Dept., Barcelona, ES A. Berruti, ASST Spedali Civili, Brescia, IT J.y. Blay, Centre Léon Bérard, Lyon, FR J. Capdevila, Vall d'Hebron University Hospital, Barcelona, ES M. Caplin, Royal Free Hospital, London, UK P.G. Casali, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT S. Cavalieri, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT F. De Braud, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT L. De Cecco, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT C. de la Fouchardiere, Centre Léon Bérard, Lyon, FR F. De Lorenzo, ECPC, European Cancer Patient Coalition, Brussels, BE M. Deraco, Fondazione IRCCS Istituto NazionaleTumori, Milan, IT N. Fazio, European Institute of Oncology, Milan, IT S. Franceschi, Centro Riferimento Oncologico, Struttura Complessa Epidemiologia Oncologica, Aviano, IT A.M. Frezza, Fondazione IRCCS Istituto NazionaleTumori, Milan, IT M. Garassino, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT J.A. Gietema, University Medical Center, Groningen, NL R. Glynne-Jones, Mount Vernon Centre for Cancer Treatment, London, UK V. Gregoire, Centre Léon Bérard, Lyon, FR A. Gronchi, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT E. Kapiteijn, University Medical Center, Leiden, NL H.J. Klumpen, University of Amsterdam UMC, Amsterdam, NL R. Ladenstein, St.Anna-Kinderspital, Children’s Cancer Research Institute, Vienna, AT C. Lebbé, Saint Louis Hospital, Paris, FR L. Licitra, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT L.D. Locati, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT D. Lorusso, Policlinico Universitario Gemelli, Unità di Oncologia Ginecologica, Roma, IT A. Necchi, National Cancer Institute - IRCCS Foundation, Medical Oncology Dept., Milan, IT M. Niger, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT K. Oliver, International Brain Tumour Alliance, Tadworth, UK F.A. Peccatori, European Institute of Oncology, Milan, IT C. Piazza, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT S. Piperno-Neumann, Curie Institute, Paris, FR I. Ray-Coquard, Centre Léon Bérard, Lyon, FR C. Resteghini, Fondazione IRCCS Istituto Nazionali Tumori, Milan, IT M. Seckl, Imperial College Hammersmith Campus, London, UK C. Simon, Centre Hospitalier Universitaire Vaudois, Lausanne, CH R. Soffietti, City of Health and Science University Hospital, Torino, IT S. Stacchiotti, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT R.A. Stahel, Comprehensive Cancer Center University Hospital, Zurich, CH S. Strauss, UCL Cancer Institute, London, GB A. Trama, Fondazione IRCCS Istituto Nazionale Tumori, Milan, IT M.J. Van den Bent, Erasmus M.C. Cancer Center, Rotterdam, NL L. Wyrwicz, Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, PL

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PROGRAMME PRE-RECORDED SESSIONS

Available from Tuesday, 1 December THE JOINT ACTION ON RARE CANCERS: WHAT NEXT? Pre-recorded sessions available from 1 December 2020 Moderators: J.Y. Blay, FR - F.A. Peccatori, IT • The rare cancer agenda 2030 • The epidemiology of rare adult solid cancers • EURACAN: where we are?

• An educational pathway on rare adult solid cancers

P.G. Casali, IT A. Trama, IT J.Y. Blay, FR A.M. Frezza, IT

UPDATE ON RARE THORACIC CANCERS Pre-recorded sessions available from 1 December 2020 Moderators: M. Garassino, IT - R.A. Stahel, CH • Mesothelioma • Thymic tumors

R.A. Stahel, CH M. Garassino, IT

UPDATE ON SARCOMAS Pre-recorded sessions available from 1 December 2020 Moderators: J.Y. Blay, FR - P.G. Casali, IT • Adult soft tissue sarcomas • GIST • Ewing sarcoma and osteosarcoma • Rare bone and soft tissue sarcomas • Improving the surgical margin in sarcomas

P.G. Casali, IT J.Y. Blay, FR S. Strauss, GB S. Stacchiotti, IT A. Gronchi, IT

UPDATE ON HEAD AND NECK CANCERS Pre-recorded sessions available from 1 December 2020 Moderators: V. Gregoire, FR - L. Licitra, IT • Laryngeal & hypopharyngeal carcinoma • Oropharyngeal carcinoma • Nasopharyngeal carcinoma & sinonasal cancers • Salivary gland tumors • Oral cavity tumors • Advances in molecular biology

C. Piazza, IT V. Gregoire, FR L. Licitra, IT L.D. Locati, IT C. Simon, CH L. De Cecco, IT

UPDATE ON NEUROENDOCRINE TUMORS Pre-recorded sessions available from 1 December 2020 Moderators: M. Caplin, GB - F. De Braud, IT • Thoracic NETs • Gastroenteropancreatic NETs

M. Caplin, GB N. Fazio, IT

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UPDATE ON CNS TUMORS Pre-recorded sessions available from 1 December 2020 Moderators: R. Soffietti, IT - M.J. Van den Bent, NL • Gliomas • Rare CNS tumors • Hereditary cancer risk syndromes

R. Soffietti, IT M.J. Van den Bent, NL J. Balmana, ES

UPDATE ON ENDOCRINE GLAND TUMORS Pre-recorded sessions available from 1 December 2020 Moderators: C. de la Fouchardiere, FR - L. Licitra, IT • Adrenal cancer • Thyroid cancer • The epidemiological evidence of sovradiagnosis

A. Berruti, IT J. Capdevila, ES S. Franceschi, IT

UPDATE ON DIGESTIVE RARE CANCERS Pre-recorded sessions available from 1 December 2020 Moderators: F. De Braud, IT - L. Wyrwicz, PL • Biliary tumors • Anal carcinoma • Peritoneal mesothelioma & pseudomyxoma

H.J. Klumpen, NL R. Glynne-Jones, GB M. Deraco, IT

UPDATE ON RARE UROGENITAL CANCERS Pre-recorded sessions available from 1 December 2020 Moderators: J.A. Gietema, NL - A. Necchi, IT • Testicular cancer • Penile cancer • Survivorship as a healthcare issue • Survivorship as a clinical issue

J.A. Gietema, NL A. Necchi, IT T. Albreht, SI R. Ladenstein, AT

UPDATE ON RARE FEMALE GENITAL CANCERS Pre-recorded sessions available from 1 December 2020 Moderators: F.A. Peccatori, IT - M. Seckl, GB • Non-epithelial ovarian tumors • Trophoblastic tumors • Vulvar and vaginal cancers

I. Ray-Coquard, FR M. Seckl, GB D. Lorusso, IT

UPDATE ON RARE SKIN TUMORS AND UVEAL MELANOMA Pre-recorded sessions available from 1 December 2020 Moderators: E. Kapiteijn, NL - S. Piperno-Neumann, FR • Merkel cell carcinoma • Cutaneous adnexal malignancies • Uveal melanoma

C. Lebbé, FR S. Cavalieri, IT M. Angi, IT

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PROGRAMME (16-17 JANUARy) LIVE SESSIONS

Saturday, 16 January LIVE SESSION - THE JOINT ACTION ON RARE CANCER: WHAT NEXT? Moderators: F.A. Peccatori, IT - R.A. Stahel, CH 11:30 Introduction 11:40 Round table: The Rare Cancer Agenda 2030

FA. Peccatori, IT - R.A. Stahel, CH J.Y. Blay, FR - P.G. Casali, IT F. De Lorenzo, IT - K. Oliver, GB F.A. Peccatori, IT - A. Trama, IT

12:10 Q&A and General discussion LIVE SESSION - UPDATE ON RARE THORACIC CANCERS Moderators: M. Garassino, IT - R.A. Stahel, CH 12:40 Q&A 13:00 Clinical case discussion

M. Garassino, IT - R.A. Stahel, CH

LIVE SESSION - UPDATE ON SARCOMAS Moderators: J.Y. Blay, FR - P.G. Casali, IT 13:30 Q&A

13:50 Clinical case discussion

J.Y. Blay, FR - P.G. Casali, IT A. Gronchi, IT - S. Stacchiotti, IT S. Strauss, GB A.M. Frezza, IT

LIVE SESSION - UPDATE ON HEAD & NECK CANCERS Moderators: V. Gregoire, FR - L. Licitra, IT 14:15 Q&A

14:35 Clinical case discussion

L. De Cecco, IT - V.t Gregoire, FR L. Licitra, IT - L.D. Locati, IT C. Piazza, IT - C. Simon, CH C. Resteghini, IT

LIVE SESSION - UPDATE ON NEUROENDOCRINE TUMORS Moderators: M. Caplin, GB - F. De Braud, IT 15:00 Q&A

M. Caplin, GB - F. De Braud, IT N. Fazio, IT

15:20 Clinical case discussion LIVE SESSION - UPDATE ON CNS TUMORS Moderators: R. Soffietti, IT - M.J. Van den Bent, NL 15:45 Q&A 16:05 Clinical case discussion

J. Balmana, ES - R. Soffietti, IT M.J. Van den Bent, NL

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LIVE SESSIONS

Sunday, 17 January LIVE SESSION - UPDATE ON ENDOCRINE GLAND TUMORS Moderators: C. de la Fouchardiere, FR - L. Licitra, IT 11:30 Q&A

A. Berruti, IT - J. Capdevila, ES C. de la Fouchardiere, FR S. Franceschi, IT - L. Licitra, IT

11:50 Clinical case discussion LIVE SESSION - UPDATE ON DIGESTIVE RARE CANCERS Moderators: F. De Braud, IT - L. Wyrwicz, PL 12:15 Q&A

12:35 Clinical case discussion

F. De Braud, IT - M. Deraco, IT R. Glynne-Jones, GB H.J. Klumpen, NL - L. Wyrwicz, PL M. Niger, IT

LIVE SESSION - UPDATE ON RARE UROGENITAL CANCERS Moderators: J.A. Gietema, NL - A. Necchi, IT 13:00 Q&A

T. Albreht, SI - J.A. Gietema, NL R. Ladenstein, AT - A. Necchi, IT

13:20 Clinical case discussion LIVE SESSION - UPDATE ON RARE FEMALE GENITAL CANCERS Moderators: F.A. Peccatori, IT - M. Seckl, GB 13:45 Q&A

D. Lorusso, IT - F.A. Peccatori, IT I. Ray-Coquard, FR - M. Seckl, GB

14:05 Clinical case discussion LIVE SESSION - UPDATE ON RARE SKIN TUMORS & UVEAL MELANOMA Moderators: E. Kapiteijn, NL - S. Piperno-Neumann, FR 14:30 Q&A

M. Angi, IT - S. Cavalieri, IT E. Kapiteijn, NL - C. Lebbé, FR S. Piperno-Neumann, FR

14:50 Clinical case discussion 15:05 Closing remarks

P.G. Casali, IT

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GENERAL INFORMATION PARTICIPANT’S PROFILE • Medical degree • Specialization/residency in medical oncology, radiation oncology, surgical oncology or equivalent

LEARNING OBJECTIVES Update on the latest clinical development with a background perspective on the state-of-the-art and evidence based practice.

OFFICIAL LANGUAGE The official language is English. Translation will not be provided.

REGISTRATION Registration for the event is free but mandatory.

Interested oncologists should register online at www.eso.net or at www.e-eso.net.

CONFIRMATION OF REGISTRATION Registration will be confirmed by e-mail.

All the contents will be recorded and accessible via the e-ESO website during and after the event (registration to access the contents will remain open after the event).

CME ACCREDITATION CERTIFICATES Participants will be issued a certificate of attendance.

Application for CME recognition will be submitted to the Accreditation Council of Oncology in Europe (ACOE). The American Medical Association (AMA) and the Accreditation Council for Continuous Medical Education (ACCME) designate this type of educational activity for a maximum of 1 AMA PRA category 1 credits per hour of activity.

ESCO CREDITS The Course enables ESCO students to earn ESCO credits and therefore access more ESCO benefits. Full and active participation in the Course earns participants 22 ESCO credits.

Visit www.esco.org for information on how to join ESCO.

ORGANISING SECRETARIAT European School of Oncology Rare Tumours Programme c/o Fondazione IRCCS Istituto Nazionale dei Tumori Via G. Venezian, 1 - 20133 Milan - Italy Fax +39 0223902531 - www.eso.net - Email: raretumours@eso.net