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Administration routes for mRNA vaccines
from mRNA Vaccine
by Jerry Carter
Types of mRNA vaccine
Non-replicating mRNA Self-amplifying mRNA
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Open reading frame is a nucleic acid sequence that encodes antigens.
Open Reading Frame
5’-G P P P UTR SP ORF UTR AAAAAA(140-150)-3’
CAP
Cap enables mRNA to translate in the right direction. Poly A can increase the mRNA stability and the expression of antigen protein, playing an important role in the translation and stability of mRNA.
5‘Untranslated Region 3‘Untranslated Region
Regulatory elements in 5'U T R and 3'U T R stabilize mRNA and increase antigen protein translation. Poly A Tail
