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Datasheet of MRK003
Description: Description of MRK003: MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM and NHL cell lines and patient cells. Examination of signaling events after treatment showed time-dependent decrease in levels of the notch intracellular domain, Hes1 and c-Myc. MRK003 downregulated cyclin D1, Bcl-Xl and Xiap levels in NHL cells and p21, Bcl-2 and Bcl-Xl in MM cells. In addition, MRK003 caused an upregulation of pAkt, indicating crosstalk with the PI3K/Akt pathway. (source: Leukemia (2012) 26, 340–348; doi:10.1038/leu.2011.192). For the detailed information about the solubility of MRK003 in water, the solubility of MRK003 in DMSO, the solubility of MRK003 in PBS buffer, the animal experiment（test） of MRK003,the in vivo,in vitro and clinical trial test of MRK003,the cell experiment（test） of MRK003,the IC50, EC50 and Affinity of MRK003, please contact DC Chemicals..
Chemical Information Catalog
DC3122
Purity of current batch:
>98%
Molecular Weight (MW)
551.59
Molecular Formula
C25H31F6N3O2S
CAS No.
623165-93-5
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.