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Datasheet of Dovitinib
Description: Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor. Dovitinib inhibited proliferation of ZNF198-FGFR1 and BCR-FGFR1 trans Formed Ba/F3 cells with IC50 values of 150 nM and 90 nM, respectively. The phosphorylation of each fusion gene, ERK, and STAT5 was inhibited as well at the same time. Dovitinib also inhibited proliferation of the FGFR1OP2-FGFR1-positive KG1 and KG1A cell lines and induced apoptosis. Furthermore, dovitinib significantly inhibited the growth of primary cells from 8p11 myeloproliferative syndrome (EMS) patients dose-dependently. For the detailed information about the solubility of Dovitinib (TKI-258, CHIR-258) in water, the solubility of Dovitinib (TKI-258, CHIR-258) in DMSO, the solubility of Dovitinib (TKI-258, CHIR-258) in PBS buffer, the animal experiment（test） of Dovitinib (TKI-258, CHIR-258),the in vivo,in vitro and clinical trial test of Dovitinib (TKI-258, CHIR-258),the cell experiment（test） of Dovitinib (TKI-258, CHIR-258),the IC50, EC50 and Affinity of Dovitinib (TKI-258, CHIR-258), please contact DC Chemicals.
Chemical Information Catalog
DC3141
Purity of current batch:
>98%
Molecular Weight (MW)
500.53
Molecular Formula
C21H21FN6O.C3H6O3.H2O
CAS No.
915769-50-5
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.