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Datasheet of HSP990
Description: NVP-HSP990(HSP990) is an orally bioavailable inhibitor of Hsp90(IC50=13 nM; Hsp90α) with potential antineoplastic activity. in vitro: NVP-HSP990 triggered apoptosis in a panel of human multiple myeloma cells, induced cell-cycle arrest, PARP cleavage, downregulation of client proteins, the inability to reactivate phospho-STAT3 following exogenous IL-6 stimulation, and it synergized with azacytidine and bortezomib in cell lines and primary multiple myeloma samples. Exposure of MM cells to a combination of NVP-HSP990 and either melphalan or histone deacetylase (HDAC) inhibitors caused synergistic inhibition of viability, increased induction of apoptosis, and was able to overcome the primary resistance of the cell line RPMI-8226 to HSP90 inhibition. in vivo: HSP990 was given to control mice every 3 days for 14 days at close to the maximum tolerated dose, which was most likely to reveal any effect on phototransduction machinery biogenesis. HSP990-treated retinae showed a significant reduction in GRK1 levels, compared with vehicle-treated control. Moreover, HSP990-treated retinae exhibited retinal morphology that was indistinguishable from age-matched vehicle-treated animals, with rhodopsin localized in the OS..
Chemical Information Catalog
DC4178
Purity of current batch:
>98%
Molecular Weight (MW)
379.39
Molecular Formula
C20H18FN5O2
CAS No.
934343-74-5
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.