ANTIBODIES FOR ALZHEIMER’S DISEASE W O R L D ’ S L E A D I N G S E R V I C E A N D P R O D U C T S P R O V I D E R F O R A N T I B O D I E S State-of-art Technology Platforms · Assay Development · One-stop Development Service · Highquality & Customized Services · Full Package of QC Tests 1
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ABOUT CREATIVE BIOL ABS Creative Biolabs is the leading antibody service provider with extensive experience in a variety of antibody production and engineering field for both basic science research and pharmaceutic industries. We offer high quality ready-to-use catalogue antibodies, as well as flexible and comprehensive customized services for the antibody production. With high level professional scientists and advanced antibody production platform, we are dedicated to offering various antibodies for a wide range of applications, and designing a specific antibody project to tailor the best service to best fit your requirements.
Introduction ADVANCE YOUR NEXT DISCOVERY
Today around 47 million people survive with dementia, globally. This number is projected to increase to more than 131 million by 2050. About 2.1 million Alzheimer's patients having age of 85 years or older were reported in year 2017. Alzheimer's disease (AD) is one of the most common multifactorial diseases, including a range of abnormal cellular/molecular processes occurring in different regions of the brain. This disease is considered to be a major contributor to dementia in the elderly people. The pathophysiology involves accumulation of extracellular plaques containing the β-amyloid protein which is generated by the breakdown of the β-amyloid precursor protein (APP) in the brain. Another mechanism involves formation of intracellular neurofibrillary tangles of hyperphosphorylated tau protein. The AD can be classified into two types, familial AD (FAD) and sporadic AD (SAD) based on heritability apart from this the early-onset AD (EOAD) and late-onset AD (LOAD) forms are based on the age of onset. Some proteins, such as APOE, APP, BACE (b-amyloid cleaving enzyme), secretases, PS1/2 and tau proteins are reported in AD brain and have been correlated with disease. It is still unclear whether this disease comprises genetic or environmental factors or both.
3
Introduction
ADVANCE YOUR NEXT DISCOVERY 4
Hypothetical model of AD pathophysiology (Pathophysiological pathway and Amyloidgenic pathway)
Pathophysiology and factors (Mutations, NFT, Oxidative stress, mitochondrial dysfunction) involved in AD
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Alzheimer's Disease Pathway
5
Alzheimer’s Disease Therapeutic Targets ADVANCE YOUR NEXT DISCOVERY 6
Name of target
Source
Functions
Amyloid protein precursor (APP)
Hippocampus, olfactory bulb
Formation of Aβ
Muscarinic acetylcholine receptor (mAchR)
Hippocampus
Hyperphosphorylation of tau protein
Nicotinergic acetylcholine receptor (nAChR)
Cerebral cortex
Cognitive, memory function and also involve in progression of sensory information
Triggering receptor expressed on myeloid cells 2 (TREM2)
Myeloid cells
amyloid pathology
Calcitonin gene- regulated peptide (CGRP)
Hypothalamus, ventromedial nucleus of the thalamus, amygdala, grey matter, hippocampus and denate gyrates
Neurotransmitter
C-C chemokine receptor type-5 (CCR5)
Cortical neurons, hippocampal
Recruitment of leukocytes to inflammatory sites
β-Secretase: Aspartyl Proteases(BACE)
Astrocyte
Formation of Aβ
γ-Secretase: Presenilin I (PSEN1)
Medial temporal lobe cortex
Formation of Aβ
Protein tyrosine phosphatase 1B (PTP1B)
Hippocampal, microglial
Learning, memory, endoplasmic reticulum, stress, regulation of synapse dynamics and microglial mediated Neuroinflammation.
Nuclear facto r E2 related factor-2 (Nrf2)
Temporal lobe, microglia and astrocytes
Butyrylcholinesterase (BCHE)
Basal forebrain
Neuritic plaques and neurofibrillary tangles
Phosphodisterase (PDE)
Hippocampus, Cortex stratium
Hydrolysis of CGMP
N-myc downstream-regulated gene 2 (NDRG2)
Astrocytes, glia cells
Differentiation, cell proliferation and cell apoptosis
Antioxidant Maintaining redox balance and eliminate damage proteins
Alzheimer’s Disease Therapeutic Targets Source
Functions
Serotonin 5-HT6 receptor
Cortical
Improving cognition dysfunction, synaptic plasticity
Gama aminobutyric Acid A receptor (GABA)
Cerebral cortex, temporal lobes, frontal and occipital lobes
Neurotransmitter in cerebral cortex
Monoamine oxidase B (MAO-B)
Astrogila, hippocampus, cerebral cortex and astrocyte
Metabolism of monoamine neurotransmitter
NAD (P)H Quinone oxidoreductase 1 (NADPHQ1)
Oxidative stress, abnormality in redox balance
Neurotrophic Receptor Tyrosine Kinase 1 (NRTK1)
Basal forebrain Nucleus Basalis (NB)
Development of CNS and PNS, promotion of cell survival
Gamma-secretase metabotropic glutamate receptor
Cortical and Hippocampal
Releasing of ca2+
Peroxisome proliferator activated receptor-γ (PPARs)
Astrocytes and microglial cells
Lipid storage, adipocyte differentiation, and lipid storage and glucose homeostasis
CP-AMPARs
Hippocampi
Boost synaptic Ca2+
Parkinson disease protein 7(DJ-1/PARK7)
Hippocampus
Antioxidant, molecular chaperon, protein degeneration and transcriptional regulation
Angiotensin receptor
Astrocyte, neurons, microlia and cerebrovascular endothelial cells
Non-amyloid-beta component precursor (NACP)
Neocortex, hippocampus, olfactory bulb, Striatum, thalamus, and cerebellum
Amyloidogenesis and plaque formation
c-Jun N-terminal kinases (JNK)
Cortex hippocampus and cerebellum
Neuronal apoptosis, neural tube defects and oxidative stress
Dopamine 2 receptor
Central nervous system
Aβ plaques
Anti-inflammatory compounds synaptic signalling
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Name of target
7
Amyloid protein precursor (APP) ADVANCE YOUR NEXT DISCOVERY 8
Human APP gene was first discovered in 1987 from β-amyloid and the gene was mapped to chromosome 21. APP belongs to membrane proteins containing extracellular domain and short cytoplasmic region. APP releases Aβ by two cleavage processes, one in the extracellular domain (β-secretase cleavage) and another one in the transmembrane region (γ-secretase cleavage). Different types of APP proteins can be formed by alternative splicing from the single gene. APP695 is a major splice form in neurons. APP is cleaved by two different proteolytic pathways, one is a non-Amyloidogenic and other one is Amyloidogenic pathway. For this process, two main enzymes γsecretase and β-secretase are responsible.
Amyloidgenic process of APP hypothesis and formation of Aβ-42. APP protein can be processed by different enzymes like β-secretase, γsecretase and α- secretase. sAPPβ and sAPPα is produced with peptides C83 and C99.
APP Antibodies Cat
Product Name
APP
TAB-225
APP
Clone
Host
Species Reactivity
Application
Anti-Human Abeta Antibody (Bapineuzumab) Bapineuzumab
Mouse
Human
WB, FuncS, IF, Neut, ELISA, FC, IP
TAB-226
Anti-Human Abeta Antibody (Crenezumab)
Crenezumab
Mouse
Human
WB, IF, IP, Neut, FuncS, ELISA, FC
APP
TAB-227
Anti-Human Abeta Antibody (Ponezumab)
Ponezumab
Mouse
Human
WB, ELISA, IP, FC, FuncS, Neut, IF
APP
TAB-228
Anti-Human Abeta Antibody (Solanezumab)
Solanezumab
Mouse
Human
WB, FuncS, IF, Neut, ELISA, FC, IP
APP
PABL-404
Recombinant Mouse Anti-APP Antibody (WO2)
WO2
Mouse
Human
WB, ELISA, FuncS
APP
TAB-229
Anti-Human Abeta Antibody (Gantenerumab)
Gantenerumab
Human
Human
FuncS, IF, Neut, ELISA, FC, IP, ICC
APP
PABL-011
Recombinant Mouse Anti-APP Antibody (3D6)
3D6
Mouse
Human
WB, ELISA, FuncS
APP
PABL-012
Recombinant Human Anti-APP Antibody (9TL)
9TL
Human
Human
WB, FuncS
APP
PABL-013
Recombinant Mouse Anti-APP Antibody (C705)
C705
Mouse
Human
WB, ELISA, FuncS
APP
PABL-401
Recombinant Mouse Anti-APP Antibody (10D5)
10D5
Mouse
Human
WB
APP
PABL-403
Recombinant Mouse Anti-APP Antibody (c706)
c706
Mouse
Human
ELISA
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Target
9
APP Antibodies
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Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
APP
HPAB-0008-YJ
Recombinant Mouse Anti-APP Antibody (508F)
508F
Mouse
Human
ELISA
APP
HPAB-0105-YJ
Recombinant Humanized Anti-APP Antibody (hu5E3)
hu5E3
Human
Human
ELISA, WB
APP
HPAB-0117CQ
Recombinant Human Anti-APP Antibody (Hu15C11)
Hu15C11
Human
Human
ELISA, WB, IP, FuncS
APP
HPAB-0118CQ
Recombinant Human Anti-APP Antibody (Fv1E4)
Fv1E4
Human
Human
ELISA, Inhib
APP
HPAB-0119CQ
Recombinant Human Anti-APP Antibody (h12A11v1)
h12A11v1
Human
Human
ELISA, FuncS
APP
HPAB-0121CQ
Recombinant Mouse Anti-APP Antibody (MAB 2.1)
MAB 2.1
Mouse
Human
ELISA, IHC, FuncS
APP
HPAB-0176-FY
Recombinant Mouse Anti-APP Antibody (5C9)
5C9
Mouse
Human
AG
APP
HPAB-0242-FY
Recombinant Human Anti-APP Antibody (BBS3/F5.100)
BBS3/F5.10 0
Human
Human
WB
APP
HPAB-0255-YJ
Recombinant Human Anti-APP Antibody (CBA45YJ)
CBA45YJ
Human
Human
ELISA, WB, Inhib, FuncS
APP
PABW-009
Recombinant Mouse Anti-APP Antibody (PFA1)
PFA1
Mouse
Human
ELISA
APP
PABX-014
Recombinant Rabbit Anti-APP Antibody (M204)
M204
Rabbit
Human
WB, ELISA, FuncS
APP
PABL-404
Recombinant Mouse Anti-APP Antibody (WO2)
WO2
Mouse
Human
WB, ELISA, FuncS
Beta-amyloid Antibodies Cat
Product Name
Clone
Host
Species Reactivity
Application
Aβ1-40 + Aβ1-42
HPAB-0871-CN
Recombinant Mouse Anti-Aβ1-40 + Aβ1-42 Antibody (AL-217)
AL-217
Mouse
Human
ELISA, Dot, Neut
Aβ1-40 + Aβ1-42
HPAB-0872-CN
Recombinant Mouse Anti-Aβ1-40 + Aβ1-42 Antibody (AL-224)
AL-224
Mouse
Human
ELISA, Dot, Neut
Aβ1-40 + Aβ1-42
HPAB-0873-CN
Recombinant Mouse Anti-Aβ1-40 + Aβ1-42 Antibody (AL-225)
AL-225
Mouse
Human
ELISA, Dot, Neut
Aβ42
FAMAB0023YC
Recombinant Mouse Anti-Aβ42 Antibody (AM 2.9)
AM 2.9
Mouse
Human
ELISA
Aβ42
FAMAB0024YC
Recombinant Mouse Anti-Aβ42 Antibody (AM 3.26)
AM 3.26
Mouse
Human
ELISA
Aβ42
FAMAB-0148CN
Recombinant Human Anti-Aβ42 Antibody (AS)
AS
Human
Human
WB
Aβ42
FAMAB-0160CN
Recombinant Human Anti-Aβ42 Antibody (scFv59)
scFv59
Human
Human
WB, ELISA, IF, IHC
Aβ42
HPAB-0511-WJ
Recombinant Mouse Anti-Aβ42 peptide Antibody (3F5)
3F5
Mouse
Human
ELISA, FC
Aβ42
HPAB-AP849YC
Recombinant Mouse Anti-Aβ 42 Antibody (AP017/YC)
AP017/YC
Mouse
Human
ELISA, Dot
Aβ 1-42
HPAB-M0417YC
Recombinant Human Anti-Aβ 1-42 Antibody (Abet0369)
Abet0369
Human
Human
ELISA, Inhib
Aβ 1-42
HPAB-M0420YC
Recombinant Human Anti-Aβ 1-42 Antibody (Abet0382)
Abet0382
Human
Human
ELISA, Inhib
Aβ 1-42
HPAB-M0421YC
Recombinant Human Anti-Aβ 1-42 Antibody (Abet0380-GL)
Abet0380GL
Human
Human
ELISA, WB, Inhib
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Target
11
Beta-amyloid Antibodies
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Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
Beta-amyloid
HPAB-0339LY
Recombinant Humanized Anti-Beta-amyloid Antibody (hC2)
hC2
Humanized
Human
ELISA, IHC
Beta-amyloid
HPAB-0958WJ
Recombinant Human Anti-Beta-amyloid Antibody (LP09027)
LP09027
Human
Human
ELISA
Amyloid
HPAB-J0035-YC
Recombinant Mouse Anti-Amyloid Antibody (A8)
A8
Mouse
Human
ELISA, IHC, WB, FuncS
Amyloid beta
HPAB-0850LY
Recombinant Mouse Anti-Amyloid beta Antibody (7E7)
7E7
Mouse
Human
ELISA
Amyloid beta
HPAB-0851LY
Recombinant Mouse Anti-Amyloid beta Antibody (6C2)
6C2
Mouse
Human
ELISA
Amyloid beta
HPAB-1131WJ
Recombinant Mouse Anti-Aβ Antibody (4396C)
4396C
Mouse
Human
ELISA
Amyloid beta
HPAB-1135WJ
Recombinant Human Anti-Aβ Antibody (h10D5) h10D5
Human
Human
ELISA
Amyloid beta
HPAB-1157WJ
Recombinant Human Anti-Aβ Antibody (266)
266
Human
Human
ELISA
Aβ 4-40
HPAB-AP254-YC
Recombinant Mouse Anti-Aβ 4-40 Antibody (NT4X-167)
NT4X-167
Mouse
Human
ELISA, Inhib
Aβ 4-40
HPAB-AP255-YC
Recombinant Mouse Anti-Aβ 4-40 Antibody (NT4X-83)
NT4X-83
Mouse
Human
ELISA, Inhib
Aβ oligomer
HPAB-1066WJ
Recombinant Human Anti-Aβ oligomer Antibody (h4H5)
h4H5
Human
Human
ELISA
Aβ oligomer
HPAB-0256-YJ
Recombinant Humanized Anti-Aβ oligomer Antibody (6E4HV0LV0)
6E4HV0LV0
Human
Human
FuncS
Aβ42-CC oligomer
HPAB-0100CQ
Recombinant Mouse Anti-Aβ42-CC oligomer Antibody (mAb20)
mAb20
Mouse
Human
ELISA, IHC
AChR Antibodies Cat
Product Name
Clone
Host
Species Reactivity
Application
AChR
CBMAB-082CQ
Mouse Anti-AChR Antibody (mAb192)
mAb192
Mouse
Human, Mouse, Rat
ELISA, WB, BL
AChR
MHH-33
Recombinant Human Anti-AChR Antibody
Human
Human
ELISA, WB, IP, FuncS
AChR
FAMAB-0224YC
Recombinant Rat Anti-AChR Antibody (mAb195)
mAb195
Rat
Human
FuncS
AChR
PABC-007
Recombinant Rat Anti-AChR Antibody (mAb192)
mAb192
Rat
Human
WB, FuncS
AChR
PABZ-007
Recombinant Rat Anti-AChR Antibody (mAb198)
mAb198
Rat
Human
WB, ELISA
AChR
TAB-0636CLV
Anti-Human AChR Antibody (P90-131)
P90-131
Human
Human
WB, ELISA
AChR
TAB-0637CLV
Anti-Human AChR Antibody (P90-65)
P90-65
Human
Human
WB, ELISA
AChR
TAB-0638CLV
Anti-Human AChR Antibody (IgG1-637)
IgG1-637
Human
Human
WB, ELISA
AChR
TAB-0639CLV
Anti-Human AChR Antibody (IgG4-637)
IgG4-637
Human
Human
WB, ELISA
ADVANCE YOUR NEXT DISCOVERY
Target
13
APOE Antibodies
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Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
APOE
HPAB-0115CQ
Recombinant Mouse Anti-APOE Antibody (2E8)
2E8
Mouse
Human
ELISA, BL
APOE
HPAB-N0315-YC
Recombinant Mouse Anti-APOE Antibody (HJ156)
HJ156
Mouse
Human
ELISA, WB
APOE
HPAB-N0316-YC
Recombinant Mouse Anti-APOE Antibody (HJ151)
HJ151
Mouse
Human
ELISA, WB
APOE
HPAB-N0317-YC
Recombinant Mouse Anti-APOE Antibody (HJ153)
HJ153
Mouse
Human
IP, ELISA, WB
APOE
MOB-0669MZ
Recombinant Mouse Anti-Human APOE Antibody (clone F7E8)
F7E8
Mouse
Human
ELISA, IHC-Fr, IHC-P, IP, WB
APOE
MOR-0215
Hi-Affi™ Recombinant Rabbit Anti-APOE Monoclonal Antibody (DS215AB)
DS215AB
Rabbit
Human
FC, IHC-P, IP, WB
APOE
MOR-4534
Hi-Affi™ Recombinant Rabbit Anti-APOE Monoclonal Antibody (TH42DS)
TH42DS
Rabbit
Human, Mouse, Rat
WB, IF, ICC
APOE
TAB-0963CLV
Anti-Human APOE Antibody (807A-M0028-B02)
807A-M0028B02
Human
Human
ELISA
APOE
TAB-0964CLV
Anti-Human APOE Antibody (807B-M0004-A03)
807B-M0004A03
Human
Human
ELISA
APOE
TAB-0965CLV
Anti-Human APOE Antibody (807B-M0004-H03)
807B-M0004H03
Human
Human
ELISA
Tau Antibodies Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
MAPT
HPAB-0198-YJ
Recombinant Mouse Anti-MAPT Antibody (13A6)
13A6
Mouse
Human, Monkey
Immunoassay, IP
MAPT
HPAB-0485-FY
Recombinant Mouse Anti-MAPT Antibody (6B2G12)
6B2G12
Mouse
Human
WB, IP
MAPT
PABL-340
Recombinant Mouse Anti-TAU Antibody (AT8)
AT8
Mouse
Human
ELISA, FuncS
MAPT
PABC-456
Recombinant Mouse Anti-MAPT Antibody (chCBTAU-22.1)
chCBTAU-22.1
Mouse
Human
ELISA, WB, IHC, FC
MAPT
PABC-454
Recombinant Mouse Anti-MAPT Antibody (chCBTAU-7.1)
chCBTAU-7.1
Mouse
Human
ELISA, WB, IHC, FC
MAPT
PABC-452
Recombinant Human Anti-MAPT Antibody (dmCBTAU-27.1)
dmCBTAU-27.1
Human
Human
ELISA, WB, IHC, Inhib
MAPT
HPAB-0042-WJ
Recombinant Human Anti-MAPT Antibody (hACI-36-2B6-Ab1)
hACI-36-2B6-Ab1
Human
Human
ELISA, WB
ADVANCE YOUR NEXT DISCOVERY
MAPT
NS-090CN
Recombinant Mouse Anti-MAPT Antibody (HJ8.5)
HJ8.5
Mouse
Human
WB, ELISA, IHC, IP
15
MAPT
HPAB-N0171-YC
Recombinant Human Anti-MAPT Antibody (hu37D3.v28.A4 hIgG4-S228P.YTE)
hu37D3.v28.A4 hIgG4-S228P.YTE
Human
Human
ELISA, FuncS
MAPT
HPAB-0093-FY
Recombinant Human Anti-MAPT Antibody (NI105.4A3)
NI-105.4A3
Human
Human
WB, ELISA
MAPT
HPAB-0099-WJ
Recombinant Human Anti-MAPT Antibody (NI105.6C5)
NI-105.6C5
Human
Human
ELISA, FC
Tau Antibodies Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
MAPT
HPAB-N0170-YC
Recombinant Humanized Anti-MAPT Antibody (NOV018YC)
NOV018YC
Human
Human
ELISA, Inhib
ADVANCE YOUR NEXT DISCOVERY
MAPT
HPAB-0108-WJ
Recombinant Rabbit Anti-MAPT Antibody (Otau(S400))
Otau(S400)
Rabbit
Human
ELISA
MAPT
HPAB-0106-WJ
Recombinant Human Anti-MAPT Antibody (TAM1)
TAM-1
Human
Human
ELISA, WB
MAPT
HPAB-0029-WJ
Recombinant Mouse Anti-MAPT Antibody (PT3)
PT3
Mouse
Human
ELISA, WB
MAPT
HPAB-0484-FY
Recombinant Mouse Anti-MAPT Antibody (scFv235)
scFv235
Mouse
Human
WB, IP
Tau
TAB-524CT
Anti-Human Oligomeric tau Therapeutic Antibody (F9T)
F9T
Mouse
Human
WB, ELISA, IHC
Tau
TAB-526CT
Anti-Human Oligomeric tau Therapeutic Antibody (H2A)
H2A
Mouse
Human
WB, ELISA, IHC
16
Tau
TAB-538CT
Anti-Human Tau Therapeutic Antibody (2.20.4)
2.20.4
Mouse
Human
ELISA, IF
Tau
TAB-529CT
Anti-Human Tau Therapeutic Antibody (2H9)
2H9
Mouse
Human
WB, ELISA, IF, IHC
Tau
TAB-527CT
Anti-Human Tau Therapeutic Antibody (16B5)
16B5
Humanized
Human
WB, ELISA, IHC
Tau
TAB-519CT
Anti-Human Tau Therapeutic Antibody (1F12C2)
1F12C2
Mouse
Human
WB, ELISA
Tau
TAB-533CT
Anti-Human Tau Therapeutic Antibody (DC8E8)
DC8E8
Humanized
Human
WB, ELISA, IP, IHC, Neut
Tau Antibodies Cat
Product Name
Clone
Host
Species Reactivity
Application
Tau
TAB-521CT
Anti-Human Tau Therapeutic Antibody (4E6E3)
4E6E3
Mouse
Human
WB, ELISA
Tau
TAB-536CT
Anti-Human Tau Therapeutic Antibody (ADx201)
ADx201
Mouse
Human
WB, ELISA, IHC
Tau
TAB-525CT
Anti-Human Oligomeric tau Therapeutic Antibody (D11C)
D11C
Mouse
Human
WB, ELISA, IHC
Tau
TAB-532CT
Anti-Human Tau Therapeutic Antibody (pS396/pS404_1)
pS396/pS404_1
Chicken
Human
WB, ELISA, IP, IHC
Tau
TAB-531CT
Anti-Human Tau Therapeutic Antibody (pT212/pS214_2)
pT212/pS214_2
Chicken
Human
WB, ELISA, IP, IHC
MAPT
PABL-680
Recombinant Chicken Anti-phospho-tau Antibody (pT231/pS235_1)
pT231/pS235_1
Chicken
Human
WB, ELISA, FACS, BL
MAPT (pS396)
HPAB-N0175YC
Recombinant Human Anti-MAPT (pS396) Antibody (hC10-2_N32S_A101T)
hC102_N32S_A101T
Human
Human
Dot, WB, Inhib, IP
MAPT (pS422)
HPAB-0300-YJ
Recombinant Humanized Anti-MAPT (pS422) Antibody (hu 086)
hu 086
Human
Human
FC, ELISA, IF
Phosphoryla ted Tau
TAB-0430CL
Anti-Human Phosphorylated Tau Therapeutic Antibody (Ta1501)
Ta1501
Mouse
Human
ELISA, FuncS
Phosphoryla ted Tau
TAB-0437CL
Anti-Human Phosphorylated Tau Therapeutic Antibody (Ta9)
Ta9
Mouse
Human
ELISA, FuncS
Hyperphosp horylated Tau (pS396)
HPAB-2331LY
Recombinant Humanized AntiHyperphosphorylated Tau (pS396) Antibody (D1.2)
D1.2
Humanized
Human
Dot, WB, Inhib, ELISA
ADVANCE YOUR NEXT DISCOVERY
Target
17
BACE1 Antibodies Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
BACE1
HPAB-0285-YC
Recombinant Mouse Anti-BACE1 Antibody (5H10)
5H10
Mouse
Human
ELISA, FuncS
ADVANCE YOUR NEXT DISCOVERY
BACE1
HPAB-0672-CN
Recombinant Mouse Anti-BACE1 Antibody (M2-1003) M2-1003
Mouse
Human
ELISA, FC, IHC, Neut
BACE1
HPAB-0673-CN
Recombinant Mouse Anti-BACE1 Antibody (M2-1000) M2-1000
Mouse
Human
ELISA, FC, IHC, Neut
BACE1
MOR-0315
Hi-Affi™ Recombinant Rabbit Anti-BACE1 Monoclonal Antibody (DS315AB)
DS315AB
Rabbit
Human
WB, IP
BACE1
NEUT-036CQ
Recombinant Mouse Anti-BACE1 Antibody (CBL278)
CBL278
Mouse
Human, Mouse
ELISA, IP, Neut
BACE1
NEUT-037CQ
Recombinant Mouse Anti-BACE1 Antibody (CBL696)
CBL696
Mouse
Human, Mouse
IP, Neut
BACE1
PABL-408
Recombinant Human Anti-BACE1 Antibody (YW412.8.31)
YW412.8.31
Human
Human
ELISA, BL, Neut
18
BACE1
TAB-1153CL
Anti-Human BACE1 Antibody (2G3)
2G3
Mouse
Human
ELISA
BACE1
TAB-1154CL
Anti-Human BACE1 Antibody (5G7)
5G7
Mouse
Human
ELISA
BACE1
TAB-1155CL
Anti-Human BACE1 Antibody (14F10)
14F10
Mouse
Human
ELISA
SNCA Antibodies Cat
Product Name
Clone
Host
Species Reactivity
Application
SNCA
CBMAB-090LC
Recombinant Human Anti-SNCA Therapeutic Antibody (aSynA)
aSynA
Human
Human
ELISA, FuncS, WB
SNCA
FAMAB-0260-CN
Recombinant Human Anti-SNCA Antibody (D10)
D10
Human
Human
ELISA
SNCA
FAMAB-0261-CN
Recombinant Human Anti-SNCA Antibody (6E)
6E
Human
Human
ELISA
SNCA
FAMAB-0262-CN
Recombinant Human Anti-SNCA Antibody (4B)
4B
Human
Human
ELISA
SNCA
FAMAB-0263-CN
Recombinant Human Anti-SNCA Antibody (3E)
3E
Human
Human
ELISA
SNCA
HPAB-0023-FY
Recombinant Mouse Anti-SNCA Antibody (49/G)
49/G
Mouse
Human
ELISA
SNCA
HPAB-0033-YC
Recombinant Human Anti-SNCA Antibody (NI-202.12F4)
NI-202.12F4
Human
Human
ELISA, WB, IHC, FuncS
SNCA
HPAB-0034-YC
Recombinant Human Anti-SNCA Antibody (NI-202.3G12)
NI-202.3G12
Human
Human
ELISA, WB
SNCA
HPAB-0035-YC
Recombinant Human Anti-SNCA Antibody (NI-202.3D8)
NI-202.3D8
Human
Human
ELISA, WB
SNCA
HPAB-0328-YJ
Recombinant Humanized Anti-SNCA Antibody (h5C1)
h5C1
Human
Human
ELISA, WB
SNCA
HPAB-0368LY
Recombinant Mouse Anti-SNCA Antibody (9E4)
9E4
Mouse
Human
IP, WB
SNCA
HPAB-653-FY
Recombinant Mouse Anti-SNCA Antibody (38E2/7)
38E2/7
Mouse
Human
WB, IP, ELISA
SNCA
HPAB-654-FY
Recombinant Mouse Anti-SNCA Antibody (38Fll/2_8)
38Fll/2_8
Mouse
Human
ELISA
ADVANCE YOUR NEXT DISCOVERY
Target
19
SNCA Antibodies ADVANCE YOUR NEXT DISCOVERY 20
Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
SNCA
HPAB-AP186-YC
Recombinant Mouse Anti-SNCA Antibody (m1H7)
m1H7
Mouse
Human
FuncS
SNCA
HPAB-AP188-YC
Recombinant Humanized (Human/Mouse) AntiSNCA Antibody (1H7 H3L3)
1H7 H3L3
Human
Human
FuncS
SNCA
HPAB-M0696-YC
Recombinant Mouse Anti-SNCA Antibody (IGP101)
IGP101
Mouse
Human
ELISA, FuncS
SNCA
HPAB-N0389-YC
Recombinant Humanized Anti-SNCA Antibody (2E6-HDL1)
2E6-HDL1
Human
Human
ELISA, IP, FuncS
SNCA
HPAB-N0390-YC
Recombinant Mouse Anti-SNCA Antibody (m2E6)
m2E6
Mouse
Human
ELISA, IP, FuncS
SNCA
MOB-0599MZ
Recombinant Mouse Anti-Human SNCA Antibody (clone 20D4)
20D4
Mouse
Human
ELISA, WB
SNCA
MOR-0154
Hi-Affi™ Recombinant Rabbit Anti-alpha + beta Synuclein Monoclonal Antibody (DS154AB)
DS154AB
Rabbit
Mouse, Rat, Human
FC, WB, ICC/IF
SNCA
MOR-3354
Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (DS3354AB)
DS3354AB
Rabbit
Human
IHC, ICC, FC, IP
SNCA
MOR-4530
Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (TH38DS)
TH38DS
Rabbit
Human
WB, IF, ICC, IHC-P, FC
SNCA
NEUT-1977CQ
Recombinant Human Anti-SNCA Antibody (NAC32)
NAC32
Human
Human
IHC, WB, BL
SNCA
NS-005CN
Recombinant Mouse Anti-SNCA Antibody (13F3)
13F3
Mouse
Human, Mouse
WB, ELISA, FC
SNCA
NS-088CN
Recombinant Mouse Anti-SNCA Antibody (1F7)
1F7
Mouse
Human
WB, ELISA, IHC
TREM2 Antibodies Cat
Product Name
Clone
Host
Species Reactivity
Application
TREM2
HPAB-0152-CN
Recombinant Human Anti-TREM2 Antibody (Pil.02.002)
Pil.02.002
Human
Human, Mouse
ELISA, FC
TREM2
HPAB-0153-CN
Recombinant Human Anti-TREM2 Antibody (Pil.02.005)
Pil.02.005
Human
Human, Mouse
ELISA, FC
TREM2
HPAB-0155-CN
Recombinant Mouse Anti-TREM2 Antibody (7E5)
7E5
Mouse
Human, other Mammalian
WB, ELISA, FC, IHC, IF, IP
TREM2
HPAB-0156-CN
Recombinant Mouse Anti-TREM2 Antibody (10C1)
10C1
Mouse
Human, other Mammalian
WB, ELISA, FC, IHC, IF, IP
TREM2
HPAB-0157-CN
Recombinant Humanized Anti-TREM2 Antibody (hu9F5)
hu9F5
Human
Human, other Mammalian
WB, ELISA, FC, IHC, IF, IP
TREM2
HPAB-2960LY
Recombinant Human Anti-TREM2 Antibody (Pi1.02.007)
Pi1.02.007
Human
Human, Mouse
ELISA, FC
TREM2
HPAB-3341LY
Recombinant Humanized Anti-TREM2 Antibody (4D11)
4D11
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3342LY
Recombinant Humanized Anti-TREM2 Antibody (78C5)
78C5
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3343LY
Recombinant Humanized Anti-TREM2 Antibody (6G12)
6G12
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3344LY
Recombinant Humanized Anti-TREM2 Antibody (8F11)
8F11
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3345LY
Recombinant Humanized Anti-TREM2 Antibody (8E10)
8E10
Humanized
Human
FC, WB, IP, ELISA, IHC
ADVANCE YOUR NEXT DISCOVERY
Target
21
TREM2 Antibodies ADVANCE YOUR NEXT DISCOVERY 22
Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
TREM2
HPAB-3374LY
Recombinant Humanized Anti-TREM2 Antibody (40D5)
40D5
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3375LY
Recombinant Humanized Anti-TREM2 Antibody (43B9)
43B9
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3376LY
Recombinant Humanized Anti-TREM2 Antibody (44A8V1)
44A8V1
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3377LY
Recombinant Humanized Anti-TREM2 Antibody (44A8V2)
44A8V2
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3378LY
Recombinant Humanized Anti-TREM2 Antibody (44B4V1)
44B4V1
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3379LY
Recombinant Humanized Anti-TREM2 Antibody (44B4V2)
44B4V2
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3380LY
Recombinant Humanized Anti-TREM2 Antibody (29F7)
29F7
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-3381LY
Recombinant Humanized Anti-TREM2 Antibody (32G1)
32G1
Humanized
Human
FC, WB, IP, ELISA, IHC
TREM2
HPAB-N0292-YC
Recombinant Rat Anti-TREM2 Antibody (14D3)
14D3
Rat
Human
ELISA, Inhib
TREM2
TAB-168CQ
Anti-Human TREM2 Antibody (Ab21)
Ab21
Human
Human, Mouse
ELISA, FC, WB, FuncS
TREM2
TAB-169CQ
Anti-Human TREM2 Antibody (Ab52)
Ab52
Human
Human, Mouse
ELISA, FC, WB, FuncS
CCR5 Antibodies Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
CCR5
HPAB-0047-YC
Recombinant Humanized Anti-CCR5 Antibody (huPR0140)
huPR0140
Human
Human
Block
CCR5
HPAB-0131CQ
Recombinant Human Anti-CCR5 Antibody (Pz02.1C11)
Pz02.1C11
Human
Human
ELISA, FC
CCR5
HPAB-1038-FY
Recombinant Anti-CCR5 Antibody (36F11)
36F11
Human
Human
ELISA, FC
CCR5
HPAB-1659-FY
Recombinant Human Anti-CCR5 Antibody (XF27/28.36F11)
XF27/28.36F11
Human
Human
ELISA
CCR5
HPAB-1660-FY
Recombinant Mouse Anti-CCR5 Antibody (Pz01.F3)
Pz01.F3
Mouse
Human
ELISA
CCR5
HPAB-1662-FY
Recombinant Mouse Anti-CCR5 Antibody (PzO3.1C5)
PzO3.1C5
Mouse
Human
ELISA
CCR5
MOB-0372CT
Recombinant Mouse anti-Human CCR5 Monoclonal antibody (56634.222)
56634.222
Mouse
Human
FC, ICC
ADVANCE YOUR NEXT DISCOVERY
CCR5
MOR-0522
Hi-Affi™ Recombinant Rabbit Anti-CCR5 Monoclonal Antibody (DS522AB)
DS522AB
Rabbit
Human
WB, FC
23
CCR5
NEUT-268CQ
Recombinant Mouse Anti-CCR5 Antibody (CBL472)
CBL472
Mouse
Human
FC, CyTOF, ICC, Neut
CCR5
NS-017CN
Recombinant Mouse Anti-CCR5 Antibody (PA14)
PA14
Mouse
Human
ELISA, WB, FC
CCR5
PABC-446
Recombinant Mouse Anti-CCR5 Antibody (4B08)
4B08
Mouse
Human
ELISA
CCR5
PABL-345
Recombinant Mouse Anti-The extracellular domain of CCR5 Antibody (RoAb13)
RoAb13
Mouse
Human
BL, ELISA, FACS
CGRP Antibodies
ADVANCE YOUR NEXT DISCOVERY 24
Target
Cat
Product Name
Clone
Host
Species Reactivity
Application
CGRP
HPAB-0099CQ
Recombinant Human Anti-CGRP Antibody (G1)
G1
Human
Human, Rat
ELISA, BL
CGRP
HPAB-1075-FY
Recombinant Anti-CGRP Antibody (G2)
G2
Mouse
Human, Rat
ELISA
CGRP
HPAB-2072LY
Recombinant Mouse Anti-CGRP Antibody (CBL077)
CBL077
Mouse
Human
ELISA
CGRP
HPAB-3104LY
Recombinant Humanized Anti-CGRP Antibody (Ab1)
Ab1
Humanized
Human
ELISA
CGRP
HPAB-3113LY
Recombinant Humanized Anti-CGRP Antibody (Ab12)
Ab12
Humanized
Human
ELISA
CGRP
HPAB-3114LY
Recombinant Humanized Anti-CGRP Antibody (Ab13)
Ab13
Humanized
Human
ELISA
CGRP
HPAB-3115LY
Recombinant Humanized Anti-CGRP Antibody (Ab14)
Ab14
Humanized
Human
ELISA
CGRP
TAB-163CL
Anti-Human CGRP Antibody (ALD403)
ALD403
Humanized
Human
ELISA
CGRP
TAB-425CQ
Anti-Human CGRP Antibody (Eptinezumab)
Eptinezumab
Human
Human
ELISA, IHC, FC, IP, IF, Inhib
CGRP
TAB-428CQ
Anti-Human CGRP Antibody (Fremanezumab)
Fremanezumab
Human
Human
ELISA, IHC, FC, IP, IF, Inhib
CGRP
TAB-429CQ
Anti-Human CGRP Antibody (Galcanezumab)
Galcanezumab
Human
Human
ELISA, IHC, FC, IP, IF, Inhib
PSEN1/BPTF/CTNNB1/BCHE Antibodies Cat
Product Name
PSEN1
BRD-1139MZ
Chicken Anti-Presenilin 1 Polyclonal IgY
PSEN1
MOB-1686CT
Recombinant Mouse anti-Human PSEN1 Monoclonal antibody (45-5D4)
PSEN1
MOR-2883
Hi-Affi™ Recombinant Rabbit Anti-PSEN1 Monoclonal Antibody (DS2883AB)
PSEN1
TAB-714CL
Anti-Human PSEN1 Therapeutical Antibody
BPTF
DrMAB-239
Recombinant Human Anti-Human BPTF Antibody, clone D378
BPTF
MOB-1471MZ
CTNNB1 CTNNB1
Clone
Host
Species Reactivity
Application
Chicken
Human
WB, ELISA
45-5D4
Mouse
Human
IP, WB
DS2883AB
Rabbit
Human
WB, IP, ICC, FC, IHC-P
Rabbit
Human
ELISA
D378
Human
Human
ELISA, IP-MS
Recombinant Mouse Anti-Human BPTF Antibody (clone 3454D4b)
3454D4b
Mouse
Human
WB
NS-008CN
Recombinant Mouse Anti-CTNNB1 Antibody (13C6)
13C6
Mouse
Human
ELISA, IHC
PABZ-140
Recombinant Mouse Anti-Rabbit CTNNB1 (residue 19-44) Antibody (BC-22)
BC-22
Mouse
Rabbit
ELISA, BL ELISA
ADVANCE YOUR NEXT DISCOVERY
Target
25
BCHE
FAMAB-0031CQ
Recombinant Mouse Anti-BCHE Antibody (mAb2)
mAb2
Mouse
Human, Rhesus monkey, Horse, Cat, Tiger, Pig, Bovine
BCHE
FAMAB-0028CQ
Recombinant Mouse Anti-BCHE Antibody (11D8)
11D8
Mouse
Human
ELISA, WB
BCHE
FAMAB-0029CQ
Recombinant Mouse Anti-BCHE Antibody (B2 12-1)
B2 12-1
Mouse
Human
ELISA
BCHE
FAMAB-0030CQ
Recombinant Mouse Anti-BCHE Antibody (B2 18-5)
B2 18-5
Mouse
Human, Rhesus monkey, Horse, Cat, Tiger
ELISA
ANTIBODIES FOR ALZHEIMER’S DISEASE A D VA N C E YO U R NEXT DISCOVERY
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