Laboratory Animal Science

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Premier Publications to Serve the Laboratory Animal Science Community •

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Management, Compliance, and Animal Welfare New Edition of a Bestseller!

The IACUC Handbook Third Edition Edited by

Jerald Silverman

University of Massachusetts Medical School, Worcester, USA

Mark A. Suckow

University of Notre Dame, Indiana, USA

Sreekant Murthy

Rowan University, Glassboro, New Jersey, USA

“… a comprehensive collection of best practices; all of which are compliant with the federal guidelines and requirements. The sections labeled "regulatory" have been reviewed by staff at NIH Office of Laboratory Animal Welfare (OLAW) and USDA APHIS/Animal Care (AC) for consistency and compliance with the PHS Policy and the USDA Animal Welfare Act Regulations (AWAR). … Both NIH/OLAW and APHIS/AC commend the authors and editors for their outstanding efforts and for moving the biomedical research community forward in its formulation of best practices and commonly accepted professional guidance in this complex arena.”

—From the Introduction by Dr. Patricia A. Brown, Director of the Office of Laboratory Animal Welfare Dr. Chester A. Gipson, Deputy Administrator USDA/APHIS/Animal Care

Praise for the second edition: “…. easy to read, complete with a multitude of reference material ... useful to any new IACUC members or members of IACUC who have additional questions regarding policies and regulations concerning animal programs at their or other institutions.”

—Sandra L. Jex, DVM, ALN Magazine, Vol. 6, No. 4, May/June 2007

“... I highly recommend it for the libraries of all those who are part of an IACUC or contribute to IACUC support.”

—Rebecca S. Schwiebert, D.V.M., Ph.D, C.A.C.L.A.M., American Journal of Veterinary Research, Vol. 69, No. 1

This Third Edition comprehensively addresses the significant changes in the pertinent regulatory environment and interpretation of applicable federal laws, regulations, and policies. It provides multiple references and commentary on the new edition of the Guide for the Care and Use of Laboratory Animals, the new AVMA Guidelines for the Euthanasia of Animals: 2013 Edition, and the Office of Laboratory Animal Welfare’s Frequently Asked Questions. The Third Edition also features an updated survey of IACUC practices from institutions around the United States, offering wisdom gained from their experience. In addition, it includes a chapter that provides an international perspective on how animal welfare reviews can function in other countries.

Table of Contents: Introduction.

Origins of the IACUC. Circumstances Requiring an IACUC. Creation of an IACUC. Reporting Lines of the IACUC. General Composition of the IACUC and Specific Roles of the IACUC Members.

Frequency and Conduct of Regular IACUC Meetings.

General Format of IACUC Protocol Forms.

Submission and Maintenance of IACUC Protocols.

General Concepts of Protocol Review.

Amending IACUC Protocols. Continuing Review of Protocols.

Justification for the Use of Animals.

Justification of the Number of Animals to Be Used.

Animal Acquisition and Disposition.

Animal Housing, Use Sites, and Transportation.

Pain and Distress.

Euthanasia.

Surgery.

Antigens, Antibodies, and Blood Collection.

Occupational Health and Safety.

Personnel Training.

Confidential and Proprietary Information.

General Concepts of the Program Review and Facility Inspection.

Inspection of Animal Housing Areas.

Inspection of Individual Laboratories.

Inspection of Surgery Areas.

Assessment of Veterinary Care.

Laboratory Animal Enrichment.

Animal Mistreatment and Protocol Noncompliance.

Postapproval Monitoring.

The European Ethical Review Framework: Collaborative Issues.

Index.

Catalog no. K15383, May 2014, 827 pp., ISBN: 978-1-4665-5564-8, $89.95 / £57.99

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Management, Compliance, and Animal Welfare Bestseller!

Bestseller!

Managing the Laboratory Animal Facility

Management of Laboratory Animal Care and Use Programs

Jerald Silverman

Edited by

Second Edition

University of Massachusetts Medical School, Worcester, USA

Mark A. Suckow

“I am pleased that Dr. Silverman has put out a second edition. I felt … that he was talking directly to me—in his folksy style of presentation—about any one of the facility issues I’ve faced over the years. The not-so-hypothetical Great Eastern University from his Lab Animal column is again used to help us address those management scenarios that we see each and every day. For myself, I will assign reading the sections on per diem in my lab animal management class to help my students better understand this oft times difficult topic. As well, Jerry has offered many insights and approaches to help both the new and experienced lab animal manager… .”

Fred A. Douglas

—Bruce W. Kennedy, MS RLATG CMAR, Compliance Associate, Research & Graduate Studies, California State Polytechnic University, Pomona, USA

A guide to providing high-quality management of laboratory animal facilities in a financially sound manner, this book promotes a basic understanding of management and leadership concepts in laboratory animal science.

While retaining the focus of its predecessor, this edition contains more than 100 pages of new and expanded material. It includes an entirely new chapter on leadership, a greatly expanded chapter on the management of human resources, a new appendix on productivity goals and measurements, and a revised appendix on how to calculate per diem rates.

University of Notre Dame, Indiana, USA Purdue University, West Lafayette, Indiana, USA

Robert H. Weichbrod

National Eye Institute, Bethesda, Maryland, USA

The management of biomedical research using animals has become increasingly complex due to new technology, increased regulatory oversight, and recognition of the need for animals free of disease and distress. Providing both factual and theoretical information, the content of this book is drawn from the substantial experience of authors who are noted experts in the field. Laboratory animal management is a discipline that is likely to experience continued growth and an increase in complexity. This book presents the basic knowledge and information needed to meet typical professional challenges.

Catalog no. 2287, November 2001, 408 pp.

ISBN: 978-0-8493-2287-7, $109.95 / £69.99 Also available as eBook

Catalog no. 55569, July 2008, 328 pp.

ISBN: 978-1-4200-5556-6, $87.95 / £55.99 Also available as eBook

Animal Welfare in Animal Agriculture

Husbandry, Stewardship, and Sustainability in Animal Production Edited by

Wilson G. Pond

The COST Manual of Laboratory Animal Care and Use

Refinement, Reduction, and Research Edited by

Bryan Howard

Cornell University, Ithaca, New York, USA

Former Director of Animal Welfare, University of Sheffield, UK

Fuller W. Bazer

Timo Nevalainen

Bernard E. Rollin

Gemma Perretta

Through a multidisciplinary approach, this book takes readers on a journey through the complex maze of issues that surrounds animal welfare today. The text links current and historical uses of animals and our views toward them with the concept of sustainable agriculture, addressing the role that welfare plays in a strong and viable food system.

Contributors present their views on what constitutes genuine animal welfare and how it is attained. They discuss topics including ethics, food safety, ecology, biotechnology, and the contributions of animals to society. Unique in its depth, breadth, and balance, this book underscores the need for dialog on animal welfare.

COST Action B-24 established four working groups to research and discuss issues relevant to laboratory animal science. These included the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the groups’ findings, The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research provides a consensual European view of best practices for individuals and institutions caring for and working with laboratory animals.

Texas A&M University, College Station, USA Colorado State University, Fort Collins, USA

Catalog no. K12159, November 2011, 333 pp.

ISBN: 978-1-4398-4842-5, $93.95 / £59.99

University of Kuopio, Finland Italian National Research Council, Santa Maria di Galeria, Italy

Catalog no. K11184, October 2010, 439 pp.

ISBN: 978-1-4398-2492-4, $93.95 / £59.99

Also available as an eBook

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Handbook of Laboratory Animal Science

Handbook of Laboratory Animal Science

Third Edition, Volumes I, II, and III Edited by

Jann Hau

University of Copenhagen & Rigshhospitalet, Denmark

Steven J. Schapiro

The University of Texas, Bastrop, USA

Continuing to set a precedent for quality information in laboratory animal science, the third edition of the Handbook of Laboratory Animal Science brings together contributions from leading experts across the world. The chapters in each volume can be read as a stand-alone text without the necessity to consult other chapters for information, although the entire handbook is an integrated text with respect to giving an in-depth introduction to laboratory animal science.

With contributions from eminent scientists who share their knowledge and hands-on expertise from their own research, these volumes are a critical resource for veterinary and biomedical researchers, laboratory managers and administrators, and other laboratory animal professionals.

Praise for previous volumes of the Handbook: "[A] valuable reference book … for undergraduate and graduate laboratory animal science courses. … well organized and well referenced. I would highly recommend this book as a reference text for all scientists using traditional laboratory animal species … ."

— Contemporary Topics in Laboratory Animal Science

"Both volumes of this book are well written, user friendly…it fills a current void by collecting together current practices in the scientific use of animals. Each chapter is well referenced and the book would be a valuable addition to the reference collections of animal facilities and research establishments."

— Bryan Howard, Animal Welfare

" … information of the highest quality. . . both volumes of this book will be valuable additions to the shelves of any veterinary surgeon involved in the field, either as a named vet or as a member of the multidisciplinary scientific team required in modern biomedical research."

— Paul Townsend, The Veterinary Record

"The text is quite easy to navigate using the chapter contents and index. The photographs and tables are clear and well used throughout. …The vast scope of information that this handbook contains is diverse, informative, and quite useful. The strength of these volumes is in their ability to cover a broad range of topics yet in such detail. This set would be an asset to the graduate student and researcher needing an excellent reference manual."

— Sandra L. Jex, Animal Lab News

“ … extremely well-written and clear. The chapters provide authoritative introductions to a wide range of animal models and, as such, it will be a very useful resource for researchers, laboratory animal veterinarians and regulators, for those teaching laboratory animal science, as well as to anyone with an interest in the variety of uses to which animals are put in the biomedical sciences.

Volume I Third Edition

Essential Principles and Practices Edited by

Jann Hau and Steven J. Schapiro Now in its third edition, topics in Volume I include the history of animal research, ethical concerns, regulation and legislation, facilities and equipment, genetics, health monitoring, nutrient requirements and feeding schedules, statistical analysis, surgical and non-surgical techniques, and anesthesia, as well as humane endpoints and the treatment of pain and suffering in laboratory animals. The book presents more material on the international harmonization of practices and on the continued implementation of the refinement, reduction, and replacement of animal usage in laboratories.

Contents — Includes a 16-page full color insert: The Contribution of Laboratory Animals to Medical Progress — Past, Present, and Future Ethics of Animal Research, An Overview of Global Legislation, Regulation and Policies Assessment of Animal Care and Use Programs and Facilities Education and Training Laboratory Animal Science and Service Organizations Laboratory Animal Allergy and Zoonoses Laboratory Animal Facilities and Equipment for Conventional, Barrier, and Containment Housing Systems Laboratory Animal Genetics and Genetic Quality Control Health Status and Health Monitoring Nutrient Requirements, Experimental Design, and Feeding Schedules in Animal Experimentation Impact of the Biotic and Abiotic Environment on Animal Experiments Experimental Design and Statistical Analysis Common Nonsurgical Techniques and Procedures Applications of Radio-Telemetry in Small Laboratory Animals Immunization for Production of Antibodies Laboratory Animal Analgesia, Anesthesia, and Euthanasia Welfare Assessment and Humane Endpoints Surgery: Basic Principles and Procedures Microsurgical Procedures in Experimental Research Postmortem Procedures Alternatives: Refinement, Reduction and Replacement of Animal Uses in the Life Sciences Generation and Analysis of Genetically Modified Mice Physiological, Hematological, and Clinical Chemistry Parameters (including Conversion Factors) Catalog no. 84550, December 2010, 740 pp.

ISBN: 978-1-4200-8455-9, $149.95 / £95.00

— Robert Hubrecht, UFAW, Wheathampstead, UK, Animal Welfare

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Handbook of Laboratory Animal Science

Volume II Third Edition

Volume III Third Edition

Edited by

Edited by

Jann Hau and Steven J. Schapiro

Jann Hau

Animal Models

Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains the comparative considerations underlying the choice of animal species and strains in different research disciplines.

Efficient and humane experimental work with animals, in which subjects experience no avoidable pain and mental distress, requires skillful and conscientious staff. To this end, scientists apply the three Rs: replacing experiments on live animals with alternative methods, reducing the number of animals necessary to obtain valid results within experiments, and refining techniques to minimize the discomfort experienced by the animal participants. This volume explores new developments in animal research with these ideals in mind.

Features in this new edition: • Presents contributions by international experts in their respective fields • Focuses on the pertinent comparative aspects in the multiple contexts in which laboratory animals are used • Includes ten new chapters • Examines spontaneous genetic mutants and the genetically modified animal models available within different research areas • Contains full color throughout the book, with approximately 50 color images

Contents: Animal Models Animal Models for Human Behavior Animal Models for Psychological Disorders Animal Models in Neuroscience Induced Animal Models of Parkinson’s Disease Animal Models in Aging and Alzheimer’s Disease Animal Models in Pain Research Animal Models in Pharmacology and Toxicology Animal Models for Otolaryngological Disorders Animal Models of Lung Physiology During Anesthesia Animal Models of Female Reproduction and Fetal Development Animal Models in Vaccinology Animal Models in Aids Research Animal Models for the Study of Helicobacter Infection Animal Models in Mycology Animal Models in Biodefense Research Animal Models in Oral Health Science Animal Models of Hearing Loss and Tinnitus

Animal Models

University of Copenhagen & Rigshospitalet, Denmark

Steven J. Schapiro

The University of Texas MD Anderson Cancer Center, Bastrop, USA

Building upon the success of the bestselling Handbook of Laboratory Animal Science and complementing Volumes I and II of the third edition, this new volume completes the task of providing a comprehensive overview of animal models in all biomedical disciplines. The book covers most of the important lab animal science bases. As with Volume II, this book focuses on the pertinent comparative aspects of the many different contexts in which animals are used as well as on the spontaneous genetic mutants and the genetically modified animal models available within different research areas.

• Provides a summary chapter on the humane use of animals in research • Reviews the use of laboratory animals for the study of diseases of the different organ systems, for infectious diseases, and for human behavior • Includes new chapters on the use of animal models for alcohol and drug abuse research and sleep disorders • Presents new chapters on cardiovascular disorders, digestive disorders, and regenerative medicine

Contents: Animal Models of Spinal Cord Injury Animal Models for Tropical Parasitic Diseases Animal Models of Cardiovascular Disease Animal Models of Sudden Infant Death Syndrome More Animal Models of Developmental Processes and Developmental Disorders for Social Genomics and Beyond Animal Models of Metabolic and Inflammatory Diseases Animal Models for Eye Diseases Animal Models of Human Cancer Reduction and Refinement Applied to Animal Models Catalog no. K15351, December 2013, 334 pp.

ISBN: 978-1-4665-5512-9, $119.95 / £76.99 Also available as an eBook

Catalog no. 84577, April 2011, 480 pp.

ISBN: 978-1-4200-8457-3, $189.95 / £108.00 Also available as eBook

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Series Editor: Mark A. Suckow, University of Notre Dame, Indiana, USA

***New and Recent Additions to Our Bestselling Series***

Catalog no. 2499 September 2013, 271 pp., Soft Cover ISBN: 978-0-8493-2499-4 $59.95 / £38.99

Catalog no. K12511 October 2012, 256 pp., Soft Cover ISBN: 978-1-4398-5421-1 $59.95 / £38.99

Catalog no. K11462 December 2012, 406 pp., Soft Cover ISBN: 978-1-4398-2986-8 $59.95 / £38.99

Ideal for Animal Caretakers, Technicians, & Laboratory Animal Veterinarians Amply illustrated with figures and tables, each book in the 13-volume series is a single-source reference that allows for the humane, healthy, and efficient handling of laboratory animals. These reader-friendly volumes detail basic information and common procedures for individuals performing research with laboratory animals,

including duties of animal facility management, animal husbandry, regulatory compliance, and technical procedures. They also provide possible sources and suppliers of animals, feed, sanitation supplies, cages, and research and veterinary supplies.

Each Book Includes: • Important Biological Features • Husbandry • Management • Veterinary Care • Experimental Methodology • Resources • Bibliography 6

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Series Editor: Mark A. Suckow, University of Notre Dame, Indiana, USA

14-VOLUME SET • Catalog no. 2560, ISBN: 978-0-8493-2560-1, $749.95 / £479.00

The Laboratory Xenopus sp.

The Laboratory Zebrafish

Catalog no. 91093, December 2009 180 pp., Soft Cover ISBN: 978-1-4200-9109-0 $59.95 / £38.99

Catalog no. K10378, December 2010 274 pp., Soft Cover ISBN: 978-1-4398-0743-9 $59.95 / £38.99

The Laboratory Rabbit Second Edition

The Laboratory Guinea Pig Second Edition

Catalog no. 91050, April 2010 148 pp., Soft Cover ISBN: 978-1-4200-9105-2 $59.95 / £38.99

The Laboratory Ferret Catalog no. K12861, March 2012 123 pp., Soft Cover ISBN: 978-1-4398-6181-3 $59.95 / £38.99

Catalog no. K11598, June 2011 172 pp., Soft Cover ISBN: 978-1-4398-3556-2 $59.95 / £38.99

The Laboratory Swine Second Edition Catalog no. K10783, February 2010 138 pp., Soft Cover ISBN: 978-1-4398-1528-1 $59.95 / £38.99

The Laboratory Nonhuman Primate

The Laboratory Cat

Catalog no. 2562, September 2001, 288 pp., Soft Cover ISBN: 978-0-8493-2562-5, $59.95 / £38.99

Catalog no. 2567, November 1997, 160 pp., Soft Cover ISBN: 978-0-8493-2567-0, $59.95 / £38.99

The Laboratory Hamster and Gerbil

The Laboratory Small Ruminant

Catalog no. 2566, December 1998, 168 pp., Soft Cover ISBN: 978-0-8493-2566-3, $59.95 / £38.99

Catalog no. 2568, March 1999,176 pp., Soft Cover ISBN: 978-0-8493-2568-7, $59.95 / £38.99

The Laboratory Canine Catalog no. 2893, October 2006, 184 pp., Soft Cover ISBN: 978-0-8493-2893-0, $59.95 / £38.99 For more information and complete contents, visit www.crcpress.com

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Laboratory Animal Bacteriology Coming Soon!

Handbook of Laboratory Animal Bacteriology Second Edition

Axel Kornerup Hansen

University of Copenhagen, Frederiksberg, Denmark

Dennis Sandris Nielsen

University of Copenhagen, Frederiksberg, Denmark

About the First Edition: “…this book provides precise methodology for the isolation and identification of bacteria that interfere with research protocols. It is logically organized, instructive, and progresses through animal sampling, bacterial culture, isolation, differentiation, and identification. … The book is a valuable guide to the bacteriological monitoring of rodent and rabbit research animal colonies. … It should be useful to laboratory animal health monitoring laboratories and to those needing overall information on how to perform laboratory animal bacteriological procedures. It will also be of interest to facility managers, clinical veterinarians, veterinary pathologists, and researchers interested in the management of organisms known to interfere with the colony health of rabbits and rodents used in research protocols” —Contemporary Topics in Laboratory Animal Science, March 2000

This second edition of a bestseller covers how to isolate bacteria in laboratory rodents and rabbits to assist veterinary pathologists and other animal caretakers in the management of these organisms. It emphasizes those bacteria known to interfere with research protocols, and offers methods for isolation and differentiation among related bacteria. It also enables the user to isolate and identify bacteria that is a part of the normal flora of these animals. The book is for facility managers, clinical veterinarians, veterinary pathologists, and researchers.

The book provides information on the general aspects of bacteriology, how to sample and identify bacteria in the animals, and how these bacteria interfere with animal models and the methods used to investigate this. It then describes the various bacterial species to be found in laboratory rodents and rabbits. While this in the first edition was divided according to cultivation and Gram staining characteristics, which was the standard at the time, it is now divided according to a more systematic phylum based approach, which the new molecular biological methods have made standard. This means that bacterial species, previously regarded as closely related, now may appear in two different phyla. Also, these chapters cover a range of bacteria identified to be of importance in laboratory rodents and rabbits over the last 10-15 years.

Features: • Defines, for each bacteria: the habitats, clinical importance, morphology, relevant media, physical, biochemical, and immunological characteristics, and molecular biology • Includes new chapters on the Mechanisms Behind Bacterial Impact on Animal Models and on a Systematic Overview of Bacteria • Expands greatly the chapter on Cultivation Methods and the Identification of Bacteria • Offers tips on differentiating between related species of bacteria and explains proper staining techniques and serology • Describes all bacterial species which may be isolated during routine investigations in rodents and rabbits

Selected Contents: Laboratory Animal Bacteriology – the Past, the Presence and the Future.

Sampling Animals for Bacteriological Examination.

Cultivation and Identification of Bacteria.

Immunological Methods.

Molecular Biology Based Methods for Microbiota Characterization.

Mechanisms behind Bacterial Impact on Animal Models.

Systematic Classification of Bacteria.

Firmicutes.

Bacteroidetes.

Proteobacteria.

Actinobacteria.

Spirochaetae.

Tenericutes.

Verrucomicrobia, Deferribacteres, Fusobacterium and TM7.

Appendixes: Producers of Reagents for Laboratory Animal Bacteriology.

Biosafety Levels for Microbiological Laboratories.

Catalog no. K22007, November 2014, 300 pp., ISBN: 978-1-4822-1544-1, $119.95 / £76.99 Also available as an eBook

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Procedural Techniques

Suturing Principles and Techniques in Laboratory Animal Surgery John J. Bogdanske, Scott Hubbard-Van Stelle, Margaret Rankin Riley, and Beth M. Schiffman Research Animal Resources Center (RARC), University of Wisconsin, Madison, USA

This color manual and accompanying DVD introduce the basic principles of, and the materials and instruments required for, suturing and wound closure on animals in a research or veterinary facility. It covers instrumentation holding and handling; needle types and applications; and suture material, packaging, and applications. It also provides in-depth coverage of various suture patterns and associated principles for proper knot tying, including step-by-step descriptions, video clips with narration, and handouts for each suture pattern.

• Addresses multiple learning styles by using the written word, video, audio, and color pictures for each suture pattern • Contains high-quality pictures of each technique that depict step-by-step instructions for each suture pattern • Includes a DVD with narrated video clips demonstrating each technique • Focuses on providing a quality instructional resource for teaching and demonstrating suturing techniques • Comes in a spiral-bound format that makes it easy to use in a laboratory setting • Offers guidance on vessel ligation, the use of skin staples, and choosing appropriate needle and suture material

Selected Contents: Instrumentation. Needle Types. Suture Material. Suture Pattern Descriptions and DVD Narration. Suture Patterns: Handouts. Study Breaks: DVD Narration. Suture Considerations for Exotics and Other Species. Glossary. Index.

Catalog no. K15275, June 2013, 123 pp., Soft Cover/Comb Binding, ISBN: 978-1-4665-5343-9, $59.95 / £38.99

Laboratory Mouse and Laboratory Rat Procedural Techniques John J. Bogdanske, BA; Scott Hubbard-Van Stelle, AS, CVT, RLATG; Margaret Rankin Riley, BS; and Beth M. Schiffman, BS, CVLT, RLATG Research Animal Resources Center (RARC), University of Wisconsin, Madison, USA

“Laboratory Rat and Laboratory Mouse Procedural Techniques Manual and DVD are short, easily read/watched manuals that review the very basic handling for the animal care technician through the clear use of discussion and accompanying photographs, enhanced with a clear, understandable DVD demonstrating each procedure discussed. Not only is the safety of the laboratory specimen of concern, but even more importantly, the safety of the human laboratory technicians and researchers. The reader is assumed to have fundamental laboratory rodent training in place. This is not meant as a primary training tool but to review and refresh existing understanding. Each of the texts is similar in organization and content which conveniently aids in navigation of topics.”

—Sandra L. Jex, DVM, Animal Lab News

Buy the Set and Save! Two Manuals and Two DVDs Catalog no. K12298, November 2010, 192 pp., Soft Cover / Comb Binding, ISBN: 978-1-4398-5050-3, $108.00 / £68.99

Also available individually: Laboratory Mouse Procedural Techniques

Laboratory Rat Procedural Techniques

Catalog no. K12294, November 2010, 100 pp., Soft Cover ISBN: 978-1-4398-5042-8, $59.95 / £38.99

Catalog no. K12295, November 2010, 92 pp., Soft Cover ISBN: 978-1-4398-5044-2, $59.95 / £38.99

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Non-Clinical Vascular Infusion Technology "Owen Green and Guy Healing have shown the importance of the 3Rs in infusion technology at international meetings and in producing this book.”

—From the Foreword by Kathryn Chapman, Head of Innovation and Translation, the National Centre for the Replacement, Refinement and Reduction of Animals in Research

NEW!

New!

Non-Clinical Vascular Infusion Technology

Non-Clinical Vascular Infusion Technology

Volume I The Science

Volume II The Techniques

Owen P. Green

Edited by

LeVerts Ltd., Peterborough, UK

Owen P. Green

Guy Healing

LeVerts Ltd., Peterborough, UK

AstraZeneca, Cheshire, UK

Guy Healing

With the evolution of vascular infusion technology, its use in the preclinical safety assessment of pharmaceuticals has become increasingly widespread. Hence, a need has developed for a single source on the scientific principles behind this technology. This book brings together current knowledge and underlying practices from around the world to help refine the procedures and enhance the understanding of infusion technology. It addresses the physical and physiological aspects including body fluid dynamics, physico-chemical factors, vascular infusion dynamics, formulation-specific considerations, and equipment compatibility.

AstraZeneca, Cheshire, UK

• Identifies and shares best practices for non-clinical vascular infusion • Relates physico-chemical and physiological principles to vascular infusion delivery • Comments at various points throughout each chapter on scientific principles related to vascular infusion delivery • Presents modern practices and procedures in line with up-to-date equipment development • Provides guidance on choices for the most acceptable methodologies from an animal welfare perspective • Offers recommendations for in-life assessments in order to monitor the success or problems with the vascular infusion delivery • Makes comparisons with human data in many areas

• Presents step-by-step procedures and practical tips covering a wide range of common animal models, augmented by the liberal use of illustrations • Emphasizes best practices in accordance with the 3Rs—reduction, refinement, and replacement of animal usage in laboratories • Discusses pathology within each species chapter and relevant equipment in each chapter • Covers catheterization techniques, including entrance and exit locations • Offers detailed information on surgical preparation for primates and minipigs, along with advice about the use of preoperative anesthesia, postsurgical analgesics, and antibiotic administration, as well as valuable input on surgical suite design

Following in the footsteps of the original Handbook of Pre-clinical Continuous Intravenous Infusion, this completely revised edition answers the needs of researchers and technicians by providing step-by-step instructions for a wide range of infusion techniques delivered to multiple species. With sections devoted to rats, mice, rabbits, dogs, minipigs, nonhuman primates, and juvenile animals, this thorough text includes procedures for multidose infusion toxicity and reproductive toxicology studies and provides guidance on the use of a variety of equipment, including tail cuffs, harnesses, and implanted buttons.

Selected Contents:

Selected Contents:

Body Fluid Dynamics. Physico-Chemical Factors. Vascular Infusion Dynamics. Formulation Considerations. Prestudy analytical assessments: Equipment compatibility. Annex: Common excipients and vehicles.

Rat. Mouse. Dog. Primate. Rabbit and Reproductive Studies. Minipig.

Juvenile Animals.

Catalog no. K13453, September 2013, 215 pp.

ISBN: 978-1-4398-7449-3, $99.95 / £63.99

Also available as an eBook

Catalog no. K13451, December 2013, c. 344 pp.

ISBN: 978-1-4398-7445-5, $119.95 / £76.99

Also available as an eBook

Buy the Set and Save!

Non-Clinical Vascular Infusion Technology Two Volume Set: Science and Techniques Catalog no. K13447, January 2014, c. 520 pp.

ISBN: 978-1-4398-7440-0, $179.95 / £114.00 Also available as an eBook

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Swine Bestseller!

Swine in the Laboratory

Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition Edited by

M. Michael Swindle

Medical University of South Carolina, Charleston, USA

To diminish the learning curve associated with using swine as models, Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition provides practical technical information for the use of swine in biomedical research. It focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest. This edition contains neverbefore-published images, additional chapters on toxicology and radiobiology, sections on anesthesia and perioperative care, and expanded details on anatomy and endoscopy.

Includes a DVD with three-dimensional, full-color images

Contents: Biology, Handling, Husbandry, and Anatomy Anesthesia, Analgesia, and Perioperative Care Wound Closure and Integument Gastrointestinal Procedures Liver and Biliary System Pancreas and Spleen Urinary System and Adrenal Glands General Principles Of Surgery and Surgical Anatomy Nephrectomy Reproductive System Cardiothoracic and Vascular Surgery/Chronic Intravascular Catheterization Head and Neck Surgery/Central Nervous System Musculoskeletal System and Orthopedic Procedures Cardiovascular Catheterization, Electrophysiology, and Imaging Laboratory Procedures Endoscopic, Laparoscopic, and Minimally Invasive Surgery Xenotransplantation and Transgenic Technologies Toxicology Radiobiology Imaging Techniques: CT, RI and Pet Scanning Ossabaw Island Miniature Swine: Cardiometabolic Syndrome Assessment Catalog no. 9278, March 2007, 496 pp.

ISBN: 978-0-8493-9278-8, $169.95 / £107.00 Also available as eBook

The Minipig in Biomedical Research Edited by

Peter A. McAnulty, Anthony D. Dayan, Niels-Christian Ganderup, and Kenneth L. Hastings "…the breadth and scope of this book extends into other disciplines by exploring minipigs as a disease model for a myriad of conditions including diabetes mellitus, osteoporosis, atherosclerosis, and oral disease. …

The text does an excellent job of explaining what is currently known while also highlighting areas where standard protocols are lacking and areas where more research is needed, such as characterizing and sequencing the porcine genome. This may spur further investigations into the biology of minipigs by increasing researcher confidence and comfort level working with this species in the future."

—Kristy Conn, Laboratory Animal Practitioner, Vol. 45, No. 3, December 2012

"Overall, this book will be a very useful reference source on the minipig for anyone involved with this species in biomedical research. It has elements that will also be of value to toxicologists, and what information is not covered in the book can probably be found through the references provided."

—Guy Healing, AstraZeneca, UK, BTS Newsletter, Issue 41, December 2012

Features: • Describes best practices in husbandry, transport, and experimentation • Explains and illustrates clinical, practical, and experimental techniques and procedures • Provides many examples of successful use of the minipig in basic and regulatory toxicity studies of drugs and devices • Discusses clinical and physiological findings and laboratory values in health and disease • Includes a 48-page color insert The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research and the development of drugs and chemicals. The book is written by acknowledged experts in the field and draws on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical and other industries. This accessible manual explores the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; all areas of toxicity testing; and the uses of the minipig as a disease model. Regulatory aspects of its use are also considered.

Contents: Origin and Management of the Minipig History and Development of Miniature, Micro- and Minipigs Welfare and Experimental Usage of the Minipig Pharmacology and ADME Studies in the Minipig Safety Assessment in the Minipig – Principal Body Systems Genetics and Immunology Disease Models Regulatory Perspective and Use of the Minipig in Developing Marketed Products New Horizons and Perspectives Catalog no. K10559, December 2011, 662 pp.

ISBN: 978-1-4398-1118-4, $189.95 / £89.00 Also available as eBook

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11

Mice and Rats Forthcoming!

Pathology of the Developing Mouse

A Systematic Approach Edited by

Histologic Basis of Mouse Endocrine System Development A Comparative Analysis Matthew Kaufman

University of Edinburgh (Retired), Scotland

Alexander Yu. Nikitin

Brad Bolon

The Ohio State University, Department of Veterinary Sciences, USA

This volume provides a complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity.

The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: • Baseline anatomic and physiologic traits of developing mice • Principles of good experimental design and statistical analysis for mouse developmental pathology studies

Cornell University, Ithaca, New York, USA

John P. Sundberg

The Jackson Laboratory, Bar Harbor, Maine, USA

• Aids in the analysis of genetically engineered mice with embryonic abnormalities • Contains more than 100 high-magnification color plates organized in folders by organ name.

• Includes scanned serial sections of embryos at defined stages of post conception • Illustrates similarities and differences between the mouse endocrine system and that of other species Catalog no. 88181, October 2009, 240 pp.

ISBN: 978-1-4200-8818-2, $164.95 / £106.00 Also available as eBook

• Procedures for anatomic pathology examinations • Methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids • Options and protocols for in situ molecular pathology analysis • Guides to the interpretation of anatomic pathology and clinical pathology changes in the animal

Contents: Introduction. The Case for Developmental Pathology and Development Pathologists. Fundamentals of Mouse Developmental Biology. Essentials of Mouse Genetics and Nomenclature.

Indispensable Terminology for Mouse Developmental Pathology Studies. Normal Development of the Mouse Embryo and Extraembryonic Membranes. Teratogens and Teratogenic Mechanisms in Mouse Developmental Pathology. Experimental Methods in Mouse Developmental Pathology. Principles of Experimental Design for Mouse Developmental Pathology Studies. Necropsy Sampling and Data Collection for Studying the Anatomy, Histology and Pathology of Mouse Development. Clinical Pathology Analysis in the Developing Mouse. Histotechnological Processing of Developing Mice. Gene Distribution Studies in Developing Mice. Protein Localization in Developing Mice. Quantitative Morphological Assessment in Mouse Developmental Pathology Studies. Ultrastructural Evaluation of Developing Mice. Three-Dimensional Imaging in Mouse Developmental Pathology Studies. Analytical Practices for Mouse Developmental Pathology. Pathology of the Developing Mouse from Conception to Weaning. Pathology of the Placenta. Mouse Developmental Pathology Assessments in High-Throughput Phenogenomic Facilities. A Statistical Analysis Primer for Mouse Developmental Pathology Studies. Index.

Experimental Surgical Models in the Laboratory Rat Edited by

Alfredo Rigalli and Veronica Elina Di Loreto

Rosario National University, Argentina

Written for biomedical researchers, this manual on experimental surgery in rats, summarizes a series of techniques that have been applied at the Bone Biology Laboratories at the School of Medicine at Rosario National University in Argentina. Stopping short of an exhaustive analysis of the techniques, the manual describes the basis of each surgical technique, the necessary materials—including catheters, precautions to consider, the methodology to apply, and the possible results to be obtained. The descriptions of each technique appear with diagrams and pictures.

Catalog no. 93266, May 2009, 232 pp.

ISBN: 978-1-4200-9326-1, $154.95 / £99.00 Also available as eBook

Catalog no. 70088, April 2015, 424 pp.

ISBN: 978-1-4200-7008-8, $119.95 / £76.99 Also available as an eBook

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Nonhuman Primates

Stereotaxic and Chemoarchitectural Atlas of the Brain of the Common Marmoset

Pocket Handbook of Nonhuman Primate Clinical Medicine Edited by

(Callithrix jacchus)

Angela Courtney

Craig D. Hardman and Ken W. S. Ashwell

Sources of clinical treatment information on nonhuman primates are traditionally scattered across journals, textbooks, conferences, personal conversations, and more. However, when a clinician on the treatment floor is faced with a patient needing immediate treatment, an informed decision must be made expeditiously.

University of New South Wales, Sydney, Australia

"… the most comprehensive collection of marmoset brain images gathered in one reference to date. … The accompanying DVD presents the plates in vivid color, increasing the image detail and their portability.

The book’s inclusion of neural structure volumetric data, MRI images, stereotaxic references, and immunohistochemically mapped chemoarchitectural sections qualifies it as a seminal marmoset brain reference."

—Stephen Denny, Laboratory Animal Practitioner, Vol. 46, No. 2, June 2013

The Stereotaxic and Chemoarchitectural Atlas of the Brain of the Common Marmoset (Callithrix jacchus) is the most detailed atlas of the marmoset brain available. An essential tool for researchers developing more effective therapies for disabling and debilitating neurological disorders, the book contains: • Fully delineated, high-quality (400x magnification) images of Nissl-stained, acetylcholinesterase histochemically stained and parvalbumin, calbindin and neurofilament immunohistochemically stained coronal and sagittal sections, as well as structural magnetic resonance images (MRIs) for direct comparisons • Line diagrams with delineations of all cortical and subcortical structures, with grid overlays so the precise position of each structure can be located stereotaxically relative to the interaural line and infraorbital margin • Quantitative data regarding volume and cell number of many of the structures delineated in the atlas, regularly updated on an accompanying website • Standard nomenclature widely used in the Paxinos group of atlases, allowing users to compare and contrast homologous nuclei in different species using the major available atlases The book combines modern imaging (MRI) with an accurate stereotaxic and chemoarchitectonic section atlas, making the fullest use of available technologies. The companion DVD includes all the images in full color. Designed by publishing neuroanatomists, this book/DVD will be a cornerstone in marmoset brain research for years to come.

Contents: Introduction Ecology, Behavior and Evolution of the Common Marmoset The Marmoset in Neuroscience Research Key Features of This Book Animals and Ethical Considerations Methods: MRI, Perfusion and Tissue Processing Imaging, Principles of Delineation and Abbreviation Quantitation of Volumes and Neuronal Populations of Motor Nuclei Bases for Delineation of Specific Regions and Nuclei References Named Structures and Abbreviations Index of Atlas Plates Atlas Plates

University of California, Davis, USA

An alternative to conducting a literature search in time-sensitive situations, Pocket Handbook of Nonhuman Primate Clinical Medicine supplies guidance and initial direction on diagnosis and treatment, including working doses based on past case experience. The frank, tothe-point nature of the text makes readers feel as if they had just asked a colleague how to approach a clinical problem and obtained a quick, “what you need to know” answer. The chapter authors draw on personal experience to describe commonly encountered clinical conditions and how to treat these cases—including not only the dos but also the don’ts. This format gives readers easy access to clinical signs, diagnostic criteria, and options for treatment.

This volume is a convenient, concise, case-based handbook written by and for clinicians in charge of the diagnosis and treatment of nonhuman primate patients. Available in both print and electronic formats, this handbook saves readers from having to wade through pages of data and case studies to find answers when time is a factor on the clinic floor.

Features: • Provides formulary and drug dosages, special precautions, and important notations • Discusses common diseases and clinical problems and outlines treatment based on current medicine • Presents full-color illustrations • Fits in a lab coat pocket for easy reference

Contents: Anesthesia in Nonhuman Primates Pain Management Wounds and Wound Care Basic Fluid Therapy Management of Gastrointestinal/Abdominal Conditions Thorax Conditions Bacterial, Mycotic, Viral, and Parasitic Infections Gestational Concerns: When to Intervene and What to Do Dentistry in Nhps Dermatologic and Ophthalmologic Conditions Strategies for Managing Behavior Problems Formularies: Drug Dosages Index Catalog no. K13021, October 2012, 232 pp.

Soft Cover, ISBN: 978-1-4398-6728-0, $99.95 / £63.99 Also available as eBook

Catalog no. K11718, January 2012, 515 pp.

ISBN: 978-1-4398-3778-8, $179.95 / £114.00 Also available as eBook

For more information and complete contents, visit www.crcpress.com

13

Animal Models

Biodefense Research Methodology and Animal Models

Diseases

A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis

Second Edition

Edited by

Edited by

James R. Swearengen

National Biodefense Analysis and Countermeasures Center, Frederick, Maryland, USA

Significant advances have been made in animal model development for biological research since the publication of the first edition of this volume, and the ramifications of the FDA’s Animal Efficacy Rule have become better understood in the scientific community. With each chapter completely updated with the latest research findings, this volume spans the spectrum of coverage from basic research to advanced development of medical countermeasures. Topics discussed include a history of biological agents as weapons, concepts and strategies involved in biowarfare and bioterrorism, animal models in biodefense research, and infectious disease aerobiology. The book also presents studies involving a range of specific diseases and toxins.

Catalog no. K11643, February 2012, 415 pp.

ISBN: 978-1-4398-3632-3, $135.95 / £86.00 Also available as eBook

Franz Joel Leong, Veronique Dartois, and Thomas Dick

Novartis Institute for Tropical Diseases, Singapore

Written by notable authorities from the several disciplines involved with tuberculosis (TB) research, this book is the first pictorial histopathology atlas with annotations on TB. Addressing serious and growing concerns over the outbreak and treatment of TB, the atlas introduces TB histopathology to students, scientists, and doctors. The atlas takes the unusual approach of covering multiple species histopathology. It provides a simple, annotated, and visual presentation of the comparative histopathology of TB in human and animal models. The editors have compiled information that helps TB scientists distinguish among the features of all major animal models available. They provide guidance for selecting the best animal model(s) to answer specific questions and to test the efficacy of drug candidates.

Catalog no. K11591, September 2010, 236 pp.

Soft Cover, ISBN: 978-1-4398-3527-2, $129.95 / £84.00 Also available as eBook

Animal Models of Diabetes

Toxoplasmosis of Animals and Humans

Second Edition, Frontiers in Research

Second Edition

Edited by

J.P. Dubey

USDA/ARS, Beltsville, Maryland, USA

Eleazar Shafrir

Hadassah University Hospital, Jerusalem, Israel

" … provides excellent background and specific information on each model … ."

— Leanne Alworth, in Laboratory Animal Practitioner

“I recommend those veterinary pathologists read this book before beginning experiments using diabetic model animals.”

— Akira Yabuki, Veterinary Pathology

Providing researchers with current information regarding the use of models in experiments, this text covers both Type 1 and Type 2 diabetes. It compiles relevant time-saving information on most, if not all, current well-recognized models for both types of diabetes, including mice, rats, mini-pigs, and Rhesus monkeys, and provides extensive references for more in-depth study. Among several other topics, it discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. It also addresses the importance of recent findings on pathogenesis of diabetes and its complications in relation to human disease.

Catalog no. 9534, April 2007, 384 pp.

ISBN: 978-0-8493-9534-5, $200.00 / £127.00

In the two decades since the publication of the first edition of this volume, there has been an explosion of knowledge concerning T. gondii and toxoplasmosis.

Still used extensively as a cell model, its genome has recently been published, making it a subject of even greater scientific interest. Keeping the organizational style that made the previous edition so popular, this second edition now includes: • Expanded information on the cultivation, maintenance, and preservation of T. gondii • Expanded information on the cell biology and molecular biology of the parasite • Reviews of all literature from the past 20 years for each domestic animal • Summarized information on the worldwide prevalence of toxoplasmosis in pregnant women Catalog no. 92367, November 2009, 336 pp.

ISBN: 978-1-4200-9236-3, $159.95 / £102.00 Also available as eBook

Also available as eBook

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Neuroscience

Translational Pain Research

From Mouse to Man

Neurobiology of Chemical Communication

Edited by

Edited by

Lawrence Kruger

Carla Mucignat-Caretta

University of California, Los Angeles, USA

University of Padova, Italy

Alan R. Light

Exploring the role of the chemical senses in mediating intraspecific communication, this volume examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, cats, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of the different species.

University of Utah, Salt Lake City, USA

Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, this cutting-edge work effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Among other topics, it addresses groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors, and ATP. Catalog no. K10609, November 2009, 432 pp.

ISBN: 978-1-4398-1209-9, $169.95 / £124.00 Also available as eBook

Viral Hemorrhagic Fevers Edited by

Sunit K. Singh

Molecular Biology Unit, Faculty of Medicine, Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi, India

Daniel Ruzek

Biology Centre ASCR- Institute of Parasitology, Ceske Budejovice, Czech Republic

Viral hemorrhagic fevers (VHFs) are a group of febrile illnesses caused by RNA viruses from several viral families. These infectious viruses lead to a potentially lethal disease syndrome characterized by fever, malaise, vomiting, mucosal and gastrointestinal bleeding, edema, and hypotension. The four viral families known to cause VHF disease in humans naturally reside in an animal reservoir host or arthropod vector. This volume presents the most current information on each virus. It examines the fevers caused by these viruses, their mechanisms for spreading, their molecular pathogenesis, host pathogen immune interactions, and detection, treatment, and prevention.

Catalog no. K15274, February 2014, 612 pp.

ISBN: 978-1-4665-5341-5, $149.95 / £95.00 Also available as an eBook

Phenomics Edited by

John M. Hancock

Cambridge University, UK

Phenomics is the new discipline of using standardized measurement techniques to characterize the phenotypic effects of random or systematic genome modifications (for example randomly generated mutations or systematic gene knockouts). This approach is now being used in an increasing range of species and systems. In this book, experts working in phenomics in most of the major species and systems that are currently being studied present overviews of the field from their different, but overlapping perspectives.

Catalog no. K20494, February 2014, 286 pp.

ISBN: 978-1-4665-9095-3, $129.95 / £82.00 Also available as an eBook

Catalog no. K13962, July 2013, 596 pp.

ISBN: 978-1-4398-8429-4, $149.95 / £95.00 Also available as an eBook

For more information and complete contents, visit www.crcpress.com

15

Chemistry and Hematotoxicology

Animal Clinical Chemistry

A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition

Animal Hematotoxicology A Practical Guide for Toxicologists and Biomedical Researchers G.O. Evans

Edited by

A. George Owen and Company, UK

G.O. Evans

This book is designed to help new entrants to the fields of laboratory animal hematology and toxicology, where the challenges are stimulating and the “rules” for human hematology do not always apply. In a clear, cohesive, and concise manner, the book covers the full range of the discipline, from basic principles to diagnostic evaluation.

A. George Owen and Company, UK

In addition to tests recommended by regulatory authorities, this globally relevant resource includes information about clinical chemistry tests as well as hepato-, nephro-, cardio-, and endocrine toxicity. It also covers pre-analytical and analytical variables, which play a far more important role in interpreting data from animal studies as compared to human studies when variables can be well controlled with less physiological effect. Furthermore, this edition takes its discussion of biomarkers to the next level, exploring newer and related investigations, such as metabolomics/NMR and multiplex technology.

• Addresses normal and abnormal clinical chemistry of lab animals • Provides more in-depth coverage of acute phase response proteins and cytokine measurements • Includes current biochemical investigation techniques such as metabolomics/NMR and multiplex technology • Explores troponins, lipids, and electrolytes

Contents: General Enzymology Assessment of Hepatotoxicity Assessment of Nephrotoxicity Assessment of Gastrointestinal and Pancreatic Toxicities Fluid Balance, Electrolytes, and Mineral Metabolism Assessment of Cardiotoxicity and Myotoxicity Proteins Lipids Assessment of Endocrine Toxicity Assessment of Neurotoxicity Preanalytical Variables Analytical Variables and Biosafety Data Processing and Interpretation References for Laboratory Animal Clinical Chemistry Data Appendices: References for Laboratory Animal Clinical Chemistry Data SI Unitage and Conversions "Expectable" Ranges for Plasma/Serum General Abbreviations Some Common Biochemical Abbreviations

Chapters are written to cover the three main blood cell types—erythrocytes, leukocytes, and thrombocytes—and potential toxic effects on these cells. A chapter on immunotoxicology is included as this scientific discipline is closely aligned to hematology. Other chapters are devoted to preanalytical and analytical variables that affect animal studies.

Information has been collated from published papers, textbooks, and unpublished data: references are provided at the end of each chapter or in Appendix A, where readers are provided with some key references on published reference ranges for laboratory animals.

Features: • Provides information on main laboratory animal species with tables of reference values • Includes a chapter on bone marrow evaluation containing material on micronucleus tests in genetic toxicology • Explores differences in cell counting techniques

Contents: Hemopoiesis Pre-analytical Factors, Analytical Factors, Statistics Bone Marrow Evaluation Iron, Tranferrin, Vitamin B12, Folate, and Erythropoietin Erythrocytic Disorders Leukocytic Disorders Hemostasis Immunological Toxicology Catalog no. 80091, July 2008, 224 pp.

ISBN: 978-1-4200-8009-4, $96.95 / £59.99 Also available as eBook

Catalog no. 80113, April 2009, 368 pp.

ISBN: 978-1-4200-8011-7, $91.95 / £58.99 Also available as eBook

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Reptiles

Animal Behavior

Animal Behavior Desk Reference

Bestseller!

Infectious Diseases and Pathology of Reptiles

A Dictionary of Animal Behavior, Ecology, and Evolution, Third Edition

Color Atlas and Text

Edward M. Barrows

Edited by

Georgetown University, Washington, D.C., USA

Elliott Jacobson

University of Florida College of Veterinary Medicine, Gainesville, USA

“… an excellent resource. … should sit side by side on the shelves of those working in reptile medicine or pathology. This book will prove informative and beneficial for students, residents, clinicians, and pathologists working with reptiles.”

— Dr. J. A. St. Leger, Seaworld, San Diego, in Veterinary Pathology

"Every so often, a book arrives on the scene that is destined to become a classic, and that time has come again. Elliot R. Jacobson … has compiled a book of such scope and magnitude that it will likely grace the reference library collection of virtually every veterinarian and pathologist working with reptiles … .”

— Zoo News

Featuring 1,200 high-quality color photos of normal anatomy and histology, as well as gross, light, and electron microscopic images of pathogens and diseases, this exceptionally comprehensive atlas provides definitive information on every known infectious disease affecting reptiles. Beginning with a thorough review of reptile biology, anatomy, and histology, leading authorities then address specific topics such as immunology, circulating inflammatory cells, necropsy techniques, pathogen identification and isolation, molecular diagnosis, and serodiagnostics. The atlas also catalogs specific pathologies due to viruses, bacteria, fungi, and parasites. Included are numerous never-before published electron microscope findings of reptile lesions.

Contents: Overview of Reptile Biology, Anatomy, and Histology Reptile Immunology Circulating Inflammatory Cells Reptile Necropsy Techniques Host Response to Infectious Agents and Identification of Pathogens in Tissue Section Identifying Reptile Pathogens Using Electron Microscopy Molecular Diagnostics Serodiagnostics Viruses and Viral Diseases of Reptiles Bacterial Diseases of Reptiles Mycotic Diseases in Reptiles Parasites and Parasitic Diseases of Reptiles Isolation of Pathogens Catalog no. 2321, April 2007, 736 pp.

ISBN: 978-0-8493-2321-8, $210.00 / £134.00 Also available as eBook

“This reference is a tremendous undertaking in thoroughly researching the terminology and citing references for additional clarification of concepts and phrases.”

—Sandra L. Jex, DVM, Animal Lab News

"This dictionary departs from other standard dictionaries … in that every definition is drawn from a cited reference; many have several. This allows readers who want to see how these terms were used in the context of a scholarly article or monograph to find the full citation in the bibliography at the back of the book and to retrieve the reference in a library. Definitions are, however, complete enough to give readers the full meaning of terms ... Highly recommended for all college, university, and public libraries."

—R. G. Sabin, Rice University, CHOICE

Features: • Discusses how definitions impact the way people communicate • Serves as an access point to the primary literature through extensive referencing • Presents variations in meaning that have developed for many different terms over time • Indicates controversies regarding the meanings of many terms with author-date citations Providing a common ground and platform for precise scientific communication in animal behavior, ecology, evolution, and related branches of biology, this volume contains more than 800 new terms and definitions, 48 new figures, and thousands of additions and improvements.

Using a dictionary format to present definitions in a standard, easily accessible manner, the book emphasizes conceptual terms and focuses on nouns, rather than verbs or adjectives. Term hierarchies are presented with bulleted entries and terms with multiple definitions are included as superscripted entries. All sources are cited and most are paraphrased to conform to uniform style and length.

The dictionary also includes nontechnical and obsolete terms, synonyms, pronunciations, and notes and comments, as well as etymologies, term originators, and related facts. Appendices address organism names, organizations, and databases.

Devoted to the precise and correct use of scientific language, this third edition of a bestselling standard enables students and scientists alike to communicate their findings and promote the efficient advancement of science.

Catalog no. K11649, April 2011, 800 pp.

ISBN: 978-1-4398-3651-4, $159.95 / £99.00 Also available as eBook

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