The Most Influential Women Leaders To Watch In 2023

From Editor’ s Desk

- Horace

Womenareeffectivechangeagents,anddiversityandgenderparityinleadershipand decision-makingareincreasinglyacknowledgedinallwalksoflife.Womenstillmakeup averysmallpercentageofthosewhomakedecisionsinpolitics,business,andsociety

Theneedtoclosethepaygapbetweenmenandwomenhavereceivedmoreattentionin recentyears,alongwithcallsforgreatergenderequality.Despitethefactthattherehas beenalotofimprovementinthisarea,therearestillfartoofewwomeninpositionsof authority

Conqueringthestruggles,womenhaveemergedaspowerfulleaders!

ThisissueofCIOWomenofTheMostInfluentialBusinesswomentoWatchOutarethe storiesofsuchpowerfulwomen.

Featuringforthecoverstory-

ZarineManchanda,theFounderoftheZarineManchandaFoundation,isoneofThe MostInfluentialWomenLeadersToWatchIn2023.Despitefacingnumerouschallenges, Zarine'sdeterminationandresiliencehelpedherovercomesetbacksinherbusinessand philanthropicendeavors.Throughherfoundation,shehassignificantlyimpactedsociety, andhersuccessstoryisatestamenttothepowerofperseveranceinthefaceofadversity. Zarine'sunwaveringcommitmenttocreatingaluxuriousandsociallyresponsibleworld hasearnedherawell-deservedspotonthislistofinfluentialwomenleaders.

Zarineisawell-knownfigureintheworldofIndianpoliticsandbusiness.Herjourneyto successhasbeendifficult,assheovercameseveralchallengestoreachwheresheis today.Inthebeginning,Zarine'sgoalwastobuildherpoliticalbase.However,itwasnot aneasytasktoachieve.ShestruggledforalongtimetocrackintoBollywood,which wasadifficultanddepressingperiodinherlife.Despitethesesetbacks,Zarineremained determinedandfocusedonhergoals.

Shalmali W. halmaliS

"Rule your mind or it will rule you”

This list is NOT a ranking. The companies on listed in magazine serve different aspects of the market, making ranking them in any order except revenue impossible and unfair. We try to bring a perfect platform for business organization to showcase their valued products/ services.

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LIFEHISTORY

NormaJeaneMortensonwasgiventhe nameMarilynMonroeonthedayof herbirth,June1,1926,attheLos AngelesGeneralHospitalinLos Angeles,California.GladysPearl Baker(néeMonroe;1902–1984),her mother,wasborninPiedrasNegras, Coahuila,Mexicotoalow-income familyfromtheMidwestthathad movedtoCaliforniaattheturnofthe century.GladysPearlBakerdiedin 1984.GladysBakerwasjust15years oldwhenshetiedtheknotwithJohn NewtonBaker,amanwhowasnine yearshersenior.Robert,wholived from1918to1933,andBerniecewere theirtwochildren(1919–2014).In 1923,shehadherpetitionfordivorce andrequestforexclusivecustodyof thechildrengranted.However,shortly afterwards,Bakerabductedthe childrenandtransportedthemtohis homestateofKentucky

ThefactthatMonroehadasisterwas notrevealedtoheruntilshewas12 yearsold,andthetwodidnotinitially meetuntil1944,whenMonroewas either17or18yearsold.Followingthe endofhermarriage,Gladysfound employmentatConsolidatedFilm Industriesasafilmnegativecutter.She wedMartinEdwardMortensenin 1924,butthecouplesplitonlyafew shortmonthsaftertheirmarriageand werelegallyseparateduntil1928.The resultsofDNAtestingconductedin 2022suggestedthatMonroe's biologicalfatherwasCharlesStanley Gifford(1898-1965),acoworkerof Gladys'swithwhomshehadanaffair intheyear1925.Thisinformationwas revealedin2022.Doris(1920–1933), theolderofMonroe'stwootherhalfsiblings,andCharles,theyoungerof Monroe'stwootherhalf-brothers,were bothbornduringGifford'smarriageto hisfirstwife.

DespitethefactthatGladyswas emotionallyandfinanciallyunprepared forakid,Monroehadasecureand happylifeinhisearlyyears.Inthe

littletownofHawthorne,Gladysmade thedecisiontoentrustherdaughterto thecareofAlbertandIdaBolender, evangelicalChristianfosterparents.In addition,sheresidedthereforaperiod ofsixmonthsbeforebeingcompelled toreturntothecityinordertofind work.Afterthat,shestartedspending theweekendswithherkid.[24]Gladys purchasedamodesthomein Hollywoodwiththeassistanceofa loanfromtheHomeOwners'Loan Corporationduringthesummerof 1933.Shethenbroughtherdaughter Monroe,whowasthensevenyearsold, tolivewithher

ThecircumstancesofMonroe'syouth werethefirstimpetusforherpursuitof acareerintheentertainmentindustry: "Ididn'tliketheenvironmentaround mebecauseitwassortofbleak... WhenIfoundoutthatthiswasacting, Iimmediatelythoughttomyself, "That'swhatIwanttodo!"WhenIwas younger,someofmyfosterfamilies wouldtakemetothemoviesasa meanstogetmeoutofthehome,andI wouldwindupstayingthereforthe wholedayandfarintothenight.Iwas atinychildsittingupfrontallby myselfwithsuchalargescreen,andI reallylovedit.

OnJune19,1942,afewdaysaftershe turned16,shetiedtheknotwithJames Dougherty,afactoryworkerwhowas 21yearsoldandthesonoftheir neighbors.Shefeltthatsheand Doughertywereaninappropriatefitfor oneanother,andshesubsequentlysaid thatshewas"dyingofboredom" throughouttheirmarriage.They eventuallygotadivorce.

Shehadprominentpartsinthefilm noirNiagara,whichexplicitly dependedonhersexappeal,andthe comediesGentlemenPreferBlondes andHowtoMarryaMillionaire,which cementedherstarimageasa"dumb blonde."By1953,Monroewasoneof themostmarketableactressesin Hollywood.Thephotographsofher nakedbodywereonthecoverand

centerfoldoftheveryfirstissueof Playboy,whichwaspublishedthe sameyear Throughouthercareer,she hadalargepartintheformationand controlofherpublicimage,butshe wasdisheartenedwhenshewas typecastandunderpaidbythestudio. Shewasgivenatemporarysuspension atthebeginningof1954forrefusingto participateinafilmproject,butshe laterreturnedtoactinTheSevenYear Itch(1955),whichwasoneofthemost financiallysuccessfulfilmsofher career Sheafterwardswedanotherman.She wedJoeDiMaggioonJanuary14th, 1954,intheSanFranciscoCityHall, andtheceremonytookplacethere. Afterthat,theydrovetoSanLuis Obispo,andthenspenttheir honeymoonatthemountainlodgeof Monroe'slawyer,LloydWright,which waslocatedjustoutsideofIdyllwild, California.In1955,theyfinallyparted waysanddivorced.

AfterthemonthofOctober1955,the newrelationshipbetweenMonroeand Millergrewmoreserious.In1956, MonroewedMillerashersecond husband.AdivorcebetweenMonro andMillerwouldtakeplacein1961. Thepublicwasveryinterestedinthe turbulentpersonallifeofMonroe.She battledaddictionaswellasmental issuesthroughoutherlife.Her marriagestoJoeDiMaggio,aformer baseballstar,andArthurMiller,a writer,bothreceivedagreatdealof mediaattentionbutultimatelyresulted indivorce.HerdeathonAugust4, 1962,attheageof36,wastheresultof anoverdoseofbarbituratesthat occurredatherresidenceinLos Angeles.Itwasdeterminedthatsuicide wasthemostlikelycauseofherdeath.

MAJORLIFEEVENTS

Atthebeginningofhercareerasan actress,NormaJeanechangedher nameonceagain,thistimetoMarilyn Monroe(Monroewasher grandmother'smaidenname).Monroe appearedinherfirstmovieparton

February11,1947.Shehadalready bleachedherdarkhairblondeand calledherselfMarilynMonroe.

MarilynMonroemadeherdebutinthe filmindustryin1947withan uncreditedappearanceasatelephone operatorinthefilmTheShockingMiss Pilgrim.Shealsohadcameorolesin thefilmsYouWereMeantForMeand GreenGrassofWyoming.Inthesame year,shewascastinDangerousYears foralittlepart.

TheGoldenGlobeAwardforBest ActressinaMotionPictureMusicalor ComedywasgiventoMonoreonJune 29,1956,andshereceivedtheaward forherperformanceinthefilmSome LikeitHot.

OnJune29,1956,Marilynbecomes MarilynMillerafterconvertingto Judaismandmarryingthewriter ArthurMiller ArthurMillerwasher longtimeboyfriend.

OnJanuary21,1953,shemadeher debutintheleadingroleinherfirstbig picture.Monoroe'sdebutinaleading rolecameinNiagara.Shetookonthe roleofafemmefatalewhoplottedthe deathofherhusband.Shewasmet withgenerallyfavorablecomments, despitethefactthatthemajorityof reviewersconcentratedontheblatantly sexualaspectsofherperformance.

Monroeemergedasaprominentsex symbolandoneofHollywood'smost bankableactorsin1953afterstarring inthreefilmsthatwerereleasedthat year.Inthefirst,aTechnicolorfilm noirtitledNiagara,sheportrayeda femmefatalewhoplottedtokillher husband,whowasplayedbyJoseph Cotten.Bythattime,MarilynMonroe andhermake-upartistAllan"Whitey" Snyderhadcreatedwhatwould becomeknownasher"trademark" make-uplook.Thisstylehadblack browsarchedupward,paleskin,red lipsthat"glistened,"andabeauty mark.AccordingtoSarahChurchwell, "Niagara"isoneofMarilynMonroe's

mostblatantlysexualfilmsthatshe starredinthroughouthercareer The factthatMonroe'sbodywasseenin somemomentswithnothingmorethan asheetoratowelcoveringitwas surprisingtoviewersofthetime.The mostwell-knownmomentfrom Niagaraisathirty-secondlongshot takenfrombehindMarilynMonroein whichsheisseenstrollingwithher hipsswinging;thisphotowasused prominentlyintheadvertisingforthe picture.

OnMay19,1962,Monroewas requestedtoperformatJohnF Kennedy'sbirthdayparty,whereshe didsoalongwithaspeciallyprepared

lyric.Shedidsowhilesinging"Happy Birthday."TheGoldenGlobeAwards wereheldonMarch5,1962,and MarilynwontheawardforWorldFilm Favorite.

CONTROVERSIES

NudeCalendar

AfterMonroeadmittedtotheworldin Marchof1952thatin1949shehad appearedforanudecalendar,she foundherselfinthemiddleofa controversythatlastedfortherestof herlife.Afterdiscoveringboththe photosandthefactthatshehadbeen publiclysuspectedofbeingthemodel

afewweeksearlier,theproduction companyandMonroecametothe conclusionthat,inordertoprotecther career,itwouldbebestforhertoadmit tothemwhathadhappenedwhile emphasizingthatshehadbeenbrokeat thetime.Becauseofthismethod,she wasabletowinthesympathiesofthe generalpublicandgeneratemore interestinherfilms,forwhichshewas nowgettingtopbilling.Monroewas featuredonthecoverofLifemagazine asthe"TalkofHollywood"afterthe

incident,andgossipwriterHedda Hopperpronouncedhertobethe "cheesecakequeen"turned"boxoffice hit"afterthescandal.[98]Thepublic excitementinMonroewascapitalized onbyquicklyreleasingthreeofher films:"ClashbyNight,""Don'tBother toKnock,"and"We'reNotMarried!"

UtilizationofaSubstance

Monroehadareputationforbeing toughtodealwith,whichonlybecame

worseashercareergrew.This reputationwouldcontinuetohurther career.Shewasoftenlateordidnot showupatall,didnotrememberher lines,andinsistedonseveralretakes beforeshewaspleasedwithher performance.Shealsodidnot rememberherlines.Herrelianceon heractingtutors,firstNatashaLytess andsubsequentlyPaulaStrasberg,also annoyedthefilmmakerswhoworked withher.Ithasbeenhypothesizedthat Monroe'sdifficultiesstemfromamix ofperfectionism,poorself-esteem,and performanceanxietyonstage.

Onfilmsets,shefeltthatshehadlittle controloverherperformance,but duringpictureshootings,shehadmore inputintohowshewasportrayedand wasabletobemoreimprovisatory ratherthanaccordingtoascript.She foundthatfilmsetsweremorestressful thanphotoshoots.Shestartedabusing barbiturates,amphetamines,and alcoholinanefforttotreatheranxiety andchronicsleeplessness;however, thisonlymadeherproblemsworseand shedidnotdevelopastrongaddiction toanyofthesesubstancesuntil1956. Herissueswereaggravatedbyheruse ofthesesubstances.

Herpassingaway

Monroe'sbodywasdiscoveredather houseinBrentwoodwhenshewas36 yearsold.Isitpossiblethatshetook herownlife?Anaccident?Ascheme tohidethetruththatwashatchedby theKennedys?Ahomicidecommitted byoneofhermedicalpractitioners? Aftersixtyyears,thereisstillagreat dealofcontroversyaroundthe circumstancessurroundingher untimelydeath.

HOWSHEBECAMEFAMOUS

Herinnatebeautywasafactorin openingdoorsforher,buttheeffortshe putinwasthedrivingforcebehindher meteoricclimbtosuperstardom."She hadapassiontoimproveherselfby readingbooksonpsychology,

philosophy,poetry,art,theatre,and everythingelse,"addsVogel."You nameit,shereadbooksonit."Even aftershehadachievedfameasa Hollywoodactress,shepursuedher interestindramabyenrollingatthe famousActorsStudioinNewYorkand studyingunderLeeStrasberg.Shedid thisbecauseshehadtheambitiontobe adramastudent.Shewasapioneerin manyrespects,andinmanywaysshe wasafeministbeforethewordwas fullyrecognizedorunderstood. Afterbeingrehiredby20thCentury Fox,MarilynMonroeswiftly establishedherselfasthemost marketablestaratthecompany. Followingherroleasatragicfemme fataleinthefilmNiagara(1953),she wentontostarinasuccessionoffilms thathelpedcreateher"dumbblonde" reputation.Thesefilmsinclude timelessmasterpiecessuchasHowto MarryaMillionaire(1953),TheSeven YearItch(1955),andSomeLikeItHot (1962).(1959).Herusualpart,which wasthatofaditzycharmerwith perfectcomictiming,setherapart frompeerssuchasElizabethTaylor, DorisDay,andAudreyHepburn, whosecharactersexemplifiedmany typesoffemininity.Day'sbenign"girl nextdoor"attitudeinvokedthe attractivenessoftheyoungeractress' pin-upcareer,whileTaylor's seductressesbattledwithMonroe's effervescentblondes.Dayalsohada roleintheproductionofthefilm"The SevenYearItch."Hepburn,onthe otherhand,isknownforcultivatingan imageofaristocraticelegance,whichis characterizedbyhersocial sophisticationandflair.

Whenoneconsidersthestar'stroubled personallife,itisevenmore remarkabletoseehowfarshehas comeprofessionally.Monroewas famouslydifficulttoworkwithdueto thefactthatshewasalwayslateto shootsandoftenmessedupherlines. Butshewasnospoiledprincess."Inall honesty,"addsVogel,"shesuffered fromtremendousstagefright.""She

wasanervousmesswhileshooting sequences,sometimesbreakingout intoarashorbecomingphysically unwellatthenotionofacting."Asa meansofcopingwiththetraumatic experiencesshehadgonethroughand theanxiousfeelingsshehad,she misusedthebarbituratesand amphetaminesthatherphysicianshad carelesslygiventoher.

Asweenteranewyear,it'simportant torecognizethewomenleaders makingasignificantimpactintheir respectivefields.Frompoliticsto business,thesewomenarebreaking barriers,shatteringglassceilings,and pavingthewayforfuturegenerations ofwomen.Theyleadwithcourage, innovation,andcompassion,andtheir influenceisfeltworldwide.These womenleaderswillcontinuetoinspire uswiththeirachievements,andwe can'twaittoseewhatthey'll accomplishnext.

ZarineManchanda,theFounderof theZarineManchandaFoundation, isoneofTheMostInfluentialWomen LeadersToWatchIn2023.Despite facingnumerouschallenges,Zarine's determinationandresiliencehelpedher overcomesetbacksinherbusinessand

philanthropicendeavors.Throughher foundation,shehassignificantly impactedsociety,andhersuccessstory isatestamenttothepowerof perseveranceinthefaceofadversity Zarine'sunwaveringcommitmentto creatingaluxuriousandsocially responsibleworldhasearnedhera well-deservedspotonthislistof influentialwomenleaders.

AddingVersatilitytotheOrigin

ZarinewasborninHimachalPradesh intoaprominentfamily,whereher fatherwasasuccessfulbusinessman andministerinthestate.Asayoung girl,shedreamedofbecominga Bollywoodactressandmovedto Mumbaitopursueherdream. However,despiteattendingmany auditionsandactingclasses,successin

theindustryremainedelusive. Undeterred,Zarinepursuedapolitical careerandwasadvisedtoopena charityfoundation,whichledtothe birthoftheZarineManchanda Foundationin2019.Sincethen,the foundationhasadministeredalmost 300donationprogramstothepoorest residentsofMumbai,earningherthe moniker"PrincessofthePoor"and significantmediacoverageinIndia's mostrenownedmagazinesand newspapers.

Inspiredbythesuccessofher foundation,ZarineopenedtheZarine ManchandacaféduringtheCOVID-19 pandemic,whichpresentednumerous challengesbutquicklybecameatalkof thetownvenueforBollywood'sA-list crowd.Withfranchiseinquiriesand proposalsforhercafépouringinfrom

Entrepreneurship Era Post-pandemic

Zarinereflectsonhowthe pandemichaschanged entrepreneurshipinIndia. Whileshecannotspeakfor otherCEOs,Zarinehas noticedsomebusiness changes.Toherknowledge, thepandemichasforcedmany companiestorethinktheir approachtowork.Remote workhasbecomemore common,whichhashadan isolationisteffectonpeoplein Indiaandworldwide. However,thepandemichas alsounleashedapowerful force—thedesireforpeopleto feelandexperienceadeep individualconnectionwhen theyareoutandabout.

Zarinebelievesthisdesirefor connectionhascreatedan opportunityforherbusinesses. Shestrivestocreateasenseof welcomingandbelongingwith acamaraderiethatgoes beyondtypicalbusiness customerrelations.Shecalls this"spiritualcharm,"which hashelpedherbusinesses thriveeveninthepostpandemicera.

"Through a vision of luxury with a spiritual touch, Zarine Manchanda has created a unique and compassionate niche for her businesses, which has helped her stand out in a highly competitive market."

Indiaandtheworld,Zarine's entrepreneurialspirittookflight.She subsequentlyopenedacloudkitchen fooddeliveryservice,Zarine Manchanda'sHeavenlyFlavors,anda seven-starpremiumsecuritycompany, whichcomplementedeachotherin filmsetsandprivategatherings.And mostrecently,sheopenedZarine Manchanda'sFlavorsoftheHimalayas athercloudkitchenlocation,serving thefirstHimachalicuisineinMumbai.

TurningChallengesintoSuccess

Zarineisawell-knownfigureinthe worldofIndianpoliticsandbusiness. Herjourneytosuccesshasbeen difficult,assheovercameseveral challengestoreachwheresheistoday. Inthebeginning,Zarine'sgoalwasto buildherpoliticalbase.However,it wasnotaneasytasktoachieve.She struggledforalongtimetocrackinto Bollywood,whichwasadifficultand depressingperiodinherlife.Despite thesesetbacks,Zarineremained determinedandfocusedonhergoals.

Zarinedecidedtoopenherfoundation, whichwasaturningpointinherlife. Thefoundationgaveheranewsense ofpurposeanddirectionandhelped hertoovercomethechallengesshe facedinhercareer.Throughthe foundation,Zarinepositivelyimpacted society,enablinghertogainthe confidenceandsupportsheneededto succeed.

Despitethesuccessofherfoundation, Zarinefacednewchallengeswhenthe Covid-19pandemichit.Thepandemic affectedherfoundationandcafé,and shehadtofindnewwaystocontinue hercharitableworkandkeepher businessrunning.However,Zarine's determinationandresiliencehelpedher overcomethesechallenges,andshe couldresumeregularbusinesshoursin hercaféandincreasethenumberof charityprogramsinherfoundation.

LuxurywithaSpiritualTouch

Zarineenvisionedprovidingher customerswithaluxuriousexperience whileincorporatingspiritualelements intoherventureswhenshestartedher business.Shefoundedvarious companies,fromacharityfoundationto acaféandcloudkitchen,andpremium securityservices,eachwithunique charmandessence.Zarine'sUSPforall hercompaniesisluxuryandspiritual charm,whichmeansthathercustomers canexpectapremiumexperiencewitha touchofspirituality.Whetheritisa7starcaféorpremiumsecurityservice, eachofZarine'sbusinessesisdesigned toprovideasenseofcalmandpeace amidstthechaosandbusynessof everydaylifeinMumbai.

Zarine'sfoundationalsoreflectsher visionofluxurywithaspiritualtouch. Whilethereisalongqueueof companiesparticipatingintheirCSR activities,sheknowsthatexpandingto providemorefacilitiesandservicesfor thepoorwillbedonewithanelementof luxury,asshebelievesthatthepoor deservetoexperiencethesamelevelof luxuryasthemorefortunateandrich. Throughhervisionofluxurywitha spiritualtouch,Zarinehascreateda uniquenicheforherbusinesses,which hashelpedherstandoutinahighly competitivemarket.Herfocuson providingapremiumexperience incorporatingspiritualityhasresonated withhercustomers,andherbusinesses continuetothrive.

NoLookingBack

Zarinehasauniqueperspectivewhenit comestolookingbackandgiving advicetoheryoungerself.Shebelieves inlivinginthepresentmomentand focusingonwhatistocomeinthe future.Havinglostbothherparents recently,sheunderstandstheimportance ofcherishingeverymomentandliving lifetothefullest.

Zarineiscontentwithherlife's pathandtruststhateverything happensforareason.Shebelieves indoingGod'swill,servingthe poorthroughherphilanthropic work,andrunningherbusinesses withintegrity Asanempowered womanandinspirationalrole model,Zarineencouragesothers tofocusontheirgoalsand maximizeeveryopportunity.Her advicetoheryoungerselfisto staytruetohervaluesandbeliefs andtotrustinthejourneythatlife hasinstore.

CreatingOwnLegacy

Zarinehasbigplansforthefuture. Withyearsofexperiencerunning successfulbusinesses,sheis determinedtocontinueher father'slegacyinherway While shestartedwithafoundationto helpthoseinneedinMumbai,she hassinceexpandedtoopena luxuriousseven-starcafe,acloud kitchenfooddeliveryservice,and apremiumsecuritycompany-all bearinghername.

Zarineplanstoexpandher businessesglobally,withinquiries forfranchisespouringinfrom Indiaandbeyond.However,even withherambitiousplans,Zarine alwaysremembersherlife's missionandpurpose-todogood karma,showgoodintentions,and becompassionatetothepoor.She firmlybelievesthatallher businessesshouldhavea componentofcharity,gooddeeds, luxury,andspiritualcharm.With herdriveandpassion,Zarine Manchandaisaforcetobe reckonedwithinthebusiness world,andsheshowsnosignsof slowingdown.Sheremains committedtopositivelyimpacting theworld,oneventureatatime.

LEADING WITH COMPASSION

Instincts,HardWork,and WillingnesstoTakeRisks

Zarinebelievesthatwhileeducationis important,successinentrepreneurship isdefinedmorebyanindividual's instincts,hardwork,andwillingnessto takerisks.Shecreditshersuccessto theDNAofherparentsandherown braveryandfearlessnature,which havehonedherinstinctsandmadeher anempoweredwomanand inspirationalrolemodel.

Zarine'sperspectivesuggeststhatwhile educationprovidesvaluable knowledgeandskills,anindividual's innatequalitiesandpersonaldrive ultimatelydeterminetheirsuccessas anentrepreneur Thishighlightsthe importanceofcourage,determination, andresilienceinachievingone'sgoals andhowtheycanshapeone'slife trajectory.

LeadingwithCompassion

Zarinecreditshermotherforinstilling thevaluesofhonesty,purity,and

ethics.Hermotheralwaysreminded herthatGod'seyesarewatching, profoundlyimpactingherleadership style.ToZarine,trueleadershipisnot aboutwieldingpowerinathreatening wayorusingaloudvoice.Instead,itis aboutempoweringthepeoplewho workforhercompaniesandensuring theyareproudtobeaffiliatedwithher brandandbusinessenterprises.

ThisadvicehashelpedZarinetolead withcompassionandservice,always focusingonthegreatergood.She believesthatthestrongestleaders embodythesequalities,andshestrives toliveuptothisstandardeveryday Byputtingpeoplefirstandleading withintegrity,Zarinehasbuilta successfulandrespectedbrandthat positivelyimpactstheworld.

PhenomenalGrowthTrajectory

Zarinehasexperiencedphenomenal growthinherbusinessesoverthe years.Heruniqueconceptofluxury withaspiritualtouchhasgainedhera

loyalfollowing,andshehasbecomea householdnameinMumbaiand beyond.Hergrowthtrajectoryhasbeen soimpressivethatmultiplemedia outletsapproachhervirtuallyevery day.Themediacoveragehasbeen positive,bringingthebusinessand philanthropiccommunitiestoherdoor toexplorebusinessdevelopmentand expansioninallsectorsandcornersof theglobe.

ZarinebelievesthatherUSPofluxury andspiritualcharmhassignificantly influencedherlong-standingsuccess. Thesetraitscomenaturallytoher, givenherparents'DNA,andtheyhave resonatedwithhercustomers,clients, andeventhepoorthatsheserves. Indianswanttoenjoyluxuriesinlife, buttheyalsowanttofeelgoodabout whotheyaredoingbusinesswith.

Zarine'sfocusonluxurywitha spiritualtouchhascreatedapositive reactioninthebusinesscommunity, andeveryoneseemsinspiredbythe company'spillars.Hervisionforher enterprisesisclear,andshebelieves

thatherfocusonluxuryandspiritual charmisontherighttrack.

PlansforExpansion

Zarineisconsideringvarious opportunitiestofurtherherservices andexpandherbusinessesglobally. Shehasalreadymadeanamefor herselfinMumbaiwithherdiverse rangeofcompanies,includingacharity foundation,acaféandcloudkitchen, andpremiumsecurityservices,all offeringaluxuriousexperiencewitha spiritualtouch.Zarine'sfirststep towardsexpansionisthrough franchisingopportunitiesforhercafé

andpremiumsecuritycompanies.Sheplans totakeheruniqueconceptofluxurywitha spiritualtouchtotheglobalmarket,where shehopestoestablishherbrandandcreatea loyalcustomerbase.

However,Zarine'svisiongoesbeyondjust expandingherbusinesses.Sheisalso committedtosignificantlyimpactingsociety throughherfoundation.HerCSRprocesses arealreadyinplay,andsheplanstotakeher foundationtothenextlevelbyproviding freefoodcanteensforthepoor,numerous ambulances,andmobilemedicalclinicsto providenecessarymedicalcareintheslum cells,andschools,orphanages,andoldage carefacilitiesbearinghername.

ZARINE MANCHAND ZARINE MANCHAND ZARINE MANCHAND

CanYouJustImagine

Zarinehasledaremarkablelife journeyfilledwithnumeroussuccesses andaccolades.Shebelieves,Ifherlife weretobechronicledinabook,it wouldaptlybetitled"CanYouJust Imagine."Thisexpressionresonates withherbecausesheusesthephrase extensivelyandforalltheincredible featsshehasaccomplishedinher globalbrandingandbusinessventures despitefacingchallengessuchasthe COVID-19pandemic.

Throughouthercareer,shehasbeen recognizedwithnumerousprestigious awards,includingtwoNational awards,aGovernor'saward,andthe NelsonMandelapeaceaward,which bestowedadoctorateuponher.Her mediapresencehasbeenconstant,and herimpacthasextendedbeyondjust thebusinessworld,encompassing philanthropy,fashion,andpolitics. Zarine'ssuccesscanbeattributedto herboldvisionandtheabilitytouse herimaginationtocreateinnovative andstrategicplansforhercompanies.

Asanentrepreneur,sheencourages buddingbusinessleaderstothink outsidetheboxandfindtheirunique sellingpoints.

GuidingWords

Zarinehasapowerfulmessagefor aspiringentrepreneurs.Throughher experiencesandsuccesses,she emphasizestheimportanceofbeing boldandtakingrisks.Manchanda believesbuddingentrepreneursshould refrainfromfollowingthecrowdbut

insteadfindtheiruniquesellingproposition(USP)andactboldlyon it.

Hermessageisclear:toachievesuccess,onemustbewillingtostep outsideoftheircomfortzoneandthinkoutsidethebox.This approach,Manchandabelieves,willultimatelyleadtoastrongerand moresecurepathtowardachievingone'sgoals.

Today,Zarineisasuccessfulentrepreneurandphilanthropistwhohas significantlyimpactedsociety.Herjourneytosuccesshasbeenfilled withchallengesandsetbacks,butshehasshownthatanythingis possiblewithdeterminationandhardwork.Zarine'sstoryinspires manyandisatestamenttothepowerofresilienceandperseverance inadversity

HARBOUR BRIDGE

The National Icon of Australia!

HARBOUR BRIDGE

HISTORY

TheSydneyHarbourBridgeisasteelarchbridgethatislocatedinAustralia andcrossesSydneyHarbour(also knownasPortJackson).Thebridge, whichhaditsinauguralopening ceremonyin1932,isnowusedasthe primaryconnectorforpublic transportationbetweenSydneyandits northernsuburbs.Becauseithasaspan ofaround500meters(1,650feet),itis consideredtobeoneofthelongest steel-archbridgesintheworld.Along itslength,itisequippedwithtwo pedestrianwalkways,ahighway,and fourseparaterailwaylines.

In1924,Bradfieldwasinchargeof overseeingthebeginningofthe project.Becauseofthedepthof SydneyHarbour'swaters,itwas impossibletoemploytemporary supports,thereforethesteelarchwas constructedfromeithersideofthe harbor.Thetwosidesfinallyconverged inthemiddleintheyear1930,anda grandceremonywasheldtocelebrate thebridge'sofficialopeningonMarch 19,1932.

CULTURALSIGNIFICANCE

TheSydneyHarbourBridgewas designatedashavingexceptional nationalhistoricvaluebythe AustralianHeritageCouncil.Its buildingwasasignificanteventin Australianhistory.Itsinaugurationin 1932wasessentialinthebuildingof contemporarySydneyandservedasa focalpointfornationaloptimism throughouttheGreatDepression.The HarbourBridgehasbecomealasting nationallandmarkandhasinspired manyofAustralia'sleadingartists.Itis oneoftheworld'smostmagnificent archbridges.Althoughitdoesnothave theworld'slongestarchspan,itsmass andloadcapacityarelargerthanthose ofothersignificantarchbridges,and

nootherbridgeinAustraliaequalsto itstechnologicalimportance.The bridgewasthemostexpensive engineeringfeatincontemporary Australia,andalthoughbeingover80 yearsold,ithasyettomeetitsfull capacity.TheSydneyHarbourBridge isespeciallynotableforitsaffiliation withJohnJobCrewBradfield,oneof Australia'smostillustriouscivil, structural,andtransportengineers, whoproducedtheoverall specificationsandoversawthewhole project.

LOCATION

TheSydneyHarbourBridgeinthe countryofAustraliamaybefoundata latitudeof-33.852222andalongitude of151.210556.TheSydneyHarbour BridgeislocatedinAustralia.From Sydney'sCentralBusinessDistrictall thewayuptotheNorthShore.

HOWTOREACH(MODESOF TRANSPORTATION)

ByTrain

ByTram

ByFerry Taxi Bus

THENEARESTAIRPORT

SydneyAirportistheclosestairportto theSydneyHarbourBridge(SYD) NEARESTRAILWAYSTATION

MilsonsPointStation

NEARESTFERRYSTATION

FerrystationsnearSydneyHarbour BridgeinSydney

KirribilliWharf

MilsonsPointWharf

JeffreyStreetWharf

NEARESTPLACEOF ACCOMODATIONANDCOSTTO HARBOURBRIDGE

FourSeasonsHotel

TheFourSeasonsHotelSydneyis colorfulandelegant,withmagnificent harbourfrontviewsandaluxuryday spawithspecialskincareand aromatherapytreatments.Itislocated inthehistoricRocksneighborhood, onlyashortwalkfromthecity'sretail andcommercialdistricts. Thecosteachnightis$300pernight

TheSebelQuayWestSuites

WhenyoustayatTheSebelQuayWest SuitesSydney,youcanexpectnothing butamazinghospitality,elegant accommodations,andexquisite service.Our5-starhotelprovideslarge apartment-styleapartmentswithviews oftherenownedSydneyHarbour Bridge,OperaHouse,TheRocks,and CircularQuay.TheSebelQuayWest SuitesSydneyissuitableforshort getaways,specialevents,andlongtermvacations,andislocatedinthe historicRocksarea,12.4kilometers

fromSydneyAirportandtheFerry Terminal.

Cost:$240pernight

HotelKithDarlingHarbour

HotelKithDarlingHarbourisa modernurbansanctuary Thisboutique hotelhasfoursmallroomtypes, includingthePetitequeenandPetite twinroomseriesfortravelers searchingforafashionableand comfortableplacetobedafteralong dayout,aswellastheStandardqueen roomsandQueenwithBalconyrooms forthatmorewiggleroom.

Cost:$230

CrownTowersSydney

CrownTowersSydneyisthegold standardinAustralia'spremiumhotel sector,havingreceivedaForbesaward forguestsafety.Eachaccommodation

hasstylish,contemporarydécorthat capturesthespiritofthestunningand distinctiveharborsideposition,with wonderfullyframedviewsofSydney's skyline.

Cost:$500pernight

MUSTFOODTOTRYOUT

XOCrispyFriedDumpling(5)Scallop Steamed(2pieces)

HalfshellscallopsteamedwithXOchilli andshallotsoysauce

QuailwithSaltandPepper(2pieces)

Stir-FrywithDriedChickenandBlack BeansBlackBeanSaucewithFired ChickenThighFillet(skinon)

MushroomwithSeasonalVegetablesin SoySauceVegetableSupreme

ChopsofMandarinPork

DuckinPlumSaucewithFriedPork ChopsTossedinSoyandChinkiang BlackVinegar

DucklingCrispywithSugarCaneand

PlumSauce

FilletPanFriedwithWasabiWasabiSlatheredSteakCube

StirFriedSalmonCubewithXOChilli

XOChipotleSeafoodDuckwith MushroomSoupandDryConpoy

SeafoodBeancurdSoupSoupwithHot andSourSauceSoupwithCrabmeat andSweetCorn

THINGSTODOANDTHINGS NOTTODO.

THINGSTODO

1.HarborCruisewithLunchBuffet

2.HarborCruisewithPremium3CourseDinner

3.Open-TopBigBusHop-onHop-off Tour

4.3-HourCatamaranWhaleWatching Tour

5.HarbourE-BikeTourGuided

6.CLIMBtothehighestarchofthe HarbourBridge.

7.Admirethesunriseorsunsetfromthe HarbourBridge.

THINGSNOTTODO

1.Goingonastrollwithoutatourguide

2.Stayingoutlateatnight.

3.Attemptingtoenterthewater BESTTIMETOVISIT.

Ifyou'reconsideringaBridgeClimbing Adventure,youmaybewonderingwhen theoptimumtimetoclimbtheSydney HarbourBridgeis.Thequickansweris thatyoucandosowheneveryouchoose. WhatmakestheBridgesowonderfulis thatitprovidesafantasticperspectiveof thecity,theharbor,anditsenvironsatall timesofday.

Climbsareheldatdawn,noon,sunset, andatnight.Eachtimeofdayhas variousfeaturesthatmakeaClimb uniqueandwellworthrevisiting.

CLIMBINGDURINGTHEDAYIS ENJOYABLE.

Duringtheday,youcanhearSydney's hecticbuzz,fromshipssailingbelow toSydneysidersgoingabouttheir business.

ViewsoftheazureseasofSydney Harbour,theOperaHouse,andthe splendoroftheRoyalBotanicGardens willbeavailableasyourise. TheClimngiteamcanalsoprovideyou withsomefantasticphotographs.

CLIMBINGATNIGHTCAN PROVIDEABEAUTIFULNIGHT VIEW

Atnight,Sydneycomesalivewith brilliantlightsandalivelynightlife.In theevening,theBridgeClimbofferslit 360-degreeviewsofthecityandits surrounds.

CLIMBINGATDAWN

Thesaying"theearlybirdgetsthe worm"accuratelyreflectsmorning climbing.Believeuswhenwesuggest thatgettingupearlytowatchthedawn overSydneyHarbourisworthwhile.

CLIMBINGATTWILIGHT

Thetransformationofthedayinto theeveningfromtheSummitisa spectacularsightthatmustbe experiencedtobeappreciated.The benefitofatwilightClimbisthat yougetthebestofbothworlds: SydneyduringthedayandSydney atnight.

NEARBYPLACES

PylonLookout

TheentrancetothePylonLookout andMuseum,oneofthetopSydney touristsites,islocatedatthefirst pylon.

TheOperaBar

Yes,thislocationallowsyoutokill twobirdswithonestone!TheOpera Bar,whichsituatedrightopposite theSydneyHarbourBridge,hasone ofthegreatestviewsofthebridge. Youmaygetupupandpersonal withtheSydneyOperaHousebefore relaxingwithadrinkandsome harbourbridgeshots.

BluesPointReserve(McMahons Point)

BluesPointReserveatMcMahons Pointisalocalfavoritebecauseit providestheidealsettingforapicnic withaview Welivedfairlyneartothis locationandpasseditonourwayto theboat.Despitethefactthatwesawit everyday,itstillastoundedus. Atlowtide,atinybeachemerges, allowingyoutosnapaphotosquareon (andyoucanevengetsomeoneinthe frametoofferperspective,asourniece graciouslydidabove!).

CahillExpressway

TheCahillExpresswayisanexcellent locationforanighttimephotoofthe HarbourBridge,particularlyifyou happentobeintownduringVivid. Youcanobtainaviewofthewhole harbour,includingthebridgeandthe OperaHouse.DuringVivid,youmay capturesomeincrediblelighttrails, likeourbuddyLeedidwiththisphoto.

ObservatoryHill

ObservatoryHillprovidesa spectacularviewoftheHarbourBridge andTheRocks.Thereisalargegrass

torelaxon,whichisidealforapicnic andaterrificareatoviewthesunset (whichhappensintheopposite directiontothebridgebutstilladds lovelysoftlighttophotos).It'salso freetoparticipate.

AVAILABLETOURS

BigBusSydneyandBondiHop-on Hop-offTour

ASydneyandBondiBeachbustrip providesalloftheadvantagesofa guidedtour,suchashassle-free transportationandonboardaudio commentary,whileallowingyouto exploretheattractionsatyourown speed.Ticketsaregoodfor24or48 hours,allowingyoutojumponandoff atsightssuchasSydneyHarbour,the Rocks,theRoyalBotanicGarden,and HydePark,orjustrelaxandenjoythe sceneryfromanopen-topdoubledeckerbus.

SydneyTheRocksGuidedWalking Tour

Onthisguidedwalkingtourof Sydney'shistoricarea,discoverthe

mysteriesofSydney'slegacy.Your guidewillleadyoualongshady lanewaysandcobbledcourtyards whereyou'lldiscoversomeofSydney's earliestbuildings,includingCadman's Cottage,builtin1816,andthe GarrisonChurch,builtinthe1840s, withstunningviewsofSydney HarbourandtheCampbellsCove Wharves.

SydneyBikeTours

Thiscitybicycletripallowsyoutosee Sydneylikeanative,withfourdistinct itinerarychoices.Allowyourguideto handletherouteandnavigationwhile youenjoytheview,passingattractions liketheSydneyHarbourBridgeand theSydneyOperaHouse.Youcan

chooseabiketourthatfitsyour scheduleandbudgetbyofferinga varietyoftourlengthsandfocalpoints.

SydneyHarbourHighTeaCruise

Enjoyaleisurelyafternoonsailaround SydneyHarbour,completewithhigh teatreatsandsparklingchampagne. Duringthis1.5-hourpicturesque viewingtour,you'llgetgreatviewsof classicSydneysitesincludingthe SydneyOperaHouse,SydneyHarbour Bridge,FortDenison,andthecity skyline.Upgradetogetawindowsea withgreatviewsoftherenowned gorgeousharborcity.Keepyour cameraavailableforamazingpicture opportunitiesineverydirection.

Reserveatablefora2-Course1.5Houror3-Course3-Hourlunchcruise inSydneyHarbour Asyourboatglides downtheriver,you'llseeiconic SydneysightsincludingtheSydney OperaHouseandtheSydneyHarbour Bridge.Yourseateddiningexperience includesdedicatedserviceforyour chosentwoorthree-coursemeal.As youtakeinthescenery,avarietyof freshseafood,pork,andveggiemeals areoffered.Upgradewhenmaking yourreservationtoensureawindow seat.

SydneyHarbourTopDeckLunch Cruise

AI TOOLS ARE FINALLY CHANGING THE

BIOPHARMA LANDSCAPE

BIOPHARMA

ThebiopharmaindustryAItools

arefinallychangingbecauseof howquicklyandhowmuch medicalandscientificprogressisbeing made.Newbusinessmodelsarebeing madebecausepatientswanttobemore involvedandhaveabetterexperience. Biopharma’snewcurrencyisdatathat ismade,captured,analyzed,andused inreal-timebynewmedicaldevices. Oneofthemostimportantthingsthat setcompaniesapartishowwellthey cangetinsightsandprooffrom multipledatasources.Sincethisisthe case,digitaltransformationisa strategicmust.Thisreportexplains howtechnologiesthatAItoolsare finallychanginguseartificial intelligencewillaffectthebiopharma valuechainandspeedupthedigital transformationofbiopharma. Eventhoughthereisalotof innovationintheindustry,biopharma companiesarefacingacomplexand difficultenvironmentduetomore competitionandlongerR&Dcycle times,lesstimeonthemarket,patents thatareabouttoexpire,fallingpeak sales,pressurearoundreimbursement, andmorescrutinyfromregulators.As we’veshowninourseriesofreportson “Measuringthereturnfrom pharmaceuticalinnovation,”these factorsarecausingtheprojectedreturn oninvestmentthatlargebiopharma companiescouldgetfromtheirlatestagepipelinestodropbyanalarming amount,whichthreatenstheirlongtermfuturesAItoolsarefinally changing.

HerearesomewaysthatAItoolsare finallychangingtheworldof biopharma:

Somebiopharmacompanieswanttheir chiefinformationofficers(CIOs)to leadtheirdigitaltransformationefforts, whileothershavehiredchiefdigital officers(CDOs),whoareoftenfrom otherindustries,orchiefdigital

informationofficers(CDIOs),who combinemanyoftheskillsofaCIO andaCDO.

Ÿ AItoolsarefinallychanging

Ÿ scientificprogress

Ÿ Artificialintelligence

Nomatterwhattheirjobtitleis,those inchargeofdigitaltransformationin biopharmacompaniesneedtousedata andnewdigitaltechnologiestothe fullesttochangetheirbusinessand operatingmodels.Themostanticipated andimportantofthesetechnologiesare thosethatfallundertheterm“AI.”

Atthemoment,machinelearning(ML) isthemostimportantpartofmanyAI technologies.Recentimprovementsin MLalgorithmsandthemore complicatedpartofMLcalleddeep learning(DL)arewhataregetting peopleexcited.Untilrecently,many companiesdidn’thavetheskillsto makethemostofAItoolsarefinally changing.Thisisbecausefindingthe rightusecases,makingcustom solutions,andusingthesesolutionsat thescalerequiredaccesstolargedata sets,specializedinfrastructureand processingpower,andateamofdata andanalyticsexperts.7Usingitona largescalealsorequiredalotofmoney tobespent.

Today,thisisquicklychangingastech giantsandstart-upsthatwereearlyto useAIofferAI-baseddevelopment toolsandappsasproductsand services,sothatothercompaniescan alsouseAI.Biopharmacompanies haveaccesstolargedatasets,andthe resourcestogetthecomputingpower andtoptechnicaltalenttheyneedand areinagoodpositiontoprofitfromAI iftheyinvestearlyAItoolsarefinally changing.

1.ThemarketforAIinbiopharma

MarketsandMarketspredictsthatthe marketforAItoolsarefinallychanging inthebiopharmaindustryandwill growfrom$208millionin2018to $3.88billionin2025,whichisa compoundannualgrowthrate(CAGR) of52.9%.

8Thesevaluesaredifferentineachof thefourregions:NorthAmerica, Europe,Asia-Pacific(APAC),andthe RestoftheWorld(RoW),which includesSouthAmerica,Africa,and theMiddleEast(seefigure3).

Between2018and2025,itisexpected thatdrugdiscovery,precision medicine,medicalimagingand diagnostics,andresearchwilldrive mostoftheAItoolsthatarefinally changinginbiopharma.Duringthe periodoftheforecast,drugdiscovery willbethebiggestmarket.Itwillgrow from$159.8millionin2015to $2,999.7millionin2025,whichisa CAGRof52.0%.Overthenextfive years,themarketforprecision medicineisexpectedtogrowby60.2% peryear,from$16.3millionin2018to $440,9million.CAGRsofover50% arealsoexpectedformedicalimaging anddiagnosticsandresearch(see figure4).

2.ThingsthataremakingAIgrow acrossthevaluechain.

ThegrowthofglobalAItoolsare finallychanginginbiopharmaandthe potentialfordigitaltransformationare causedbyseveralthings.Froma technologyanddatapointofview, transformationisbeingdrivenbythree thingsinparticular:moredata,more powerfulcomputers,andcheaper computers.

3.Biopharma’sfuturewillbedriven byAI

Biopharmacompanieswilluse technologiestospeedupinnovation, streamlineprocesses,andgetridof

barriersasaresultofdigital transformation.AItechnologieswillbe attheforefrontofthischange.They willhelpimproveefficiency,power newproductsorservices,enablenew businessmodels,andcreatea biopharmaindustrythatisvery differentfromwhatitisnowAItools arefinallychanging.

4.AIwillaffecteverypartofthe biopharmaceuticalvaluechain.

AIwillaffectthewholebiopharma valuechain.Atfirst,itwilldothisby collectingandcombininginformation fromdata(seefigure15).Hereare someexamplesofhowAIcouldbe usedinthedifferentpartsofthevalue chainAItoolsarefinallychanging.

5.Researchandfindout

UsingAIandcomputationalbiologyto findnewdrugsandmakethembetter couldmakeahugedifferenceinhow productivepeopleare.Inturn,thiswill makeresearchanddiscoveryless expensive,faster,andbetter.Itwillcut downonthenumberofdrugsthat don’tworkbyfindingpatternsinalot ofdata.Itwillalsoimprovetarget identification,safetyandeffectiveness assessments,andmodelingthat predictswhatwillhappenand“testing inthecomputer.”

OneimportantthingthatAItoolsare finallychangingispredictinghow moleculeswillinteractwitheachother Thishelpsusfigureouthowdiseases work.Inturn,thesemechanismscould helpfindnewbiomarkers,find,design, validate,andoptimizenewdrug candidates,andfindexistingdrugsthat couldbeusedforotherpurposes.

CombiningAIwithothertechnologies likeorgan-on-a-chip,3Dcellcultures, andothercellmodelsthatmimic humanbiologyin-vitrocouldreduce theneedtotestonanimalsandcould eventuallyleadtotheendofPhase1

clinicaltrialsinhealthyvolunteers.

Atthemoment,over148start-up companiesandover33large biopharmacompaniesareusingAIto researchandfindnewdrugs.Theydo thisthroughpartnershipsorontheir own.

40–41.Companiesarealsolooking intothepossibilityofusingAIto designandrunpreclinicalexperiments, whichcouldhelpcutdownthetimeit takestofind,develop,andreleasea newdrugAItoolsarefinallychanging.

6.Clinicaldevelopment

Clinicaltrialsarereadyforchange becausetheyaretakinglonger,cost more,andhavealotofmanualsteps. Also,alotoftrialsareneverfinished. ClinicalTrials.govwasusedtoregister morethan30,000clinicaltrialsin 2018.Sincetheyear2000,nearly 300,000trialshavebeenregistered. Butlessthan5,000trialsreportedtheir resultsin2018,andsince2000,less than35,000registeredstudieshave reportedtheirresultsAItoolsare finallychanging.

Biopharmacompaniesarecurrently lookingintohowtheycanuseAI technologytoimprovetheirclinical trials.Thisincludesimprovingtrial designandpatientrecruitment, analyzingbothtrialresultsand evidencefromtherealworld,and automatingthepublicationofresultsto makeitfasterandmoreefficient.Ifthe implementationgoeswell, developmentcostscouldgodown, peoplewouldbemorelikelytofollow therules,andtheresultswouldbe better&AItoolsarefinallychanging.

Also,havingaccesstolargeamounts ofdataandAI-poweredanalyticscould leadtothecreationofhighlyeffective personalizedtherapieswithouttheneed forlarge-scaleclinicaltrials.

7.Makingthingsandgetting supplies

Biopharmamanufacturingandsupply chainscreatealotofreal-timedatathat hasn’tbeenusedinausefulwayfor manyyears.ButAItoolsarefinally changingtechnologiesthatcould changetheseprocessesbyprocessing andmakingdecisionsaboutdatainreal time.Thiscouldmakesupplychains trulydata-driven.Thepotentialfor end-to-endvisibilityinmanufacturing andsupplychainswillhelpbiopharma companiesimprovetheirsupplychain planning,inventorymanagement, demandforecasting,logistics optimization,workforceplanning,and purchasing.

Biopharmacompanieswillbeableto managetheirsupply,quality,safety, security,andcostsbetteriftheycan changeprocessesandtrack medicationsinreal-time.Thiswilllead tosmartermanufacturingandsupply chaindecisions.

Thebusinessworldislikelytomove awayfromlinearsupplychainsand towarddigitalsupplynetworksthatare open,flexible,andlinked(DSNs). DSNsusedigitaltechnologieslike sensors,roboticprocessautomation (RPA),blockchain,andadvanced analyticstoimprovethevisibility, traceability,andcontrolofproducts andinventory.MLappliedto productiondatatobuildcompliance andqualityriskmodelsthathelp predictfailuresandcompliance problemsisalreadyhelpingseveral companies.Atthesametime,RPAand NLPcouldautomatethecreationand filingofcompliancereportsAItools arefinallychanging.

Cellandgenetherapies,whichare examplesofnext-generationproducts, willprobablyneedadifferentsetof skillstomakeandshipthantraditional molecules.Thesecapabilitiesshould

includeadvancedanalyticsand workflowautomationtomakeiteasy tocoordinatepatientcellcollection, manufacturingcapacity,coldchain logistics,anddeliveryofviable productstothetransfusioncenter

8.Launchandbusiness

Biopharmacompaniescouldbenefit greatlyfrombeingabletoseehow theirproductsaresoldfromstartto finish.UsingAIcanhelpcompanies planproductlaunchesbetter,get patientsmoreinvolved,helpdoctors makedecisionsandrunmarketing operations,andpredictdecisionsabout marketaccessandpricing.AItoolsare finallychangingandarealreadybeing usedtotrytoimproveengagementby customizingbehavioralnudgestoeach person’spersonality,motivations,care journey,andengagementchallenges.

Customizedengagementwith healthcareprofessionals(HCPs)could helpmakesurethattherightHCPsget therightinformationattherighttime. AIcanbeusedtodivideHCPsinto different“personas”basedontheir habits,preferences,andhowopenthey aretomarketingmessages.Tosupport reimbursementmodelsfornew curativetherapiesandservices,itwill likelybecomeimportanttogather evidencetoshowproofofvalueAI toolsarefinallychanging.

9.Post-marketsurveillanceand patient

supportprograms

Afteradrugisreleased,biopharma companiesmayalsoneedinteroperable healthdatatokeeptrackofpatients, communicatewiththemfroma distance,andofferthempersonalized treatmentoptionsattherighttime.For this,patientdatamustbeintegrated andanalyzedinreal-timetofigureout ifandwhenaninterventionisneeded. ItwillbeimportanttouseAIto improvesafety,especiallytofind

possiblebadthingshappeningorbad thingshappeninginreal-timeAItools arefinallychanging.

Itwillalsobeimportanttolearnmore aboutpatientmonitoringthanjust safety,andmanybiopharmacompanies andstart-upsarefocusingonthisarea. AI-poweredpatientsupportprograms couldchangethewaybiopharma interactswithitscustomers,improve enrollment,adherence,andretention, andimprovetheoveralloutcomefor patients.