Sequence Liability Identification
100% Guaranteed Sequence Liability Identification Services Post-translational modifications (PTMs) affect affinity, stability, potency and homogeneity of an antibody, resulting in complicated process of downstream development. PTMs include glycosylation, oxidation, isomerization, free thiol, pyro-Glutamate, C-terminal Lysine, etc. To identify the sequences within antibody variable regions, we has developed algorithms to improve the potential product quality. We also reduce your cost via foreseeing potential risks.
Our End-to-End Sequence Solutions We dedicate to helping clients make smarter decisions on eliminating the program earlier in the antibody development process or selecting liability free antibodies for further studies.
Scope
Material needed Deliverables
We provide sequence liability identification service for variable heavy and variable light chains. The following PTMFs can be analyzed including, but not limited to, N-linked glycosylation, deamidation, isomerization, oxidation, pyro-glutamate formation, and c-terminal lysine. Before performing sequence liability identification service, please deliver amino acid sequence of finalized heavy and light chain variable regions. Final report with potential sequence liabilities will be analyzed and sent to you.
Other Related Services
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Antibody variable region sequencing and cloning;
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N-terminal protein sequencing service;
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De novo antibody sequencing.
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