Urinary
Royal Canin Urinary U/C: a 12-month trial in dogs with genetic hyperuricosuria
A long term trial on the efficacy of Royal Canin urate management diet is under way. Preliminary results show absence of urolithiasis recurrence and low urinary uric acid concentration. Hyperuricosuria consists in the excessive excretion of uric acid in the urine that predisposes dogs to urate urolithiasis. Some breeds, such as Dalmatians, have a genetic susceptibility to hyperuricosuria. This study was conducted to assess the efficacy of Royal Canin Veterinary diet Urinary U/C, formulated for urate urolithiasis management. Adult dogs with documented genetic hyperuricosuria (tested homozygous for the genetic trait that results in hyperuricosuria) and a history of urate urolithiasis were enrolled, with medical assessment at baseline and at 2, 6 and 12 months after initiating the test diet.
#8 - May 2013
including uric acid and allantoin. No dog developed lower urinary tract signs except for 1 dog with transient self-resolving signs 5 days prior to his last visit at 12 months. In the 6 dogs that completed visit 2, median urine specific gravity remained low (1.015 at baseline and 1.016 at 2 months), while median pH significantly decreased (from 7.5 to 6.0, p<0.005). Median 24hour uric acid and allantoin excretion did not change (p=0.46). The 4 dogs that completed the study maintained their 24 hours urine uric acid excretion at 12 months.
Intro Veterinary nutrition: here and now! Although still lacking some awareness among veterinary practitioners (only 7% of pets which would need a veterinary diet are actually fed this diet), nutrition is becoming recognised with the importance it deserves within the veterinary scientific community. The positive impact of proper nutrition on dog and cat health is well established. Adding nutritional assessment and recommendations into
24-hour urinary uric acid and allantoin excretion in 6 dogs at baseline and after 2 months
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Uric acid
Allantoin
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1750 μmol / 24hr
Q1 median
1500
max Q3
1250
the care of small animals also helps to develop a bond between the owner and the veterinary healthcare team, resulting in healthier pets. Royal Canin is obviously actively supporting such initiatives. Delphine Moniot, Marie-Anne Hours (Scientific Support Manager - R&D) & Gregory Casseleux (Scientific Communication Manager - Europe)
ACVN & ECVCN residents: the future of veterinary nutrition
These data suggest that a very low protein diet is not necessary to maintain levels of urinary uric acid concentration and excretion in predisposed dogs in order to minimize recurrence of urate urinary stones.
In our journey of continuous improvement and commitment to animal health, the veterinary profession has always been a respected and trustful partner. Nutrition is at the heart of Royal Canin, that’s why, as a company, we have decided to share with nutrition residents what cannot be learned at the university, to help them understand stakes linked to petfood industry.
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After 2 months
Baseline
To date, 6 dogs have completed the 2-month visit and 4 have completed the study. At baseline, 5/6 dogs were fed the low protein diet (protein level at or slightly below the NRC Recommended Allowance) recommended in most textbooks on management of canine urate stones. Owners were instructed to feed Royal Canin Veterinary diet Urinary U/C mixed with enough warm water to induce a SG (specific gravity) of ± 1.020, and energy intakes were adjusted according to the dog’s body condition score at each visit. Twenty-four hours urine collection was performed before each visit by the owner (voluntary voiding) (baseline, and after 2, 6 and 12 months), and urine samples were pooled for assays of all purine metabolic end-products,
Just out of the press! Available on-line articles:
The primary objective of the ACVN (American College of Veterinary Nutrition) and the ECVCN (European College of Veterinary and Comparative Nutrition) is to advance the specialty area of veterinary nutrition and increase the competence of those who practice in this field by establishing requirements for certification in veterinary nutrition, encouraging continuing professional education, promoting research, and enhancing the dissemination of new knowledge of veterinary nutrition through didactic teaching and postgraduate programs.
After 2 months
Westropp JL, Larsen JA, Queau Y, Fascetti AJ, Bannasch D, Biourge V. Evaluation of Urate urolithiasis Recurrence and Urinary uric acid and Allantoin Excretion in dogs consuming Royal Canin Veterinary diet Urinary U/C. Poster presented at the European Congress of veterinary Internal Medicine, Maastricht, 2012.
• Dietary sodium is not a threat to healthy old cats (see News from Research #1) Reynolds BS, et al. Effects of dietary salt intake on renal function: a 2-year study in healthy aged cats. J Vet Intern Med 2013.Accepted February 7, 2013. • Faster growth rate: a predictive parameter for cat obesity? (see News from Research #5) Serisier S, et al. Faster growth rate in ad libitum fed cats: a risk factor predicting the likelihood of becoming overweight during adulthood. Journal of Nutritional Science (2013) free online access.
© ROYAL CANIN SAS 2013. All Rights Reserved - Credits: F. Duhayer, Labat/Rouquette, J.M. Labat
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In January, Royal Canin has opened its Central R&D doors to 14 residents in nutrition
In January, 14 European and American residents in nutrition were involved in a “product development process” during one week at the Royal Canin headquarters in France. The program included research approach and principles in collaboration with the Waltham Centre for Pet Nutrition (WCPN), as well as topics of raw materials, processing, palatability, feeding trials, quality control and regulation. This was a great opportunity to facilitate exchanges between European and American residents, and to give them access to our ways of working based on collective intelligence and shared knowledge.
Coming nutrition congresses: • 13th annual AAVN (American Academy of Veterinary Nutrition) Clinical Nutrition & Research Symposium: Seattle, Washington, USA, June 12th 2013 •1 7th congress of the ESVCN (European Society of Veterinary and Comparative Nutrition) : Ghent, Belgium, September 19-21st 2013 • Waltham International Nutrition Sciences Symposium (WINSS): Portland, Oregon, USA, October 1-4th 2013