Types of mRNA vaccine Non-replicating mRNA Self-amplifying mRNA
Open reading frame is a nucleic acid sequence that encodes antigens.
Open Reading Frame
5’-G
P P P UTR
CAP Cap enables mRNA to translate in the right direction.
SP
5‘Untranslated Region
ORF
UTR
3‘Untranslated Region
Regulatory elements in 5'U T R and 3'U T R stabilize mRNA and increase antigen protein translation.
AAAAAA(140-150)-3’ Poly A Tail Poly A can increase the mRNA stability and the expression of antigen protein, playing an important role in the translation and stability of mRNA.
