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Datasheet of Tenovin-1
Description: Tenovin-1 is a inhibitor of SIRT1 and SIRT2; activator of p21 and p53. Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro. in vitro: Tenovin-1 elevates the amount of p53 protein within 2 hr of treatment. This compound also increases the levels of the p53-downstream target p21CIP/WAF1 protein and mRNA, confirming that tenovin-1 can induce expression from an endogenous p53-dependent promoter. Tenovin-6 inhibits the growth of S. cerevisiae cultures with an IC50 of 30 μM and is more toxic to yeast than the less water-soluble tenovin-1. in vivo: Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts.
Chemical Information Catalog
DC1065
Purity of current batch:
>98%
Molecular Weight (MW)
369.48
Molecular Formula
C20H23N3O2S
CAS No.
380315-80-0
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.