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Datasheet of TPEN
Description: TPEN is a cell permeable, high-affinity heavy metal (Zn2+>Fe2+>Mn2+) chelator that exhibits low affinity For Mg2+ and Ca2+. The compound is lipid-soluble and has been shown to permeate artificial and natural membranes. Research shows that TPEN induces apoptosis in human and rat thymocytes through DNA fragmentation and Caspace-3 activation. TPEN also induces mitochondrial cytochrome C translocation to the cytosol in human PBL. A recent study has proved this chelator to work in conjunction with the fluorescent probe Fura-2 (sc-202163) in biophysical studies of Ca2+. For the detailed information about the solubility of TPEN in water, the solubility of TPEN in DMSO, the solubility of TPEN in PBS buffer, the animal experiment（test） of TPEN, the in vivo,in vitro and clinical trial test of TPEN, the cell experiment（test） of TPEN, the IC50, EC50 and Affinity of TPEN , please contact DC Chemicals.
Chemical Information Catalog
DC2081
Purity of current batch:
>98%
Molecular Weight (MW)
424.54
Molecular Formula
C26H28N6
CAS No.
16858-02-9
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.