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Datasheet of GW-9662
Description: GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with ~10 and ~1000-fold functional selectivity in cells against PPARα and PPARδ, respectively. in vitro: GW9662 is a selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). GW9662 blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM), therefore is more potent than BADGE. PPARγ antagonist GW9662 may inhibit the foam-cell formations in atherosclerosis. GW9662 induces functional estrogen receptor in mouse mammary organ culture. Anticancer, inhibits growth of human mammary tumor cell lines. The induction of ERα by GW9662, including newer analogs, may permit use of anti-ER strategies to inhibit breast cancer in ER-patients. in vivo: Pretreatment with LPS (1 mg/kg i.p.) significantly attenuates all markers of renal injury and dysfunction caused by ischemia/reperfusion (I/R) injury in rats. Most notably, GW9662 (1 mg/kg i.p.) abolishes the protective effects of LPS .
Chemical Information Catalog
DC2079
Purity of current batch:
>98%
Molecular Weight (MW)
276.68
Molecular Formula
C13H9ClN2O3
CAS No.
22978-25-2
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.