In Vivo ADME Creative Biolabs offers a suite of in vivo ADME services that, in addition to supporting your drug
discovery, pre-clinical testing and clinical planning, we also provide data support for animal species selection and dosing options. Our experienced scientists have expertise in mass balance, PK/TK and
tissue distribution studies to determine clearance pathways and rates after systemic exposure, metabolite profiles, tissue half-life, etc. With years of experience, we can use the radiolabeled
materials you provide or custom radiosynthesis on your behalf to design and perform in vivo ADME testing.
Our Capabilities
Absorptaion - Drug plasma concentration - Absorption site investigation
Distribution
- Tissue distributions (over 30 organs) - QWBA (Quantitative Whole Body Autoradiography) - Micro-autoradiography - Plasma protein binding - Blood/plasma partition rate - Placental transfer
Metabolism
Excretion
- Metabolite analytical method set-up - Metabolic profile (plasma, urine, bile and tissues) - Metabolite identification
- Excretion rate (urine, feces, expiration air and bile) - Enterohepatic circulation - Lymphatic partition rate - Excretion into milk
Isotopes: 14C, 3H, 33S, 35S, 90Y, 125I and 111In Species: Mouse, rat, guinea pig, rabbit, dog, minipig, marmoset and monkeys Administration Routes: Oral, intravenous, continuous intravenous, transdermal, subcutaneous, intramuscular, intratracheal, instillation, intrarectal and intraduodenal Services: Bioavailability, single and multiple-dose pharmacokinetics, toxicokinetic, bioequivalence, dose ranging and proportionality, mass balance, biliary vs urinary excretion, tissue distribution, metabolite profiling and identification, PK/PD study in oncology animal models
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