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Datasheet of TMS
Description: CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.1 It is 50-fold selective For the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.1 In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.2 For the detailed information about the solubility of TMS in water, the solubility of TMS in DMSO, the solubility of TMS in PBS buffer, the animal experiment（test） of TMS, the in vivo,in vitro and clinical trial test of TMS, the cell experiment（test） of TMS, the IC50, EC50 and Affinity of TMS , please contact DC Chemicals.
Chemical Information Catalog
DC2080
Purity of current batch:
>98%
Molecular Weight (MW)
300.35
Molecular Formula
C18H20O4
CAS No.
24144-92-1
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.