ARTIGO DE REVISÃO
REVIEW ARTICLE
Algarve Médico, 2018; 3 (2): 24 - 29
Experimental models of mammary sentinel node biopsy Gabriela Valadas1, Daniel Cartucho1 1
Serviço de Cirurgia II - Centro Hospitalar Universitário do Algarve
gabriela.valadas@chalgarve.min-saude.pt
Abstract Breast cancer is globally the most frequent type of cancer in women. Significant improvements in detection and therapy have been observed in the last two decades. Animal models play a significant role in the effort to develop correct strategies. To study the complex mechanisms of oncologic disease and the process of metastases in the animal, the choice of the animal model is important. The authors consider the various models and search for a system that can effectively address the questions at hand. Animal models have been found to be useful in studying complex biological behaviours and validating basic scientific findings due to similarities with humans. For the study of the mammary sentinel node, animal models can be large animals (pigs or sheep) or rodents (rats, mice or guinea pigs). Questions on the sentinel node could be answered with the aid of an animal model. Each model has, however, its strengths and weaknesses. The authors consider the characteristics necessary for a good pre-clinical model of the breast sentinel node.
Keywords: Breast tumou; experimental models; sentinel node model
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