Peptides for Motherhood

Peptidesfor motherhood

byDr.Jen

DR. JEN PFLEGHAAR

Integrative Medicine Physician

Hello! A little about me!

Dr Jen Pfleghaar is a double board certified physician in Integrative Medicine and Emergency Medicine. She attended medical school at Lake Erie College of Osteopathic Medicine. She then went on to residency at St Vincent’s Mercy Medical Center for Emergency Medicine and spent one year flying with Life Flight as a flight physician Dr Jen now works at local emergency rooms in the community and her office in Perrysburg, OH practicing Integrative Medicine and Medical Aesthetics. She is a graduate from The University of Arizona: Andrew Weil Center for Integrative Medicine's fellowship program Dr Jen loves speaking and lectures to physicians at conferences including the AOA (American Osteopathic Association). She hosts the podcast The Integrative Health Podcast with Dr. Jen Her own health history of Hashimoto’s (which is now in remission) sparked her interest in Integrative Medicine She is very passionate about helping patients with chronic disease and teaching them now to let the body heal itself. She is a published author of the book- Eat. Sleep. Move. Breathe: A Beginner's Guide to a Healthy Lifestyle She is a board member for IDA- Invisible Disabilities Association Her hobbies include spending time with her husband and four children, being in nature, weightlifting, wake surfing on the Maumee river and reading the Bible.

ARE YOU A BUSY MOTHER?

”We are often so stressed and anxious that it affects not only our personal health but our family. Working on our personal health will have a ripple effect to everyone around us!”

Dr. Jen

Biohacking as a mother! Here we go!

I think the hardest part about being a mother is comparing yourself to all the “other” mothers out there AND also comparing yourself to some biohacker on Instagram that has never had children. First of all comparison is the thief of joy! Don’t do it!

Live your own amazing life and know that your introduction can not be compared to someone’s else finale.

This verse helps me a lot.

“Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your request to God.” Philippians 4:6 NIV We are often so stressed and anxious that it affects not only our personal health but our family. Working on our personal health will have a ripple effect to everyone around us!

Now what to do? First (always) work on your gut health. Figure out if you have problems there first that might be making your feel tired, mess with your hormones or be causing you discomfort. You can find more information about how to heal your gut at my website www healthybydrjen com

After you have your gut health improved also make sure you are setting your sites on optimal sleep and movement These are also nonnegotiables for being optimal and biohacking as a mother

Great, now that we have all of that figured out we can move onto the peptides that can help support you as you age and support your optimal self!

What is it?

5-amino-1MQ is a compact molecule that impedes the function of nicotinamide Nmethyltransferase (NNMT), an enzyme crucial in metabolism and energy regulation, particularly within fat tissue. Through NNMT inhibition, 5-amino-1MQ stimulates the elevation of nicotinamide adenine dinucleotide (NAD+), a vital cofactor essential for cellular metabolism.

5-AMINO 1 MQ

This leads to an enhanced metabolic rate and the activation of a gene recognized as sirtuin-1 (SIRT1), commonly dubbed the "longevity gene." SIRT1 plays a role in diminishing the likelihood of numerous conditions, including diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.

Nicotinamide N-methyltransferase (NNMT) is an enzyme pivotal in cellular metabolism and energy control. Elevated NNMT levels disrupt proper metabolism, correlating with conditions like type-2 diabetes and obesity, as they hinder fat burning and promote fat accumulation.

5-amino 1 MQ cames a a pill. It’s used

1 - 3 times a day.

Oral dosing 50 - 100 mg daily

Can use with NAD+

ref: PMC5826726

What is it?

Dhh-b (dihydrohonokiol-B bioactive honokiol extracted from magnolia bark) 1-2 capsules during the day (similar anxiolytic effect of to Benzos)

Used for anxiety. Also appears to have neuroprotectice activity. Studies on neuroprotective effects

DHH-B

D I H Y D R O H O

N O K I O L - B

B I O A C T I V E

H O N O K I O L

E X T R A C T E D

F R O M

M A G N O L I A

B A R K

Research

“DHH-B is a potent anxiolytic-like agent and that GABA(A) receptorgated Cl(-)-channel complex is involved in the anxiolytic-like efficacy of DHH-B.

PMID: 11370711

DOI: 10.1211/0022357011775848

This data indicates that DHH-B demonstrates neuroprotective effects against Abeta by stimulating GABA(C) receptors

PMID: 15899548

Dosing: 10 mg one to two times daily

Pain modulation:

Some studies have explored the use of KPV-containing peptides for their analgesic (pain-relieving) properties. These peptides may interact with pain receptors or signaling pathways in the body to alleviate pain

KPV

THE KPV PEPTIDE IS A SHORT PEPTIDE SEQUENCE COMPOSED OF THREE AMINO ACIDS: LYSINE (K), PROLINE (P), AND VALINE (V).

Wound healing

Peptides containing the KPV sequence have also been investigated for their role in promoting wound healing and tissue repair. These peptides may stimulate cellular processes involved in tissue regeneration and remodeling.

Inflammation modulation

Certain peptides, including those containing the KPV sequence, have been studied for their antiinflammatory effects. These peptides may help regulate the body's immune response and reduce inflammation in various conditions.

How do you use it?

KPV comes in sprays, cream and pills

Work with your doctor to deterine what would be best for your condition

Benefits:

Anti-inflammatory Effects: BPC-157 has demonstrated antiinflammatory properties, which may contribute to its ability to reduce pain and inflammation associated with injury or conditions such as arthritis.

BPC 157

BODY PROTECTION COMPOUND-157, IS A SYNTHETIC PEPTIDE CONSISTING OF 15 AMINO ACIDS

Sccelerated Healing: BPC-157 has been shown in animal studies to promote the healing of various tissues, including muscle, tendon, ligament, and bone It may stimulate the formation of new blood vessels (angiogenesis) and enhance the regeneration of damaged tissues

Gastrointestinal Health: Research suggests that BPC-157 may have protective effects on the gastrointestinal tract, promoting the healing of ulcers and other digestive disorders.

Joint Health: BPC-157 has shown promise in protecting and repairing cartilage and other joint tissues, making it potentially beneficial for conditions like osteoarthritis and sports-related injuries.

How it works:

Insulin secretion: GLP-1 stimulates the release of insulin from pancreatic beta cells in response to elevated blood glucose levels. This helps to lower blood sugar levels after meals, preventing hyperglycemia.

G L U C A G O N -

L I K E P E P T I D E - 1

( G L P - 1 ) I S A

H O R M O N E

P R O D U C E D I N

T H E

I N T E S T I N E S ,

S P E C I F I C A L L Y

I N T H E

I N T E S T I N A L L -

C E L L S , I N

R E S P O N S E T O

F O O D I N T A K E .

Glucagon inhibition: GLP-1 suppresses the secretion of glucagon from pancreatic alpha cells. Glucagon normally raises blood sugar levels by promoting the breakdown of glycogen in the liver, so inhibiting its release helps to prevent excessive glucose production

Slowing gastric emptying: GLP-1 slows down the rate at which food moves through the stomach and into the intestines. This helps to regulate the absorption of nutrients and glucose from the digestive system, contributing to better blood sugar control

Satiety: GLP-1 also acts on the brain to promote feelings of fullness and satiety, which can help to reduce food intake and contribute to weight management

Benefits

May have synergistic effects on improving glucose metabolism and insulin secretion By targeting multiple pathways involved in blood sugar regulation, GLP-1/GIP peptides may offer potential therapeutic benefits for conditions such as type 2 diabetes mellitus and obesity.

GLP-1/GIP

G L P - 1 / G I P

P E P T I D E R E F E R S

T O A

C O M B I N A T I O N

O F T W O

P E P T I D E S :

G L U C A G O N - L I K E

P E P T I D E - 1 ( G L P -

1 ) A N D G A S T R I C

I N H I B I T O R Y

P O L Y P E P T I D E

( G I P .

GLP-1 is a hormone produced by the intestines in response to food intake. It plays a crucial role in regulating blood sugar levels by stimulating insulin secretion from pancreatic beta cells, inhibiting glucagon secretion (which helps lower blood sugar), slowing gastric emptying, and promoting satiety.

GIP, also known as glucosedependent insulinotropic peptide, is another hormone produced by the intestines in response to nutrient ingestion Its primary role is to stimulate insulin release from pancreatic beta cells in response to elevated blood glucose levels

Zepbound Monjaro

Should work with a doctor to prescribe and get you ready to be on these peptides!

How does it work?

GHRH peptides work by binding to specific receptors on the surface of somatotropic cells in the pituitary gland, triggering a cascade of signaling events that ultimately result in the release of growth hormone into the bloodstream.

Stimulation of Growth

Growth hormone plays a crucial role in promoting growth and development during childhood and adolescence. GHRH peptides may be used therapeutically to stimulate growth in children with growth hormone deficiency or other growth disorders Growth hormone is known to have anabolic effects on skeletal muscle, promoting muscle growth, repair, and recovery. GHRH peptides may be used by athletes and bodybuilders to enhance muscle growth and improve athletic performance

GHR PEPTIDES

GROWTH HORMONERELEASING HORMONE (GHRH) PEPTIDES ARE A CLASS OF COMPOUNDS THAT STIMULATE THE RELEASE OF GROWTH HORMONE (GH) FROM THE PITUITARY GLAND IN THE BRAIN.

Regulation of Metabolism

Growth hormone influences metabolism by promoting the breakdown of fats (lipolysis) and stimulating the production of insulinlike growth factor 1 (IGF-1), which mediates many of the metabolic effects of growth hormone. GHRH peptides may be used to enhance metabolism and promote fat loss in certain individuals.

Other things

Anti-aging Effects: Growth hormone has been implicated in the aging process, and declining levels of growth hormone are associated with age-related changes in body composition, metabolism, and physical function Some individuals use GHRH peptides as part of antiaging or rejuvenation therapies to restore youthful levels of growth hormone and mitigate age-related decline

Cognitive Function: There is evidence to suggest that growth hormone may play a role in cognitive function and brain health. GHRH peptides have been studied for their potential cognitive-enhancing effects and may be of interest in the field of cognitive aging and neurodegenerative diseases

Benefits:

Stimulating Collagen Production: GHK-Cu is believed to promote the synthesis of collagen, a protein essential for maintaining the structure and elasticity of the skin. Increased collagen production can lead to smoother, firmer skin and a reduction in the appearance of wrinkles and fine lines.

GHK-CU

G H K - C U , A L S O K N O W N

A S C O P P E R P E P T I D E

G H K - C U , I S A P E P T I D E

C O M P O S E D O F T H R E E

A M I N O A C I D S :

G L Y C Y L - H I S T I D Y L -

L Y S I N E W I T H A

C O P P E R ( C U )

M O L E C U L E A T T A C H E D .

I T O C C U R S

N A T U R A L L Y I N T H E

B O D Y A N D I S F O U N D

I N V A R I O U S T I S S U E S ,

I N C L U D I N G T H E

B L O O D P L A S M A , S A L I V A , A N D U R I N E

Enhancing Wound Healing: GHK-Cu has been shown to accelerate wound healing by promoting the migration of skin cells, reducing inflammation, and stimulating the production of growth factors involved in tissue repair.

Antioxidant Activity: GHK-Cu exhibits antioxidant properties, which help protect skin cells from oxidative stress caused by free radicals. This antioxidant activity may contribute to its anti-aging effects and ability to improve skin texture and tone.

Hair Growth Stimulation: Some research suggests that GHK-Cu may promote hair growth by stimulating the proliferation of hair follicle cells and prolonging the anagen (growth) phase of the hair growth cycle.

Benefits:

Improves glucose uptake, improved insulin secretion, reduces stress and anxiety, increases with exercises, regulates appetite, increases with mindfulness and human connection.

OXYTOCIN

O X Y T O C I N I S A

H O R M O N E A N D

N E U R O T R A N S M I T T E R

O F T E N R E F E R R E D T O

A S T H E " L O V E

H O R M O N E " O R

" B O N D I N G H O R M O N E "

D U E T O I T S R O L E I N

S O C I A L B O N D I N G ,

T R U S T , A N D

E M O T I O N A L

C O N N E C T I O N .

Where is it produced?

Produced primarily in the hypothalamus region of the brain and released by the pituitary gland, oxytocin plays a crucial role in various physiological and psychological processes.

How to take it:

A nasal spray is the most common way to take it with doses ranging from 10 - 100 units Work with your doctor for dosing!

When to use it:

Some people pair it with PT-141 for arousal amd intimacy indications. There have been studies on oxytocins role in autism.

WHERETOGETPEPTIDES?

LVLUPA

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Integrative Peptides

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Healthgevity

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NEXT STEPS!

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I can’t wait to work with you!

Dr. Jen