TUBERCULOSIS RESEARCH
Tackling TB Continued
New in 2020 PARTHISA: Pregnancy Associated Immune Responses to TB and HIV in India and South Africa Expanding on our growing portfolio of work on the immunology of pregnancy and tuberculosis and HIV, this study will look for immunologic signatures that can signal latent TB infection and active disease. We will compare these markers in both HIV positive and negative pregnant and post-partum women, and we will compare placental cells in pregnant women with no evidence of infection or diseases, active TB disease, and latent TB infection, in order to learn more about immunologic responses during pregnancy and suppression of tuberculosis. Study Team: Jyoti Mathad, Amita Gupta, Ramesh Bhosale, Shilpa Naik, Neetal Nevrekar, Vandana Kulkarni, Nishi Suryavanshi, Mallika Alexander, Neeta Pradhan, Neil Martinson
HATHI Trial: Reducing Alcohol Use among People with Tuberculosis and HIV in India This 5-year study will enroll 450 patients, half with tuberculosis and half with HIV/TB coinfection, and will assess whether treatment that integrates cognitive behavioral therapy and motivational enhancement therapy is more effective in mitigating alcohol abuse and improving treatment outcomes. The study is being conducted at DY Patil Hospital and BJGMC in Pune. Study Team: Amita Gupta, Geetanjali Chander, Nishi Suryavanshi, Arjun Kakrani, Dr. Gaikwad, Jonathan Golub, David Dowdy, Prasad Bogam, Nikhil Gupte, Vidya Mave, Gauri Dhumal
CATALYST Trial: Studying Safer, Shorter Course, More Effective Treatments among Children with Drug-Resistant Tuberculosis CATALYST is a multi-national trial being conducted in India, South Africa, and Philippines. The BJGMCJHU clinical research site Pune will enroll HIV+/- children under the age of 15 who have confirmed or diagnosed drug-resistant TB. The current standard treatment is lengthy (9-11 months) and has significant side effects, thus this study is assessing new formulations that are child-friendly. Study Team: Mandar Paradkar, Aarti Kinikar, Nishi Suryavanshi, Amita Gupta
Our research team in Pune, India, is among few groups worldwide to focus on the immunological changes associated with pregnancy and post-partum stages of life.
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