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Datasheet of PP2
Description: PP2(AGL 1879) is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases with IC50s of 4/5/5/100 nM for p56lck/p59fynT/Hck/Src respectively. PP2 inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). PP2 does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 ?M), or ZAP-70 (IC50 > 100 ?M). PP2 inhibits the activation of focal adhesion kinase as well as its phosphorylation at Tyr577. PP2 also inhibits anti-CD3-stimulated tyrosine phosphorylation of human T-cells with an IC50 value of 600 nM. PP2 suppressed cell proliferation and altered cell cycle distribution of the OV1063 cells in a dose- and time-dependent manner. Immunoblotting analysis indicated that PP2 decreased the level of pp60Src protein.
Chemical Information Catalog
DC5008
Purity of current batch:
>98%
Molecular Weight (MW)
301.77
Molecular Formula
C15H16ClN5
CAS No.
172889-27-9
Solubility (25째C)
DMSO
Storage
Store at -20째C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20째C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.