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Datasheet of Teriflunomide
Description: Teriflunomide (A77 1726), the active metabolite of an approved antirheumatic drug Leflunomide, is an emerging oral therapy for multiple sclerosis (MS). Teriflunomide has demonstrated anti-inflammatory, antiproliferative and immunosuppressive effects. Teriflunomide is an immunomodulator with a unique mechanism of action. Although the mechanism of action for Teriflunomide is not fully understood, research supports that Teriflunomide inhibits the proliferation of stimulated T and B lymphocytes in the periphery thought to be responsible for the damaging inflammatory process in MS, while generally maintaining normal immune function. Teriflunomide selectively and reversibly inhibits DHODH, a key enzyme in de novo pyrimidine synthesis required by rapidly dividing lymphocytes. Through this effect, it limits the expansion of stimulated T- and B-cells in the periphery and diminishes the numbers of activated T- and B-cells available to migrate into the central nervous system (CNS). Because the salvage pathway for pyrimidine synthesis is not affected by Teriflunomide, resting lymphocytes maintain their viability and remain unaffected by Teriflunomide.
Chemical Information Catalog
DC4221
Purity of current batch:
>98%
Molecular Weight (MW)
270.21
Molecular Formula
C12H9F3N2O2
CAS No.
163451-81-8
Solubility (25째C)
DMSO
Storage
Store at -20째C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20째C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.