LEAKY BRAIN & MULTIPLE SCLEROSIS
By: Dr. Titus Chiu
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Welcome to Notes on Leaky Brain and Multiple Sclerosis.
We’ll be exploring the surprising link between concussions and MS, and what you can do about it.
[BONUS PDF] Notes on Leaky Brain and Multiple Sclerosis
Let's start with the basics. Concussions are a form of traumatic brain injury (TBI) that can occur due to sudden jolts or blows to the head. These injuries can result from various causes, such as falls, sports accidents, or motor vehicle collisions. When the brain experiences a sudden impact, it can collide with the skull, leadi ng to chemical changes and potential physical damage.
Concussions can manifest in a range of symptoms, including headaches, dizziness, confusion, memory problems, and changes in mood or behavior. The severity and duration of these sympto ms may vary depending on the extent of the injury.
The thing is, you don’t even need a head injury to experience a concussion. A hard enough blow to the body, or even whiplash can trigger in ammation in the nervous system, causing a concussion.
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Recent studies showed that a past history of concussion nearly doubles the risk for developing Multiple Sclerosis years after the original concussion [1][2].
And the risk increased with the number of concussio ns. So the more concussions, the higher the chances of developing MS.
[BONUS PDF] Notes on Leaky Brain and Multiple Sclerosis
So why does this occur?
Due to a little known structure buried deep within your brain– the blood brain barrier.
The blood-brain barrier (BBB) acts like a protective shield between your bloodstream and your brain. It's made up of cells c alled endothelial cells that line the walls of your brain's blood vessels. These cells are packed tightly together, forming a barrier that restricts the passage of most substances, including harmful ones, from entering the brain.
Concussions can disrupt the integrity of the BBB and increase its permeability– leading to what's known as "leaky brain".
With a leaky brain, toxic substances can enter the nervous system and trigger in ammation and potential autoimmunity. Thi s can create a vicious cycle where leaky brain caused by trauma leads to in ammation and damage in the brain, which in turn may contribute to the development or exacerbation of MS.
In fact, researchers have found that breakdown of the blood-brain barrier happens very early in the course of Multipl e Sclerosis– even before symptoms emerge [3].
The good news is that the BBB can be restored. And there’s evidence that when the BBB gets restored, symptoms from MS c an diminish [4].
Inshort–healing ispossible.
One simple way of healing your blood brain barrier is by eating more polyphenols. Polyphenols are naturally occurring co mpounds found in fruits and veggies that have powerful antioxidant and anti-in ammatory properties.
The following foods contain high levels of polyphenols:
• Berries (such as blueberries, strawberries, raspberries)
• Grapes (including red grapes and their skins)
• Green tea
• Cocoa (dark chocolate)
• Turmeric (curcumin)
[BONUS PDF] Notes on Leaky Brain and Multiple Sclerosis
By increasing your intake of these delicious, brain-healing compounds, you'll be one step closer to healing your brain and reclaiming your life.
Wondering if leaky brain is at the root cause of yo ur brain symptoms?
Take the doctor-designed quiz to discover your risk for leaky brain. Go to today. leakybrainquiz.com
[1] Montgomery, S., Hiyoshi, A., Burkill, S., Alfre dsson, L., Bahmanyar, S. and Olsson, T. (2017), Concussion in adolescence and risk of multiple sclerosis. Ann Neurol., 82: 554-561. https://doi.org/10.1002/ana.25036
[2] Povolo CA, Reid JN, Shariff SZ, Welk B, Morrow SA. Concussion in adolescence and the risk of multiple sclerosis: A retrospective cohort study. Multiple S clerosis Journal. 2021;27(2):180-187. doi:10.1177/1352458520908037
[3] Lutz SE, Smith JR, Kim DH, Olson CVL, Ellefsen K, Bates JM, Gandhi SP, Agalliu D. Caveolin1 Is Required for Th1 Cell In ltration, but Not Tight Junction Remodeling , at the Blood-Brain Barrier in Autoimmune Neuroin ammation. Cell Rep. 2017 Nov 21;21(8):2104-2117. doi: 10.1016/j.celrep.2017.10.094. PMID: 2916 6603; PMCID: PMC5728697.
[4] Sun Z, Zhao H, Fang D, Davis CT, Shi DS, Lei K, Rich BE, Winter JM, Guo L, Sorensen LK, Pryor RJ, Zhu N, Lu S, Dickey LL, Doty DJ, Tong Z, Thomas KR, Mueller AL, Grossmann AH, Zhang B, Lane TE, Fujinami RS, Odelbe rg SJ, Zhu W. Neuroin ammatory disease disrupts the blood-CNS barrier via crosstalk between proin ammatory and endothelial-to-mesenchymal-transition signaling. Ne uron. 2022 Oct 5;110(19):3106-3120.e7. doi: 10.1016/j.neuron.2022.07.015. Epub 2022 Aug 11. PMID: 35961320; PMCID: PMC9547934.
