Worldwide leaders in the application of industrial biotechnology and synthetic biology, Ingenza provides efficient scalable bioprocesses to manufacture chemicals, biologics, pharmaceuticals and biofuels, from sustainable sources.
Founded in 2003, Ingenza has grown into a leading industrial biotechnology organisation focussed upon scientific excellence and commercial bioprocess competitiveness.
Our mission is to be the partner of choice in Industrial Biotechnology and Synthetic Biology, leveraging a world class, integrated scientific team and unique, proprietary enabling technologies. Ingenza embodies a culture of innovation to develop and license proprietary, game-changing technologies through individual and strategic alliances with world leading manufacturers.
Work with Ingenza to unlock and transform ideas into sustainable and highly competitive bio-manufacturing routes.
I n g e n z a ’s m o l e c u l a r b i o l o g i s t s work in partnership with leading manufacturers worldwide, providing new biosynthetic routes to pharmaceuticals, chemicals, polymers, fuels and consumer products. Our unique capabilities derive from a team with market leading expertise, unique proprietar y technologies and a passion for the science we deliver.
Ingenza’s molecular biology team designs and constructs bespoke bio-production systems…from efficient GMP compliant, recombinant cell-lines and microbes to improved yeast for commercial bioethanol manufacture. Integrating expertise in phylogenetics, gene expression, phenotypic screening and innovative cell culture, we provide: • • • • • •
Recombinant cell-lines for human therapeutics with industry leading gene expression productivity. High level secretion of active soluble protein targets from P. pastoris. Partnered design and development of proprietary production microbes for chemical building blocks and polymer intermediates. Adapted Saccharomyces with superior productivity in bioethanol manufacture at commercial scale. New portfolios of intellectual property in bio-manufacturing for commercial partners. Engineered enzymes to enhance carbon conversion, yield and economics of sustainable bioprocessing.
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in ABLE 速 ac cel erate s new product development by designing and building complex and versatile DNA assemblies for strain and cell line engineering. Combining bioinformatics, combinatorial genetics and high throughput solid or liquid phase screening, it provides more predictable and versatile outcomes for synthetic biology, optimised protein production and drug discover y.
Ingenza’s inABLE® technology is readily applicable to establish, diversify and enhance any biological production system. Employing innovative and unique methods to combine and rearrange DNA fragments in predictable, selective configurations, it is being applied throughout Ingenza’s partnerships to: • • • • • •
Optimise target protein production in microbial or mammalian hosts. Assemble and evaluate novel, complex engineered biochemical pathways. Construct and screen high quality libraries of protein variants for improved performance. Rapidly exemplify new bioscience intellectual property. Adapt or improve properties of individual target proteins/enzymes. Diversify and deregulate pathways of natural product synthesis to discover novel activities.
inABLE® adapts established production organisms to enhance functionalities:
productivity, stability, scalability.
Ingenza’s fermentation, microbiology and cell culture team develops and scales commercial fermentation processes worldwide. Meeting process requirements from shake flask evaluation through optimisation of media and growth protocols, master cell banking and scalable process economics, our fermentation group provides customers and partners with the confidence that the ultimate bioprocess will satisfy their commercial needs.
With over 15 years experience in scaling diverse industrial fermentation processes to multi thousand litre and beyond, Ingenza’s fermentation team is equipped to translate individual engineered bioprocesses into robust and reproducible large scale manufacturing routes. Implementing GMP compliant quality protocols where appropriate, Ingenza has delivered competitive fermentation and cell culture based processes to meet broad ranging manufacturing objectives: • • • • • •
Engineered industrial microbes for competitive production of unnatural amino acids at multi-thousand litre scale. Recombinant CHO cell lines with optimised production of blood factors. Process and intellectual property exemplification for scalable manufacture of polymer intermediates. Scalable GMP compliant extracellular production of protein therapeutics using engineered microbial hosts. Efficient non-methanol based and third party IP free, GMP production systems in P. pastoris. Improved commercial bioethanol production strains, implemented at 2.5 million litre scale.
Chemistry lies at the heart of bioscience, from correct folding of heterologous proteins to efficient enzymatic biotransformation, high throughput assay or successful product purification. Seamlessly integrating a world class synthetic organic chemistry group within its multiple bioscience disciplines provides Ingenza with a unique range of skills and capabilities.
Ingenza’s synthetic chemistry team is at the forefront of bioprocess design, enzymatic route selection, enabling technology development and customer interactions, throughout Ingenza’s diverse activities. Routinely meeting specific needs in bioprocess optimisation, chemo-enzymatic biotransformation, product analysis or substrate preparation, they provide critical differentiation for Ingenza in many areas: • • • • •
Achieving bioprocesses competitiveness with established chemical manufacturing. Rapid exemplification of biosynthetic reactions through provision of unavailable reaction substrates and intermediates. Biotransformation reaction optimisation, including statistical design of reaction methodology. Optimisation of small molecule recovery from aqueous fermentation or bio-reaction streams. Integration of Ingenza bioprocess technology with customer downstream processing and scale-up.
For all general enquiries please contact Sarah Graham: EMAIL
sarah.graham@ingenza.com
TEL
+44(0)131 200 6365
FA X
+44(0)131 200 6353
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Wa l l a c e B u i l d i n g , R o s l i n B i o C e n t r e , M i d l o t h i a n , E H 2 5 9 P P, U K Te l : + 4 4 ( 0 ) 1 3 1 2 0 0 6 3 5 5 Fax: +44 (0)131 200 6353 Email: sarah.graham@ingenza.com