MEMORIAL
WOLNEI CAUMO
MARCADORES DE NEUROPLASTICIDADE E CORRELATOS BMC Neurosci. 2014 Mar 19;15:42. doi: 10.1186/1471-2202-15-42.
Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome. Vidor LP, Torres IL1, Medeiros LF, Dussán-Sarria JA, Dall’agnol L, Deitos A, Brietzke A, Laste G, Rozisky JR, Fregni F, Caumo W.
BACKGROUND: This study aimed to answer three questions related to chronic myofascial pain syndrome (MPS): 1) Is the motor cortex excitability, as assessed by transcranial magnetic stimulation parameters (TMS), related to state-trait anxiety? 2) Does anxiety modulate corticospinal excitability changes after evoked pain by Quantitative Sensory Testing (QST)? 3) Does the state-trait anxiety predict the response to pain evoked by QST if simultaneously receiving a heterotopic stimulus [Conditional Pain Modulation (CPM)]? We included females with chronic MPS (n = 47) and healthy controls (n = 11), aged 19 to 65 years. Motor cortex excitability was assessed by TMS, and anxiety was assessed based on the State-Trait Anxiety Inventory. The disability related to pain (DRP) was assessed by the Profile of Chronic Pain scale for the Brazilian population (B:PCP:S), and the psychophysical pain measurements were measured by the QST and CPM. RESULTS: In patients, trait-anxiety was positively correlated to intracortical facilitation (ICF) at baseline and after QST evoked pain (β = 0.05 and β = 0.04, respectively) and negatively correlated to the cortical silent period (CSP) (β = -1.17 and β = -1.23, respectively) (P <0.05 for all comparisons). After QST evoked pain, the DRP was positively correlated to ICF (β = 0.02) (P < 0.05). Pain scores during CPM were positively correlated with trait-anxiety when it was concurrently with high DRP (β = 0.39; P = 0.02). Controls’ cortical excitability remained unchanged after QST. CONCLUSIONS: These findings suggest that, in chronic MPS, the imbalance between excitatory and inhibitory descending systems of the corticospinal tract is associated with higher trait-anxiety concurrent with higher DRP. No: 21 FI: 2.17 Citações: 32 Clin J Pain. 2015 Nov;31(11):959-67. doi: 10.1097/AJP.0000000000000194.
Clinical Value of Serum Neuroplasticity Mediators in Identifying the Central Sensitivity Syndrome In Patients With Chronic Pain With and Without Structural Pathology. Deitos A1, Dussán-Sarria JA, Souza Ad, Medeiros L, Tarragô Mda G, Sehn F, Chassot M, Zanette S, Schwertner A, Fregni F, Torres IL, Caumo W. BACKGROUND AND OBJECTIVES: Central sensitivity syndrome (CSS) encompasses disorders with overlapping symptoms in a spectrum of structural pathology from persistent somatic nociception (eg, osteoarthritis) to absence of tissue injury such as in fibromyalgia, chronic tension-type headache, and myofascial pain syndrome. Likewise, the spectrum of the neuroplasticity mediators associated with CSS might present a pattern of clinical utility. METHODS: We studied the brain-derived neurotrophic factor (BDNF), tumor necrosis factor-α (TNF-α), and interleukins 6 (IL-6) and IL-10 in female patients with CSS absent of structural pathology (chronic tension-type headache [n=30], myofascial pain syndrome [n=29],
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