Essential Resources in
Toxicology from CRC Press
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Contents Atlas of Human Poisoning and Envenoming, Second Edition ....................................................................4 Hayes' Principles and Methods of Toxicology, Sixth Edition ........................................................................4 Inhalation Toxicology, Third Edition....................................5 Handbook of Toxicology, Third Edition ..............................5 Page 6
Page 6
Nanotoxicology: Progress toward Nanomedicine, Second Edition ....................................................................6 Environmental Risk Assessment: A Toxicological Approach....................................................6 Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Source ................................................7 Animal Models in Toxicology, Third Edition........................7 Pharmacokinetics and Toxicokinetics ..................................8 Principles of Toxicology, Third Edition ................................8
Page 9
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Ovarian Toxicology, Second Edition....................................9 Toxicologic Pathology: Nonclinical Safety Assessment ......9 Principles of Toxicology Testing, Second Edition ..............10 Lu's Basic Toxicology: Fundamentals, Target Organs, and Risk Assessment, Sixth Edition ..........10 Developmental and Reproductive Toxicology: A Practical Approach, Third Edition ..................................11 Clinical Toxicology: Principles and Mechanisms ..............11 Endocrine Toxicology, Third Edition..................................12
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Neurotoxicology, Third Edition ........................................12 Reproductive Toxicology, Third Edition ............................13 Toxicology of the Skin ......................................................13
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Toxicology of the Nose and Upper Airways......................13 Jet Fuel Toxicology ............................................................13 Contact Urticaria Syndrome..............................................14 Safety Pharmacology in Pharmaceutical Development: Approval and Post Marketing Surveillance, Second Edition ..................................................................14 Pocket Prescriber 2014......................................................14 Dermatotoxicology, Eighth Edition ..................................14
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Toxicology New!
New!
Atlas of Human Poisoning and Envenoming
Hayes' Principles and Methods of Toxicology
Second Edition
Sixth Edition
James H. Diaz
Edited by
LSUHSC, School of Public Health, New Orleans, Louisiana, USA
A. Wallace Hayes
Atlas of Human Poisoning and Envenoming is a visual and written reminder of the ubiquitous sources of toxins and toxoids in the environment and the outcomes of accidental or intentional toxic exposures in humans. The Second Edition has been restructured with bulleted text, tables, and figures resembling the vignettes that accompany national examinations. Combining the four specialties of toxicology—analytical, medical, environmental, and industrial—into one comprehensive atlas, the book presents photographs and diagrams of toxic plants and animals, their mechanisms of poisoning or envenoming, and the human responses caused by toxic exposure. Highlights of the new edition include drug abuse epidemics, nephrotoxicology and neurotoxicology, tick paralysis, petrochemical toxicants, warfare agents, workplace substance abuse monitoring, and statistical analysis of toxicological investigations.
Selected Contents: General Medical Toxicology. Diagnostic Work-Up of the Poisoned Patient. Poison Antidotes . Toxicity of Antiseptics and Drug Additives. Household Product Poisonings. Drug and Illicit Substance Abuse. Anticonvulsants and Sedative-Hypnotics. Antibiotic Toxicity. Anticancer Drug Toxicity. Environmental and Occupational Nephrotoxicology. Neurotoxicology. Environmental Toxicology. Food Poisoning. Common Poisonous Household and Garden Plants. Bites and Stings: Terrestrial Envenomings. Common Arthropod Vectors of Infectious Diseases. Tick Paralysis. Bites and Stings: Marine Envenomings. Voodoo, Hoodoo, and Cajun Traditions and Poisonings. Industrial and Occupational Toxicology. Volatile Organic Chemicals. Petrochemical Toxicity. Industrial Gas Exposures and Occupational Lung Diseases. Metal and Metalloid Poisonings. Pesticide Poisonings: Insecticides, Rodenticides, and Herbicides. Radiation Toxicology. Chemical, Biological, and Radiological Weapons and Warfare. Workplace Substance Abuse Monitoring. Miscellaneous Toxicants. Epidemiology and Statistics for Toxicology. Catalog no. K14564, October 2014, c. 904 pp. ISBN: 978-1-4665-0540-7, $199.95 / £127.00 Also available as an eBook
Harvard School of Public Health, Andover, Massachusetts, USA
Claire L. Kruger Spherix Consulting, Rockville, Maryland, USA
Praise for the Previous Edition “… this is an excellent, very favourably priced, allround toxicology textbook … .” —Paul Baldrick, Covance Laboratories Ltd, UK in BTS Newsletter
“… the information is presented in a logical sequence and it is an excellent reference source. I would recommend this book to any working one aiming to study in the area of safety sciences and it is a necessity for all those working in this area.” —Shirley Price in BTS Newsletter
Based on the paradox that all things are poisonous at certain doses and the difference between poison and remedy is quantity, the determination of safe dosage forms the basis and focus of modern toxicology. Written by a team of experts with new editors joining Dr. Hayes, this sixth edition of Hayes’ Principles and Methods of Toxicology discusses basic toxicological principles, toxic agents, target organ toxicity, testing methods, and international regulatory requirements. New chapters cover advancements in nanotechnology and all chapters are updated to reflect the changing pace of research. Readers have access to an online version of the printed book.
Selected Contents: Principles of Toxicology. Use of Toxicology in the Regulatory Process. Dose–Response: A Fundamental Concept in Toxicology. Metabolism: A Determinant of Toxicity. Toxicokinetics. Practice of Exposure Assessment. Epidemiology for Toxicologists. Principles of Pathology for Toxicology Studies. Agents. Food Safety and Foodborne Toxicants. Solvents and Industrial Hygiene. Metals. Radiation Toxicity. Plant and Animal Toxins. Methods. Humane Care and Use of Laboratory Animals in Toxicology Research. Acute Toxicity and Eye Irritancy. Genetic Toxicology. Dermatotoxicology. Inhalation Toxicology. Principles and Methods for Renal Toxicology. Gastrointestinal Toxicology. Pathophysiology and Toxicology of the Heart. Neurotoxicology. Assessment of Male Reproductive Toxicity. Test Methods for Assessing Female Reproductive and Developmental Toxicology. Glossary. Index. Catalog no. H100472, September 2014, 2184 pp. ISBN: 978-1-84214-536-4, $159.95 / £100.00 Also available as an eBook
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Toxicology New!
Inhalation Toxicology
Handbook of Toxicology Third Edition
Third Edition
Edited by
Edited by
Michael J. Derelanko
Harry Salem
Critical Path Services, LLC, Garnet Valley, Pennsylvania, USA
U.S. Army Chemical and Biological Center, Aberdeen, Maryland, USA
Sidney A. Katz Rutgers University, Camden, New Jersey, USA
Praise for the Previous Edition “ … an invaluable source of information for the professional toxicologist … helps the advanced student of toxicology to understand the specific aspects of inhalation toxicology. For the professor of toxicology, it is an abundant source of material that can be used in graduate and postgraduate teaching.” —Hermann M. Bolt, Toxicological and Environmental Chemistry
“ … this wide-ranging book provides a comprehensive overview of inhalation toxicology and will be of interest to most people working in this field.” —Tom Allen, The British Toxicology Society Newsletter
Fully updated with new research and discoveries since the last edition, this third edition of Inhalation Toxicology emphasizes the relationship between the respiratory system and toxicology of inhaled substances. Filled with contributions from internationally recognized scientists from academic, industrial, and governmental sectors, the book presents chapters on the updated testing procedures and equipment guidelines for Europe and North America. This edition includes new material on nonoparticles, the use of microelectronics for studying inhalation toxicology, and emergency response strategies. The book presents questions and answers at the end of each chapter to enhance educational utility.
Selected Contents: Inhalation Methods and Measurements. Inhalation Risk Assessment at the Environmental Protection Agency. The Use of Large Animals in Inhalation Toxicology. Toxic Load Modeling. Combustion Toxicology. Inhalation Toxicology Mechanisms. Toxicogenomics of Low-Level Nerve Agent Vapor Exposure. Respiratory Sensitization. Hormesis: Implications for Risk Assessment. Nasal Toxicology. Inhalation Toxicology of Riot Control Agents. Chemical Warfare Agents and Nuclear Weapons. Inhalation Toxicology of Materials. Inhalation Toxicology of Alcohol/Gasoline Fuels: Current Status. Asbestos. Carbon Monoxide. Inhalation Toxicology of Biologicals. Health Aspects of Bioaerosols. Emerging Biothreats: Natural and Deliberate. Inhalation of Botulinum Toxins.
Carol S. Auletta Huntingdon Life Sciences, East Millstone, New Jersey, USA
The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Providing both fundamental and applied information, topics include genetic toxicology, human clinical toxicology, histopathology, clinical pathology, metabolism and toxicokinetics, risk assessment, and more. This edition features completely rewritten chapters on immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology, keeping pace with new developments in these areas. It includes new chapters on chemical, pharmaceutical, and juvenile toxicology, as well as pharmacology safety. Discussions on inhalation toxicology, neurotoxicology, and regulatory toxicology are now consolidated into single chapters for each specialty. The book also contains a glossary with toxicological terms presented both alphabetically and by toxicological subspecialty. For nearly 20 years, this handbook has remained a reliable reference designed to facilitate easy access to information related to the various toxicology specialties. This updated edition reflects current practices and the state of the science.
Selected Contents: Laboratory Animal Management. General Toxicology. Dermal Toxicology. Ocular Toxicology. In Vitro Methods for the Prediction of Ocular and Dermal Toxicity. Inhalation Toxicology. Neurotoxicology. Immunotoxicology. Renal Toxicology. Developmental and Reproductive Toxicity. Juvenile Toxicology. Endocrine Toxicology. Genetic Toxicology. Carcinogenesis. Histopathology. Clinical Pathology. Metabolism and Toxicokinetics of Xenobiotics. Human Clinical Toxicology. Chemical Toxicology. Pharmaceutical Toxicology. Safety Pharmacology. Risk Assessment. Regulatory Toxicology. Appendices. Catalog no. K14103, March 2014, 1018 pp. ISBN: 978-1-4398-9013-4, $169.95 / £108.00 Also available as an eBook
Catalog no. K15234, August 2014, 623 pp. ISBN: 978-1-4665-5273-9, $179.95 / £114.00 Also available as an eBook
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Toxicology Nanotoxicology Progress toward Nanomedicine, Second Edition
Environmental Risk Assessment
Edited by
A Toxicological Approach
Nancy A. MonteiroRiviere
Ted Simon
Kansas State University, Manhattan, USA
Ted Simon LLC, Winston, Georgia, USA
C. Lang Tran Institute of Occupational Medicine, Edinburgh, UK
Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition of Nanotoxicology: Progress toward Nanomedicine documents the continuing development of essential tools for the characterization of engineered nanomaterials (ENM) and for in vitro and in vivo toxicity testing. Exploring the contribution of nanosafety research to nanomedicine, the editors enlist internationally recognized experts who examine the basics and the rationale for the safe design of engineered nanomaterials (ENM). Topics include new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.
Selected Contents: Impacts of Nanotechnology on Biomedicine. Rational Approach for the Safe Design of Nanomaterials. Characterization of Manufactured Nanomaterials, Dispersion, and Exposure for Toxicological Testing. Exposure. Workplace Inhalation Exposure to Engineered Nanomaterials. Nanotechnology in Consumer Products. Modeling. Quantitative Nanostructure–Activity Relationships. Pharmacokinetics and Biodistribution of Nanomaterials. Methodologies and Techniques. Detection Methods for the In Vivo Biodistribution of Iron Oxide and Silica Nanoparticles. Quantitative Single-Cell Approaches to Assessing Nanotoxicity in Nanomedicine Systems. Imaging Techniques for Nanoparticles in Skin. Hazards. Safety Implications of Nanomaterial Exposure to Skin. Current In Vitro Models for Nanomaterial Testing in Pulmonary Systems. Nanoparticles and the Immune System. Carbon Nanotubes and Cardiovascular Disease. Current In Vitro Models for Nanomaterial Testing: The Reproductive System. Current In Vitro Models for Nanomaterial Testing: Genotoxicity Issues. Cell-Based Targeting of Anticancer Nanomaterials to Tumors. Silver Nanoparticles in Biomedical Applications. Risk Assessment. Catalog no. K21337, March 2014, 514 pp. ISBN: 978-1-4822-0387-5, $169.95 / £108.00 Also available as an eBook
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Environmental Risk Assessment: A Toxicological Approach examines various aspects of problem formulation, exposure, toxicity, and risk characterization that apply to both human health and ecological risk assessment. The book is aimed at the next generation of risk assessors and students who need to know more about developing, conducting, and interpreting risk assessments. It delivers a comprehensive view of the field, complete with sufficient background to enable readers to probe for themselves the science underlying the key issues in environmental risk. Written in an engaging and lively style by a highly experienced risk assessment practitioner, the text: • Introduces the science of risk assessment—past, present, and future • Covers problem formation and the development of exposure factors • Explains how human epidemiology and animal testing data are used to determine toxicity criteria • Provides environmental sampling data for conducting practice risk assessments • Examines the use of in vitro and ‘omics methods for toxicity testing • Describes the political and social aspects of science-based decisions in the twenty-first century • Includes fully worked examples, case studies, discussion questions, and links to legislative hearings Readers of this volume will not only learn how to execute site-specific human health and ecological risk assessments but also gain a greater understanding of how science is used in deciding environmental regulations.
Contents: Introduction. How Risk is Perceived and Expressed. Human Health Exposure Assessment. Toxicity Assessment for Human Health Risk Assessment. Risk Characterization. Ecological Risk Assessment. The Future of Risk Assessment. Appendix A: Useful Methods and Algorithms for Probabilistic Risk Assessment (PRA). Catalog no. K20881, February 2014, 406 pp. ISBN: 978-1-4665-9829-4, $149.95 / £95.00 Also available as an eBook
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Toxicology New!
Coming Soon!
Kratom and Other Mitragynines
Animal Models in Toxicology
The Chemistry and Pharmacology of Opioids from a NonOpium Source
Edited by
Edited by
Animal models are utilized in biomedical sciences to help us understand and predict responses in humans in toxicology and pharmacology, yet their use remains a source of significant controversy. This volume explores the many facets of the use of animal models in toxicology. Individual chapters cover the major species and review current laws and regulations governing animal care and use in major countries. This edition includes new chapters on telemeterized animals and imaging and adds a section on transgenic animals. Animal Models in Toxicology, Third Edition also contains extensive appendices of acronyms, regulatory and scientific websites, animal suppliers, and a lexicon of terms.
Robert B. Raffa Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA
Morphine and other opioid drugs are extracts or analogs of compounds isolated from a single source— the opium poppy (Papaver somniferum). However, biological diversity has given rise to an alternative source. Specifically, at least two alkaloids isolated from the plant Mitragyna speciosa—and their synthetic analogs—display pain-relieving activity. Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Source presents an introduction to the chemical and biological properties of these agents and discusses the nature and extent of their use and abuse. The book covers the topic from phytochemistry, medicinal chemistry, and pharmacology perspectives and describes current research in computer modeling of the binding to the various opioid receptor sub-types.
Third Edition Shayne C. Gad Gad Consulting Services, Cary, North Carolina, USA
Contents: Introduction. The Mouse. Toxicology. Transgenics. Pathology. Metabolism. The Rat. Toxicology. Pathology. Metabolism.
Contents:
The Hamster. Toxicology. Pathology. Metabolism.
Why Do Plants Contain Biologically Active Compounds? Short Overview of Mitragynines. Psychopharmacological Indole Alkaloids from. Terrestrial Plants. Salvinorin A: Example of a NonAlkaloidal Bioactive. Opioid from a Plant Source. Mitragyna speciosa (Korth.) Havil. Phytochemistry of Mitragyna speciosa. Chemistry of Mitragynines: A Brief Introduction. Chemistry of Mitragyna Compounds. Medicinal Chemistry Based on Mitragynine. Chemical Structures of Opioids. The Detection of Mitragynine and Its Analogs. The ADME of Mitragynine and Analogs. Analgesic Effects of Mitragynine and Analogs. Non-Analgesic CNS Effects. Other Opioid-Associated Endpoints. The Kratom Experience From Firsthand Reports. The Toxicology of Indole Alkaloids. Opioid-Induced Adverse Effects and Toxicity. Toxicology of Mitragynine and Analogs. The Use of Animal Models to Measure Tolerance, Dependence, and Abuse Potential. Kratom: The Epidemiology, Use and Abuse, Addiction Potential, and Legal Status.
The Guinea Pig. Toxicology. Pathology. Metabolism
Catalog no. K22408, November 2014, c. 368 pp. ISBN: 978-1-4822-2518-1, $139.95 / £89.00 Also available as an eBook
The Rabbit. Toxicology. Pathology. Metabolism The Ferret. Toxicology. Pathology. Metabolism The Dog. Toxicology. Pathology. Metabolism Primates. Toxicology. Pathology. Metabolism The Minipig. Toxicology. Pathology. Metabolism Alternative Species Clinical Pathology of Laboratory Animals Telemeterized Animal Models Image Analysis and Animal Models in Toxicology Model Selection and Scaling Susceptibility Factors Laws and Regulations Governing Animal Care and use in Research Appendix Commercial Sources of Laboratory Animals Index Catalog no. K15310, April 2015, c. 1152 pp. ISBN: 978-1-4665-5428-3, $179.95 / £114.00 Also available as an eBook
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Toxicology Coming Soon!
Coming Soon!
Pharmacokinetics and Toxicokinetics
Principles of Toxicology
Mehdi Boroujerdi
Third Edition
Albany College of Pharmacy, New York, USA
Karen E. Stine
The physiological processes involved in the absorption, distribution, metabolism, and excretion of xenobiotics and their corresponding pharmacological or toxicological responses in the body is studied through the integration of pharmacokinetics and toxicokinetics. By developing a firm understanding of this interrelation, appropriate approaches can be designed to achieve desirable outcomes. Pharmacokinetics and Toxicokinetics unifies important topics relevant to both disciplines through a logical and systematic approach, with emphasis on general principles and concepts rather than isolated observations. The author explores mathematical methodologies and discusses various approaches in mathematical modeling.
Contents: Introduction – Pharmacokinetics and Toxicokinetics Concepts Basic to Pharmacokinetics and Toxicokinetics Absorption Concepts Basic to Pharmacokinetics and Toxicokinetics Distribution Concepts Basic to Pharmacokinetics and Toxicokinetics Overall Elimination and Clearance: Concepts Basic to Pharmacokinetics and Toxicokinetics Renal Elimination of Xenobiotics Concepts Basic to Pharmacokinetics and Toxicokinetics Metabolism of Xenobiotics Kinetics of Drug Metabolism Michaelis-Menten Kinetics Factors Influencing Pharmacokinetics and Toxicokinetics of Xenobiotics in Gastrointestinal Tract Modeling in Pharmacokinetics and Toxicokinetics (PK/TK): Classical Compartmental Analysis PK/TK Models of Xenobiotics Given by a Single Bolus Injection – Using Plasma and Urine Samples PK/PD Models of Xenobiotics Given via Zero-Order Input—Using Plasma and Urine Samples PK/TK Models of Xenobiotics Absorbed via Extravascular Routes of Administration—Using Plasma and Urine Samples PK/TK Models of Xenobiotics Absorbed through the Skin PK/TK Models of Chronic Exposure/Multiple Dosing through Various Routes of Administration/Exposure Bioavailability, Bioequivalence and Biosimilar Evaluations PK/PD and TK/TD Modeling Pre-clinical and Clinical PK/TK Population Pharmacokinetics Quantitative Extrapolations Carcinogenesis Models Catalog no. K22235, February 2015, c. 560 pp. ISBN: 978-1-4822-2134-3, $159.95 / £99.00 Also available as an eBook
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Auburn University, School of Sciences, Montgomery, Alabama, USA
Thomas M. Brown GeneCTAr Com LLC, Whitefish, Montana, USA
Reflecting the broad and interdisciplinary nature of toxicology, this third edition of Principles of Toxicology explores the biochemical, physiological, and environmental aspects of the subject. This new edition is updated and revised to include reference to several major new directions in the science, including significant changes in thinking about cancer and carcinogenesis as well as the rapid expansion of toxicogenomics. The book also includes additional topics of timely interest such as radiation and additional material on food safety and natural toxins. It features updated case studies illustrating the application of toxicology to current issues and uses a convenient format for quick accessability. Figure slides are available with qualifying course adoption.
Contents: Measuring Toxicity and Assessing Risk Toxicokinetics Biotransformation Cellular Sites of Action Genomics Carcinogenesis Reproductive Toxicology and Teratology Respiratory Toxicology Cardiovascular Toxicology Neurotoxicology Hepatic Toxicology Renal Toxicology Immunotoxicology Ecological Toxicology Applications: Pharmacology and Toxicology Applications: Forensic toxicology Applications: Environmental Toxicology and Pollution Applications: Radiation Toxicology Applications: Food safety Applications: Toxins Appendix Index Catalog no. K14463, April 2015, c. 512 pp. ISBN: 978-1-4665-0342-7, $79.95 / £49.99 Also available as an eBook
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Toxicology Ovarian Toxicology
Toxicologic Pathology
Second Edition
Nonclinical Safety Assessment
Edited by
Patricia B. Hoyer The University of Arizona, College of Medicine, Tucson, USA
Today, we are exposed to an increasing number of chemicals in the environment and there is a growing awareness of the effects of these chemicals on the ovaries. Infertility resulting from environmental exposures may not be obvious until the reproductive life span is waning. As such, the potential for xenobiotic-induced infertility needs to be better understood. In recent years, research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles is gaining greater appreciation. Ovarian Toxicology, Second Edition represents a compilation of chapters prepared by researchers who have substantially contributed to our understanding of the impact of xenobiotics and environmental factors on ovarian function. The second edition substantially updates newly investigated ovotoxicants as well as improved mechanistic insights that have emerged since the first edition. This resource is ideal for scientists in academia, regulatory agencies, and industry who would benefit from a survey of the impact of xenobiotic chemicals on ovarian function.
Contents: Ovarian Function Ovarian Physiology Ovarian Metabolism of Xenobiotics Brain as a Target for Environmental Toxicants That Alter Ovarian Function Xenobiotic-Induced Oxidative Stress Ovotoxicity in Small Preantral Follicles Ovotoxic Chemical Classes Ovarian Toxicity Caused by Pesticides Endocrine Disruptors Phthalates Heavy Metals and the Ovary Cigarette Smoking and Ovarian Function Bisphenol A and the Ovary Ovarian Cancer Endocrine Effects on Ovarian Cancer New Perspectives in Chemoresistant Ovarian Cancer Ovarian Cancer Risk Assessment Assessing Ovarian Toxicity in Human Health Risk Assessment for Environmental Chemicals and Pharmaceuticals Index
Edited by
Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, and Chirukandath Gopinath As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for bench toxicologic pathologists working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Safety Assessment presents histopathologic descriptions of lesions observed in drug development. Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section includes eight “concept” chapters to orient pathologists in areas that are important for effective interaction with other pathologists as well as the many nonpathologists involved in drug development. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates.
Contents: Concepts in Drug Development. Overview of Drug Development. Nonclinical Safety Evaluation of Drugs. Toxicokinetics and Drug Disposition. Introduction to Toxicologic Pathology. Routine and Special Techniques in Toxicologic Pathology. Principles of Clinical Pathology. Toxicogenomics in Toxicologic Pathology. Spontaneous Lesions in Control Animals Used in Toxicity Studies. Organ Systems. Gastrointestinal Tract. Liver, Gallbladder, and Exocrine Pancreas. Respiratory System. Urinary System. Hematopoietic System. Lymphoid System. Bone, Muscle, and Tooth. Cardiovascular System. Endocrine Glands. Reproductive System and Mammary Gland. Skin. Nervous System. Special Senses: Eye and Ear. Catalog no. K13314, April 2013, 1015 pp. ISBN: 978-1-4398-7210-9, $259.95 / £172.00 Also available as an eBook
Catalog no. K14506, September 2013, 387 pp. ISBN: 978-1-4665-0406-6, $159.95 / £99.00 Also available as an eBook
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Toxicology Principles of Toxicology Testing
Lu's Basic Toxicology Fundamentals, Target Organs, and Risk Assessment, Sixth Edition
Second Edition Frank A Barile St. John's University, Queens, New York, USA
Edited by
Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Principles of Toxicology Testing, Second Edition begins with an introduction to the fundamentals of toxicology and proceeds to a discussion of toxicokinetics and human risk assessment. The next section describes the fundamental principles of toxicology testing in animals in greater detail. The author then examines in vitro alternatives to animal toxicology tests, emphasizing cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity.
Contents: Basic Concepts in Toxicology Testing Introduction to Principles of Toxicology Testing Effects of Chemicals Toxicokinetics Risk Assessment and Regulatory Toxicology Descriptive Animal Toxicology Tests Toxicology Testing in Vivo Acute Toxicology Testing Subchronic and Chronic Toxicology Testing Acute Dermal Toxicology Testing Acute Ocular Toxicology Testing Toxicity Testing for Fertility and Reproduction Carcinogenicity and Mutagenicity Testing in Vivo Toxicology Testing in Vitro Introduction to In Vitro Toxicology Testing Cell Culture Methodology Cell Culture Methods for Acute Toxicology Testing Acute Local Toxicology Testing in Vitro Toxicokinetic Studies in Vitro Mutagenicity and Carcinogenicity Testing in Vitro Reproductive and Teratogenicity Studies in Vitro High Throughput Screening and Microarray (MA) Analysis Toxicogenomics and Epigentic Testing in Vitro Experimental Design and Statistics Applications of Alternative Models for Toxicology Testing
Sam Kacew University of Ottawa, Ontario, Canada
Byung-Mu Lee Sungkyunkwan University, South Korea
Expert editors Kacew & Lee offer a distillation of decades of research and teaching experience in toxicology, providing authoritative guidance for both students and practicing professionals. Lu’s Basic Toxicology: Fundamentals, Target Organs, and Risk Assessment, Sixth Edition includes new information on over-the-counter preparations and lactation, nanotoxicology, and the toxicity of the endocrine system. This edition places a special focus on occupational toxicology, providing clarity and insight into a rapidly evolving subject. The book’s organizational style facilitates organization of the curriculum into four distinct sections for a focused learning experience.
Contents: General Principles of Toxicology. General Considerations. Absorption, distribution, and excretion of Toxicants. Biotransformation of Toxicants. Toxic Effects. Modifying Factors of Toxic Effects. Testing Procedures for Conventional and Nontarget Organ Toxicities. Conventional Toxicity Studies. Carcinogenesis. Mutagenesis. Developmental Toxicology. Lactation. Target Organs and Systems. Toxicology of the Immune System. Toxicology of the Liver. Toxicology of the Kidney. Toxicology of the Skin. Toxicology of the Eye. Toxicology of the Nervous System. Reproductive and Cardiovascular Systems. Toxicity of Endocrine System. Toxic Substances and Risk Assessment. Food Additives and Contaminants. Toxicity of Pesticides. Nanotoxicology. Toxicity of Metals. Over-theCounter Preparations. Environmental Pollutants. Occupational Toxicology. Toxicologic Evaluation. Catalog no. H100306, September 2012, 416 pp. Soft Cover ISBN: 978-1-84184-953-9, $99.95 / £49.99 Also available as an eBook
Catalog no. H100468, April 2013, 362 pp. Soft Cover ISBN: 978-1-84214-528-9, $119.95 / £75.00 Also available as an eBook
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Toxicology Developmental and Reproductive Toxicology
Clinical Toxicology
A Practical Approach, Third Edition
Principles and Mechanisms, Second Edition
Edited by
Frank A. Barile
Ronald D. Hood
St. John's University, Queens, New York, USA
Northport, Alabama, USA
“The field of reproductive toxicology is changing and this update is critical and mostly timely.” —Doody's Review Service
“ … one of the most comprehensive and definitive publications in the field and should be a mandatory addition to the libraries of students, researchers, and regulators alike in the field of reproductive and developmental toxicology.” —International Journal of Toxicology
A practical guide to developmental and reproductive toxicology in a regulatory environment, the third edition of Developmental and Reproductive Toxicology provides a comprehensive update of current chapters to reflect recent changes in the field. The book examines the use and interpretation of the newest research techniques, such as functional genomics and proteomics, as well as traditional approaches. It also discusses conducting tests and interpreting data in areas such as nonclinical juvenile toxicity testing, endocrine modulation, and toxicokinetics.
Selected Contents: Principles and Mechanisms. Experimental Approaches to Evaluate Mechanisms of Developmental Toxicity. Pathogenesis of Abnormal Development. Comparative Features of Vertebrate Embryology. Hazard and Risk Assessment and Regulatory Guidance. Significance, Reliability, and Interpretation of Developmental and Reproductive Toxicity Study Findings. Testing for Reproductive Toxicity. Role of Xenobiotic Metabolism in Developmental and Reproductive Toxicity, A.P. Kulkarni. Use of Toxicokinetics in Developmental and Reproductive Toxicology. Cellular, Biochemical, and Molecular Techniques in Developmental Toxicology. In Vitro Methods for the Study of Mechanisms of Developmental Toxicology. Statistical Analysis for Developmental and Reproductive Toxicologists. Quality Concerns for Developmental and Reproductive Toxicologists. Perspectives on the Developmental and Reproductive Toxicity Guidelines. Human Studies - Epidemiologic Techniques in Developmental and Reproductive Toxicology. Developmental and Reproductive Toxicity Risk Assessment for Environmental Agents. Principles of Risk Assessment-FDA Perspective.
This updated and revised second edition of Clinical Toxicology: Principles and Mechanisms examines the complex interactions associated with clinical toxicological events and chemical exposure of drug administration. It features tables for easy cross-referencing to names, indications, effects, adverse reactions, and drug interactions for more than 70 common herbal products. Outlining general physiology and pharmacology principles, the book examines symptoms of diseases and pathology caused by toxins and clinical drugs, changes in protocols for managing toxic ingestions, new antidotes, changes in treatments, and the pharmacology and toxicology of herbal products. It also explores the widely distributed chemical agents and currently used therapeutic drugs that have hazardous effects and discusses the effects of biological and chemical agents cited by the U.S. and U.N. as potential bioterrorist weapons.
Contents: Introduction to Basic Toxicological Principles. Introduction. Risk Assessment and Regulatory Toxicology. Therapeutic Monitoring of Adverse Drug Reactions. Classification of Toxins in Humans. Exposure. Effects. Dose Response. Descriptive Animal Toxicity Tests. In Vitro Alternatives to Animal Toxicity. Toxicokinetics. Chemical and Drug Receptor Interactions-Zacharoula Konsoula. ToxicogenomicsZacharoula Konsoula. Toxicity of Therapeutic Agents. Sedative/Hypnotics. Opioids and Derivatives. Sympathomimetics. Hallucinogenic Agents. Anticholinergic and Neuroleptic Drugs. Acetaminophen, Salicylates, and Nonsteroidal Antiinflammatory Drugs. Anabolic-Androgenic Steroids. Cardiovascular Toxicology. Antineoplastic Agents. Vitamins. Herbal Remedies. Toxicity of NonTherapeutic Agents. Alcohols and Aldehydes. Gases. Metals-Louis D. Trombetta and Frank A. Barile. Aliphatic and Aromatic Hydrocarbons. Insecticides. Herbicides. Rodenticides. Chemical Carcinogenesis and Mutagenesis. Reproductive and Developmental Toxicity. Radiation Toxicity. Chemical and Biological Threats to Public Safety. Catalog no. H9225, February 2010, 482 pp. ISBN: 978-1-4200-9225-7, $179.95 / £114.00 Also available as an eBook
Catalog no. H100234, December 2011, 856 pp. ISBN: 978-1-84184-777-1, $179.95 / £114.00 Also available as an eBook
For more information and complete contents, visit www.crcpress.com
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Toxicology Endocrine Toxicology
Neurotoxicology
Third Edition
G. Jean Harry
Edited by
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Third Edition
J. Charles Eldridge and James T. Stevens Wake Forest University, WinstonSalem, North Carolina, USA
Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition explores the potentially damaging influence of environmental agents on the endocrine system. Topics include the the history and status of the regulatory process, putative endocrine disruptors and mechanisms of endocrine toxicity, and the mechanisms of toxic effects in various hormonal systems. The book compares endocrine responses in humans, livestock, and wildlife and evaluates testing methods in mammalian, fish, avian, and amphibian models. It also discusses endocrine toxicology’s increased importance in environmental safety issues due to legislative directives established over the past ten years.
Contents: Testing and Methods. The U.S. EPA’s Tier 1 Screening Battery for Endocrine Disruptor Compounds. The Effects of Endocrine Disrupting Chemicals on Pubertal Development in the Rat: Use of the EDSP Pubertal Assays as a Screen. Male Reproductive Endpoints and the Rodent Hershberger Assay. Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals. Molecular Toxicology. Modulation of Estrogen Receptor Signaling by Endocrine Disrupting Chemicals. Androgen Receptor Binding and Transactivation Assays Identify Environmental Chemicals as Endocrine Disruptors. Structure-Activity Modeling of Endocrine Disruptors. Aryl Hydrocarbon Receptor Ligands: Toxic, Biochemical, and Therapeutic Effects. Mammalian Effects. The Impact of Centrally Acting Pesticidal/Environmental Toxicants on the Neuroendocrine Regulation of Reproductive Function in the Female Rodent: Relevance to Human Reproductive Risk Assessment. Time-Dependent Embryotoxicity of the Endogenous Luteolysin Prostaglandin F2a in Ruminants. Metal Toxicity in Mammalian Reproduction. Wildlife Effects. Overview of Endocrine Disruptor Ecotoxicity in Wildlife. Avian Endocrine Toxicology. EndocrineDisrupting Compounds in Aquatic Ecosystems. The Hypothalamic-Pituitary-Gonadal Axis in Anuran Amphibians. Policy and Management. Impact of Endocrine Disruptor Policies and Regulations. Impact of Endocrine Disrupting Compounds to the Water Industry. Index. Catalog no. H9309, February 2010, 422 pp. ISBN: 978-1-4200-9309-4, $159.95 / £99.00 Also available as an eBook
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Hugh A. Tilson U.S. Environmental Protection Agency, Durham, North Carolina, USA
The third edition of this book demonstrates the evolution of neurotoxicology as a discipline over the past 20 years. Topics include the use of molecular approaches to screen chemicals for potential neurotoxicity, new approaches in understanding the complex interactions of chemicals with biological systems, and the relationship between neurotoxicant exposure and the emergence of diseases such as obesity and reproductive senescence. Neurotoxicology, Third Edition also explores the principles of behavioral phenotyping of neonatal and adult mice. It discusses the potential of newly developed methods such as network analysis and molecular approaches to identify potential neurotoxicants and their modes of action.
Contents: Neuromorphology – Qualitative vs Quantitative. Blood-Brain Barrier – Maturation and Vulnerability. Behavior Principles and Phenotyping of Mice: Development and Adult Life Stages. Endocrine Disruption and Senescence: Altered Neural Function. Thyroid Hormone – Impact on the Developing and Adult Brain. The Immune System – Neuroprotective and Neurodestructive Roles. Adult Neurogenesis – Potential Target Site or Confounder for Neurotoxicity. Network Analysis Using Microarray Data to Identify Pathways. Oxidative Stress and Free Radicals – Translation of In Vitro to In Vivo. Identified Modes of Action for Neurotoxicity – Use of Alternate Model System to Address Specific Mechanistic Based Hypotheses. Biological Processes of Cell Death – Apoptosis, Necrosis, Autophagy Neurotoxins – The Fine Line Between Damage and Therapeutic Effects. The Inclusion of Epidemiological Data into the Evaluation of Human Health Risk For Neurological Effects. Susceptible Populations – Rationale, Identification, Risk Assessment. Principles and Practices of Childhood Neurodevelopment Assessments. Assessment of Adult Neurotoxicity – Exposure vs Disease Based In Vivo Brain Imaging. Catalog no. 54872, March 2010, 334 pp. ISBN: 978-1-4200-5487-3, $159.95 / £99.00 Also available as an eBook
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Toxicology Reproductive Toxicology Third Edition
Toxicology of the Nose and Upper Airways
Edited by
Edited by
Robert W. Kapp
John B. Morris
BioTox, Monroe Township, New Jersey, USA.
University of Connecticut, Storrs, USA
Rochelle W. Tyl
Dennis J. Shusterman
Research Triangle International, North Carolina, USA
University of California, San Francisco, USA
An examination of the popular and expanding field of reproductive toxicology, this expanded third edition presents cutting-edge scientific developments in this constantly evolving discipline. Topics include epigenetic mechanisms and omics; the role of genomics, proteomics, and metabolomics in human reproduction; and new guidelines with respect to research applications in the field. The contributors are experienced regulatory agency and clinical research organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research.
The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. This book represents a culmination of knowledge gained from human and experimental animal studies over the past decade. It examines the effect of selected pollutants on the upper airways of humans and animals and epidemiologic findings from populations exposed occupationally or environmentally. Topics include dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, and risk assessment.
Catalog no. 73435, September 2010, 512 pp. ISBN: 978-1-4200-7343-0, $159.95 / £99.00 Also available as an eBook
Toxicology of the Skin Nancy A. MonteiroRiviere North Carolina State University, Raleigh, USA
This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. The book discusses the skin’s anatomy and physiology; reviews dermal absorption, cutaneous metabolism, and epidermal transporters; and examines modern approaches to drug delivery across the skin barrier. It also provides examples and case studies of chemical toxicity after topical exposures. Catalog no. 79174, February 2010, 450 pp. ISBN: 978-1-4200-7917-3, $159.95 / £99.00 Also available as an eBook
Catalog no. 8187X, February 2010, 450 pp. ISBN: 978-1-4200-8187-9, $139.95 / £86.00 Also available as an eBook
New!
Contact Urticaria Syndrome Edited by
Ana M. Gimenez-Arnau Hospital del Mar, Universitat Autònoma, Barcelona, Catalunya, Spain
Howard I. Maibach University of California School of Medicine, San Francisco, USA
Contact urticaria syndrome is a group of inflammatory reactions usually appearing on the skin within minutes of contact with various substances. This new text is a state-of-the-art reference on an important topic in immunodermatology from leaders in the field of research and practice. It discusses etiology, epidemiology, and occupational relevance and examines a variety of reactions and conditions, including immunological and non-immunological forms. Topics include reactions from low-molecular-weight chemicals, animals and animal products, plants, and metals. Catalog no. K20865, October 2014, 310 pp. ISBN: 978-1-4665-9800-3, $199.95 / £121.00 Also available as an eBook
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Toxicology Specialty Safety Pharmacology in Pharmaceutical Development
Dermatotoxicology
Approval and Post Marketing Surveillance, Second Edition
Klaus Peter Wilhelm
Eighth Edition Edited by Institute for Applied Dermatologic Research, Schenefeld, Germany
Hongbo Zhai Foster City, California, USA
Shayne C. Gad Gad Consulting Services, Cary, North Carolina, USA
Safety pharmacology is the evaluation and study of the pharmacological effects of a potential drug that are unrelated to the desired therapeutic effect. This can be a problem particularly in individuals with compromised or limited organ system functions. This book discusses the topic from the regulatory requirements down to the studies that must be done to justify them. Focusing on updated test methods, interpretation, and science, the book covers the core and supplemental batteries of test procedures and provides an overview of available facilities and contract organizations for performing studies. Catalog no. K12039, April 2012, 213 pp. ISBN: 978-1-4398-4567-7, $159.95 / £100.00 Also available as an eBook
Howard I. Maibach University of California School of Medicine, San Francisco, USA
The foundational reference in dermal toxicology, this third edition contains updates to each chapter and a reorganized structure to enable easier location of topics of interest. It provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New topics include safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption. Catalog no. H100261, September 2012, 518 pp. ISBN: 978-1-84184-855-6, $179.95 / £114.00 Also available as an eBook
Pocket Prescriber 2014 Edited by
Timothy RJ Nicholson Institute of Psychiatry, London, UK
Donald RJ Singer University Hospitals Coventry and Warwickshire, UK
This book is an A-Z listing of the 500 most commonly prescribed drugs. Each entry contains key prescribing information and provides information on safety issues, warnings, drug errors, and adverse effects. The book supplies practical guidance on drug selection and includes prescribing protocols and guidelines, information for complicated prescriptions, and concise management summaries for the common medical emergencies. It includes the new European Resuscitation Council algorithms and clinically useful reminders of basic pharmacology. This concise, up-todate prescribing guide contains all the “must-have” information that doctors, nurse prescribers, and medical students need at their fingertips. Catalog no. K23350, May 2014, 308 pp., Soft Cover ISBN: 978-1-4822-4131-0, $23.99 / £15.99
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Check Out These New
TOXICOLOGY TITLES Hayes’ Principles and Methods of Toxicology Sixth Edition Edited by
A. Wallace Hayes Harvard School of Public Health, Andover, Massachusetts, USA
Claire L. Kruger Spherix Consulting, Rockville, Maryland, USA
Featuring new chapters on: • • • • •
Dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology
Catalog no. H100472, September 2014, 2184 pp. ISBN: 978-1-84214-536-4, $159.95 / £100.00 Also available as an eBook
Inhalation Toxicology Third Edition Edited by
Harry Salem U.S. Army Chemical and Biological Center, Aberdeen, Maryland, USA
Sidney A. Katz Rutgers University, Camden, New Jersey, USA
Essential information on: • Regulatory aspects of testing, equipment and risk assessment • Lungs-on-a-chip technology • Asbestos fibers • Nanoparticles Catalog no. K15234, August 2014, 623 pp. ISBN: 978-1-4665-5273-9, $179.95 / £114.00 Also available as an eBook
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