Histamine
Histamine
Histamine
HISTAMINEINTOLERANCE
By:Dr.MargaretChristensen,MD,IFMCP
Dr.GailClaytonDCN,CNS,MS,RPh,LDN
MoldDetoxDiet2020©
HISTAMINEASANORMALIMMUNERESPONSE
LOWHISTAMINEDIET
Swelling–tobringin fluidtowashoutdebris
ROS
ROS Histamine Histamine Histamine
ROS
Allowsimmune mediatorstogettosite ofinfection
Travelsanywherein thebody–eventothe brain
MoldDetoxDiet2020©
IMMUNE RESPONSE
Histamine
NUTRIENTS ABSORBED
Histamine
Mycotoxinscausethelossofthe immuneregulation
HISTAMINEINTOLERANCE
CNS HORMONAL
Migraines
Fatigue
Anxiety/panic/palpitations
Dizziness
OverproductionorInabilitytobreakdown
Symptomsvaryfrompersontoperson GUT
Bloodpressurefluctuations withfoods
Fibromyalgia
Difficultyregulatingbodytemp
Psychosisandhallucinations
Bipolar/Schizophrenia
Alcoholism
RESPIRATORY
Nasalcongestion/sneezing
Difficultybreathing
Asthma
ReactiveAirwayDisease
Nausea,vomitingafter eating
Abdominalpain
Bloating
SIBO/SIFO
Foodintolerances
Constipation/Diarrhea
SKIN
Flushing
Hives
Rashesw/eating
HISTAMINEMETABOLISM:DAOANDHNMT
GItract-DAO
Genetic
Riboflavin(B2)B2
Enzymesupplementation
Dysbiosis
CNS-HNMT
PropermethylationofB12&folate
Minerals–Mb,Cu,Se,Zn
VitaminAA
VitaminDD
CLINICALPEARL:
CNSsymptomsdoesnotmeanthereisn’taDAOdeficiency!
MoldDetoxDiet2020©
FIRSTREMOVEHIGHHISTAMINEFOODS
HISTAMINESYMPTOMS?
oFirstremovehighhistamine foods
oImprovementinsymptoms quickly
oRe-introductionofthosefoods oneatatime.
oLeaveoutproblematicfoods
Histamine
HISTAMINEFOODASSESSMENT
Highhistamine Containing
oFermentedfoods andalcohol
oCuredmeats
oDriedfruits
oMostcitrusfruits
oNuts
oSmokedorcured fish
oLeftovermeats
InhibitDAO Synthesis
oAlcohol
oEnergydrinks
oBlacktea
oMatetea
oGreentea
Histamine Liberator
oAlcohol
oBanana/strawberries
oChocolate/Cow’smilk
oNuts
oPapaya/pineapple
oShellfish
oTomatoes
oWheatgerm
oArtificialpreservatives anddyes.
FoodstoConsider
Adding:
oOrganmeats–kidney(organic)
oGreenpeasprouts
oLong-chainedfats, MUFA,saturatedfats, Omega3s
LOWHISTAMINEFOODS
LeafyHerbs
HerbalTeas
CookingOils:
OliveandCoconut Oils
DairySubstitutes:
Coconut,Rice,Hemp,& AlmondMilk
FreshMeat&poultry(freshorfrozen)
Freshlycaughtfish;Eggs
LOW HISTAMINE FOODS
Gluten-freegrains
Rice;Quinoa
SunflowerSeedButter
Freshfruits:
Mango,Pear,Kiwi, Watermelon,Apple, Cantaloupe,Grapes
FreshVegetables
Except:Tomatoes,Spinach, Avocado,&Eggplant
METHYLATION
HISTAMINE SYMPTOMS
NOTSLEEPING?
•LowHistamineDiet
•Pharmaceuticals
•Supplements
OTCANTIHISTAMINES
TIPS DOSING OTC
oCetirizine(Zyrtec)
oFexofenadine(Allegra)
oRanitidine
oLoratadine
oDiphenhydramine (Benadryl)
oCetirizine10mgdaily
oFexofenadine60mg twicedailyor180mg oncedaily
oRanitidine75-150mg twicedaily
oLoratadine10mgdaily
oDiphenhydramine 12.5-50mgupto4 timesdaily
oTrydifferentones forthebest results
oAvoidthepills containingdyes
oMaycombine Cetirizineand Loratadinefor bestresults
RXANTIHISTAMINES/MASTCELLSTABILIZERS
DOSING RX
oHydroxyzine(Atarax)
oKetotifen(Zaditor)
oCromolynsodium (Nasalcrom)
oMontelukast(Singular)
oOmalizumab(Xolair)
oLDN(LowDose Naltrexone)
oIVIG
oHydroxyzinedosing:10100mgupto4timesdaily
oKetotifendoing:1mg twicedaily
oCromolynsodiumdosing is200mgorally4xdaily
oMontelukastdosingis 10mgdaily
oXolairdosing75-375mg SQevery3-4weeks
oLDN1.5-4.5mgat bedtime
TIPS
oHydroxyzine-improves oraltolerance;improves REMsleep
oKetotifentabletorliquid
oCromolynsodium-Take 30minpriortomeals.
oSingularalsocomesin chewable.Nottobe takenmorethanonce perday
oStartwithXolairiflossof oraltolerance
oStartatlowerdoseand increaseevery2weeks
PHENOLCONTAININGFOODS
SENSITIVITIESTO Polyphenols
oImproperprocessing
oTrappedinmetaboliccycle
oGeneticpredisposition
oCommonherbs
Foodsrichin polyphenolsinclude: Brightlycoloredfruits
Brightlycoloredvegetables
Redwine
Coffee
Blackandgreenteas
Darkchocolate Spices
Gutbacteriaandyeast alsomakephenols
MoldDetoxDiet2020©
CAUTION:PHENOLSENSITIVITY
oBehaviorproblems
oSelf-stimmingbehaviors
oRed,flushedcheeks/ears
oDarkcirclesaroundeyes
oNightsweats
oWakingupatnight
oHyperactivity
oInappropriatelaughter (evenings)
oFatigueinadults
SYMPTOMS TREATMENT SULFATION MoldDetoxDiet2020©
SNPs
oPST
oSUOX
oCBS
oFeingoldDiet(low phenol/salicylate)
oMagnesium
oMolybdenum
oB6
oXylenaseenzyme(NoFenolbyHoustonEnzymes
oLabs:Hightaurine, Xanthanurate,high Homocysteine
Startwithmicrodosesfor severelysensitiveindividuals
UNABLETOTAKEFULLDOSES?
•Addin2ndlayerofstabilizing supplements
•Workuptofulldoseastolerated
•Microdosesintolerant?Continue withAIProtation&workon stress/limbicretraining
IgE-PRELOADEDMASTCELLS
IgE
Histamine
Histamine
Histamine
MoldDetoxDiet2020©
BRAINDETOXIFIESWHILESLEEPING
o2%bodywt.
o30%energy
oVerymetabolically active
oBrainshrinkageby 20%duringREM
Brainunableto detoxifyduring wakinghours
SleepStabilizes MastCells
oLymphopensup
oFluidsenterbrain
oClearstoxins& metabolicwaste
oBraindetoxifies andresets
SLEEPCYCLE
Sunlightbetween 10amto2pm
90minutesleepcycles> multiples>7.5hoursneeded
Toomuchbluelight exposureelectronics
Hoursofsleep 10:30pmto2:30am
Shiftwork worsthealth outcomes
MASTCELLSACTIVATETHEAMYGDALA
WI-FI EMFs EMOTIONS
SUNLIGHT CHEMICALS
TEMPERATURE CHANGES
MoldDetoxDiet2020©
STRESSAFFECTSEVERYSINGLEORGAN
o75-95%alldoctorvisitsstress-related
oMycotoxinscauseunduestressburden
FIGHTORFLIGHT MoldDetoxDiet2020©
AMYGDALAANALYZESALLINCOMING
STIMULI
oTHREAT?Stresschemistryreleased
oHistamine,Epinephrine,Norepinephrine, &Dopamine
LOWERING“TRIGGERLOAD”THRESHOLD
TRIGGERLOAD
oCombinationofstressors
oGOAL=lowertriggerload
oWorsetohavemultiplesmalltriggers
oMakesyou“allergic”toyourenvironment
TRIGGERLOADTHRESHOLD
Histamine
THRESHOLD BREECHED
DYSGLYCEMIA OBESITY
MoldDetoxDiet2020©
RETRAINTHEBRAIN
FIGHT OR FLIGHT REST AND DIGEST
Difficulttoturn backoff.Stays chronicallyalert!
Mustretrainthebrainto notrespondtonormal incomingstimuli!
Retrainingthebraintoletgoofthestressresponseisan importantpartofrestoringtheimmuneresponse!
MoldDetoxDiet2020©
LIMBICRETRAININGPROGRAMS
GUPTAAMYGDALARETRAINING
www.guptaprogramme.com
DYNAMICNEURALRETRAININGSYSTEM (DNRS)
ByAnnieHopper
www.retrainingthebrain.com
OTHERHELPFULTECHNIQUES:
Tapping
Meditation 12-Stepprograms Deepbreathing
Naturewalks
Restorativeyoga
MoldDetoxDiet2020©
STRESSREDUCTIONCURRENT,PAST,PTSD,LIMBICDYSFUNCTION
oMeditation/prayer
oTapping oEMDR
o12-stepprograms
oCommunitysupport
oDeepbreathingexercises
oBalancetime–havefun
oAlpha-stim
oAcupuncture
oYoga
oMassage
oExercise
oLimit“screen”time
oAvoidthenewsoremotion grabbingTVcommentary (politics)
oAvoidcaffeine
oSmallermorefrequentmeals
oBreakfastbefore10am
oAIPdietplan
oHydration
oAdaptogens
oSpirituality&yourhigher power